Sotalol in the treatment of fetal dysrhythmias.

abstract：BACKGROUND:The cellular content of cAMP generated by activation of adenylylcyclase (AC) through the beta-adrenergic receptor (betaAR) is a key determinant of a cell's response to catecholamine stimulation. We tested the hypothesis that increased AC content, independently of betaAR number, increases responsiveness to ca...

journal_title：Circulation

authors： Gao MH,Lai NC,Roth DM,Zhou J,Zhu J,Anzai T,Dalton N,Hammond HK

更新日期：1999-03-30 00:00:00

abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) reduces body weight and cardiovascular mortality in morbidly obese patients. Glucagon-like peptide-1 (GLP-1) seems to mediate the metabolic benefits of RYGB partly in a weight loss-independent manner. The present study investigated in rats and patients whether obesity-induced ...

journal_title：Circulation

authors： Osto E,Doytcheva P,Corteville C,Bueter M,Dörig C,Stivala S,Buhmann H,Colin S,Rohrer L,Hasballa R,Tailleux A,Wolfrum C,Tona F,Manz J,Vetter D,Spliethoff K,Vanhoutte PM,Landmesser U,Pattou F,Staels B,Matter CM,Lut

更新日期：2015-03-10 00:00:00

abstract：BACKGROUND:After cardiopulmonary bypass (CPB), pulmonary hypertension and its associated increased vascular reactivity are a major source of morbidity, particularly for children with increased pulmonary blood flow. Although post-CPB pulmonary hypertension is well described, its mechanisms remain incompletely understood...

journal_title：Circulation

authors： Reddy VM,Hendricks-Munoz KD,Rajasinghe HA,Petrossian E,Hanley FL,Fineman JR

更新日期：1997-02-18 00:00:00

abstract：BACKGROUND:Improvements are known to occur in right ventricular (RV) ejection fraction after the use of a left ventricular assist device (LVAD); less is known, however, about the mechanism of this improvement. The concept of ventricular/arterial coupling was applied to investigate whether systolic pump function or afte...

journal_title：Circulation

authors： Morita S,Kormos RL,Mandarino WA,Eishi K,Kawai A,Gasior TA,Deneault LG,Armitage JM,Hardesty RL,Griffith BP

更新日期：1992-11-01 00:00:00

abstract：:The importance of pulmonary artery size and the value of a standardized pulmonary artery index (PAI) in predicting outcome after Fontan's repair have previously been reported and questioned. We retrospectively reviewed 29 patients undergoing modified Fontan repair at The Children's Hospital of Philadelphia to examine ...

journal_title：Circulation

authors： Bridges ND,Farrell PE Jr,Pigott JD 3rd,Norwood WI,Chin AJ

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:There are few comparative data regarding long-term nonfatal outcomes for women versus men after coronary artery bypass grafting (CABG). This study compares gender differences in cardiac events in a population of hospital survivors up to 11 years after isolated CABG surgery in Ontario, Canada. METHODS AND RE...

journal_title：Circulation

authors： Guru V,Fremes SE,Austin PC,Blackstone EH,Tu JV

更新日期：2006-01-31 00:00:00

abstract：BACKGROUND:Enteroviruses (EVs) and adenoviruses (ADVs) have been considered common causes of myocarditis and dilated cardiomyopathy. In the present study, we report on the association of parvovirus B19 (PVB19) genomes in the clinical setting of acute myocarditis. METHODS AND RESULTS:This study included 24 consecutive ...

journal_title：Circulation

authors： Kühl U,Pauschinger M,Bock T,Klingel K,Schwimmbeck CP,Seeberg B,Krautwurm L,Poller W,Schultheiss HP,Kandolf R

更新日期：2003-08-26 00:00:00

abstract：BACKGROUND:Combining 2 signals of cardiomyocyte injury, cardiac troponin I (cTnI) and T (cTnT), might overcome some individual pathophysiological and analytical limitations and thereby increase diagnostic accuracy for acute myocardial infarction with a single blood draw. We aimed to evaluate the diagnostic performance ...

journal_title：Circulation

authors： van der Linden N,Wildi K,Twerenbold R,Pickering JW,Than M,Cullen L,Greenslade J,Parsonage W,Nestelberger T,Boeddinghaus J,Badertscher P,Rubini Giménez M,Klinkenberg LJJ,Bekers O,Schöni A,Keller DI,Sabti Z,Puelacher C,

更新日期：2018-09-04 00:00:00

abstract：BACKGROUND:This study proposes 2 new echocardiographic indices with potential application in acute coronary artery occlusion to differentiate between viable and necrotic myocardium and to identify reperfusion. We investigated whether the ratio between systolic lengthening and combined late and postsystolic shortening (...

journal_title：Circulation

authors： Lyseggen E,Skulstad H,Helle-Valle T,Vartdal T,Urheim S,Rabben SI,Opdahl A,Ihlen H,Smiseth OA

更新日期：2005-12-20 00:00:00

abstract：:The effects of verapamil (0.02-0.2 mg/kg) on contractility in normal and partially ischemic myocardium were compared with the changes following propranolol (0.01-1.0 mg/kg). Regional contractile function was studied in open-chest dogs with ultrasonic crystals and ischemia was controlled by graded occlusion of a caroti...

journal_title：Circulation

authors： Smith HJ,Goldstein RA,Griffith JM,Kent KM,Epstein SE

更新日期：1976-10-01 00:00:00

abstract：:The loss of coronary vasodilator reserve after ischemia-reperfusion may be due to endothelial injury, and this vascular dysfunction may contribute to functional alterations observed after ischemia. To determine whether endothelial dysfunction occurs after relatively brief periods of moderate low-flow ischemia in vivo,...

journal_title：Circulation

authors： Headrick JP,Angello DA,Berne RM

更新日期：1990-12-01 00:00:00

abstract：:This study describes the efficacy of the right gastroepiploic artery (GEA) as graft material for coronary artery bypass grafting (CABG) as assessed by exercise thallium 201 myocardial scintigraphy in eight patients (age, 59.4 +/- 9.35 years [mean +/- SD]) who underwent CABG with the GEA graft in the past 2 years. Plan...

journal_title：Circulation

authors： Kusukawa J,Hirota Y,Kawamura K,Suma H,Takeuchi A,Adachi I,Akagi H

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:A paucity of literature is available on the effects of age and coronary artery bypass grafting (CABG) on the outcomes of patients undergoing mitral valve (MV) repair versus replacement. METHODS AND RESULTS:A matched study was performed using prospectively collected data from the Emory cardiovascular databas...

journal_title：Circulation

authors： Thourani VH,Weintraub WS,Guyton RA,Jones EL,Williams WH,Elkabbani S,Craver JM

更新日期：2003-07-22 00:00:00

abstract：:In a study of 307 white patients who underwent coronary angiography, the relationship of coronary artery disease (CAD) to plasma levels of lipoprotein Lp(a) and other lipid-lipoprotein variables was examined. Lp(a) resembles low-density lipoprotein (LDL) in several ways, but can be distinguished and quantified by elec...

journal_title：Circulation

authors： Dahlen GH,Guyton JR,Attar M,Farmer JA,Kautz JA,Gotto AM Jr

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Radiofrequency catheter ablation is the treatment of choice for patients with paroxysmal supraventricular tachycardias refractory to medical therapy. However, in symptomatic patients with inappropriate sinus tachycardia resistant to drug therapy, catheter ablation of the His' bundle with permanent pacemaker ...

journal_title：Circulation

authors： Lee RJ,Kalman JM,Fitzpatrick AP,Epstein LM,Fisher WG,Olgin JE,Lesh MD,Scheinman MM

更新日期：1995-11-15 00:00:00

abstract：:The capability of a pulsed Doppler flowmeter combined with a phased-array imaging system to measure volume flow was tested in vitro and in patients undergoing cardiac catheterization. The Doppler-phased-array system (DPA) was used to determine vessel diameter and a superimposed cursor was used to locate the range and ...

journal_title：Circulation

authors： Magnin PA,Stewart JA,Myers S,von Ramm O,Kisslo JA

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:Elevated pulse pressure is associated strongly with adverse cardiovascular outcome; however, the genetic basis of this condition is unknown. This study examined whether genotypic variation in the extracellular matrix protein fibrillin-1, the Marfan gene, was associated with aortic stiffening and therefore co...

journal_title：Circulation

authors： Medley TL,Cole TJ,Gatzka CD,Wang WY,Dart AM,Kingwell BA

更新日期：2002-02-19 00:00:00

abstract：BACKGROUND:Inducible nitric oxide synthase (iNOS, or NOS2) reduces the severity of accelerated graft arteriosclerosis (AGA) in transplanted organs, although the precise mechanism is unclear. METHODS AND RESULTS:We transplanted wild-type murine hearts into either wild-type or NOS2-null recipient mice; we then measured ...

journal_title：Circulation

authors： Qian Z,Gelzer-Bell R,Yang Sx SX,Cao W,Ohnishi T,Wasowska BA,Hruban RH,Rodriguez ER,Baldwin WM 3rd,Lowenstein CJ

更新日期：2001-11-06 00:00:00

abstract：:This review of the clinical studies of thromboxane synthase inhibitors (TXSIs) and thromboxane receptor blocking drugs (TXRBs) covers the years 1981 to the present. Clinical studies on TXSIs include those in normal volunteers as well as those in patients with angina, peripheral vascular disease and Raynaud's syndrome,...

journal_title：Circulation

authors： Fiddler GI,Lumley P

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:A recent study has shown that the implantable atrial defibrillator can restore sinus rhythm in patients with recurrent atrial fibrillation when therapy was delivered under physician observation. The objective of this study was to evaluate the safety and efficacy of ambulatory use of the implantable atrial de...

journal_title：Circulation

authors： Daoud EG,Timmermans C,Fellows C,Hoyt R,Lemery R,Dawson K,Ayers GM

更新日期：2000-09-19 00:00:00

abstract：:As the appreciation of structural heart disease in children and adults has increased and as catheter-based closure procedures are now being performed in clinical practice, cardiovascular physicians have multiple compelling new reasons to better understand cardiac anatomic and spatial relationships. Current 2-dimension...

journal_title：Circulation

authors： Kim MS,Hansgen AR,Wink O,Quaife RA,Carroll JD

更新日期：2008-05-06 00:00:00

abstract：:We assessed factors during an initial episode of ventricular fibrillation that may be predictive of recurrence. Of 141 consecutive patients with acute ischemic heart disease who survived an initial episode of ventricular fibrillation, 41 (29%) had recurrent ventricular fibrillation during hospitalization. The incidenc...

journal_title：Circulation

authors： Logan KR,McIlwaine WJ,Adgey AA,Pantridge JF

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) in inflamed atherosclerotic plaques may contribute to extracellular matrix remodeling and the onset of acute thrombotic complications. METHODS AND RESULTS:To test the hypothesis that optical molecular imaging with the use of an activatable near-infrared fluorescence (NIRF) p...

journal_title：Circulation

authors： Deguchi JO,Aikawa M,Tung CH,Aikawa E,Kim DE,Ntziachristos V,Weissleder R,Libby P

更新日期：2006-07-04 00:00:00

abstract：:We assessed the reversibility of functional and morphological changes of arterialized vein segments by returning them to the venous circulation. Thirteen dogs underwent right carotid and femoral veno-arterial grafting. After 12 weeks, veno-arterial grafts were removed for contractility (norepinephrine [NE] and 5-hydro...

journal_title：Circulation

authors： Fann JI,Sokoloff MH,Sarris GE,Yun KL,Kosek JC,Miller DC

更新日期：1990-11-01 00:00:00

abstract：:The ability to quantify the quality of cardiovascular care critically depends on the translation of recommendations for high-quality care into the measurement of that care. As payers and regulatory agencies increasingly seek to quantify healthcare quality, the implications of the measurement process on practicing phys...

journal_title：Circulation

authors： Spertus JA,Eagle KA,Krumholz HM,Mitchell KR,Normand SL,American College of Cardiology.,American Heart Association Task Force on Performance Measures.

更新日期：2005-04-05 00:00:00

abstract：:Mitral valve closure during cardiopulmonary resuscitation may result from direct cardiac compression. An alternative hypothesis is that with a rise in intrathoracic pressure, mitral valve closure can occur but may be influenced by whether the lungs are inflated or deflated. To test this hypothesis, we placed a large-b...

journal_title：Circulation

authors： Halperin HR,Weiss JL,Guerci AD,Chandra N,Tsitlik JE,Brower R,Beattie C,Wurmb E,Cadden J,Weisfeldt ML

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:The maternal circulatory system and hormone balance both change dynamically during pregnancy, delivery, and the postpartum period. Although atrial natriuretic peptides and brain natriuretic peptides produced in the heart control circulatory homeostasis through their common receptor, NPR1, the physiologic and...

journal_title：Circulation

authors： Otani K,Tokudome T,Kamiya CA,Mao Y,Nishimura H,Hasegawa T,Arai Y,Kaneko M,Shioi G,Ishida J,Fukamizu A,Osaki T,Nagai-Okatani C,Minamino N,Ensho T,Hino J,Murata S,Takegami M,Nishimura K,Kishimoto I,Miyazato M,Hara

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:The extent of the peri-infarct zone by magnetic resonance imaging (MRI) has been related to all-cause mortality in patients with coronary artery disease. This relationship may result from arrhythmogenesis in the infarct border. However, the relationship between tissue heterogeneity in the infarct periphery a...

journal_title：Circulation

authors： Schmidt A,Azevedo CF,Cheng A,Gupta SN,Bluemke DA,Foo TK,Gerstenblith G,Weiss RG,Marbán E,Tomaselli GF,Lima JA,Wu KC

更新日期：2007-04-17 00:00:00

abstract：BACKGROUND:Endothelin (ET), a coronary vasoconstrictor, mediates its activity through the specific receptors ET-A and ET-B, which may demonstrate different activity under pathophysiological conditions. Thoracic inferior vena cava constriction (TIVCC) is an experimental model of congestive heart failure that is characte...

journal_title：Circulation

authors： Cannan CR,Burnett JC Jr,Lerman A

更新日期：1996-02-15 00:00:00

abstract：BACKGROUND:Left ventricular (LV) reconstruction surgery leads to early improvement in LV function in ischemic cardiomyopathy (ICM) patients. This study was designed to evaluate the impact of mitral valve (MV) repair associated with LV reconstruction on LV function 1-year after surgery in ICM patients assessed by real-t...

journal_title：Circulation

authors： Qin JX,Shiota T,McCarthy PM,Asher CR,Hail M,Agler DA,Popović ZB,Greenberg NL,Smedira NG,Starling RC,Young JB,Thomas JD

更新日期：2003-09-09 00:00:00