Selective serotonin reuptake inhibitors and myocardial infarction.


BACKGROUND:Depression is an independent risk factor for myocardial infarction (MI). Selective serotonin reuptake inhibitors (SSRIs) may reduce this risk through attenuation of serotonin-mediated platelet activation in addition to treatment of depression itself. METHODS AND RESULTS:case-control study of first MI in smokers 30 to 65 years of age was conducted among all 68 hospitals in an 8-county area during a 28-month period. Cases were patients hospitalized with a first MI. Approximately 4 community control subjects per case were randomly selected from the same geographic area using random digit dialing. Detailed information regarding use of antidepressant medication as well as other clinical and demographic data were obtained by telephone interview. A total of 653 cases of first MI and 2990 control subjects participated. After adjustment, using multivariable logistic regression, for age, sex, race, education, exercise, quantity smoked per day, body mass index, aspirin use, family history of MI, number of physician encounters, and history of coronary disease, diabetes, hypertension, or hypercholesterolemia, the odds ratio for MI among current SSRI users compared with nonusers was 0.35 (95% CI 0.18, 0.68; P<0.01). Non-SSRI antidepressant users had a nonsignificant reduction in MI risk with wide confidence intervals (adjusted odds ratio 0.48, CI 0.17, 1.32; P=0.15). However, analysis of this group was limited by the small number of exposed subjects. CONCLUSIONS:The use of SSRIs may confer a protective effect against MI. This could be attributable to the inhibitory effect SSRIs have on serotonin-mediated platelet activation or possibly amelioration of other factors associated with increased risk for MI in depression.






Sauer WH,Berlin JA,Kimmel SE




Has Abstract


2001-10-16 00:00:00












  • Inducible nitric oxide synthase inhibition of weibel-palade body release in cardiac transplant rejection.

    abstract:BACKGROUND:Inducible nitric oxide synthase (iNOS, or NOS2) reduces the severity of accelerated graft arteriosclerosis (AGA) in transplanted organs, although the precise mechanism is unclear. METHODS AND RESULTS:We transplanted wild-type murine hearts into either wild-type or NOS2-null recipient mice; we then measured ...


    pub_type: 杂志文章


    authors: Qian Z,Gelzer-Bell R,Yang Sx SX,Cao W,Ohnishi T,Wasowska BA,Hruban RH,Rodriguez ER,Baldwin WM 3rd,Lowenstein CJ

    更新日期:2001-11-06 00:00:00

  • Multifactorial actions of beta-adrenergic blocking drugs in ischemic heart disease: current concepts.

    abstract::It is generally agreed that the conditions leading to myocardial ischemia occur when the oxygen demands of the myocardium exceed the oxygen supply. The major limitations of oxygen supply to the myocardium are atherogenic disease and vasospasm of the coronary arteries. The major hemodynamic determinants of myocardial o...


    pub_type: 杂志文章


    authors: Frishman WH

    更新日期:1983-06-01 00:00:00

  • Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men.

    abstract:BACKGROUND:The role of a cluster of risk factors characteristic for the insulin resistance syndrome as a predictor for coronary heart disease (CHD) has not been studied previously. METHODS AND RESULTS:Clustering of cardiovascular risk factors was analyzed by factor analysis to investigate whether these clusters (facto...


    pub_type: 杂志文章


    authors: Lempiäinen P,Mykkänen L,Pyörälä K,Laakso M,Kuusisto J

    更新日期:1999-07-13 00:00:00

  • Spectral energy of the first heart sound in acute myocardial ischemia. A correlation with electrocardiographic, hemodynamic, and wall motion abnormalities.

    abstract::First heart sound (S1) energy spectra in isovolumic systole, hemodynamics, and angiographic left ventricular wall motion (LVWM) at rest and with atrial pacing were compared in 27 patients who underwent diagnostic cardiac catheterization and angiography because of chest pain. Eighteen patients were found to have corona...


    pub_type: 杂志文章


    authors: Clarke WB,Austin SM,Shah PM,Griffin PM,Dove JT,McCullough J,Schreiner BF

    更新日期:1978-03-01 00:00:00

  • Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica.

    abstract:BACKGROUND:Alpha-linolenic acid may protect against cardiovascular disease. We examined the association between adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction (MI) in a population-based case-control study in Costa Rica. METHODS AND RESULTS:The 482 case patients with a first nonfatal acute...


    pub_type: 杂志文章


    authors: Baylin A,Kabagambe EK,Ascherio A,Spiegelman D,Campos H

    更新日期:2003-04-01 00:00:00

  • Randomized comparison of percutaneous transluminal coronary angioplasty and medical therapy in stable survivors of acute myocardial infarction with single vessel disease: a study of the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte.

    abstract:BACKGROUND:Percutaneous transluminal coronary angioplasty of the infarct-related artery in stable survivors of acute myocardial infarction is often performed, even in patients without any symptoms or residual ischemia. Despite the lack of randomized studies, it is widely believed that this intervention will improve the...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Zeymer U,Uebis R,Vogt A,Glunz HG,Vöhringer HF,Harmjanz D,Neuhaus KL,ALKK-Study Group.

    更新日期:2003-09-16 00:00:00

  • Analysis of left ventricular function from multiple gated acquisition cardiac blood pool imaging. Comparison to contrast angiography.

    abstract::Global ventricular function was evaluated by both multiple gated cardiac blood pool scans (MUGA) and contrast ventriculograms in a group of 17 patients with suspected coronary artery disease. The contrast ventriculograms were analyzed frame by frame to generate a volume versus time curve for each patient, while the tr...


    pub_type: 杂志文章


    authors: Burow RD,Strauss HW,Singleton R,Pond M,Rehn T,Bailey IK,Griffith LC,Nickoloff E,Pitt B

    更新日期:1977-12-01 00:00:00

  • Effects of nifedipine on intrinsic myocardial stiffness in man.

    abstract::To determine whether alteration of intrinsic myocardial stiffness is responsible for the reduction of left ventricular filling pressure and volume by nifedipine in patients with impaired baseline ventricular function, we evaluated the hemodynamic responses in 32 patients undergoing diagnostic cardiac catheterization. ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kurnik PB,Courtois MR,Ludbrook PA

    更新日期:1986-07-01 00:00:00

  • Anticardiolipin antibodies and recurrent coronary events: a prospective study of 1150 patients. Thrombogenic Factors, and Recurrent Coronary Events Investigators.

    abstract:BACKGROUND:The association of anticardiolipin (aCL) antibodies with coronary artery disease has been shown in several studies but remains controversial. We evaluated the association of aCL and anti-beta(2)-glycoprotein I (abeta(2)GPI) antibodies with the risk of recurrent cardiac events in postinfarction patients. MET...


    pub_type: 杂志文章,多中心研究


    authors: Bili A,Moss AJ,Francis CW,Zareba W,Watelet LF,Sanz I

    更新日期:2000-09-12 00:00:00

  • Chronic hypoxia stimulates periarterial sympathetic nerve development in chicken embryo.

    abstract:BACKGROUND:Epidemiological findings suggest an association between low-for-age birth weight and the risk to develop coronary heart diseases in adulthood. During pregnancy, an imbalance between fetal demands and supply may result in permanent alterations of neuroendocrine development in the fetus. We evaluated whether c...


    pub_type: 杂志文章


    authors: Ruijtenbeek K,le Noble FA,Janssen GM,Kessels CG,Fazzi GE,Blanco CE,De Mey JG

    更新日期:2000-12-05 00:00:00

  • Mass Screening for Untreated Atrial Fibrillation: The STROKESTOP Study.

    abstract:BACKGROUND:The aims of the present study were to define the prevalence of untreated atrial fibrillation (AF) in a systematic screening program using intermittent ECG recordings among 75- to 76-year-old individuals and to study the feasibility of initiating protective oral anticoagulant (OAC) treatment. METHODS AND RES...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Svennberg E,Engdahl J,Al-Khalili F,Friberg L,Frykman V,Rosenqvist M

    更新日期:2015-06-23 00:00:00

  • Activation of hypoxia-inducible factor-1 in bacillary angiomatosis: evidence for a role of hypoxia-inducible factor-1 in bacterial infections.

    abstract:BACKGROUND:Bartonella species are the only known bacterial pathogens causing vasculoproliferative disorders in humans (bacillary angiomatosis [BA]). Cellular and bacterial pathogenetic mechanisms underlying the induction of BA are largely unknown. METHODS AND RESULTS:Activation of hypoxia-inducible factor-1 (HIF-1), t...


    pub_type: 杂志文章


    authors: Kempf VA,Lebiedziejewski M,Alitalo K,Wälzlein JH,Ehehalt U,Fiebig J,Huber S,Schütt B,Sander CA,Müller S,Grassl G,Yazdi AS,Brehm B,Autenrieth IB

    更新日期:2005-03-01 00:00:00

  • Increased carotid wall stress in vascular Ehlers-Danlos syndrome.

    abstract:BACKGROUND:Vascular Ehlers-Danlos syndrome (vEDS), also known as EDS type IV, an inherited disorder of connective tissue, results from mutations in the gene encoding type III procollagen (COL3A1). Affected patients are at risk for arterial dissection or rupture, the main cause of death. To understand the pathogenesis o...


    pub_type: 杂志文章


    authors: Boutouyrie P,Germain DP,Fiessinger JN,Laloux B,Perdu J,Laurent S

    更新日期:2004-03-30 00:00:00

  • Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart.

    abstract:BACKGROUND:The maternal circulatory system and hormone balance both change dynamically during pregnancy, delivery, and the postpartum period. Although atrial natriuretic peptides and brain natriuretic peptides produced in the heart control circulatory homeostasis through their common receptor, NPR1, the physiologic and...


    pub_type: 杂志文章


    authors: Otani K,Tokudome T,Kamiya CA,Mao Y,Nishimura H,Hasegawa T,Arai Y,Kaneko M,Shioi G,Ishida J,Fukamizu A,Osaki T,Nagai-Okatani C,Minamino N,Ensho T,Hino J,Murata S,Takegami M,Nishimura K,Kishimoto I,Miyazato M,Hara

    更新日期:2020-02-18 00:00:00

  • Prediction of improvement of regional left ventricular function after surgical revascularization. A comparison of low-dose dobutamine echocardiography with 201Tl single-photon emission computed tomography.

    abstract:BACKGROUND:Although both 201Tl scintigraphy and low-dose dobutamine echocardiography (LDDE) have been proposed as effective methods of assessing myocardial viability, their relative efficacies are unknown. The aim of the present study was to compare the two imaging techniques in the prediction of improvement of regiona...


    pub_type: 杂志文章


    authors: Arnese M,Cornel JH,Salustri A,Maat A,Elhendy A,Reijs AE,Ten Cate FJ,Keane D,Balk AH,Roelandt JR

    更新日期:1995-06-01 00:00:00

  • QT interval is linked to 2 long-QT syndrome loci in normal subjects.

    abstract:BACKGROUND:The rate-corrected QT interval (QTc) is heritable, and the discovery of quantitative trait loci that influence the QTc would be an important step in identifying the genes responsible for life-threatening arrhythmias in the general population. We studied 66 pairs of unselected normal dizygotic (DZ) twin subje...


    pub_type: 杂志文章


    authors: Busjahn A,Knoblauch H,Faulhaber HD,Boeckel T,Rosenthal M,Uhlmann R,Hoehe M,Schuster H,Luft FC

    更新日期:1999-06-22 00:00:00

  • Singlet oxygen-induced arrhythmias. Dose- and light-response studies for photoactivation of rose bengal in the rat heart.

    abstract::In a study of aerobically perfused rat hearts, the in situ photoactivation (530-590 nm) of rose bengal (a process that leads to the production of singlet oxygen and superoxide) has been shown to lead to the rapid development of electrocardiographic abnormalities and arrhythmias. With rose bengal concentrations of 1,00...


    pub_type: 杂志文章


    authors: Kusama Y,Bernier M,Hearse DJ

    更新日期:1989-11-01 00:00:00

  • Human monocyte-endothelial cell interaction induces synthesis of granulocyte-macrophage colony-stimulating factor.

    abstract:BACKGROUND:Adhesion of monocytes to the endothelium is an initial step in the early stages of atherosclerosis and inflammation. Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates a range of functional activities of monocytes, including regulation of monocyte adhesion and induction of cytokine producti...


    pub_type: 杂志文章


    authors: Takahashi M,Kitagawa S,Masuyama JI,Ikeda U,Kasahara T,Takahashi YI,Furukawa Y,Kano S,Shimada K

    更新日期:1996-03-15 00:00:00

  • Differences in beta-adrenergic neuroeffector mechanisms in ischemic versus idiopathic dilated cardiomyopathy.

    abstract:BACKGROUND:We measured the content and activities of components of the beta-adrenergic receptor-G protein-adenylate cyclase complex and adrenergic neurotransmitter levels in left and right ventricular myocardial preparations derived from 77 end-stage failing human hearts from patients with idiopathic dilated cardiomyop...


    pub_type: 杂志文章


    authors: Bristow MR,Anderson FL,Port JD,Skerl L,Hershberger RE,Larrabee P,O'Connell JB,Renlund DG,Volkman K,Murray J

    更新日期:1991-09-01 00:00:00

  • Myocardial Infarction in the ISCHEMIA Trial: Impact of Different Definitions on Incidence, Prognosis, and Treatment Comparisons.

    abstract::Background: In ISCHEMIA, an initial invasive strategy did not significantly reduce rates of cardiovascular events or all-cause mortality compared with a conservative strategy in patients with stable ischemic heart disease and moderate/severe myocardial ischemia. The most frequent component of composite cardiovascular ...


    pub_type: 杂志文章


    authors: Chaitman BR,Alexander KP,Cyr DD,Berger JS,Reynolds HR,Bangalore S,Boden WE,Lopes RD,Demkow M,Perna GP,Riezebos RK,McFalls EO,Banerjee S,Bagai A,Gosselin G,O'Brien SM,Rockhold FW,Waters DD,Thygesen KA,Stone GW,Whit

    更新日期:2020-12-03 00:00:00

  • Acetylcholine release in human heart atrium: influence of muscarinic autoreceptors, diabetes, and age.

    abstract:BACKGROUND:An imbalance of sympathetic and parasympathetic drive to the heart is an important risk factor for cardiac death in patients with coronary heart disease, diabetes, and renal insufficiency. The amount of neurotransmitter released from peripheral autonomic nerves is modulated by presynaptic receptor systems. I...


    pub_type: 杂志文章


    authors: Oberhauser V,Schwertfeger E,Rutz T,Beyersdorf F,Rump LC

    更新日期:2001-03-27 00:00:00

  • Antiplatelet drug response status does not predict recurrent ischemic events in stable cardiovascular patients: results of the Antiplatelet Drug Resistances and Ischemic Events study.

    abstract:BACKGROUND:The biological response to antiplatelet drugs has repeatedly been shown to predict the recurrence of major adverse cardiovascular events (MACEs). However, most studies involved coronary artery disease patients with recent vessel injury shortly after the initiation of antiplatelet therapy. Data on stable card...


    pub_type: 杂志文章


    authors: Reny JL,Berdagué P,Poncet A,Barazer I,Nolli S,Fabbro-Peray P,Schved JF,Bounameaux H,Mach F,de Moerloose P,Fontana P,Antiplatelet Drug Resistances and Ischemic Events (ADRIE) Study Group.

    更新日期:2012-06-26 00:00:00

  • Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range.

    abstract:BACKGROUND:Oral anticoagulation (OAC) therapy is effective in atrial fibrillation but requires vigilance to maintain the international normalized ratio in the therapeutic range. This report examines how differences in time in therapeutic range (TTR) between centers and between countries affect the outcomes of OAC thera...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Connolly SJ,Pogue J,Eikelboom J,Flaker G,Commerford P,Franzosi MG,Healey JS,Yusuf S,ACTIVE W Investigators.

    更新日期:2008-11-11 00:00:00

  • Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice.

    abstract:BACKGROUND:Receptor-mediated activation of myocardial Gq signaling is postulated as a biochemical mechanism transducing pressure-overload hypertrophy. The specific effects of Gq activation on the functional and morphological adaptations to pressure overload are not known. METHODS AND RESULTS:To determine the effects o...


    pub_type: 杂志文章


    authors: Sakata Y,Hoit BD,Liggett SB,Walsh RA,Dorn GW 2nd

    更新日期:1998-04-21 00:00:00

  • Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia.

    abstract:BACKGROUND:Heparin-induced thrombocytopenia (HIT) is an immune-mediated syndrome caused by heparin. Complications range from thrombocytopenia to thrombocytopenia with thrombosis. We report a prospective, historical- controlled study evaluating the efficacy and safety of argatroban, a direct thrombin inhibitor, as antic...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Lewis BE,Wallis DE,Berkowitz SD,Matthai WH,Fareed J,Walenga JM,Bartholomew J,Sham R,Lerner RG,Zeigler ZR,Rustagi PK,Jang IK,Rifkin SD,Moran J,Hursting MJ,Kelton JG,ARG-911 Study Investigators.

    更新日期:2001-04-10 00:00:00

  • Occurrence and properties of the hyperpolarization-activated current If in ventricular myocytes from normotensive and hypertensive rats during aging.

    abstract:BACKGROUND:Cellular electrophysiological alterations may contribute to arrhythmogenesis in cardiac hypertrophy. An L-like current occurs in left ventricular myocytes (LVMs) isolated from the hypertrophied heart of old spontaneously hypertensive rats (SHR). Factors that influence L occurrence during development of cardi...


    pub_type: 杂志文章


    authors: Cerbai E,Barbieri M,Mugelli A

    更新日期:1996-10-01 00:00:00

  • Autoimmunity in idiopathic dilated cardiomyopathy. Characterization of antibodies against the beta 1-adrenoceptor with positive chronotropic effect.

    abstract:BACKGROUND:Autoantibodies against the beta 1-adrenoceptor have been detected in the sera of patients with idiopathic dilated cardiomyopathy (DCM). The mechanisms by which these autoantibodies can alter normal receptor function are investigated, and the results are interpreted in the light of the beneficial effects of b...


    pub_type: 杂志文章


    authors: Magnusson Y,Wallukat G,Waagstein F,Hjalmarson A,Hoebeke J

    更新日期:1994-06-01 00:00:00

  • Direct evidence for a crucial role of the arterial wall in control of atherosclerosis susceptibility.

    abstract:BACKGROUND:Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit marked differences in atherosclerosis susceptibility. We sought to determine whether the difference in atherosclerosis susceptibility resides at the level of arterial walls. METHODS AND RESULTS:Thoracic aortic segments from 8-week-old female B6 an...


    pub_type: 杂志文章


    authors: Pei H,Wang Y,Miyoshi T,Zhang Z,Matsumoto AH,Helm GA,Tellides G,Shi W

    更新日期:2006-11-28 00:00:00

  • Spontaneous variability of complex ventricular arrhythmias detected by long-term electrocardiographic recording.

    abstract::Variations in the frequency of complex ventricular arrhythmias were evaluated by consecutive 24-hour long-term electrocardiographic recordings over 4 days using a two-channel recorder and computer-assisted analysis system with a weighted relative mean error of 7.5 +/ 5% (SD). Twenty patients (mean age 58 +/- 9 years ...


    pub_type: 杂志文章


    authors: Michelson EL,Morganroth J

    更新日期:1980-04-01 00:00:00

  • Activation patterns of Purkinje fibers during long-duration ventricular fibrillation in an isolated canine heart model.

    abstract:BACKGROUND:The roles of Purkinje fibers (PFs) and focal wave fronts, if any, in the maintenance of ventricular fibrillation (VF) are unknown. If PFs are involved in VF maintenance, it should be possible to map wave fronts propagating from PFs into the working ventricular myocardium during VF. If wave fronts ever arise ...


    pub_type: 杂志文章


    authors: Tabereaux PB,Walcott GP,Rogers JM,Kim J,Dosdall DJ,Robertson PG,Killingsworth CR,Smith WM,Ideker RE

    更新日期:2007-09-04 00:00:00