Restraining infarct expansion preserves left ventricular geometry and function after acute anteroapical infarction.

abstract：BACKGROUND:Myocardial uptake of either 201Tl or 99mTc-sestamibi (sestamibi) is known to plateau at high coronary flow rates. However, few direct comparisons have been made between these tracers to determine what effect differences in the uptake plateau for the two tracers may have on the detection of coronary stenoses ...

journal_title：Circulation

authors： Glover DK,Ruiz M,Edwards NC,Cunningham M,Simanis JP,Smith WH,Watson DD,Beller GA

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Human pluripotent stem cell (hPSC)-derived endothelial cells (ECs) have limited clinical utility because of undefined components in the differentiation system and poor cell survival in vivo. Here, we aimed to develop a fully defined and clinically compatible system to differentiate hPSCs into ECs. Furthermor...

journal_title：Circulation

authors： Lee SJ,Sohn YD,Andukuri A,Kim S,Byun J,Han JW,Park IH,Jun HW,Yoon YS

更新日期：2017-11-14 00:00:00

abstract：BACKGROUND:We have demonstrated that brain natriuretic peptide (BNP) is a cardiac hormone predominantly synthesized in and secreted from the ventricle. We have also reported that, compared with atrial natriuretic peptide (ANP), the plasma concentration of BNP is increased to a greater degree in patients with congestive...

journal_title：Circulation

authors： Hama N,Itoh H,Shirakami G,Nakagawa O,Suga S,Ogawa Y,Masuda I,Nakanishi K,Yoshimasa T,Hashimoto Y

更新日期：1995-09-15 00:00:00

abstract：BACKGROUND:Although insulin resistance has been implicated in the pathogenesis of left ventricular (LV) hypertrophy, previous studies have yielded inconsistent results and are limited by referral bias. METHODS AND RESULTS:We examined the relations between echocardiographic LV measurements and glucose tolerance status ...

journal_title：Circulation

authors： Rutter MK,Parise H,Benjamin EJ,Levy D,Larson MG,Meigs JB,Nesto RW,Wilson PW,Vasan RS

更新日期：2003-01-28 00:00:00

abstract：BACKGROUND:We have demonstrated that myocardial acceleration during isovolumic contraction (IVA) is a sensitive index of right ventricular contractile function. In this study, we assessed the usefulness of IVA to measure left ventricular (LV) contractile function and force-frequency relationships in an experimental pre...

journal_title：Circulation

authors： Vogel M,Cheung MM,Li J,Kristiansen SB,Schmidt MR,White PA,Sorensen K,Redington AN

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Percutaneous transluminal coronary angioplasty (PTCA) of the infarct-related artery was performed within 42 days of recombinant tissue-type plasminogen activator (rt-PA) administration in 1,414 of the 3,534 patients who participated in the Thrombolysis In Myocardial Infarction (TIMI) II study. Primary angiog...

journal_title：Circulation

authors： Baim DS,Diver DJ,Feit F,Greenberg MA,Holmes DR,Weiner BH,Williams DO,Schweiger MJ,Brown BG,Frederick MM

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Extracorporeal membrane oxygenation (ECMO) is considered when respiratory failure (RF) persists despite increasing conventional mechanical ventilation (CMV). High-frequency jet ventilation (HFJV) can improve ventilation with comparable mean airway pressure (PAW) to that found on CMV. This study was undertake...

journal_title：Circulation

authors： Kocis KC,Meliones JN,Dekeon MK,Callow LB,Lupinetti FM,Bove EL

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:In patients with mitral regurgitation, surgical intervention produces immediate improvement in symptoms, but the long-term incidence and significance of postoperative congestive heart failure are unknown. METHODS AND RESULTS:The long-term outcome of 576 operative survivors of surgical correction of pure mit...

journal_title：Circulation

authors： Enriquez-Sarano M,Schaff HV,Orszulak TA,Bailey KR,Tajik AJ,Frye RL

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:The extent of microvascular obstruction during acute coronary occlusion may determine the eventual magnitude of myocardial damage and thus, patient prognosis after infarction. By contrast-enhanced MRI, regions of profound microvascular obstruction at the infarct core are hypoenhanced and correspond to greate...

journal_title：Circulation

authors： Wu KC,Zerhouni EA,Judd RM,Lugo-Olivieri CH,Barouch LA,Schulman SP,Blumenthal RS,Lima JA

更新日期：1998-03-03 00:00:00

abstract：:Digitalis has been shown to improve the impaired ventricular function associated with coronary artery disease as well as to increase myocardial oxygen consumption and produce coronary vasoconstriction. To elucidate the net result of these contrasting effects, six patients with coronary artery disease and left ventricu...

journal_title：Circulation

authors： Vogel R,Kirch D,LeFree M,Frischknecht J,Steele P

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND:The Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery (SYNTAX) trial demonstrated that in patients with 3-vessel or left main coronary artery disease, coronary artery bypass graft surgery (CABG) was associated with a lower rate of cardiovascular death, myocardial infarction, s...

journal_title：Circulation

authors： Cohen DJ,Osnabrugge RL,Magnuson EA,Wang K,Li H,Chinnakondepalli K,Pinto D,Abdallah MS,Vilain KA,Morice MC,Dawkins KD,Kappetein AP,Mohr FW,Serruys PW,SYNTAX Trial Investigators.

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:Data on outcomes after Stanford type A aortic dissection in patients with Marfan syndrome are limited. We investigated the primary surgery and long-term results in patients with Marfan syndrome who suffered aortic dissection. METHODS AND RESULTS:Among 1324 consecutive patients with aortic dissection type A,...

journal_title：Circulation

authors： Rylski B,Bavaria JE,Beyersdorf F,Branchetti E,Desai ND,Milewski RK,Szeto WY,Vallabhajosyula P,Siepe M,Kari FA

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Increased carotid intimal-medial thickness (IMT) and coronary artery calcification (CAC) are used as 2 markers of early atherosclerosis. Our objectives were to assess whether increased IMT and CAC are related and to determine the relationship between cardiovascular risk factors and carotid IMT in young adult...

journal_title：Circulation

authors： Davis PH,Dawson JD,Mahoney LT,Lauer RM

更新日期：1999-08-24 00:00:00

abstract：BACKGROUND:Bone marrow implantation (BMI) was shown to enhance angiogenesis in a rat ischemic heart model. This preclinical study using a swine model was designed to test the safety and therapeutic effectiveness of BMI. METHODS AND RESULTS:BM-derived mononuclear cells (BM-MNCs) were injected into a zone made ischemic ...

journal_title：Circulation

authors： Kamihata H,Matsubara H,Nishiue T,Fujiyama S,Tsutsumi Y,Ozono R,Masaki H,Mori Y,Iba O,Tateishi E,Kosaki A,Shintani S,Murohara T,Imaizumi T,Iwasaka T

更新日期：2001-08-28 00:00:00

abstract：BACKGROUND:Weight loss in obese insulin-resistant but not in insulin-sensitive persons reduces coronary heart disease risk. To what extent changes in gene expression are related to atherosclerosis and cardiovascular function is unknown. METHODS AND RESULTS:We studied the effect of diet restriction-induced weight loss ...

journal_title：Circulation

authors： Verreth W,De Keyzer D,Pelat M,Verhamme P,Ganame J,Bielicki JK,Mertens A,Quarck R,Benhabilès N,Marguerie G,Mackness B,Mackness M,Ninio E,Herregods MC,Balligand JL,Holvoet P

更新日期：2004-11-16 00:00:00

abstract：BACKGROUND:The transient outward potassium current (I(to)) encoded by the Kv4 family of potassium channels is important in the repolarization of cardiac myocytes. KChIPs are a recently identified group of Ca2+-binding accessory subunits that modulate Kv4-encoded currents. KChIP2 is the only family member expressed in t...

journal_title：Circulation

authors： Deschênes I,DiSilvestre D,Juang GJ,Wu RC,An WF,Tomaselli GF

更新日期：2002-07-23 00:00:00

abstract：BACKGROUND:MicroRNAs (miRs) participate in many cardiac pathophysiological processes, including ischemia/reperfusion (I/R)-induced cardiac injury. Recently, we and others observed that miR-494 was downregulated in murine I/R-injured and human infarcted hearts. However, the functional consequence of miR-494 in response ...

journal_title：Circulation

authors： Wang X,Zhang X,Ren XP,Chen J,Liu H,Yang J,Medvedovic M,Hu Z,Fan GC

更新日期：2010-09-28 00:00:00

abstract：:Coronary artery bypass grafts, angioplasty, and thrombolysis are beneficial procedures for patients with coronary artery disease. However, these procedures can fail by mechanisms related to interactions between platelets and the damaged arterial wall. An experimental model for studying some of the mechanisms of platel...

journal_title：Circulation

authors： Folts J

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:We investigated whether L-arginine induces regression of preexisting atheromatous lesions and reversal of endothelial dysfunction in hypercholesterolemic rabbits, whether similar effects can be obtained by cholesterol-lowering therapy with lovastatin, and which mechanism leads to these effects. METHODS AND ...

journal_title：Circulation

authors： Böger RH,Bode-Böger SM,Brandes RP,Phivthong-ngam L,Böhme M,Nafe R,Mügge A,Frölich JC

更新日期：1997-08-19 00:00:00

abstract：BACKGROUND:Thrombolytic therapy is a promising alternative to valve replacement in the management of prosthetic valve thrombosis. We sought to determine the short- and long-term results of treating thrombosed St. Jude heart valves with thrombolytic therapy as the primary treatment modality. METHODS AND RESULTS:Between...

journal_title：Circulation

authors： Silber H,Khan SS,Matloff JM,Chaux A,DeRobertis M,Gray R

更新日期：1993-01-01 00:00:00

abstract：:To assess the impact of operative reduction of left ventricular outflow obstruction in hypertrophic cardiomyopathy, measurements of great cardiac vein flow, oxygen and lactate content, left ventricular pressures, and cardiac index were measured at rest and during pacing stress in 20 consecutive patients (13, myotomy-m...

journal_title：Circulation

authors： Cannon RO 3rd,McIntosh CL,Schenke WH,Maron BJ,Bonow RO,Epstein SE

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Whether cardiac rehabilitation (CR) is effective in patients older than 75 years, who have been excluded from most trials, remains unclear. We enrolled patients 46 to 86 years old in a randomized trial and assessed the effects of 2 months of post-myocardial infarction (MI) CR on total work capacity (TWC, in ...

journal_title：Circulation

authors： Marchionni N,Fattirolli F,Fumagalli S,Oldridge N,Del Lungo F,Morosi L,Burgisser C,Masotti G

更新日期：2003-05-06 00:00:00

abstract：:Continuous retrograde coronary sinus cardioplegia (CSCP) has previously been carefully evaluated experimentally and shown to be efficacious during ischemia, even in the presence of coronary lesions and in the hypertrophied state. A new technique of retrograde cardioplegia delivery through the right atrium, using right...

journal_title：Circulation

authors： Salter DR,Goldstein JP,Abd-Elfattah A,Murphy CE,Brunsting LA,Wechsler AS

更新日期：1987-11-01 00:00:00

abstract：:The specific and sensitivity of serum creatine phosphokinase cardiac specific isoenzyme (MB) in the diagnosis of acute myocardial infarction (AMI) was evaluated. An ion-exchange chromatographic technique was used to isolate MB. Sera layered on mini-columns of DEAE-Sephadex were eluted with Tris-buffered sodium chlorid...

journal_title：Circulation

authors： Varat MA,Mercer DW

更新日期：1975-05-01 00:00:00

abstract：:To investigate whether a fixed external reference system should be used to most accurately describe regional left ventricular wall motion, we used vectors to analyze a simple model of ventricular contraction. If measured in a fixed external reference system, motion of implanted radiopaque midwall markers may contain t...

journal_title：Circulation

authors： Clayton PD,Jeppson GM,Klausner SC

更新日期：1982-06-01 00:00:00

abstract：:The rapid injection into the coronary circulation of solutions containing microbubbles produces an ultrasonic contrast effect in the myocardium. The time-intensity curves generated by sequential videodensitometric analysis of contrast intensity, which is corrected for myocardial background intensity, resembles the cur...

journal_title：Circulation

authors： Quiñones A,Cheirif BJ

更新日期：1991-05-01 00:00:00

abstract：:Ventricular dysfunction, elevated pulmonary vascular resistance, and residual distal pulmonary artery distortion contribute to early mortality after a Fontan operation; they may be transient or reversible. A baffle fenestration, allowing right-to-left shunting, maintains cardiac output and limits right atrial pressure...

journal_title：Circulation

authors： Bridges ND,Lock JE,Castaneda AR

更新日期：1990-11-01 00:00:00

abstract：:Periodic fluctuations in the R-R interval have been used as noninvasive measures of cardiac autonomic tone. For example, a reduced heart rate variability has been shown to correlate with an increased mortality in patients recovering from myocardial infarction. The effects that physiologic perturbations such as exercis...

journal_title：Circulation

authors： Billman GE,Hoskins RS

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Brugada syndrome (BrS) primarily associates with the loss of sodium channel function. Previous studies showed features consistent with sodium current (INa) deficit in patients carrying desmosomal mutations, diagnosed with arrhythmogenic cardiomyopathy (or arrhythmogenic right ventricular cardiomyopathy). Exp...

journal_title：Circulation

authors： Cerrone M,Lin X,Zhang M,Agullo-Pascual E,Pfenniger A,Chkourko Gusky H,Novelli V,Kim C,Tirasawadichai T,Judge DP,Rothenberg E,Chen HS,Napolitano C,Priori SG,Delmar M

更新日期：2014-03-11 00:00:00

abstract：:Catheter ablation has gained a prominent role in the management of atrial fibrillation (AF), with recent data providing positive evidence on hard outcomes, including hospitalization and mortality. Ablation, however, exposes the patient to a rather unique situation, combining risks for both major bleeding and thromboem...

journal_title：Circulation

authors： Martin AC,Godier A,Narayanan K,Smadja DM,Marijon E

更新日期：2018-08-07 00:00:00