Human monocyte-endothelial cell interaction induces synthesis of granulocyte-macrophage colony-stimulating factor.

abstract：BACKGROUND:Depression is an independent risk factor for myocardial infarction (MI). Selective serotonin reuptake inhibitors (SSRIs) may reduce this risk through attenuation of serotonin-mediated platelet activation in addition to treatment of depression itself. METHODS AND RESULTS:case-control study of first MI in smo...

journal_title：Circulation

authors： Sauer WH,Berlin JA,Kimmel SE

更新日期：2001-10-16 00:00:00

abstract：BACKGROUND:Alteration of the circadian rhythm and increased vascular senescence are linked to cardiovascular disease. Per2, a circadian gene, is known to regulate endothelium-dependent vasomotion. However, the mechanism by which Per2 affects endothelial function is unknown. We hypothesize that endothelial dysfunction i...

journal_title：Circulation

authors： Wang CY,Wen MS,Wang HW,Hsieh IC,Li Y,Liu PY,Lin FC,Liao JK

更新日期：2008-11-18 00:00:00

abstract：BACKGROUND:This study was performed to determine whether chronic cocaine abuse is associated with left ventricular hypertrophy in humans. METHODS AND RESULTS:A consecutive series of 40 chronic cocaine abusers 23-44 years old who were enrolled in an inpatient drug rehabilitation program were considered for the study. S...

journal_title：Circulation

authors： Brickner ME,Willard JE,Eichhorn EJ,Black J,Grayburn PA

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is a prevalent public health problem that affects about one-third of the US population and leads to serious vascular complications with increased risk for coronary artery disease. How bone marrow hematopoiesis contributes to diabetes mellitus complications is incompletely understood. We inv...

journal_title：Circulation

authors： Hoyer FF,Zhang X,Coppin E,Vasamsetti SB,Modugu G,Schloss MJ,Rohde D,McAlpine CS,Iwamoto Y,Libby P,Naxerova K,Swirski FK,Dutta P,Nahrendorf M

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:The Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery (SYNTAX) trial demonstrated that in patients with 3-vessel or left main coronary artery disease, coronary artery bypass graft surgery (CABG) was associated with a lower rate of cardiovascular death, myocardial infarction, s...

journal_title：Circulation

authors： Cohen DJ,Osnabrugge RL,Magnuson EA,Wang K,Li H,Chinnakondepalli K,Pinto D,Abdallah MS,Vilain KA,Morice MC,Dawkins KD,Kappetein AP,Mohr FW,Serruys PW,SYNTAX Trial Investigators.

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:Several individual pharmacological agents, such as antiplatelet drugs, beta-blockers, ACE inhibitors, and lipid-lowering agents, have proven efficacy in reducing mortality in patients with acute coronary syndromes. However, the impact of the combination of these agents on clinical outcomes has not been studi...

journal_title：Circulation

authors： Mukherjee D,Fang J,Chetcuti S,Moscucci M,Kline-Rogers E,Eagle KA

更新日期：2004-02-17 00:00:00

abstract：:Coronary occlusion in the dog results in irreversible myocardial cell injury which develops first in subendocardial areas of severe ischemica and subsequently spreads into mid and subepicardial areas of moderate ischemia. The effect of propranolol on this progression of ischemic injury was evaluated. Three groups of d...

journal_title：Circulation

authors： Rasmussen MM,Reimer KA,Kloner RA,Jennings RB

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:Human cardiac troponin I is known to be phosphorylated at multiple amino acid residues by several kinases. Advances in mass spectrometry allow sensitive detection of known and novel phosphorylation sites and measurement of the level of phosphorylation simultaneously at each site in myocardial samples. METHO...

journal_title：Circulation

authors： Zhang P,Kirk JA,Ji W,dos Remedios CG,Kass DA,Van Eyk JE,Murphy AM

更新日期：2012-10-09 00:00:00

abstract：:Syncope and sudden death occurs in certain purebred Pug dogs which have been found to have intermittent sinus pauses and paroxysmal second degree heart block on electrocardiographic (ECG) study. We have established a colony of such dogs to study this problem and here report the results of histological examination of t...

journal_title：Circulation

authors： James TN,Robertson BT,Waldo AL,Branch CE

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Intravascular irradiation with beta-emitters has been proposed for inhibition of restenosis in coronary arteries after balloon angioplasty or stent implantation. Previous studies have shown the effectiveness of gamma-radiation to prevent recurrent restenosis, even in the presence of an implanted stent. The l...

journal_title：Circulation

authors： Amols HI,Trichter F,Weinberger J

更新日期：1998-11-10 00:00:00

abstract：:After a change in cardiac output, the magnitude of potential blood volume redistribution was investigated in 10 dogs anesthetized with chloralose. All of the venous return was pumped into a reservoir, using servocontrolled pumps to maintain fixed superior and inferior vena cava pressures. The cardiac output was set at...

journal_title：Circulation

authors： Rothe CF,Gaddis ML

更新日期：1990-01-01 00:00:00

abstract：:Ethmozin, a phenothiazine derivative, is an antiarrhythmic drug synthesized in the USSR. Preliminary data suggest that it is effective against a diversity of ectopic arrhythmias. The present study, carried out in the USSR, was designed to assess efficacy and patient tolerance of this new drug. Thirty-seven patients wi...

journal_title：Circulation

authors： Podrid PJ,Lyakishev A,Lown B,Mazur N

更新日期：1980-02-01 00:00:00

abstract：BACKGROUND:Activation of the sympathetic nervous system has important prognostic implications in chronic heart failure. Nonselective versus selective beta-adrenergic receptor antagonists may have differential effects on norepinephrine release from nerve terminals mediated by prejunctional beta(2)-adrenergic receptors. ...

journal_title：Circulation

authors： Azevedo ER,Kubo T,Mak S,Al-Hesayen A,Schofield A,Allan R,Kelly S,Newton GE,Floras JS,Parker JD

更新日期：2001-10-30 00:00:00

abstract：BACKGROUND:Continuous-flow rotary pumps with axial design are increasingly used for left ventricular assist support. The efficacy of this design compared with pulsatile, volume displacement pumps, with respect to characteristics of left ventricular unloading, and exercise performance remains largely unstudied. METHODS...

journal_title：Circulation

authors： Haft J,Armstrong W,Dyke DB,Aaronson KD,Koelling TM,Farrar DJ,Pagani FD

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:The accumulation of macrophage-derived foam cells in atherosclerotic lesions correlates with increased local release of matrix-degrading metalloproteinases (MMPs) and a thin fibrous cap. The activity of these enzymes is controlled by specific tissue inhibitors of metalloproteinases (TIMPs). METHODS AND RESU...

journal_title：Circulation

authors： Moreau M,Brocheriou I,Petit L,Ninio E,Chapman MJ,Rouis M

更新日期：1999-01-26 00:00:00

abstract：BACKGROUND:During the development of heart failure (HF), the chief myocardial energy substrate switches from fatty acids to glucose. This metabolic switch, which recapitulates fetal cardiac energy substrate preferences, is thought to maintain aerobic energetic balance. The regulatory mechanisms involved in this metabol...

journal_title：Circulation

authors： Sack MN,Rader TA,Park S,Bastin J,McCune SA,Kelly DP

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Although type B aortic dissection has been treated with beta blockers to lower the arterial blood pressure (BP), there has been little evidences about reduction in heart rate (HR). We assessed whether tight HR control improved the outcome of medical treatment in patients with aortic dissection. METHODS AND ...

journal_title：Circulation

authors： Kodama K,Nishigami K,Sakamoto T,Sawamura T,Hirayama T,Misumi H,Nakao K

更新日期：2008-09-30 00:00:00

abstract：BACKGROUND:During septic shock, the vasoconstrictor response to norepinephrine is seriously blunted. Animal experiments suggest that hyperpolarization of smooth muscle cells by opening of potassium (K) channels underlies this phenomenon. In the present study, we examined whether K-channel blockers and/or nitric oxide (...

journal_title：Circulation

authors： Pickkers P,Dorresteijn MJ,Bouw MP,van der Hoeven JG,Smits P

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:In recent clinical trials, glycoprotein IIb/IIIa blockers have demonstrated effectiveness in preventing adverse events after angioplasty in high-risk patients. However, uncertainty exists regarding the cost-effective selection of patients to receive antiplatelet therapy. METHODS AND RESULTS:All 4962 patient...

journal_title：Circulation

authors： Weintraub WS,Thompson TD,Culler S,Boccuzzi SJ,Becker ER,Kosinski AS,Mahoney E

更新日期：2000-07-25 00:00:00

abstract：:Coronary arteriography was performed before and after the intracoronary injection of nitroglycerin to determine the presence or absence of spasm in patients within the first 12 hours of acute myocardial infarction. Coronary arterial spasm was demonstrated in six of fifteen (40%) acute myocardial infarctions associated...

journal_title：Circulation

authors： Oliva PB,Breckinridge JC

更新日期：1977-09-01 00:00:00

abstract：:Increased ventricular volume is one of the most powerful predictors of reduced survival in patients with heart disease. Despite its well-documented prognostic significance, the magnitude of the progression of ventricular dilatation from the acute to the chronic phase of myocardial infarction has only recently been app...

journal_title：Circulation

authors： Pfeffer MA,Pfeffer JM

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Cardiac hypertrophy and subsequent heart failure triggered by chronic hypertension represent major challenges for cardiovascular research. Beyond neurohormonal and myocyte signaling pathways, growing evidence suggests inflammatory signaling pathways as therapeutically targetable contributors to this process....

journal_title：Circulation

authors： Heymans S,Corsten MF,Verhesen W,Carai P,van Leeuwen RE,Custers K,Peters T,Hazebroek M,Stöger L,Wijnands E,Janssen BJ,Creemers EE,Pinto YM,Grimm D,Schürmann N,Vigorito E,Thum T,Stassen F,Yin X,Mayr M,de Windt LJ,

更新日期：2013-09-24 00:00:00

abstract：BACKGROUND:Inotropic drugs are often used to treat acute, severe heart failure resulting from acute myocardial infarction and other unstable coronary artery syndromes. However, catecholamine inotropic agents may potentiate coronary thrombosis via a platelet alpha2-adrenergic mechanism, thus exacerbating the original pr...

journal_title：Circulation

authors： Sill JC,Bertha B,Berger I,Uhl C,Nugent M,Folts J

更新日期：1997-09-02 00:00:00

abstract：BACKGROUND:AMP-activated protein kinase (AMPK) is a stress-activated protein kinase that works as a metabolic sensor of cellular ATP levels. Here, we investigated whether AMPK signaling has a role in the regulation of the angiotensin II (Ang II)-induced proliferation signal in rat vascular smooth muscle cells (VSMCs). ...

journal_title：Circulation

authors： Nagata D,Takeda R,Sata M,Satonaka H,Suzuki E,Nagano T,Hirata Y

更新日期：2004-07-27 00:00:00

abstract：BACKGROUND:This study aimed to assess if clampless off-pump coronary artery bypass grafting (CABG) decreases risk-adjusted mortality, stroke rate, and morbidity in unselected patients in comparison to conventional CABG. METHODS AND RESULTS:Between July 2009 and November 2010, data of 1282 consecutive patients undergoi...

journal_title：Circulation

authors： Börgermann J,Hakim K,Renner A,Parsa A,Aboud A,Becker T,Masshoff M,Zittermann A,Gummert JF,Kuss O

更新日期：2012-09-11 00:00:00

abstract：BACKGROUND:Despite successful restoration of epicardial vessel patency with primary percutaneous coronary intervention, coronary microvascular injury occurs in a large proportion of patients with ST-segment-elevation myocardial infarction, adversely affecting clinical and functional outcome. Ticagrelor has been reporte...

journal_title：Circulation

authors： van Leeuwen MAH,van der Hoeven NW,Janssens GN,Everaars H,Nap A,Lemkes JS,de Waard GA,van de Ven PM,van Rossum AC,Ten Cate TJF,Piek JJ,von Birgelen C,Escaned J,Valgimigli M,Diletti R,Riksen NP,van Mieghem NM,Nijveldt R,

更新日期：2019-01-29 00:00:00

abstract：:In this paper we examine the relationship between risk factors and angiographically determined coronary artery disease for blacks and whites enrolled in the Coronary Artery Surgery Study (CASS). Analysis of data from the CASS registry indicated that blacks had a higher incidence of hypertension and current cigarette s...

journal_title：Circulation

authors： Maynard C,Fisher LD,Passamani ER,Pullum T

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Age is an important determinant of outcomes for patients with acute coronary syndromes (ACS); however, community practice reveals a disproportionately lower use of cardiovascular medications and invasive treatment even among elderly patients with ACS who would stand to benefit. Reasons include limited trial ...

journal_title：Circulation

authors： Alexander KP,Newby LK,Cannon CP,Armstrong PW,Gibler WB,Rich MW,Van de Werf F,White HD,Weaver WD,Naylor MD,Gore JM,Krumholz HM,Ohman EM,American Heart Association Council on Clinical Cardiology.,Society of Geriatric Cardiology

更新日期：2007-05-15 00:00:00

abstract：BACKGROUND:Patients with diabetes mellitus (DM) are at high risk of developing congestive heart failure (CHF). However, the relationships between glucose levels and CHF in people with or without a history of DM have not been well characterized. METHODS AND RESULTS:We evaluated the associations between fasting plasma g...

journal_title：Circulation

authors： Held C,Gerstein HC,Yusuf S,Zhao F,Hilbrich L,Anderson C,Sleight P,Teo K,ONTARGET\/TRANSCEND Investigators.

更新日期：2007-03-20 00:00:00

abstract：BACKGROUND:Sodium glucose cotransporter 2 inhibitors may reduce kidney hyperfiltration, thereby preventing diabetic kidney disease progression, which may in turn reduce cardiovascular risk, including heart failure. However, the mechanisms that regulate renal function responses to sodium glucose cotransporter 2 inhibiti...

journal_title：Circulation

authors： Kidokoro K,Cherney DZI,Bozovic A,Nagasu H,Satoh M,Kanda E,Sasaki T,Kashihara N

更新日期：2019-07-23 00:00:00