Iron-load increases the susceptibility of rat hearts to oxygen reperfusion damage. Protection by the antioxidant (+)-cyanidanol-3 and deferoxamine.

abstract：BACKGROUND:Previous experimental studies have shown that nitric oxide (NO) modulates cardiac function by an abbreviation of systolic contraction and an enhancement of diastolic relaxation. However, the response to NO donors of patients with severe pressure-overload hypertrophy and diastolic dysfunction is unknown. MET...

journal_title：Circulation

authors： Matter CM,Mandinov L,Kaufmann PA,Vassalli G,Jiang Z,Hess OM

更新日期：1999-05-11 00:00:00

abstract：BACKGROUND:Angiogenic placental growth factor (PlGF) concentrations rise during pregnancy, peaking at the end of midpregnancy. Low PlGF concentrations during pregnancy are associated with pregnancy complications with recognized later-life cardiovascular risk. We hypothesized that low PlGF concentrations, especially in ...

journal_title：Circulation

authors： Benschop L,Schalekamp-Timmermans S,Broere-Brown ZA,Roeters van Lennep JE,Jaddoe VWV,Roos-Hesselink JW,Ikram MK,Steegers EAP,Roberts JM,Gandley RE

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:The effect of isoproterenol on increasing the peak amplitude of the L-type calcium current is reduced in myocytes dispersed from the epicardial border zone (EBZ) of the 5-day infarcted canine heart when compared with control cells from noninfarcted hearts. This suggests that specific alterations in the beta-...

journal_title：Circulation

authors： Steinberg SF,Zhang H,Pak E,Pagnotta G,Boyden PA

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Erosion and rupture of coronary atheromas are the events preceding the vast majority of acute coronary syndromes. The shoulder regions of atheromas, the sites at which erosion or rupture is most likely to occur, are the sites at which mast cells accumulate. These cells are filled with neutral proteases capab...

journal_title：Circulation

authors： Kovanen PT,Kaartinen M,Paavonen T

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Electrophysiological mechanisms by which adenosine may activate cardiac afferent neurons are unknown. Slow afterhyperpolarizations (AHPs) follow action potentials in a subset of vagal C afferents, rendering them inexcitable. The purpose of this study was to test the hypothesis that adenosine increases vagal ...

journal_title：Circulation

authors： Middlekauff HR,Doering A,Weiss JN

更新日期：2001-03-06 00:00:00

abstract：BACKGROUND:Systemic administration of heparin can decrease mortality and morbidity of acute ischemic coronary syndromes such as unstable angina and myocardial infarction. Hemorrhage is the major limiting factor in the clinical use of systemic heparin. The objective of the present study was to determine whether local de...

journal_title：Circulation

authors： Nunes GL,Thomas CN,Hanson SR,Barry JJ,King SB 3rd,Scott NA

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Administration of aprotinin during extracorporeal circulation reduces blood loss and improves platelet function. METHODS AND RESULTS:To evaluate the protective effect of aprotinin on platelets, 50 patients undergoing cardiopulmonary bypass were randomized before surgery to one of three groups. Seventeen pat...

journal_title：Circulation

authors： Mohr R,Goor DA,Lusky A,Lavee J

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Platelet activation plays a pivotal role in the pathogenesis of acute coronary disease. Monocytes are involved in the progression of atherosclerosis and are potent activators of blood coagulation through their ability to synthesize tissue factor (TF). The aim of this study was to compare markers of monocyte ...

journal_title：Circulation

authors： Jude B,Agraou B,McFadden EP,Susen S,Bauters C,Lepelley P,Vanhaesbroucke C,Devos P,Cosson A,Asseman P

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Assessment of systemic right ventricular (RV) function is a key point in the follow-up of patients with transposition of the great arteries (TGA). Current echocardiographic assessment of RV function is at best an estimate, and cardiac magnetic resonance (CMR) is considered the gold standard. However, this te...

journal_title：Circulation

authors： Salehian O,Schwerzmann M,Merchant N,Webb GD,Siu SC,Therrien J

更新日期：2004-11-16 00:00:00

abstract：BACKGROUND:Brain natriuretic peptide is a novel natriuretic peptide that is secreted predominantly from the ventricles, and its plasma levels have been shown to be markedly increased in patients with chronic congestive heart failure. This study was designed to examine the plasma levels of brain natriuretic peptide as w...

journal_title：Circulation

authors： Morita E,Yasue H,Yoshimura M,Ogawa H,Jougasaki M,Matsumura T,Mukoyama M,Nakao K

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:The atrioventricular (AV) node is insensitive to changes in extracellular potassium concentration, [K+]o, because of the absence of the inward rectifier potassium current (IK1). However, we propose that in the presence of adenosine, elevated [K+]o should increase the adenosine-activated inward rectifier pota...

journal_title：Circulation

authors： Martynyuk AE,Morey TE,Belardinelli L,Dennis DM

更新日期：1999-01-19 00:00:00

abstract：BACKGROUND:Observational studies suggest that there are differences in adherence to antihypertensive medications in different classes. Our objective was to quantify the association between antihypertensive drug class and adherence in clinical settings. METHODS AND RESULTS:Studies were identified through a systematic s...

journal_title：Circulation

authors： Kronish IM,Woodward M,Sergie Z,Ogedegbe G,Falzon L,Mann DM

更新日期：2011-04-19 00:00:00

abstract：BACKGROUND:Thiazolidinediones have been reported to protect against ischemia-reperfusion injury. Their protective actions are considered to be peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-dependent; however, it is unclear how PPAR-gamma activation confers resistance to ischemia-reperfusion injury. MET...

journal_title：Circulation

authors： Wu JS,Cheung WM,Tsai YS,Chen YT,Fong WH,Tsai HD,Chen YC,Liou JY,Shyue SK,Chen JJ,Chen YE,Maeda N,Wu KK,Lin TN

更新日期：2009-03-03 00:00:00

abstract：BACKGROUND:Dynamic intraventricular flow velocities after valve replacement for aortic stenosis have been associated with high in-hospital morbidity and mortality. The aims of the present study were to determine the mechanisms and preoperative predictors of abnormal flow velocity (AFV) after valve replacement for aorti...

journal_title：Circulation

authors： Bartunek J,Sys SU,Rodrigues AC,van Schuerbeeck E,Mortier L,de Bruyne B

更新日期：1996-02-15 00:00:00

abstract：BACKGROUND:In patients with mitral stenosis, reduced cardiac output or altered pulmonary hemodynamics may increase sympathetic nerve activity. However, the magnitude of the increase in sympathetic activity in such patients and the effect of valvuloplasty on this activity are unknown. METHODS AND RESULTS:We microneurog...

journal_title：Circulation

authors： Ashino K,Gotoh E,Sumita S,Moriya A,Ishii M

更新日期：1997-11-18 00:00:00

abstract：BACKGROUND:The wide range of clinical presentation of orthostatic vasovagal syncope suggests different underlying changes in the cardiac autonomic modulation. METHODS AND RESULTS:To evaluate the beat-by-beat modifications in the neural control of heart period preceding a syncopal event, we studied RR interval variabil...

journal_title：Circulation

authors： Furlan R,Piazza S,Dell'Orto S,Barbic F,Bianchi A,Mainardi L,Cerutti S,Pagani M,Malliani A

更新日期：1998-10-27 00:00:00

abstract：BACKGROUND:Prolonged survival of xenografted neonatal cardiomyocytes was achieved by blocking the CD28/B7 costimulatory pathway via CTLA4-Ig gene transfer. We examined the long-term survival of xenografted neonatal cardiomyocytes by adenovirus-mediated CTLA4-Ig expression and transient CD40 blockade with anti-CD40L mon...

journal_title：Circulation

authors： Li TS,Ito H,Kajiwara K,Hamano K

更新日期：2003-10-07 00:00:00

abstract：BACKGROUND:Recombinant DNA technologies have facilitated the development of a set of polymorphic DNA markers covering the human genome. General linkage analysis in families predisposed to inherited disease is now feasible. Linkage analysis can help identify a disease gene even when relatively little is known about the ...

journal_title：Circulation

authors： Keating M

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Recently, it has been shown that stem/progenitor cells may repair damaged/lost endothelial cells in vein grafts and wire-injured arteries. In the present study, we investigated endothelial cell turnover and regeneration in apolipoprotein E (apoE)(-/-)/transgenic mice carrying LacZ genes driven by an endothel...

journal_title：Circulation

authors： Foteinos G,Hu Y,Xiao Q,Metzler B,Xu Q

更新日期：2008-04-08 00:00:00

abstract：BACKGROUND:During heart development, the ventricular activation sequence changes from a base-to-apex to an apex-to-base pattern. We investigated the possibility of impulse propagation through remnants of atrioventricular (AV) connections in quail hearts. METHODS AND RESULTS:In 86 hearts (group A, HH30-34, n=15; group ...

journal_title：Circulation

authors： Kolditz DP,Wijffels MC,Blom NA,van der Laarse A,Markwald RR,Schalij MJ,Gittenberger-de Groot AC

更新日期：2007-01-02 00:00:00

abstract：BACKGROUND:Recently, it was shown that intraindividual variation in low-density lipoprotein cholesterol (LDL-C) predicts both cerebrovascular and cardiovascular events. We aimed to examine whether this extends to cognitive function and examined possible pathways using a magnetic resonance imaging substudy. METHODS:We ...

journal_title：Circulation

authors： Smit RA,Trompet S,Sabayan B,le Cessie S,van der Grond J,van Buchem MA,de Craen AJ,Jukema JW

更新日期：2016-07-19 00:00:00

abstract：BACKGROUND:Cardiac troponin and B-type natriuretic peptide (BNP) concentrations are associated with adverse cardiovascular outcome in primary prevention populations. Whether statin therapy modifies this association is poorly understood. METHODS AND RESULTS:We measured high-sensitivity cardiac troponin I (hsTnI) in 12 ...

journal_title：Circulation

authors： Everett BM,Zeller T,Glynn RJ,Ridker PM,Blankenberg S

更新日期：2015-05-26 00:00:00

abstract：:Four revolutions are transforming the cardiology of our day. The first is a social revolution. It has resulted in plummeting esteem for the medical profession reflecting disenchantment coupled with the rapid emergence of the recognition that health care is a right rather than a privilege. The second revolution, interv...

journal_title：Circulation

authors： Sobel BE

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:The outcome of resuscitated patients after cardiac arrest complicating acute myocardial infarction remains poor, primarily because of the relatively low success rates of cardiopulmonary resuscitation management. Existing data suggest potential beneficial effects of early myocardial reperfusion, but the predi...

journal_title：Circulation

authors： Garot P,Lefevre T,Eltchaninoff H,Morice MC,Tamion F,Abry B,Lesault PF,Le Tarnec JY,Pouges C,Margenet A,Monchi M,Laurent I,Dumas P,Garot J,Louvard Y

更新日期：2007-03-20 00:00:00

abstract：BACKGROUND:Increased plasma levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been identified as predictors of cardiac dysfunction and prognosis in congestive heart failure and ischemic heart disease. In severe sepsis patients, however, no information is available yet about the prognos...

journal_title：Circulation

authors： Brueckmann M,Huhle G,Lang S,Haase KK,Bertsch T,Weiss C,Kaden JJ,Putensen C,Borggrefe M,Hoffmann U

更新日期：2005-07-26 00:00:00

abstract：BACKGROUND:Venous coronary artery bypass grafts (CABGs) are prone to accelerated atherosclerosis. In atherosclerotic diseases, serum C-reactive protein (CRP) levels have become an important diagnostic and prognostic marker. The origin of CRP in this setting remains to be elucidated. METHODS AND RESULTS:Monoclonal anti...

journal_title：Circulation

authors： Jabs WJ,Theissing E,Nitschke M,Bechtel JF,Duchrow M,Mohamed S,Jahrbeck B,Sievers HH,Steinhoff J,Bartels C

更新日期：2003-09-23 00:00:00

abstract：BACKGROUND:Traditional risk factors have been linked to atherosclerotic heart disease in women. However, the effect of risk factors and menopausal status on the mechanism of sudden coronary death is unknown. METHODS AND RESULTS:We examined 51 cases of sudden coronary death and 15 hearts from women who died of trauma. ...

journal_title：Circulation

authors： Burke AP,Farb A,Malcom GT,Liang Y,Smialek J,Virmani R

更新日期：1998-06-02 00:00:00

abstract：BACKGROUND:The optimal strategy for treating coronary bifurcation lesions remains a subject of debate. With bare-metal stents, single-stent approaches appear to be superior to systematic 2-stent strategies. Drug-eluting stents, however, have low rates of restenosis and might offer improved outcomes with complex stentin...

journal_title：Circulation

authors： Hildick-Smith D,de Belder AJ,Cooter N,Curzen NP,Clayton TC,Oldroyd KG,Bennett L,Holmberg S,Cotton JM,Glennon PE,Thomas MR,Maccarthy PA,Baumbach A,Mulvihill NT,Henderson RA,Redwood SR,Starkey IR,Stables RH

更新日期：2010-03-16 00:00:00

abstract：BACKGROUND:Endothelial dysfunction may contribute to the risk of premature atherosclerosis in patients with diabetes. Endothelin (ET-1) may be involved in this process by activating smooth muscle cell mitogenesis and leukocyte adhesion. We sought to assess the activity of endogenous ET-1 in a group of patients with typ...

journal_title：Circulation

authors： Cardillo C,Campia U,Bryant MB,Panza JA

更新日期：2002-10-01 00:00:00

abstract：:The continuity equation suggests that a ratio of velocities at two different cardiac valves is inversely proportional to the ratio of cross-sectional areas of the valves. To determine whether a ratio of mitral/aortic valve orifice velocities is useful in determining aortic valve area in patients with aortic stenosis, ...

journal_title：Circulation

authors： Richards KL,Cannon SR,Miller JF,Crawford MH

更新日期：1986-05-01 00:00:00