Congestive heart failure after surgical correction of mitral regurgitation. A long-term study.

abstract：BACKGROUND:A family history of premature coronary artery disease (CAD) in a first-degree relative is an independent risk factor for coronary disease. Both genetic and environmental influences are likely to be responsible and may interact, but their relative importance is unclear. METHODS AND RESULTS:We studied endothe...

journal_title：Circulation

authors： Clarkson P,Celermajer DS,Powe AJ,Donald AE,Henry RM,Deanfield JE

更新日期：1997-11-18 00:00:00

abstract：BACKGROUND:The usefulness of adriamycin (ADR), a potent antitumor antibiotic, is limited by the development of life-threatening cardiomyopathy and congestive heart failure. Subcellular changes leading to heart failure are suggested to be mediated by a drug-induced increase in free radicals and lipid peroxidation. In an...

journal_title：Circulation

authors： Siveski-Iliskovic N,Hill M,Chow DA,Singal PK

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) has been proposed as an independent risk factor for cardiovascular disease and has been positively associated with body weight and body fatness. We examined the hypothesis that weight loss would reduce plasma CRP levels in obese postmenopausal women. METHODS AND RESULTS:In a sample ...

journal_title：Circulation

authors： Tchernof A,Nolan A,Sites CK,Ades PA,Poehlman ET

更新日期：2002-02-05 00:00:00

abstract：BACKGROUND:Elevated pulse pressure is associated strongly with adverse cardiovascular outcome; however, the genetic basis of this condition is unknown. This study examined whether genotypic variation in the extracellular matrix protein fibrillin-1, the Marfan gene, was associated with aortic stiffening and therefore co...

journal_title：Circulation

authors： Medley TL,Cole TJ,Gatzka CD,Wang WY,Dart AM,Kingwell BA

更新日期：2002-02-19 00:00:00

abstract：BACKGROUND:Aortopulmonary collaterals (APC) have been associated with an increased risk of choreoathetosis after deep hypothermic circulatory arrest (DHCA). To study the effects of APC on cerebral hemodynamics and metabolism before and after DHCA, a piglet model was developed. METHODS AND RESULTS:Protocol 1: Eight 4- ...

journal_title：Circulation

authors： Kirshbom PM,Skaryak LA,DiBernardo LR,Kern FH,Greeley WJ,Gaynor JW,Ungerleider RM

更新日期：1995-11-01 00:00:00

abstract：:Left main coronary artery disease (i.e., greater than or equal to 50% stenosis) was found in 1,477 of 20,137 patients in the Coronary Artery Surgery Study (CAS) registry. Of these patients, 53 (3.6%) were asymptomatic. Asymptomatic and symptomatic patients were similar in regard to 1) severity of left main coronary ar...

journal_title：Circulation

authors： Taylor HA,Deumite NJ,Chaitman BR,Davis KB,Killip T,Rogers WJ

更新日期：1989-06-01 00:00:00

abstract：:Twenty-four-hour ambulatory ECG recording was performed in 26 patients with variant angina to evaluate the diurnal distribution of ST-segment elevation in relation to chest pain and the incidence of arrhythmias during the episodes. During a recording period of 52 days, 364 ST-segment elevations of 1 mm or greater were...

journal_title：Circulation

authors： Araki H,Koiwaya Y,Nakagaki O,Nakamura M

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) plasma levels have been associated with short- and long-term occurrence of coronary events. We investigated whether circulating inflammatory cell responsiveness to low-grade stimuli could contribute to the reported association between CRP and coronary events. METHODS AND RESULTS:We ...

journal_title：Circulation

authors： Liuzzo G,Angiolillo DJ,Buffon A,Rizzello V,Colizzi C,Ginnetti F,Biasucci LM,Maseri A

更新日期：2001-05-08 00:00:00

abstract：BACKGROUND:Isoprostanes (iPs) are free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Several iPs exert biological effects in vitro and may contribute to the functional consequences of oxidant stress. For example, iPF(2alpha)-III (8-iso PGF(2alpha)) and iPE(2)-III modulate plate...

journal_title：Circulation

authors： Audoly LP,Rocca B,Fabre JE,Koller BH,Thomas D,Loeb AL,Coffman TM,FitzGerald GA

更新日期：2000-06-20 00:00:00

abstract：BACKGROUND:Acetylsalicylic acid (ASA), or aspirin, plus clopidogrel is becoming the standard antithrombotic treatment in people with coronary disease. Novel approaches such as the use of platelet-selective nitric oxide (NO) donors may provide additional protection against thrombosis. We evaluated the antithrombotic pro...

journal_title：Circulation

authors： Vilahur G,Segalés E,Salas E,Badimon L

更新日期：2004-09-21 00:00:00

abstract：BACKGROUND:In the twin-to-twin transfusion syndrome (TTTS), pressure rather than volume overload is increasingly considered as a key factor in the pathogenesis of the cardiomyopathy of the recipient twin. If this is the case, cardiac dysfunction should be among the first signs observed with TTTS. The objective of this ...

journal_title：Circulation

authors： Raboisson MJ,Fouron JC,Lamoureux J,Leduc L,Grignon A,Proulx F,Gamache S

更新日期：2004-11-09 00:00:00

abstract：BACKGROUND:Vasoactive drugs could alter the fluid restitution from the tissue and redistribute blood volume between the macrocirculation and microcirculation. METHODS AND RESULTS:With bolus injections of vasoactive drugs in anesthetized rabbits, we measured the changes in blood and plasma density for the determination...

journal_title：Circulation

authors： Anderson SM,Rich GF,Roos C,Lee LP,Lee JS

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Resistin, a plasma protein, induces insulin resistance in rodents. Recent reports suggest that circulating levels of resistin are elevated in obese and insulin-resistant rodents and humans. Whereas rodent resistin is made in adipocytes, macrophages are a major source of human resistin. Given the convergence ...

journal_title：Circulation

authors： Reilly MP,Lehrke M,Wolfe ML,Rohatgi A,Lazar MA,Rader DJ

更新日期：2005-02-22 00:00:00

abstract：BACKGROUND:Pharmacological evidence has implicated ATP-sensitive K(+) (K(ATP)) channels as the effectors of cardioprotection, but the relative roles of mitochondrial (mitoK(ATP)) and sarcolemmal (surfaceK(ATP)) channels remain controversial. METHODS AND RESULTS:We examined the effects of the K(ATP) channel blocker HMR...

journal_title：Circulation

authors： Sato T,Sasaki N,Seharaseyon J,O'Rourke B,Marbán E

更新日期：2000-05-23 00:00:00

abstract：:The present study was performed to determine whether positron emission tomography (PET) performed after i.v. 11C-palmitate permits detection and characterization of nontransmural myocardial infarction. PET was performed after the i.v. injection of 11C-palmitate in 10 normal subjects, 24 patients with initial nontransm...

journal_title：Circulation

authors： Geltman EM,Biello D,Welch MJ,Ter-Pogossian MM,Roberts R,Sobel BE

更新日期：1982-04-01 00:00:00

abstract：:An asymptomatic 14-year-old male was found at cardiac catheterization to have a coronary artery fistula involving a vessel originating from the left main coronary artery and terminating in the right heart. Chest X-ray and electrocardiogram were within normal limits and shunt flow was too small to be detected by oximet...

journal_title：Circulation

authors： Shubrooks SJ Jr,Naggar CZ

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:From animal studies it emerged that nitric oxide is important for the modulation of CO2-mediated cerebral blood flow (CBF chemoregulation) but not for the pressor-dependent mechanism (mechanoregulation). This hypothesis was tested in 18 healthy subjects. METHODS AND RESULTS:Peak velocity (PV), diastolic vel...

journal_title：Circulation

authors： Lavi S,Egbarya R,Lavi R,Jacob G

更新日期：2003-04-15 00:00:00

abstract：BACKGROUND:Although surgery is indicated in patients with mitral regurgitation (MR) when left ventricular (LV) end-systolic (LVES) dimension is >40 mm, LV ejection fraction may decrease after mitral valve surgery. We hypothesize that significant LV remodeling before surgery is not reflected by standard echocardiographi...

journal_title：Circulation

authors： Schiros CG,Dell'Italia LJ,Gladden JD,Clark D 3rd,Aban I,Gupta H,Lloyd SG,McGiffin DC,Perry G,Denney TS Jr,Ahmed MI

更新日期：2012-05-15 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF), the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM), is capable of producing symptoms that impact quality of life and is associated with risk for embolic stroke. However, the influence of AF on clinical course and outcome in HCM remains incompletely resolved. ...

journal_title：Circulation

authors： Rowin EJ,Hausvater A,Link MS,Abt P,Gionfriddo W,Wang W,Rastegar H,Estes NAM,Maron MS,Maron BJ

更新日期：2017-12-19 00:00:00

abstract：BACKGROUND:Several nonpharmacological interventions, including exercise, are recommended in primary prevention of hypertension and other cardiovascular diseases in which the pathogenetic role of endothelial dysfunction has been suggested. We studied the effects of long-term aerobic exercise on endothelial function in p...

journal_title：Circulation

authors： Higashi Y,Sasaki S,Kurisu S,Yoshimizu A,Sasaki N,Matsuura H,Kajiyama G,Oshima T

更新日期：1999-09-14 00:00:00

abstract：BACKGROUND:Increased consumption of sugar-sweetened beverages (SSBs) has been associated with an elevated risk of obesity, metabolic syndrome, and type II diabetes mellitus. However, the effects of SSB consumption on blood pressure (BP) are uncertain. The objective of this study was to determine the relationship betwee...

journal_title：Circulation

authors： Chen L,Caballero B,Mitchell DC,Loria C,Lin PH,Champagne CM,Elmer PJ,Ard JD,Batch BC,Anderson CA,Appel LJ

更新日期：2010-06-08 00:00:00

abstract：BACKGROUND:Imaging of the flow convergence region (FCR) proximal to a regurgitant orifice has been shown to provide a method for quantifying the regurgitant flow rate. According to the continuity principle, the FCR is constituted by concentric hemispheric isovelocity surfaces centered at the orifice. The flow rate is c...

journal_title：Circulation

authors： Bargiggia GS,Tronconi L,Sahn DJ,Recusani F,Raisaro A,De Servi S,Valdes-Cruz LM,Montemartini C

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:The effect of the increasing prevalence of obesity on blood pressure (BP) secular trends is unclear. We analyzed BP and body mass index secular trends between 1998 and 2006 in children and adolescents of the Seychelles, a rapidly developing island state in the African region. METHODS AND RESULTS:School-base...

journal_title：Circulation

authors： Chiolero A,Paradis G,Madeleine G,Hanley JA,Paccaud F,Bovet P

更新日期：2009-02-03 00:00:00

abstract：BACKGROUND:Endothelin 1 has been implicated in various human diseases, including atherosclerosis. In this study, we examined the expression and localization of endothelin-converting enzyme-1 (ECE-1), the final key enzyme of endothelin 1 processing, in rat carotid arteries after balloon injury and in human coronary athe...

journal_title：Circulation

authors： Minamino T,Kurihara H,Takahashi M,Shimada K,Maemura K,Oda H,Ishikawa T,Uchiyama T,Tanzawa K,Yazaki Y

更新日期：1997-01-07 00:00:00

abstract：BACKGROUND:High-sensitivity cardiac troponin assays can help to identify patients who are at low risk of myocardial infarction in the emergency department. We aimed to determine whether the addition of clinical risk scores would improve the safety of early rule-out pathways for myocardial infarction. METHODS:In 1935 p...

journal_title：Circulation

authors： Chapman AR,Hesse K,Andrews J,Lee KK,Anand A,Shah ASV,Sandeman D,Ferry AV,Jameson J,Piya S,Stewart S,Marshall L,Strachan FE,Gray A,Newby DE,Mills NL

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:Nitric oxide signaling plays a key role in the regulation of vascular tone and platelet activation. Here, we seek to understand the impact of a genetic predisposition to enhanced nitric oxide signaling on risk for cardiovascular diseases, thus informing the potential utility of pharmacological stimulation of...

journal_title：Circulation

authors： Emdin CA,Khera AV,Klarin D,Natarajan P,Zekavat SM,Nomura A,Haas M,Aragam K,Ardissino D,Wilson JG,Schunkert H,McPherson R,Watkins H,Elosua R,Bown MJ,Samani NJ,Baber U,Erdmann J,Gormley P,Palotie A,Stitziel NO,Gup

更新日期：2018-01-16 00:00:00

abstract：BACKGROUND:Endocardial mapping of sustained arrhythmias has traditionally been performed with a roving diagnostic catheter. Although this approach is adequate for many tachyarrhythmias, it has limitations. The purpose of this study was to evaluate a novel noncontact mapping system for assessing atrial tachyarrhythmias....

journal_title：Circulation

authors： Kadish A,Hauck J,Pederson B,Beatty G,Gornick C

更新日期：1999-04-13 00:00:00

abstract：:The purpose of the present study was to evaluate potential diurnal changes in resting coronary blood flow under conditions of comparable myocardial oxygen requirements. We studied 21 conscious, resting dogs instrumented for the measurement of coronary flow, left ventricular pressure, and regional myocardial segment le...

journal_title：Circulation

authors： Fujita M,Franklin D

更新日期：1987-08-01 00:00:00

abstract：:This is the first scientific statement from the American Heart Association on maternal resuscitation. This document will provide readers with up-to-date and comprehensive information, guidelines, and recommendations for all aspects of maternal resuscitation. Maternal resuscitation is an acute event that involves many ...

journal_title：Circulation

authors： Jeejeebhoy FM,Zelop CM,Lipman S,Carvalho B,Joglar J,Mhyre JM,Katz VL,Lapinsky SE,Einav S,Warnes CA,Page RL,Griffin RE,Jain A,Dainty KN,Arafeh J,Windrim R,Koren G,Callaway CW,American Heart Association Emergency Cardio

更新日期：2015-11-03 00:00:00

abstract：:This article provides a selective overview of epidemiologic studies on the relationship between psychosocial factors and blood pressure elevation. The review focuses on English-language reports published since 1975 and emphasizes two broad areas of research: changes in mean blood pressures of third world populations u...

journal_title：Circulation

authors： James SA

更新日期：1987-07-01 00:00:00