Impact of farnesylation inhibitors on survival in Hutchinson-Gilford progeria syndrome.

abstract：BACKGROUND:Arterial grafts for CABG have been used increasingly, and the radial artery (RA) has become a preferable graft, secondary to the internal mammary artery (IMA). In the present study, we investigated and compared NO release and endothelium-derived hyperpolarizing factor (EDHF)-mediated hyperpolarization for IM...

journal_title：Circulation

authors： He GW,Liu ZG

更新日期：2001-09-18 00:00:00

abstract：BACKGROUND:Cystic kidneys and vascular aneurysms are clinical manifestations seen in patients with polycystic kidney disease, a cilia-associated pathology (ciliopathy). Survivin overexpression is associated with cancer, but the clinical pathology associated with survivin downregulation or knockout has never been studie...

journal_title：Circulation

authors： Aboualaiwi WA,Muntean BS,Ratnam S,Joe B,Liu L,Booth RL,Rodriguez I,Herbert BS,Bacallao RL,Fruttiger M,Mak TW,Zhou J,Nauli SM

更新日期：2014-02-11 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) is an accurate method for the quantitative assessment of organic mitral regurgitation (OMR). The aim of the present study was to compare the discriminative power of MRI quantification and the recommended Doppler echocardiography (ECHO)-derived integrative approach to identify...

journal_title：Circulation

authors： Penicka M,Vecera J,Mirica DC,Kotrc M,Kockova R,Van Camp G

更新日期：2018-03-27 00:00:00

abstract：:Left ventricular function was compared in 18 normal sedentary controls (mean age 28 years, range 22 - 34 years) and nine endurance-trained athletes (mean age 19 years, range 15 - 25 years) at rest and during supine bicycle exercise. Gated radionuclide angiocardiograms were performed at rest and at each level of graded...

journal_title：Circulation

authors： Bar-Shlomo BZ,Druck MN,Morch JE,Jablonsky G,Hilton JD,Feiglin DH,McLaughlin PR

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:Previous studies found that percutaneous coronary intervention (PCI) does not improve outcome compared with medical therapy (MT) in patients with stable coronary artery disease, but PCI was guided by angiography alone. FAME 2 trial (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) compa...

journal_title：Circulation

authors： Fearon WF,Nishi T,De Bruyne B,Boothroyd DB,Barbato E,Tonino P,Jüni P,Pijls NHJ,Hlatky MA,FAME 2 Trial Investigators.

更新日期：2018-01-30 00:00:00

abstract：BACKGROUND:Q waves on a 12-lead ECG are markers of a prior myocardial infarction (MI). However, they may regress or even disappear over time, and there is no specific ECG sign of a non-Q-wave MI. Fragmented QRS complexes (fQRSs), which include various RSR' patterns, without a typical bundle-branch block are markers of ...

journal_title：Circulation

authors： Das MK,Khan B,Jacob S,Kumar A,Mahenthiran J

更新日期：2006-05-30 00:00:00

abstract：BACKGROUND:Phosphatidylserine-expressing microparticles circulate in blood with a short half-life of <10 minutes. We tested the role of an endothelium-derived phosphatidylserine-binding opsonin, developmental endothelial locus-1 (Del-1), in the uptake of platelet microparticles. METHODS AND RESULTS:Cultured human umbi...

journal_title：Circulation

authors： Dasgupta SK,Le A,Chavakis T,Rumbaut RE,Thiagarajan P

更新日期：2012-04-03 00:00:00

abstract：BACKGROUND:Flowing erythrocytes and platelets are separated from the luminal endothelial cell (EC) surface by a 0.5-microm-wide space named the endothelial surface layer. We hypothesized that the disruption of the endothelial surface layer by oxidized low-density lipoproteins (Ox-LDL) contributes to atherogenic increas...

journal_title：Circulation

authors： Vink H,Constantinescu AA,Spaan JA

更新日期：2000-04-04 00:00:00

abstract：BACKGROUND:Obstruction to left ventricular outflow can be seen after surgical repair of congenital heart disease in which a ventricular septal defect (VSD) is closed by means of a baffle to the systemic great artery arising from the right ventricle (Rastelli operation, intraventricular repair, for conotruncal anomaly)....

journal_title：Circulation

authors： Rychik J,Jacobs ML,Norwood WI

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:The regional wall motion impairment and predisposition to arrhythmias in human ventricular hibernation may plausibly result from abnormal intercellular propagation of the depolarizing wave front. This study investigated the hypothesis that altered patterns of expression of connexin43, the principal gap junct...

journal_title：Circulation

authors： Kaprielian RR,Gunning M,Dupont E,Sheppard MN,Rothery SM,Underwood R,Pennell DJ,Fox K,Pepper J,Poole-Wilson PA,Severs NJ

更新日期：1998-02-24 00:00:00

abstract：BACKGROUND:This study was performed to determine whether antibodies against the amino-terminus of the beta-chain of fibrin (anti-beta) could noninvasively distinguish actively enlarging thrombi from thrombi stabilized with anticoagulants. METHODS AND RESULTS:Dogs with unilateral femoral vein thrombi were allocated int...

journal_title：Circulation

authors： Morris TA,Marsh JJ,Konopka R,Pedersen CA,Chiles PG,Fagnani R,Hagan M,Moser KM

更新日期：1997-11-04 00:00:00

abstract：:To investigate the electrocardiographic and hemodynamic changes in isolated right ventricular infarction, 0.25 ml or 0.5 ml of metallic mercury was injected into the right coronary artery of 14 closed-chest dogs. At autopsy, at least 60% of the right ventricle was necrotic in every dog. Hemodynamic observations were m...

journal_title：Circulation

authors： Chou TC,Fowler NO,Gabel M,van der Bel-Kahn J,Feltner EJ

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:In patients with atrial fibrillation, intracardiac atrial defibrillation causes discomfort. An easily applicable, short-acting analgesic and anxiolytic drug would increase acceptability of this new treatment mode. METHODS AND RESULTS:In a double-blind, placebo-controlled manner, the effect of intranasal but...

journal_title：Circulation

authors： Timmermans C,Rodriguez LM,Ayers GM,Lambert H,Smeets JL,Vlaeyen JW,Albert A,Wellens HJ

更新日期：1999-04-13 00:00:00

abstract：BACKGROUND:The morphological hallmark of tetralogy of Fallot is controversial, with much disagreement as to whether the subpulmonary infundibulum in this lesion is hypoplastic. In addition, few quantitative data are available regarding the morphometry of the subpulmonary infundibulum, what anatomic characteristics are ...

journal_title：Circulation

authors： Geva T,Ayres NA,Pac FA,Pignatelli R

更新日期：1995-08-15 00:00:00

abstract：BACKGROUND:Several centers favor replacing a diseased native heart valve with a tissue rather than a mechanical prosthesis, even in younger adult patients. However, long-term data supporting this approach are lacking. We examined the survival implications of selecting a tissue versus a mechanical prosthesis at initial ...

journal_title：Circulation

authors： Ruel M,Chan V,Bédard P,Kulik A,Ressler L,Lam BK,Rubens FD,Goldstein W,Hendry PJ,Masters RG,Mesana TG

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:In the past few years, although significant efforts have been made to assess flow distribution during retrograde cerebral perfusion with microspheres, dye, or hydrogen clearance, flow distribution in real time is still undefined. We used MR perfusion imaging to monitor flow distribution in the brain during a...

journal_title：Circulation

authors： Ye J,Ryner LN,Kozlowski P,Yang L,Del Bigio MR,Sun J,Donnelly M,Summers R,Salerno TA,Somorjai RL,Saunders JK,Deslauriers R

更新日期：1998-11-10 00:00:00

abstract：:To test the hypothesis that an area of slow conduction is present during reentrant ventricular tachycardia in man, and that the earliest activation site during ventricular tachycardia is within or orthodromically just distal to the area of slow conduction in the reentry loop, we studied 12 episodes of ventricular tach...

journal_title：Circulation

authors： Okumura K,Olshansky B,Henthorn RW,Epstein AE,Plumb VJ,Waldo AL

更新日期：1987-02-01 00:00:00

abstract：:Mitral pressure half-time (T1/2) is widely used as an independent measure of mitral valve area in patients undergoing percutaneous mitral valvotomy. However, fluid dynamics theory predicts T1/2 to be strongly dependent on chamber compliance and the peak transmitral gradient, which are variables that change dramaticall...

journal_title：Circulation

authors： Thomas JD,Wilkins GT,Choong CY,Abascal VM,Palacios IF,Block PC,Weyman AE

更新日期：1988-10-01 00:00:00

abstract：:Total anomalous pulmonary venous connection (TAPVC) is a rare cardiac congenital abnormality which usually results in death in infancy or early childhood. We describe a 52-year-old man with TAPVC and severe calcific pulmonic stenosis. Both diagnoses were suspected clinically and from the chest X-ray. Cardiac catheteri...

journal_title：Circulation

authors： Pastore JO,Akins CW,Zir LM,Buckley MJ,Dinsmore RE

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:The mechanisms of simple faint remain elusive. We propose that postural fainting is related to excessive thoracic hypovolemia and splanchnic hypervolemia during orthostasis compared with healthy subjects. METHODS AND RESULTS:We studied 34 patients 12 to 22 years old referred for multiple episodes of postura...

journal_title：Circulation

authors： Stewart JM,McLeod KJ,Sanyal S,Herzberg G,Montgomery LD

更新日期：2004-10-26 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) remains a concern in patients with β-thalassemia major (TM) and intermedia (TI); however, studies evaluating its prevalence and risk factors using systematic confirmation on right heart catheterization are lacking. METHODS AND RESULTS:This was a multicenter cross-sectio...

journal_title：Circulation

authors： Derchi G,Galanello R,Bina P,Cappellini MD,Piga A,Lai ME,Quarta A,Casu G,Perrotta S,Pinto V,Musallam KM,Forni GL,Webthal Pulmonary Arterial Hypertension Group*.

更新日期：2014-01-21 00:00:00

abstract：BACKGROUND:Expansion of an acute myocardial infarction predicts progressive left ventricular (LV) dilatation, functional deterioration, and early death. This study tests the hypothesis that restraining expansion of an acute infarction preserves LV geometry and resting function. METHODS AND RESULTS:In 23 sheep, snares ...

journal_title：Circulation

authors： Kelley ST,Malekan R,Gorman JH 3rd,Jackson BM,Gorman RC,Suzuki Y,Plappert T,Bogen DK,Sutton MG,Edmunds LH Jr

更新日期：1999-01-05 00:00:00

abstract：BACKGROUND:Rosiglitazone improves glycemic control for patients with type 2 diabetes mellitus, but there remains controversy regarding an observed association with cardiovascular hazard. The cardiovascular effects of rosiglitazone for patients with coronary artery disease remain unknown. METHODS AND RESULTS:To examine...

journal_title：Circulation

authors： Bach RG,Brooks MM,Lombardero M,Genuth S,Donner TW,Garber A,Kennedy L,Monrad ES,Pop-Busui R,Kelsey SF,Frye RL,BARI 2D Investigators.

更新日期：2013-08-20 00:00:00

abstract：BACKGROUND:Stroke is a leading cause of death and disability. Although clinical trials of the early lipid-lowering therapies did not demonstrate a reduction in the rates of stroke, data from recently completed statin trials strongly suggest benefit. METHODS AND RESULTS:The effect of pravastatin 40 mg/d on stroke event...

journal_title：Circulation

authors： Byington RP,Davis BR,Plehn JF,White HD,Baker J,Cobbe SM,Shepherd J

更新日期：2001-01-23 00:00:00

abstract：BACKGROUND:Since 1990, sternotomy has been the preferred approach for construction of a modified Blalock-Taussig shunt (MBTS) at Children's Hospital, Boston, Mass. In retrospect, we sought to test the hypothesis that this approach yields less mortality and morbidity than the traditional thoracotomy approach. METHODS A...

journal_title：Circulation

authors： Odim J,Portzky M,Zurakowski D,Wernovsky G,Burke RP,Mayer JE Jr,Castaneda AR,Jonas RA

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:High-speed rotational atherectomy uses a diamond-coated, elliptical burr to abrade occlusive atherosclerosis, especially noncompliant calcified plaque. METHODS AND RESULTS:Intravascular ultrasound (IVUS) was used to analyze 28 patients after atherectomy. Arteries treated and imaged were left main (three), l...

journal_title：Circulation

authors： Mintz GS,Potkin BN,Keren G,Satler LF,Pichard AD,Kent KM,Popma JJ,Leon MB

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Alterations in the balance of matrix metalloproteinases (MMPs) and their specific tissue inhibitors (TIMPs) are involved in left ventricular (LV) remodeling. Whether their expression is related to interstitial fibrosis or LV dysfunction in patients with chronic pressure overload-induced LV hypertrophy, howev...

journal_title：Circulation

authors： Heymans S,Schroen B,Vermeersch P,Milting H,Gao F,Kassner A,Gillijns H,Herijgers P,Flameng W,Carmeliet P,Van de Werf F,Pinto YM,Janssens S

更新日期：2005-08-23 00:00:00

abstract：:Patients with aortic stenosis develop widely variable patterns of left ventricular hypertrophy and dysfunction. We postulated that coronary atherosclerosis (CAD) may be associated with impaired left ventricular function and chamber dilatation in patients with aortic stenosis. Left ventricular mass and volumes were qua...

journal_title：Circulation

authors： Vekshtein VI,Alexander RW,Yeung AC,Plappert T,Sutton MG,Ganz P,Selwyn AP,Bittl JA

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Blood clotting activation is an important component of the inflammatory response; the outbursts of unstable angina are usually associated with increased thrombin formation and coronary mural thrombosis. METHODS AND RESULTS:To investigate 1) whether monocyte activation is responsible for the enhanced thrombi...

journal_title：Circulation

authors： Serneri GG,Abbate R,Gori AM,Attanasio M,Martini F,Giusti B,Dabizzi P,Poggesi L,Modesti PA,Trotta F

更新日期：1992-09-01 00:00:00

abstract：:A study correlating the electrocardiographic findings and the histology of the atrioventricular (AV) conduction system was carried out in 14 cases with chronic complete AV block and in 13 cases without chronic complete AV block. Patients with chronic complete AV block were divided into two groups, based on the width o...

journal_title：Circulation

authors： Ohkawa S,Hackel DB,Ideker RE

更新日期：1981-04-01 00:00:00