Abstract:
BACKGROUND:Altered composition of the gut microbiota is involved in both the onset and progression of obesity and diabetes mellitus. However, the link between gut microbiota and obesity-related cardiovascular complications has not been explored. The present study was designed to investigate the role of Akkermansia muciniphila, a mucin-degrading bacterium with beneficial effects on metabolism, in the pathogenesis of atherosclerosis in apolipoprotein E-deficient (Apoe(-/-)) mice. METHODS AND RESULTS:Apoe(-/-) mice on normal chow diet or a Western diet were treated with A muciniphila by daily oral gavage for 8 weeks, followed by histological evaluations of atherosclerotic lesion in aorta. Real-time polymerase chain reaction analysis demonstrated that the fecal abundance of A muciniphila was significantly reduced by Western diet. Replenishment with A muciniphila reversed Western diet-induced exacerbation of atherosclerotic lesion formation without affecting hypercholesterolemia. A muciniphila prevented Western diet-induced inflammation in both the circulation and local atherosclerotic lesion, as evidenced by reduced macrophage infiltration and expression of proinflammatory cytokines and chemokines. These changes were accompanied by a marked attenuation in metabolic endotoxemia. A muciniphila-mediated reduction in circulating endotoxin level could be attributed to the induction of intestinal expression of the tight junction proteins (zona occuldens protein-1 and occludin), thereby reversing Western diet-induced increases in gut permeability. Long-term infusion of endotoxin to Apoe(-/-) mice reversed the protective effect of A muciniphila against atherosclerosis. CONCLUSION:A muciniphila attenuates atherosclerotic lesions by ameliorating metabolic endotoxemia-induced inflammation through restoration of the gut barrier.
journal_name
Circulationjournal_title
Circulationauthors
Li J,Lin S,Vanhoutte PM,Woo CW,Xu Adoi
10.1161/CIRCULATIONAHA.115.019645subject
Has Abstractpub_date
2016-06-14 00:00:00pages
2434-46issue
24eissn
0009-7322issn
1524-4539pii
CIRCULATIONAHA.115.019645journal_volume
133pub_type
杂志文章相关文献
CIRCULATION文献大全abstract::An isolated perfused working rat heart model was used to investigate the extent to which various protective agents, used either singly or in combination, were able to increase the resistance of the heart to periods of transient ischemia. The aim of the studies was to develop a solution which, if infused into the coron...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.54.2.193
更新日期:1976-08-01 00:00:00
abstract:BACKGROUND:AL amyloidosis with heart failure is associated with decreased longitudinal myocardial contraction measured by pulsed tissue Doppler imaging. We sought to clarify whether new modalities of myocardial strain Doppler (change in length per unit length) or strain rate (the temporal derivative of strain) were mor...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.CIR.0000068313.67758.4F
更新日期:2003-05-20 00:00:00
abstract:BACKGROUND:Several noninvasive methods are available to investigate the severity of extracoronary atherosclerotic disease. No population-based study has yet examined whether differences exist between these measures with regard to their predictive value for myocardial infarction (MI) or whether a given measure of athero...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000120708.59903.1B
更新日期:2004-03-09 00:00:00
abstract::The effects of verapamil (0.02-0.2 mg/kg) on contractility in normal and partially ischemic myocardium were compared with the changes following propranolol (0.01-1.0 mg/kg). Regional contractile function was studied in open-chest dogs with ultrasonic crystals and ischemia was controlled by graded occlusion of a caroti...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.54.4.629
更新日期:1976-10-01 00:00:00
abstract:BACKGROUND:Noninvasively assessed pulmonary pressure elevations and left ventricular (LV) diastolic dysfunction are associated with increased mortality in adults with sickle cell disease, but their relationship to exercise intolerance has not been evaluated prospectively. METHODS AND RESULTS:Echocardiography, 6-minute...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.111.032920
更新日期:2011-09-27 00:00:00
abstract:BACKGROUND:Although hepatocyte growth factor (HGF), a novel angiogenic growth factor, plays an important role in angiogenesis, regulation of local HGF production under hypoxia has not yet been clarified in vascular smooth muscle cells (VSMC) and endothelial cells (EC). Thus, we have studied the role of HGF in hypoxia-i...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.100.suppl_2.ii-301
更新日期:1999-11-09 00:00:00
abstract:BACKGROUND:An association of chronic Chlamydia pneumoniae infection to coronary heart disease has been suggested recently. In a recent study, we demonstrated circulating immune complexes containing chlamydial genus-specific lipopolysaccharide in patients with coronary heart disease. The objective of the present study w...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.87.4.1130
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Adhesion of monocytes to the endothelium is an initial step in the early stages of atherosclerosis and inflammation. Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates a range of functional activities of monocytes, including regulation of monocyte adhesion and induction of cytokine producti...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.93.6.1185
更新日期:1996-03-15 00:00:00
abstract:BACKGROUND:Nitric oxide signaling plays a key role in the regulation of vascular tone and platelet activation. Here, we seek to understand the impact of a genetic predisposition to enhanced nitric oxide signaling on risk for cardiovascular diseases, thus informing the potential utility of pharmacological stimulation of...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.117.028021
更新日期:2018-01-16 00:00:00
abstract::We studied six patients who suffered from angina pectoris but had angiographically patent major coronary arteries. Two of the patients suffered also from congestive heart failure. Three patients had supraventricular tachyarrhythmias. Three patients had conduction disturbances. During coronary angiography the patients ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.74.5.964
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:Alterations in myocardial function and systemic vascular tone are well documented in congestive heart failure (CHF), but little information is available on the effects of CHF on pulmonary vessels. We examined the mechanisms of tone regulation of canine pulmonary arteries during pacing-induced CHF. METHODS A...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.87.5.1722
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:In humans, angiotensin converting enzyme (ACE) inhibition attenuates the vasoconstriction induced by sympathetic stimulation in a number of peripheral districts. Whether this is also the case in the coronary circulation is unknown, however. METHODS AND RESULTS:In nine normotensive patients with angiographic...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.85.6.2004
更新日期:1992-06-01 00:00:00
abstract::The major problem associated with percutaneous transluminal coronary angioplasty is recurrence of the stenotic lesion. Balloon catheter-mounted intracoronary stent devices may reduce restenosis by improving luminal morphology and flow characteristics. This study assessed the effects of a stainless steel wire, interdig...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.78.3.646
更新日期:1988-09-01 00:00:00
abstract::Premature opening of the pulmonary valve (opening independent of atrial or ventricular systole) was originally described in a case of sinus of Valsalva rupture into the right atrium. Since that time we have observed five additional cases in which the pulmonary valve opened prematurely. Entities encountered included: 1...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.55.1.128
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Development and validation of novel imaging modalities to assess the composition of human atherosclerotic plaques will improve the understanding of atheroma evolution and could facilitate evaluation of therapeutic strategies for plaque modification. Surface MRI can characterize tissue content of carotid but ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.105.538942
更新日期:2005-10-11 00:00:00
abstract:BACKGROUND:Early results of sirolimus-eluting stent implantation showed a nearly complete abolition of neointimal hyperplasia. The question remains, however, whether the early promising results will still be evident at long-term follow-up. The objective of our study was to evaluate the efficiency of sirolimus-eluting s...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.0000034447.02535.d5
更新日期:2002-09-24 00:00:00
abstract::Proarrhythmic effects of flecainide acetate have been reported during exercise, but the mechanism for the arrhythmogenic interaction between flecainide and exercise is unknown. We hypothesized that the sinus tachycardia of exercise may enhance flecainide-induced conduction slowing by increasing use-dependent sodium ch...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.79.5.1000
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Venous coronary artery bypass grafts (CABGs) are prone to accelerated atherosclerosis. In atherosclerotic diseases, serum C-reactive protein (CRP) levels have become an important diagnostic and prognostic marker. The origin of CRP in this setting remains to be elucidated. METHODS AND RESULTS:Monoclonal anti...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000092184.43176.91
更新日期:2003-09-23 00:00:00
abstract::The role of right ventricular (RV) fibrosis in pulmonary hypertension (PH) remains a subject of ongoing discussion. Alterations of the collagen network of the extracellular matrix may help prevent ventricular dilatation in the pressure-overloaded RV. At the same time, fibrosis impairs cardiac function, and a growing b...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.118.035326
更新日期:2019-01-08 00:00:00
abstract::To determine whether a ventricular (LV) end-systolic dimension (ESD) greater than or equal to 55 mm and LV left fractional shortening less than 25% are risk factors for aortic valve replacement (AVR) in patients with aortic insufficiency, we analyzed the clinical course and M-mode echocardiograms in 47 consecutive pat...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.67.1.216
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 (IL-1) are proximal inflammatory cytokines that stimulate expression of adhesion molecules and induce synthesis of other proinflammatory cytokines. In addition, TNF-alpha and IL-1 influence vascular smooth muscle cell migration and proliferation in vi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.14.1697
更新日期:2000-10-03 00:00:00
abstract::Since the discovery that neuregulin-1 (NRG-1)/ErbB signaling is indispensable in cardiac development, evidence has shown that this system also plays a crucial role in the adult heart. In patients, an inhibitory ErbB2 antibody, trastuzumab, used in the treatment of mammary carcinomas, increases the risk for the develop...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/CIRCULATIONAHA.107.690487
更新日期:2007-08-21 00:00:00
abstract:BACKGROUND:Diastolic dysfunction associated with high blood pressure (BP) leads to cardiac remodeling and fibrosis and progression to congestive heart failure. B-type natriuretic peptide (BNP) has BP-lowering, antifibrotic, and antihypertrophic properties, which makes BNP an attractive agent for attenuating the adverse...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.110.981720
更新日期:2011-03-29 00:00:00
abstract:BACKGROUND:Endurance athletes have higher high density lipoprotein (HDL) concentrations than sedentary controls. To examine the mechanism for this effect, we compared HDL apoprotein metabolism in 10 endurance athletes aged 34 +/- 6 years (mean +/- SD) and 10 sedentary men aged 36 +/- 8 years. METHODS AND RESULTS:Subje...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.1.140
更新日期:1991-07-01 00:00:00
abstract::The administration of hyaluronidase is a promising intervention to protect the ischemic myocardium in man, but evidence of the extent to which it may reduce the ultimate size of an infarct is not well-defined. Hence, open chest, anesthetized dogs were randomized into 10 control dogs which received saline and eight tre...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.58.2.220
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:High blood pressure (BP) is a major risk factor for cardiovascular diseases (CVDs), the leading cause of mortality worldwide. Both heritable and lifestyle risk factors contribute to elevated BP levels. We aimed to investigate the extent to which lifestyle factors could offset the effect of an adverse BP gene...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/CIRCULATIONAHA.117.030898
更新日期:2018-02-13 00:00:00
abstract:BACKGROUND:Vascular events during initial reperfusion after a period of hypothermic cardioplegic ischemia may play an important role in the recovery of mechanical function. Prior studies have shown (1) that dysfunction of the postischemic myocardium after normothermic ischemia can be ameliorated by vasodilation and (2)...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1993-11-01 00:00:00
abstract::The electrophysiologic effects of intravenously administered disopyramide (2 mg/kg) on three parameters of sinus node function were examined in 16 symptomatic patients with sinus node dysfunction. Based on their ECG data before study, patients were subdivided into group A (n = 8), those with sinus pauses and/or sinoat...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.59.2.226
更新日期:1979-02-01 00:00:00
abstract:BACKGROUND:Accumulating evidence suggests that several subsets of regulatory T cells that actively mediate immunologic tolerance play crucial roles in atherogenesis. Recently, orally administered anti-CD3 monoclonal antibody has been shown as an inducer of novel regulatory T cells expressing latency-associated peptide ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.109.863431
更新日期:2009-11-17 00:00:00
abstract::Prenalterol, a beta-adrenergic agonist, was given to nine patients with angiographically proved coronary artery disease. Subjects were studied during chronic beta-adrenergic blockade. The adequacy of blockade was assessed by the exercise heart rate response and by plasma concentrations of blocking agents. After increm...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.64.6.1135
更新日期:1981-12-01 00:00:00