High-frequency jet ventilation for respiratory failure after congenital heart surgery.


BACKGROUND:Extracorporeal membrane oxygenation (ECMO) is considered when respiratory failure (RF) persists despite increasing conventional mechanical ventilation (CMV). High-frequency jet ventilation (HFJV) can improve ventilation with comparable mean airway pressure (PAW) to that found on CMV. This study was undertaken to determine whether HFJV is an effective treatment and alternative to ECMO for RF after congenital heart surgery. METHODS AND RESULTS:HFJV was instituted in nine patients ranging in age from 6 days to 3.3 years with congenital heart disease meeting pulmonary criteria for ECMO. Indications for HFJV were pulmonary hypertension (six), adult-type respiratory distress syndrome (two), and pneumonitis (one). Seven patients (77%) were placed on HFJV within 24 hours of operation, and two patients required HFJV 2 weeks after operation. HFJV resulted in resolution of RF in eight of nine patients (89%). After 1 hour of HFJV, the arterial pH increased from 7.40 +/- 0.1 to 7.56 +/- 0.1 (p < 0.05) and the PaCO2 decreased from 44 +/- 15 to 29 +/- 12 mm Hg (p < 0.05). During HFJV there was no change in PaO2, although the FIO2 decreased from 0.99 +/- 0.0 to 0.73 +/- 0.2 (p < 0.05). There was no change in PAW, peak inspiratory pressures, positive end-expiratory pressures, heart rate, or mean arterial blood pressure during HFJV when compared with CMV. Mean duration of HFJV was 43 hours. Four patients were extubated and discharged from the hospital. Two patients were extubated but died from sepsis. Two patients had resolution of RF, but one died at reoperation and one from multisystem organ failure. The patient who failed HFJV therapy was placed on ECMO and died. CONCLUSIONS:This study suggests that HFJV improves ventilation and is an alternative to ECMO in patients with RF after surgery for congenital heart disease.






Kocis KC,Meliones JN,Dekeon MK,Callow LB,Lupinetti FM,Bove EL


Has Abstract


1992-11-01 00:00:00




5 Suppl








  • Propranolol therapy in patients with acute myocardial infarction: the Beta-Blocker Heart Attack Trial.

    abstract::The Beta-Blocker Heart Attack Trial was a multicenter, randomized, double-blind, placebo-controlled trial of propranolol therapy in 3837 men and women with acute myocardial infarction. The patients began their treatment 5-21 days after hospital admission (mean 13.8 days). During an average follow-up of 25 months, ther...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Goldstein S

    更新日期:1983-06-01 00:00:00

  • Flecainide-induced arrhythmia in canine ventricular epicardium. Phase 2 reentry?

    abstract:BACKGROUND:We recently reported that sodium channel block can produce opposite effects on action potential duration (APD) and refractoriness in epicardial versus endocardial tissues of the canine ventricle. In addition, strong sodium channel current inhibition was found to cause loss of the action potential dome in epi...


    pub_type: 杂志文章


    authors: Krishnan SC,Antzelevitch C

    更新日期:1993-02-01 00:00:00

  • Genetic Predisposition to High Blood Pressure and Lifestyle Factors: Associations With Midlife Blood Pressure Levels and Cardiovascular Events.

    abstract:BACKGROUND:High blood pressure (BP) is a major risk factor for cardiovascular diseases (CVDs), the leading cause of mortality worldwide. Both heritable and lifestyle risk factors contribute to elevated BP levels. We aimed to investigate the extent to which lifestyle factors could offset the effect of an adverse BP gene...


    pub_type: 临床试验,杂志文章


    authors: Pazoki R,Dehghan A,Evangelou E,Warren H,Gao H,Caulfield M,Elliott P,Tzoulaki I

    更新日期:2018-02-13 00:00:00

  • Lipid-rich atherosclerotic plaques detected by gadofluorine-enhanced in vivo magnetic resonance imaging.

    abstract:BACKGROUND:MRI of specific components in atherosclerotic plaque may provide information on plaque stability and its potential to rupture. We evaluated gadofluorine in atherosclerotic rabbits using a new MR sequence that allows plaque detection within 1 hour after injection and assessed enhancement in lipid-rich and non...


    pub_type: 杂志文章


    authors: Sirol M,Itskovich VV,Mani V,Aguinaldo JG,Fallon JT,Misselwitz B,Weinmann HJ,Fuster V,Toussaint JF,Fayad ZA

    更新日期:2004-06-15 00:00:00

  • Recommendations for the Implementation of Telehealth in Cardiovascular and Stroke Care: A Policy Statement From the American Heart Association.

    abstract::The aim of this policy statement is to provide a comprehensive review of the scientific evidence evaluating the use of telemedicine in cardiovascular and stroke care and to provide consensus policy suggestions. We evaluate the effectiveness of telehealth in advancing healthcare quality, identify legal and regulatory b...


    pub_type: 杂志文章,评审


    authors: Schwamm LH,Chumbler N,Brown E,Fonarow GC,Berube D,Nystrom K,Suter R,Zavala M,Polsky D,Radhakrishnan K,Lacktman N,Horton K,Malcarney MB,Halamka J,Tiner AC,American Heart Association Advocacy Coordinating Committee.

    更新日期:2017-02-14 00:00:00

  • Troglitazone inhibits voltage-dependent calcium currents in guinea pig cardiac myocytes.

    abstract:BACKGROUND:It has been suggested that intracellular Ca2+ overload in cardiac myocytes leads to the development of diabetic cardiomyopathy. Troglitazone, an insulin-sensitizing agent, is a promising therapeutic agent for diabetes and has been shown to prevent diabetes-induced myocardial changes. To elucidate the underly...


    pub_type: 杂志文章


    authors: Nakajima T,Iwasawa K,Oonuma H,Imuta H,Hazama H,Asano M,Morita T,Nakamura F,Suzuki J,Suzuki S,Kawakami Y,Omata M,Okuda Y

    更新日期:1999-06-08 00:00:00

  • Repeat coronary revascularization after coronary artery bypass surgery in older adults: the Society of Thoracic Surgeons' national experience, 1991-2007.

    abstract:BACKGROUND:A major advantage of coronary artery bypass graft surgery (CABG) relative to percutaneous coronary intervention is its durability, yet there is a paucity of information on rates and predictors of repeat coronary revascularization after CABG in the modern era. METHODS AND RESULTS:We included patients ≥65 yea...


    pub_type: 杂志文章


    authors: Fosbøl EL,Zhao Y,Shahian DM,Grover FL,Edwards FH,Peterson ED

    更新日期:2013-04-23 00:00:00

  • Clinical features and outcomes of women with unstable ischemic heart disease: observations from metabolic efficiency with ranolazine for less ischemia in non-ST-elevation acute coronary syndromes-thrombolysis in myocardial infarction 36 (MERLIN-TIMI 36).

    abstract:BACKGROUND:The pathobiological basis of ischemic heart disease and thus the manifestations and response to therapy can differ between women and men. In prior studies, sex-based treatment differences have been observed with the antiischemic ranolazine, with a possibly diminished effect in women. METHODS AND RESULTS:We ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Mega JL,Hochman JS,Scirica BM,Murphy SA,Sloan S,McCabe CH,Merlini P,Morrow DA

    更新日期:2010-04-27 00:00:00

  • Calcium antagonists and hypothermia: the temperature dependency of the negative inotropic and anti-ischemic properties of verapamil in the isolated rat heart.

    abstract::Using an isolated rat heart preparation under both aerobic and ischemic conditions we have characterized the temperature dependency of the slow calcium channel-blocking drug verapamil. In the first series of studies, isolated working rat hearts were subjected to global ischemia at 37 degrees, 34 degrees, 31 degrees, 2...


    pub_type: 杂志文章


    authors: Hearse DJ,Yamamoto F,Shattock MJ

    更新日期:1984-09-01 00:00:00

  • Concealed intraventricular conduction in the His bundle electrogram.

    abstract::Multiple areas of concealed intraventricular conduction are deduced on the basis of aftereffects observed in His bundle recordings. Electrocardiograms and His bundle recordings are presented from two patients with unstable bilateral bundle branch block, the instability of which depended on the interval at which ventri...


    pub_type: 杂志文章


    authors: Cohen HC,D'Cruz I,Pick A

    更新日期:1976-05-01 00:00:00

  • Transmembrane potential properties at the core of functional reentrant wave fronts in isolated canine right atria.

    abstract:BACKGROUND:The characteristics of transmembrane potential (TMP) at the core of functional reentry in the atrium are not well understood. METHODS AND RESULTS:In protocol 1 (11 dogs), isolated perfused canine right atria were mapped from the endocardial surface while simultaneous TMPs were recorded from the epicardial s...


    pub_type: 杂志文章


    authors: Athill CA,Ikeda T,Kim YH,Wu TJ,Fishbein MC,Karagueuzian HS,Chen PS

    更新日期:1998-10-13 00:00:00

  • Coronary bypass surgery in chronic stable angina.

    abstract::Over the last 20 years, operative mortality has decreased and late survival has improved for patients with chronic stable angina who have coronary artery bypass surgery. However, this favorable trend may not continue because the operation is now extended to elderly and high-risk patients. The most powerful predictors ...


    pub_type: 临床试验,杂志文章,评审


    authors: Gersh BJ,Califf RM,Loop FD,Akins CW,Pryor DB,Takaro TC

    更新日期:1989-06-01 00:00:00

  • Cardioplegic solutions for myocardial preservation: analysis of hypothermic arrest, potassium arrest, and procaine arrest.

    abstract::Separate effects of perfusion hypothermia, potassium arrest, and procaine arrest were studied in 150 hearts using the isolated rat heart preparation. Aortic flow rate (AFR), coronary flow rate (CFR), and heart rate (HR) were measured before and after ischemic periods of 90 to 300 min. Prior to the ischemic period, the...


    pub_type: 杂志文章


    authors: Harlan BJ,Ross D,Macmanus Q,Knight R,Luber J,Starr A

    更新日期:1978-09-01 00:00:00

  • Spectral analysis identifies sites of high-frequency activity maintaining atrial fibrillation in humans.

    abstract:BACKGROUND:The identification of sites of dominant activation frequency during atrial fibrillation (AF) in humans and the effect of ablation at these sites have not been reported. METHODS AND RESULTS:Thirty-two patients undergoing AF ablation (19 paroxysmal, 13 permanent) during ongoing arrhythmia were studied. Electr...


    pub_type: 杂志文章


    authors: Sanders P,Berenfeld O,Hocini M,Jaïs P,Vaidyanathan R,Hsu LF,Garrigue S,Takahashi Y,Rotter M,Sacher F,Scavée C,Ploutz-Snyder R,Jalife J,Haïssaguerre M

    更新日期:2005-08-09 00:00:00

  • Validation of the Bleeding Academic Research Consortium definition of bleeding in patients with coronary artery disease undergoing percutaneous coronary intervention.

    abstract:BACKGROUND:The Bleeding Academic Research Consortium (BARC) has recently proposed a unified definition of bleeding in patients receiving antithrombotic therapy. We investigated the relationship between bleeding events as defined by BARC and 1-year mortality in patients undergoing percutaneous coronary intervention (PCI...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Ndrepepa G,Schuster T,Hadamitzky M,Byrne RA,Mehilli J,Neumann FJ,Richardt G,Schulz S,Laugwitz KL,Massberg S,Schömig A,Kastrati A

    更新日期:2012-03-20 00:00:00

  • Adenylylcyclase increases responsiveness to catecholamine stimulation in transgenic mice.

    abstract:BACKGROUND:The cellular content of cAMP generated by activation of adenylylcyclase (AC) through the beta-adrenergic receptor (betaAR) is a key determinant of a cell's response to catecholamine stimulation. We tested the hypothesis that increased AC content, independently of betaAR number, increases responsiveness to ca...


    pub_type: 杂志文章


    authors: Gao MH,Lai NC,Roth DM,Zhou J,Zhu J,Anzai T,Dalton N,Hammond HK

    更新日期:1999-03-30 00:00:00

  • Hemodynamic findings in 123 patients with acute myocardial infarction on admission.

    abstract::Hemodynamic and clinical evaluations of 123 patients with acute myocardial infarction were performed during the first hour of admission to the hospital. In the 123 patients, the right atrial pressure was less than 10 mm Hg in 49 patients, the right atrial oxygen saturation was less than 70% in 97 patients, the arterio...


    pub_type: 杂志文章


    authors: Ramo BW,Myers N,Wallace AG,Starmer F,Clark DO,Whalen RE

    更新日期:1970-10-01 00:00:00

  • Effects of diastolic transseptal pressure gradient on ventricular septal position and motion.

    abstract::Despite the clinical prevalence of paradoxic interventricular septal (IVS) motion, its pathogenesis remains unclear. To assess the influence of the end-diastolic transseptal pressure gradient, we studied eight open-chest dogs during right ventricular (RV) volume loading (induced by opening a Dacron shunt between the p...


    pub_type: 杂志文章


    authors: Kingma I,Tyberg JV,Smith ER

    更新日期:1983-12-01 00:00:00

  • Does Previous Transradial Catheterization Preclude Use of the Radial Artery as a Conduit in Coronary Artery Bypass Surgery?

    abstract::The radial artery (RA) is a commonly used conduit for coronary artery bypass grafting, and recent studies have demonstrated that it provides superior long-term patency rates to the saphenous vein in most situations. In addition, the RA is also being used with increasing frequency as the access point for coronary angio...


    pub_type: 杂志文章,评审


    authors: Mounsey CA,Mawhinney JA,Werner RS,Taggart DP

    更新日期:2016-08-30 00:00:00

  • Risk factors related to progressive narrowing in aortocoronary vein grafts studied 1 and 5 years after surgery.

    abstract::Factors related to late narrowing of aortocoronary vein grafts are poorly understood. Repeat aortocoronary bypass graft angiography was performed in 34 patients at 13 +/- 5 months and 61 +/- 13 months after surgery. In these patients, 61 of 65 grafts (94%) were patent at 1 year; at 5 years, 39 of these patent grafts (...


    pub_type: 杂志文章


    authors: Palac RT,Meadows WR,Hwang MH,Loeb HS,Pifarre R,Gunnar RM

    更新日期:1982-08-01 00:00:00

  • Inhibition of inositol(1,4,5)Trisphosphate generation by endothelin-1 during postischemic reperfusion: A novel antiarrhythmic mechanism.

    abstract:BACKGROUND:Reperfusion of ischemic rat hearts in the presence of thrombin or norepinephrine but not endothelin-1 causes the generation of inositol 1,4,5-trisphosphate (Ins 1,4,5P3) and arrhythmias. The present study investigates the effect of endothelin-1 on these responses. METHODS AND RESULTS:Ins 1,4,5P3 generation ...


    pub_type: 杂志文章


    authors: Woodcock EA,Reyes N,Jacobsen AN,Du XJ

    更新日期:1999-02-16 00:00:00

  • Cardiac interbeat interval dynamics from childhood to senescence : comparison of conventional and new measures based on fractals and chaos theory.

    abstract:BACKGROUND:New methods of R-R interval variability based on fractal scaling and nonlinear dynamics ("chaos theory") may give new insights into heart rate dynamics. The aims of this study were to (1) systematically characterize and quantify the effects of aging from early childhood to advanced age on 24-hour heart rate ...


    pub_type: 杂志文章


    authors: Pikkujämsä SM,Mäkikallio TH,Sourander LB,Räihä IJ,Puukka P,Skyttä J,Peng CK,Goldberger AL,Huikuri HV

    更新日期:1999-07-27 00:00:00

  • C-reactive protein is associated with subclinical epicardial coronary calcification in men and women: the Framingham Heart Study.

    abstract:BACKGROUND:High C-reactive protein (CRP) levels are associated with an increased risk of cardiovascular events, even in apparently healthy individuals. It has not been established whether elevated CRP reflects an increased burden of subclinical coronary atherosclerosis. METHODS AND RESULTS:We studied a stratified rand...


    pub_type: 杂志文章


    authors: Wang TJ,Larson MG,Levy D,Benjamin EJ,Kupka MJ,Manning WJ,Clouse ME,D'Agostino RB,Wilson PW,O'Donnell CJ

    更新日期:2002-09-03 00:00:00

  • Kinetics of electrophysiologic changes during oral loading of amiodarone and after withdrawal of amiodarone in the unsedated dog.

    abstract::We examined the temporal kinetics of onset and offset of the cardiac electrophysiologic effects of orally administered amiodarone in chronically instrumented, unsedated adult dogs (n = 8). Right atrial (RA), atrioventricular nodal (AVN), and right ventricular (RV) effective refractory period (ERP), and AVN functional ...


    pub_type: 杂志文章


    authors: Tuna IC,Qi AC,Gornick C,Bolman RM 3rd,Benditt DG

    更新日期:1985-12-01 00:00:00

  • Preservation of donor heart function and high-energy stores by continuous perfusion with synthetic plasma at 22 degrees C.

    abstract::We evaluated high-energy phosphate (HEP) levels and the ability to perform work in rat hearts preserved by standard techniques (0.9% NaCl arrest and storage at 4 degrees C) and by continuous coronary perfusion at 22 degrees C, pH 7.25, and 55 mm Hg for 4 or 8 hr with Krebs-Henseleit buffer (KHB), modified Morgan's sol...


    pub_type: 杂志文章


    authors: Novick WM,Wallace HW,Root KL,Rozanski DJ,Fuller EO

    更新日期:1986-11-01 00:00:00

  • Presence of tissue factor pathway inhibitor in human atherosclerotic plaques is associated with reduced tissue factor activity.

    abstract:BACKGROUND:Plaque disruption and exposure of subendothelial procoagulants such as tissue factor (TF) to circulating factor VII/VIIa (FVII/VIIa) lead to intravascular thrombosis. Tissue factor pathway inhibitor (TFPI) is an endogenous inhibitor of TF-induced coagulation that binds to factor Xa and the TF-FVIIa catalytic...


    pub_type: 杂志文章


    authors: Caplice NM,Mueske CS,Kleppe LS,Simari RD

    更新日期:1998-09-15 00:00:00

  • Weight loss reduces C-reactive protein levels in obese postmenopausal women.

    abstract:BACKGROUND:C-reactive protein (CRP) has been proposed as an independent risk factor for cardiovascular disease and has been positively associated with body weight and body fatness. We examined the hypothesis that weight loss would reduce plasma CRP levels in obese postmenopausal women. METHODS AND RESULTS:In a sample ...


    pub_type: 临床试验,杂志文章


    authors: Tchernof A,Nolan A,Sites CK,Ades PA,Poehlman ET

    更新日期:2002-02-05 00:00:00

  • Progressive tricuspid valve disease in patients with congenitally corrected transposition of the great arteries.

    abstract:BACKGROUND:The outcome of patients with corrected transposition of the great arteries (CTGA) is variably affected by associated intracardiac defects, tricuspid valve competence, and systemic right ventricular (RV) function. The relative importance of these factors in long-term outcome has not been evaluated. METHODS A...


    pub_type: 杂志文章


    authors: Prieto LR,Hordof AJ,Secic M,Rosenbaum MS,Gersony WM

    更新日期:1998-09-08 00:00:00

  • Effect of the calcium antagonist verapamil on necrosis following temporary coronary artery occlusion in dogs.

    abstract::Calcium metabolism may play an important role in the pathogenesis of myocardial ischemic injury. The effect of the sarcolemmal calcium flux inhibitor, verapamil, on myocardial necrosis was studied in dogs subjected to temporary coronary artery occlusion. One group of dogs was untreated. A second group was given 0.8 mg...


    pub_type: 杂志文章


    authors: Reimer KA,Lowe JE,Jennings RB

    更新日期:1977-04-01 00:00:00

  • Characterization of Myocardial Repolarization Reserve in Adolescent Females With Anorexia Nervosa.

    abstract:BACKGROUND:Patients with anorexia nervosa exhibit abnormal myocardial repolarization and are susceptible to sudden cardiac death. Exercise testing is useful in unmasking QT prolongation in disorders associated with abnormal repolarization. We characterized QT adaptation during exercise in anorexia. METHODS AND RESULTS...


    pub_type: 杂志文章


    authors: Padfield GJ,Escudero CA,DeSouza AM,Steinberg C,Gibbs K,Puyat JH,Lam PY,Sanatani S,Sherwin E,Potts JE,Sandor G,Krahn AD

    更新日期:2016-02-09 00:00:00