Cellular protection during myocardial ischemia: the development and characterization of a procedure for the induction of reversible ischemic arrest.

abstract：BACKGROUND:Precise noninvasive evaluation of pulmonary artery (PA) morphology is extremely important for medical and surgical management of patients with cyanotic heart disease. In this study, the accuracy of two-dimensional echocardiography combined with color Doppler flow mapping to assess the size, stenosis, and atr...

journal_title：Circulation

authors： Hiraishi S,Misawa H,Hirota H,Agata Y,Horiguchi Y,Fujino N,Yi LH,Yashiro K,Nakae S,Kawada M

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Administration of angiogenic factors stimulates neovascularization in ischemic tissues. However, there is no evidence that angiogenesis can be induced in normoperfused skeletal muscles. We tested the hypothesis that adenovirus-mediated intramuscular (IM) gene transfer of the 121-amino-acid form of vascular e...

journal_title：Circulation

authors： Gowdak LH,Poliakova L,Wang X,Kovesdi I,Fishbein KW,Zacheo A,Palumbo R,Straino S,Emanueli C,Marrocco-Trischitta M,Lakatta EG,Anversa P,Spencer RG,Talan M,Capogrossi MC

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Health-related quality-of-life instruments have become important measures of early health outcomes after cardiac surgery. The relationship between quality of life after recovery from surgery and subsequent long-term survival has not previously been explored. Our objective was to determine whether the Duke Ac...

journal_title：Circulation

authors： Koch CG,Li L,Lauer M,Sabik J,Starr NJ,Blackstone EH

更新日期：2007-02-13 00:00:00

abstract：:The ameliorative effect of antiplatelet therapy on atherogenesis of vein grafts was assessed in autologous cephalic veins grafted into femoral arteries of 16 normolipemic and 11 hyperlipemic stump-tailed macaque monkeys. Before grafting, one half of each vein was distended at high pressure (700 mm Hg) and the other ha...

journal_title：Circulation

authors： Bonchek LI,Boerboom LE,Olinger GN,Pepper JR,Munns J,Hutchinson L,Kissebah AH

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:Wine consumption decreases the risk of myocardial infarction. Intimal hyperplasia contributes to restenosis after angioplasty. Local ethanol delivery inhibits intimal hyperplasia after balloon injury in rabbit iliac and pig coronary arteries. The effects of wine consumption on intimal response and monocyte c...

journal_title：Circulation

authors： Feng AN,Chen YL,Chen YT,Ding YZ,Lin SJ

更新日期：1999-11-30 00:00:00

abstract：:The acute hemodynamic effects of captopril were evaluated at cardiac catheterization in 16 children (age, 0.3-18 years) with cardiomyopathy. Twelve children had congestive cardiomyopathy, whereas four had restrictive cardiomyopathy. Hemodynamic measurements were obtained 30 and 60 minutes after the oral administration...

journal_title：Circulation

authors： Bengur AR,Beekman RH,Rocchini AP,Crowley DC,Schork MA,Rosenthal A

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:The production of left ventricular (LV) restoring forces generated during contraction, which are responsible for diastolic suction, is dependent on end-systolic volume (ESV) and systolic transmural and 3D deformation. We tested the hypothesis that acute coronary occlusion would result in loss of forces that ...

journal_title：Circulation

authors： Bell SP,Fabian J,Watkins MW,LeWinter MM

更新日期：1997-10-07 00:00:00

abstract：BACKGROUND:Studies have consistently shown that ventricular tachycardia (VT) and sudden cardiac death (SCD) complicate the long-term outcome after tetralogy of Fallot repair, yet the diagnostic and predictive value of electrophysiological testing in this population is uncertain. METHODS AND RESULTS:A multicenter cohor...

journal_title：Circulation

authors： Khairy P,Landzberg MJ,Gatzoulis MA,Lucron H,Lambert J,Marçon F,Alexander ME,Walsh EP

更新日期：2004-04-27 00:00:00

abstract：BACKGROUND:Hypercholesterolemia is associated with endothelial dysfunction. On the basis of the hypothesis that high plasma cholesterol per se may be a sufficient stimulus to upregulate endothelial adhesiveness and that this phenomenon might be reversible, soluble endothelial leukocyte adhesion molecules (sELAMs) were ...

journal_title：Circulation

authors： Sampietro T,Tuoni M,Ferdeghini M,Ciardi A,Marraccini P,Prontera C,Sassi G,Taddei M,Bionda A

更新日期：1997-09-02 00:00:00

abstract：BACKGROUND:A completed Fontan circulation is the goal in the management of patients with single-ventricle physiology. To achieve this end, a two-stage rather than a single-stage approach is carried out routinely at many centers. Some groups have advocated baffle fenestration for virtually all patients to minimize post-...

journal_title：Circulation

authors： Hsu DT,Quaegebeur JM,Ing FF,Selber EJ,Lamour JM,Gersony WM

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:Drugs that simultaneously decrease platelet function and inflammation may improve the treatment of cardiovascular disorders. Here, we determined whether dipyridamole and aspirin, a combination therapy used to prevent recurrent stroke, regulates gene expression in platelet-monocyte inflammatory model systems....

journal_title：Circulation

authors： Weyrich AS,Denis MM,Kuhlmann-Eyre JR,Spencer ED,Dixon DA,Marathe GK,McIntyre TM,Zimmerman GA,Prescott SM

更新日期：2005-02-08 00:00:00

abstract：BACKGROUND:Chimeric molecules comprising the A-chain of tissue-type plasminogen activator (t-PA) and the catalytic domain of urokinase-type plasminogen activator (u-PA) have intact enzymatic characteristics of u-PA, partial fibrin-binding properties of t-PA, and thrombolytic properties in animal models comparable with ...

journal_title：Circulation

authors： Collen D,Lu HR,Lijnen HR,Nelles L,Stassen JM

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:The first compounds considered for stent-based delivery, such as heparin, were chosen on the basis of promising tissue culture and animal experiments, and yet they have failed to stop restenosis clinically. More recent compounds, such as paclitaxel, are of a different sort, being hydrophobic in nature, and t...

journal_title：Circulation

authors： Hwang CW,Wu D,Edelman ER

更新日期：2001-07-31 00:00:00

abstract：BACKGROUND:Functional mitral regurgitation (MR) is caused by systolic traction on the mitral leaflets related to ventricular distortion. Little is known about whether chronic tethering causes the mitral leaflet area to adapt to the geometric needs imposed by tethering, in part because of inability to reconstruct leafle...

journal_title：Circulation

authors： Chaput M,Handschumacher MD,Tournoux F,Hua L,Guerrero JL,Vlahakes GJ,Levine RA

更新日期：2008-08-19 00:00:00

abstract：BACKGROUND:Progression of heart failure after initial myocardial injury is mediated in part by various redundant inflammatory mediators, including the widely expressed cyclooxygenase-2 (COX-2). Because COX-2 inhibitors are useful in treating many inflammation-mediated diseases, we asked whether COX-2 inhibition can att...

journal_title：Circulation

authors： Delgado RM 3rd,Nawar MA,Zewail AM,Kar B,Vaughn WK,Wu KK,Aleksic N,Sivasubramanian N,McKay K,Mann DL,Willerson JT

更新日期：2004-03-23 00:00:00

abstract：BACKGROUND:This study examined revascularization rates after acute myocardial infarction (AMI) for Aboriginal and non-Aboriginal patients sequentially controlling for admitting hospital and risk factors. METHODS AND RESULTS:Hospital data from the state of New South Wales, Australia (July 2000 through December 2008) we...

journal_title：Circulation

authors： Randall DA,Jorm LR,Lujic S,O'Loughlin AJ,Eades SJ,Leyland AH

更新日期：2013-02-19 00:00:00

abstract：BACKGROUND:The Jun family of activator protein 1 (AP-1) transcription factors (c-Jun, JunB, and JunD) is involved in fundamental biological processes such as proliferation, apoptosis, tumor angiogenesis, and hypertrophy. The role of individual AP-1 transcription factors in the stressed heart is not clear. In the presen...

journal_title：Circulation

authors： Hilfiker-Kleiner D,Hilfiker A,Kaminski K,Schaefer A,Park JK,Michel K,Quint A,Yaniv M,Weitzman JB,Drexler H

更新日期：2005-09-06 00:00:00

abstract：BACKGROUND:Because acute exercise increases systemic catecholamines, we sought to determine whether exercise training would alter daily or exercise-related catecholamine release and inactivation. METHODS AND RESULTS:In 24-hour urine collections, catecholamines and metabolites provided indexes of overall oxidative deam...

journal_title：Circulation

authors： Rogers PJ,Tyce GM,Weinshilboum RM,O'Connor DT,Bailey KR,Bove AA

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:In people with atrial fibrillation (AF), periods of sinus rhythm present an opportunity to detect prothrombotic atrial remodeling through measurement of P-wave indices (PWIs)-prolonged P-wave duration, abnormal P-wave axis, advanced interatrial block, and abnormal P-wave terminal force in lead V1. We hypothe...

journal_title：Circulation

authors： Maheshwari A,Norby FL,Roetker NS,Soliman EZ,Koene RJ,Rooney MR,O'Neal WT,Shah AM,Claggett BL,Solomon SD,Alonso A,Gottesman RF,Heckbert SR,Chen LY

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:We explored whether chronic hyperglycemia is associated with defects in endothelium-dependent vasodilatation in vivo and whether defects in the hemodynamic effects of insulin explain insulin resistance. METHODS AND RESULTS:Vasodilator responses to brachial artery infusions of acetylcholine, sodium nitroprus...

journal_title：Circulation

authors： Mäkimattila S,Virkamäki A,Groop PH,Cockcroft J,Utriainen T,Fagerudd J,Yki-Järvinen H

更新日期：1996-09-15 00:00:00

abstract：BACKGROUND:Children stable at home with dilated cardiomyopathy remain at risk of death; there is evidence of survival benefit for transplantation out to 4 years postoperatively. The limited supply of donor organs makes risk stratification imperative, but although cardiopulmonary exercise test is well established as a p...

journal_title：Circulation

authors： Giardini A,Fenton M,Andrews RE,Derrick G,Burch M

更新日期：2011-10-18 00:00:00

abstract：:The evidence supporting the thesis that hypertension can be prevented by eliminating salt from the diet is based on four principal sources: (1) epidemiological studies in unacculturated peoples showing that the prevalence of hypertension is inversely correlated with the degree of salt intake; (2) hemodynamic studies s...

journal_title：Circulation

authors： Freis ED

更新日期：1976-04-01 00:00:00

abstract：:Total body surface maps from 15 subjects with left bundle branch block and normal axis (LBBB-NA) and 10 subjects with left bundle branch block and left axis (LBBB-LA) were analyzed and compared with maps from normal subjects. In 19 of the 25 subjects with LBBB, the timing of early upper sternal positivity was similar ...

journal_title：Circulation

authors： Sohi GS,Flowers NC,Horan LG,Sridharan MR,Johnson JC

更新日期：1983-03-01 00:00:00

abstract：:Depression is commonly present in patients with coronary heart disease (CHD) and is independently associated with increased cardiovascular morbidity and mortality. Screening tests for depressive symptoms should be applied to identify patients who may require further assessment and treatment. This multispecialty consen...

journal_title：Circulation

authors： Lichtman JH,Bigger JT Jr,Blumenthal JA,Frasure-Smith N,Kaufmann PG,Lespérance F,Mark DB,Sheps DS,Taylor CB,Froelicher ES,American Heart Association Prevention Committee of the Council on Cardiovascular Nursing.,American Heart Assoc

更新日期：2008-10-21 00:00:00

abstract：BACKGROUND:Long-term survival after acute kidney injury (AKI) is poorly studied. We report the relationship between long-term mortality and AKI with small changes in serum creatinine during hospitalization after various cardiothoracic surgery procedures. METHODS AND RESULTS:This was a retrospective study of 2973 patie...

journal_title：Circulation

authors： Hobson CE,Yavas S,Segal MS,Schold JD,Tribble CG,Layon AJ,Bihorac A

更新日期：2009-05-12 00:00:00

abstract：:Aortic root motion was studied in 24 normal volunteers at rest and during the Valsalva maneuver, isometric exercise, and amyl nitrite inhalation. In addition root motion was correlated with the stroke volumes determined at cardiac catheterization in 24 patients. The root has distinct systolic movement, the amplitude a...

journal_title：Circulation

authors： Pratt RC,Parisi AF,Harrington JJ,Sasahara AA

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:To date, the uptake of drugs into the human heart by transport proteins is poorly understood. A candidate protein is the organic cation transporter novel type 2 (OCTN2) (SLC22A5), physiologically acting as a sodium-dependent transport protein for carnitine. We investigated expression and localization of OCTN...

journal_title：Circulation

authors： Grube M,Meyer zu Schwabedissen HE,Präger D,Haney J,Möritz KU,Meissner K,Rosskopf D,Eckel L,Böhm M,Jedlitschky G,Kroemer HK

更新日期：2006-02-28 00:00:00

abstract：BACKGROUND:The study was designed to verify the concept of plaques "at risk" and whether inflammation could play a role in plaque rupture and thrombosis. METHODS AND RESULTS:In 20 patients who had died of acute myocardial infarction, the thrombosed coronary artery was identified and the site of plaque rupture was trac...

journal_title：Circulation

authors： van der Wal AC,Becker AE,van der Loos CM,Das PK

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Survivors of out-of-hospital cardiac arrest not associated with acute myocardial infarction are at high risk for recurrent cardiac arrest and sudden cardiac death. The impact of the implantable cardioverter-defibrillator on long-term prognosis in these patients is uncertain. METHODS AND RESULTS:Three hundre...

journal_title：Circulation

authors： Powell AC,Fuchs T,Finkelstein DM,Garan H,Cannom DS,McGovern BA,Kelly E,Vlahakes GJ,Torchiana DF,Ruskin JN

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Although molecular biological studies suggest a pathogenic link between enterovirus infection and dilated cardiomyopathy (DCM), the frequency of detection of enteroviral RNA is not consistently high in myocardial tissue from patients with DCM. A recent study has suggested that hepatitis C virus (HCV) may als...

journal_title：Circulation

authors： Okabe M,Fukuda K,Arakawa K,Kikuchi M

更新日期：1997-07-01 00:00:00