Increased carotid intimal-medial thickness and coronary calcification are related in young and middle-aged adults. The Muscatine study.

abstract：BACKGROUND:During the 1980s, mortality from coronary artery disease (CAD) decreased markedly in the United States. This raises the question of whether a parallel decrease occurred in excess mortality due to CAD in patients undergoing surgical correction of valvular regurgitation. METHODS AND RESULTS:Survival of 752 pa...

journal_title：Circulation

authors： Tribouilloy CM,Enriquez-Sarano M,Schaff HV,Orszulak TA,Fett SL,Bailey KR,Tajik AJ,Frye RL

更新日期：1998-11-10 00:00:00

abstract：BACKGROUND:Several studies demonstrated ischemic microvascular damage in patients with acute myocardial infarction (AMI). In this study, myocardial contrast echocardiography (MCE) was used to assess the temporal changes in myocardial perfusion after reflow and to investigate the relation between MCE findings and myocar...

journal_title：Circulation

authors： Ito H,Iwakura K,Oh H,Masuyama T,Hori M,Higashino Y,Fujii K,Minamino T

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:A variable degree of smooth muscle cell (SMC) proliferation after balloon injury has been reported in previous rat studies. It is unknown whether balloon injury induces c-fos expression and whether it is related to the degree of vascular injury in vivo. Therefore, we tested the hypothesis that proportional i...

journal_title：Circulation

authors： Indolfi C,Esposito G,Di Lorenzo E,Rapacciuolo A,Feliciello A,Porcellini A,Avvedimento VE,Condorelli M,Chiariello M

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:ACE inhibitors exert both acute and chronic beneficial effects on cardiac function (eg, remodeling, diastolic dysfunction) in experimental studies and in patients. They inhibit the formation of angiotensin II as well as the degradation of endogenous bradykinin. We recently reported that bradykinin induces se...

journal_title：Circulation

authors： Anning PB,Grocott-Mason RM,Lewis MJ,Shah AM

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation is common in advanced heart failure, but its prognostic significance is controversial. METHODS AND RESULTS:We evaluated the relation of atrial rhythm to overall survival and sudden death in 390 consecutive advanced heart failure patients. Etiology of heart failure was coronary artery dis...

journal_title：Circulation

authors： Middlekauff HR,Stevenson WG,Stevenson LW

更新日期：1991-07-01 00:00:00

abstract：:Thirty-one published reports (366 patients) and 48 consecutive patients treated for postinfarction ventricular septal defect at four institutions in northern California were reviewed. Overall hospital mortality was 43% in the reviewed group and was not affected by age, concomitant myocardial revascularization, date of...

journal_title：Circulation

authors： Hill JD,Stiles QR

更新日期：1989-06-01 00:00:00

abstract：:The effect of timolol vs placebo on the frequency of anginal episodes, nitroglycerin consumption and exercise performance was investigated in a double-blind, randomized, crossover study in 23 patients with angina pectoris. The optimal dose of timolol (10-30 mg twice daily) for each patient was titrated by exercise stu...

journal_title：Circulation

authors： Aronow WS,Turbow M,Van Camp S,Lurie M,Whittaker K

更新日期：1980-01-01 00:00:00

abstract：:Although thrombolytic therapy has been a major advance in the treatment of acute myocardial infarction, in at least 25% of patients the artery remains occluded after administration. In these patients, the strategy of "rescue" or "salvage" angioplasty is frequently used although follow-up data are limited. Sixty-three ...

journal_title：Circulation

authors： Holmes DR Jr,Gersh BJ,Bailey KR,Reeder GS,Bresnahan JF,Bresnahan DR,Vlietstra RE

更新日期：1990-03-01 00:00:00

abstract：:Arterial oxygen transport (cardiac output x arterial oxygen content) may be decreased in heart failure. We studied the determinants of arterial oxygen transport in 15 patients with chronic, severe myocardial failure at rest and during cycle ergometry. During control therapy at rest, arterial oxygen tension was normal ...

journal_title：Circulation

authors： Rubin SA,Brown HV,Swan HJ

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND:Epidemiological studies aimed at correlating coronary heart disease (CHD) with serum ferritin levels have thus far yielded inconsistent results. We hypothesized that a labile iron component associated with non-transferrin-bound iron (NTBI) that appears in individuals with overt or cryptic iron overload might...

journal_title：Circulation

authors： van der A DL,Marx JJ,Grobbee DE,Kamphuis MH,Georgiou NA,van Kats-Renaud JH,Breuer W,Cabantchik ZI,Roest M,Voorbij HA,van der Schouw YT

更新日期：2006-04-25 00:00:00

abstract：:Platelets have been implicated in the pathogenesis of coronary artery disease, and a number of studies have examined platelet function and coagulation parameters in such patients. We have examined platelet coagulant activities, volumes, and aggregate ratios in 23 patients with chest pain, seven of whom had normal coro...

journal_title：Circulation

authors： Rao AK,Mintz PD,Lavine SJ,Bove AA,McDonough MT,Spann JF,Walsh PN

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:In vitro and in vivo studies have demonstrated both anticoagulant and antiproliferative effects of heparin. The purpose of this study was to assess the effect of local intramural delivery of heparin, using heparin-coated hydrogel balloons, on platelet deposition and early smooth muscle cell proliferation aft...

journal_title：Circulation

authors： Azrin MA,Mitchel JF,Fram DB,Pedersen CA,Cartun RW,Barry JJ,Bow LM,Waters DD,McKay RG

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Factors predicting the occurrence of premature coronary artery disease (CAD) may not be quantitatively the same as those predicting CAD severity, particularly in women, in whom there have been few studies. METHODS AND RESULTS:To determine factors predictive of severity of CAD and of angina pectoris, we docu...

journal_title：Circulation

authors： Wang XL,Tam C,McCredie RM,Wilcken DE

更新日期：1994-05-01 00:00:00

abstract：:We studied the effects of experimentally induced emotional stress (mental arithmetic) on different hemodynamic parameters, catecholamine levels, and serum and platelet function tests in 25 postinfarction patients and in 10 apparently healthy, age-matched control subjects. Mental stress (10 minutes) induced significant...

journal_title：Circulation

authors： Grignani G,Soffiantino F,Zucchella M,Pacchiarini L,Tacconi F,Bonomi E,Pastoris A,Sbaffi A,Fratino P,Tavazzi L

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Cell-mediated autoimmunity has been strongly implicated in the pathogenesis of viral myocarditis. METHODS AND RESULTS:Using a murine model of acute myocarditis caused by coxsackievirus B3, we analyzed the phenotypes and morphology of the infiltrating cells in the hearts by immunofluorescence and electron mi...

journal_title：Circulation

authors： Seko Y,Shinkai Y,Kawasaki A,Yagita H,Okumura K,Takaku F,Yazaki Y

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Previous experimental studies have shown that nitric oxide (NO) modulates cardiac function by an abbreviation of systolic contraction and an enhancement of diastolic relaxation. However, the response to NO donors of patients with severe pressure-overload hypertrophy and diastolic dysfunction is unknown. MET...

journal_title：Circulation

authors： Matter CM,Mandinov L,Kaufmann PA,Vassalli G,Jiang Z,Hess OM

更新日期：1999-05-11 00:00:00

abstract：:Data from 981 patients evaluated for ischemic heart disease with coronary angiography were reviewed to identify variables predictive of sudden death and duration from onset of symptoms to death. During the period of follow-up, 113 patients died. Of these deaths, 99 were classified as cardiovascular. Forty percent occu...

journal_title：Circulation

authors： Oberman A,Ray M,Turner ME,Barnes G,Grooms C

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:The alpha(v)beta3 integrin plays a critical role in cell proliferation and migration. We hypothesized that vascular cell proliferation, a hallmark of injury-induced remodeling, can be tracked by targeting alpha(v)beta3 integrin expression in vivo. METHODS AND RESULTS:RP748, a novel 111In-labeled alpha(v)bet...

journal_title：Circulation

authors： Sadeghi MM,Krassilnikova S,Zhang J,Gharaei AA,Fassaei HR,Esmailzadeh L,Kooshkabadi A,Edwards S,Yalamanchili P,Harris TD,Sinusas AJ,Zaret BL,Bender JR

更新日期：2004-07-06 00:00:00

abstract：BACKGROUND:Although several loci for familial dilated cardiomyopathy (DCM) have been mapped, the origin of a large percentage of DCM remains unclear. Mdm2, a p53-negative regulator, protects cardiomyocytes from ischemic and reperfusion-induced cell death. Mdm4, a homolog of Mdm2, inhibits p53 activity in numerous cell ...

journal_title：Circulation

authors： Xiong S,Van Pelt CS,Elizondo-Fraire AC,Fernandez-Garcia B,Lozano G

更新日期：2007-06-12 00:00:00

abstract：BACKGROUND:Early intervention with thrombolytic agents has been shown unequivocally to reduce mortality after acute myocardial infarction. Presently used agents have disadvantages such as short half-life, immunogenicity, hypotension, and bleeding complications. Therefore, there is a need to develop improved thrombolyti...

journal_title：Circulation

authors： Robinson JH,Browne MJ,Carey JE,Chamberlain PD,Chapman CG,Cronk DW,Dodd I,Entwisle C,Esmail AF,Kalindjian SB

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Although gender-specific criteria are common for defining cardiac traits such as left ventricular hypertrophy, left ventricular ejection fraction (LVEF) thresholds widely used in clinical practice have traditionally been the same for women and men, perhaps because it remains uncertain whether there is a syst...

journal_title：Circulation

authors： Chung AK,Das SR,Leonard D,Peshock RM,Kazi F,Abdullah SM,Canham RM,Levine BD,Drazner MH

更新日期：2006-03-28 00:00:00

abstract：BACKGROUND:Paraplegia continues to complicate thoracoabdominal aortic interventions. The elusive mechanism of spinal cord ischemia-reperfusion injury has delayed the development of pharmacological adjuncts. Microglia, the resident macrophages of the central nervous system, can have pathological responses after a variet...

journal_title：Circulation

authors： Bell MT,Puskas F,Agoston VA,Cleveland JC Jr,Freeman KA,Gamboni F,Herson PS,Meng X,Smith PD,Weyant MJ,Fullerton DA,Reece TB

更新日期：2013-09-10 00:00:00

abstract：BACKGROUND:Studies have implicated a role for prostaglandin (PG) E(2)-dependent matrix metalloproteinase (MMP) biosynthesis in the rupture of atherosclerotic plaque. Cyclooxygenase-2 (COX-2) and PGE synthase (PGES) are coregulated in nucleated cells by inflammatory stimuli. The aim of this study was to characterize the...

journal_title：Circulation

authors： Cipollone F,Prontera C,Pini B,Marini M,Fazia M,De Cesare D,Iezzi A,Ucchino S,Boccoli G,Saba V,Chiarelli F,Cuccurullo F,Mezzetti A

更新日期：2001-08-21 00:00:00

abstract：BACKGROUND:Radiofrequency catheter ablation of concealed posteroseptal accessory pathways (APS) has been a relatively difficult task for electrophysiologists. Without a detailed mapping procedure, the left versus the right posteroseptal AP could not be distinguished. We investigated the electrophysiological characteris...

journal_title：Circulation

authors： Chiang CE,Chen SA,Tai CT,Wu TJ,Lee SH,Cheng CC,Chiou CW,Ueng KC,Wen ZC,Chang MS

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are bone marrow stromal cells that are in phase 1 clinical studies of cellular cardiomyoplasty. However, the electrophysiological effects of MSC transplantation have not been studied. Although improvement of ventricular function would represent a positive outcome of MSC transpla...

journal_title：Circulation

authors： Chang MG,Tung L,Sekar RB,Chang CY,Cysyk J,Dong P,Marbán E,Abraham MR

更新日期：2006-04-18 00:00:00

abstract：BACKGROUND:Angiotensin (Ang) II type 1 receptor (AT1-R) induces cardiomyocyte hypertrophy and fibroblast proliferation, whereas the physiological role of AT2-R in cardiac remodeling remains poorly defined. METHODS AND RESULTS:Using Bio14.6 cardiomyopathic (CM) hamsters, we found that AT2-R sites were increased by 153%...

journal_title：Circulation

authors： Ohkubo N,Matsubara H,Nozawa Y,Mori Y,Murasawa S,Kijima K,Maruyama K,Masaki H,Tsutumi Y,Shibazaki Y,Iwasaka T,Inada M

更新日期：1997-12-02 00:00:00

abstract：:Coronary artery bypass grafts, angioplasty, and thrombolysis are beneficial procedures for patients with coronary artery disease. However, these procedures can fail by mechanisms related to interactions between platelets and the damaged arterial wall. An experimental model for studying some of the mechanisms of platel...

journal_title：Circulation

authors： Folts J

更新日期：1991-06-01 00:00:00

abstract：:Medical treatment of heart disease has improved significantly in the past 30 years. The spectacular change in the natural history of rheumatic heart disease is apparent from a 1948 article that reported that 42% of children with rheumatic heart disease died of rheumatic infection or bacterial endocarditis. Antibiotics...

journal_title：Circulation

authors： Ross RS

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:Patients with anorexia nervosa exhibit abnormal myocardial repolarization and are susceptible to sudden cardiac death. Exercise testing is useful in unmasking QT prolongation in disorders associated with abnormal repolarization. We characterized QT adaptation during exercise in anorexia. METHODS AND RESULTS...

journal_title：Circulation

authors： Padfield GJ,Escudero CA,DeSouza AM,Steinberg C,Gibbs K,Puyat JH,Lam PY,Sanatani S,Sherwin E,Potts JE,Sandor G,Krahn AD

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:Early-generation drug-eluting stents releasing sirolimus (SES) or paclitaxel (PES) are associated with increased risk of very late stent thrombosis occurring >1 year after stent implantation. It is unknown whether the risk of very late stent thrombosis persists with newer-generation everolimus-eluting stents...

journal_title：Circulation

authors： Räber L,Magro M,Stefanini GG,Kalesan B,van Domburg RT,Onuma Y,Wenaweser P,Daemen J,Meier B,Jüni P,Serruys PW,Windecker S

更新日期：2012-03-06 00:00:00