Comparison of nitric oxide release and endothelium-derived hyperpolarizing factor-mediated hyperpolarization between human radial and internal mammary arteries.

Abstract:

BACKGROUND:Arterial grafts for CABG have been used increasingly, and the radial artery (RA) has become a preferable graft, secondary to the internal mammary artery (IMA). In the present study, we investigated and compared NO release and endothelium-derived hyperpolarizing factor (EDHF)-mediated hyperpolarization for IMA and RA. METHODS AND RESULTS:IMA and RA segments taken from CABG patients were placed in an organ chamber. An NO-sensitive electrode (to directly measure NO release) or intracellular glass microelectrode (to measure membrane potential) was used to study NO or EDHF in response to acetylcholine (ACh) and bradykinin (BK) before and after incubation with indomethacin (a cyclooxygenase inhibitor), N(G)-nitro-L-arginine (an NO synthase inhibitor), and oxyhemoglobin (an NO scavenger). The resting membrane potential of the smooth muscle cells of IMA and RA was -58+/-0.84 (n=61) and -61+/-1.3 (n=46) mV, respectively (P=0.03). BK-induced EDHF-mediated hyperpolarization in the IMA was significantly greater than that in RA (BK 10(-)(7) mol/L: -10.9+/-1.5 [n=7] versus -5.8+/-0.9 [n=6] mV, P=0.04). The basal (16.8+/-1.9 versus 11.1+/-1.0 nmol/L, n=12, P=0.02) and stimulated releases of NO in IMA were significantly greater for BK (44.3+/-4.0 versus 25.8+/-3.6 nmol/L, n=8, P=0.004) and lasting longer for ACh (9.5+/-2.0 versus 6.6+/-3.6 minutes, n=12, P=0.03) than those in RA. CONCLUSIONS:The basal and stimulated releases of NO and EDHF-mediated hyperpolarization in the IMA are significantly greater than that in the RA. The lower capacity of NO release may contribute to the susceptibility of RA to the perioperative vasospasm and may have an impact on the long-term graft patency.

journal_name

Circulation

journal_title

Circulation

authors

He GW,Liu ZG

doi

10.1161/hc37t1.094930

subject

Has Abstract

pub_date

2001-09-18 00:00:00

pages

I344-9

issue

12 Suppl 1

eissn

0009-7322

issn

1524-4539

journal_volume

104

pub_type

杂志文章
  • Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group.

    abstract:BACKGROUND:HMG CoA reductase inhibitors (or statins), a new class of lipid-lowering compounds, have raised expectations for more widespread use than that of the older lipid-lowering drugs. Not only are they more effective in lowering LDL cholesterol, but they are better tolerated as well. No data exist concerning the e...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.90.4.1679

    authors: Furberg CD,Adams HP Jr,Applegate WB,Byington RP,Espeland MA,Hartwell T,Hunninghake DB,Lefkowitz DS,Probstfield J,Riley WA

    更新日期:1994-10-01 00:00:00

  • Vessel-specific Toll-like receptor profiles in human medium and large arteries.

    abstract:BACKGROUND:Inflammatory vasculopathies, ranging from the vasculitides (Takayasu arteritis, giant cell arteritis, and polyarteritis nodosa) to atherosclerosis, display remarkable target tissue tropisms for selected vascular beds. Molecular mechanisms directing wall inflammation to restricted anatomic sites within the va...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.108.789172

    authors: Pryshchep O,Ma-Krupa W,Younge BR,Goronzy JJ,Weyand CM

    更新日期:2008-09-16 00:00:00

  • Intravascular ultrasound imaging of human coronary arteries in vivo. Analysis of tissue characterizations with comparison to in vitro histological specimens.

    abstract:BACKGROUND:Intravascular ultrasound imaging was performed in 27 patients after coronary balloon angioplasty to quantify the lumen and atheroma cross-sectional areas. METHODS AND RESULTS:A 20-MHz ultrasound catheter was inserted through a 1.6-mm plastic introducer sheath across the dilated area to obtain real-time imag...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.83.3.913

    authors: Tobis JM,Mallery J,Mahon D,Lehmann K,Zalesky P,Griffith J,Gessert J,Moriuchi M,McRae M,Dwyer ML

    更新日期:1991-03-01 00:00:00

  • Long-term benefit of postconditioning.

    abstract:BACKGROUND:We previously demonstrated that ischemic postconditioning decreases creatine kinase release, a surrogate marker for infarct size, in patients with acute myocardial infarction. Our objective was to determine whether ischemic postconditioning could afford (1) a persistent infarct size limitation and (2) an imp...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/CIRCULATIONAHA.107.729780

    authors: Thibault H,Piot C,Staat P,Bontemps L,Sportouch C,Rioufol G,Cung TT,Bonnefoy E,Angoulvant D,Aupetit JF,Finet G,André-Fouët X,Macia JC,Raczka F,Rossi R,Itti R,Kirkorian G,Derumeaux G,Ovize M

    更新日期:2008-02-26 00:00:00

  • Assessment of myocardial ischemia with proton magnetic resonance: effects of a three hour coronary occlusion with and without reperfusion.

    abstract::Proton (hydrogen-1) magnetic resonance imaging techniques have potential for the detection and characterization of changes associated with myocardial ischemia. Since image contrast is dependent on T1 and T2 relaxation times, we examined these parameters in a canine preparation of occlusion of the left anterior descend...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.71.3.595

    authors: Johnston DL,Brady TJ,Ratner AV,Rosen BR,Newell JB,Pohost GM,Okada RD

    更新日期:1985-03-01 00:00:00

  • Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling.

    abstract:BACKGROUND:The endothelium acts as the sensor of shear stress and as the mediator of flow-induced changes in vessel tone and structure. The purpose of this study was to delineate the signal transduction pathway of flow-induced release of endothelium-derived relaxing factor (EDRF). METHODS AND RESULTS:We used a shear s...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.88.1.193

    authors: Ohno M,Gibbons GH,Dzau VJ,Cooke JP

    更新日期:1993-07-01 00:00:00

  • Sex differences in high density lipoprotein cholesterol among low-level alcohol consumers.

    abstract::The purpose of this study was to examine high density lipoprotein cholesterol (HDL-C) levels in a sample of community-living women and men who consumed 1 drink of alcohol/day or less. Self-reports of alcohol consumption and clinical assessments of plasma lipid and lipoprotein levels were obtained twice, at 12 months a...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.83.1.176

    authors: Weidner G,Connor SL,Chesney MA,Burns JW,Connor WE,Matarazzo JD,Mendell NR

    更新日期:1991-01-01 00:00:00

  • Cardiovascular response to dynamic exercise in patients with chronic symptomatic mild-to-moderate and severe aortic regurgitation.

    abstract::Fifteen patients with symptomatic mild-to-moderate and severe chronic aortic regurgitation (AR) performed supine bicycle exercise while measurements of rest and exercise hemodynamics and left ventricular function were obtained. A continuous Doppler method was used to determine the change in distribution of total left ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.73.1.62

    authors: Kawanishi DT,McKay CR,Chandraratna PA,Nanna M,Reid CL,Elkayam U,Siegel M,Rahimtoola SH

    更新日期:1986-01-01 00:00:00

  • Effect of difficulty affording health care on health status after coronary revascularization.

    abstract:BACKGROUND:An objective of the United States' Healthy People 2010 Initiative is to eliminate disparities based on socioeconomic status. We assessed the effect of difficulty affording health care on the health status (symptoms, function, and quality of life) of patients treated with percutaneous coronary intervention or...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.104.474775

    authors: Spertus J,Decker C,Woodman C,House J,Jones P,O'Keefe J,Borkon AM

    更新日期:2005-05-24 00:00:00

  • Transplantation of fetal myocardial tissue into the infarcted myocardium of rat. A potential method for repair of infarcted myocardium?

    abstract:BACKGROUND:Unlike skeletal myocytes, mammalian adult cardiomyocytes cannot regenerate after injury. A possible strategy to increase viability and augment ventricular function after myocardial injury is fetal myocardial tissue transplantation. The engrafted fetal cells are a potential source of growth factors and can be...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Leor J,Patterson M,Quinones MJ,Kedes LH,Kloner RA

    更新日期:1996-11-01 00:00:00

  • Left ventricular contractility predicts how the end-diastolic pressure-volume relation shifts during pacing-induced ischemia in dogs.

    abstract:BACKGROUND:Two types of ischemia, pacing-induced and coronary occlusion-induced, have different effects on left ventricular diastolic properties. During pacing-induced ischemia, the diastolic pressure-volume relation is said to shift upward, whereas during coronary occlusion, it is said to shift rightward or downward. ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.91.9.2423

    authors: Takano H,Glantz SA

    更新日期:1995-05-01 00:00:00

  • Achieving Optimal Population Cardiovascular Health Requires an Interdisciplinary Team and a Learning Healthcare System: A Scientific Statement From the American Heart Association.

    abstract::Population cardiovascular health, or improving cardiovascular health among patients and the population at large, requires a redoubling of primordial and primary prevention efforts as declines in cardiovascular disease mortality have decelerated over the past decade. Great potential exists for healthcare systems-based ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIR.0000000000000913

    authors: Foraker RE,Benziger CP,DeBarmore BM,Cené CW,Loustalot F,Khan Y,Anderson CAM,Roger VL,American Heart Association Council on Epidemiology and Prevention; Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Lifestyl

    更新日期:2021-01-12 00:00:00

  • First chronic platelet glycoprotein IIb/IIIa integrin blockade. A randomized, placebo-controlled pilot study of xemilofiban in unstable angina with percutaneous coronary interventions.

    abstract:BACKGROUND:Clinical studies have demonstrated the efficacy of intravenous administration of agents that block platelet glycoprotein IIb/IIIa receptors in the setting of percutaneous coronary revascularization. Although the optimal duration of treatment has not been determined, more prolonged receptor blockade has been ...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.96.1.76

    authors: Simpfendorfer C,Kottke-Marchant K,Lowrie M,Anders RJ,Burns DM,Miller DP,Cove CS,DeFranco AC,Ellis SG,Moliterno DJ,Raymond RE,Sutton JM,Topol EJ

    更新日期:1997-07-01 00:00:00

  • Effect of distension of the gallbladder on plasma renin activity in anesthetized pigs.

    abstract:BACKGROUND:Gallbladder pathology has been associated with cardiovascular disease. Recently, we showed that gallbladder distension in anesthetized pigs reflexly increased heart rate, arterial pressure, and coronary and renal vascular resistance through efferent sympathetic mechanisms. Renin release is affected by sympat...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.101.21.2539

    authors: Molinari C,Grossini E,Mary DA,Vacca G

    更新日期:2000-05-30 00:00:00

  • Genetically defined therapy of inherited long-QT syndrome. Correction of abnormal repolarization by potassium.

    abstract:BACKGROUND:Many members of families with inherited long-QT (LQT) syndrome have mutations in HERG, a gene encoding a cardiac potassium channel that is modulated by extracellular potassium. We hypothesized that an increase in serum potassium would normalize repolarization in these patients. METHODS AND RESULTS:We studie...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.94.5.1018

    authors: Compton SJ,Lux RL,Ramsey MR,Strelich KR,Sanguinetti MC,Green LS,Keating MT,Mason JW

    更新日期:1996-09-01 00:00:00

  • Changing clinical characteristics of coronary surgery patients. Differences between men and women.

    abstract:BACKGROUND:There is uncertainty as to the relative efficacy of coronary artery bypass graft surgery (CABG) in men and women. Differences between sexes may be of greater importance than heretofore because of increased frequency of risk factors for adverse outcome. It is the purpose of this study to examine the changing ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Weintraub WS,Wenger NK,Jones EL,Craver JM,Guyton RA

    更新日期:1993-11-01 00:00:00

  • Effects of intravenous prostacyclin in variant angina.

    abstract::A lack in prostacyclin (PGI2) production due to atherosclerosis may play a role in the pathophysiology of some of the clinical manifestations of ischemic heart disease and in particular, of coronary vasospasm. We therefore evaluated the effects of i.v. PGI2 in nine patients with variant angina and six normal volunteer...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.65.3.470

    authors: Chierchia S,Patrono C,Crea F,Ciabattoni G,De Caterina R,Cinotti GA,Distante A,Maseri A

    更新日期:1982-03-01 00:00:00

  • Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia.

    abstract:BACKGROUND:The release of endothelium-derived relaxing factors has been shown experimentally to be of pivotal importance for the maintenance of coronary blood flow during increased demand. In humans with coronary atherosclerosis, endothelial vasodilator dysfunction is not confined only to epicardial conductance vessels...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.91.9.2345

    authors: Zeiher AM,Krause T,Schächinger V,Minners J,Moser E

    更新日期:1995-05-01 00:00:00

  • Associations of parental, birth, and early life characteristics with systolic blood pressure at 5 years of age: findings from the Mater-University study of pregnancy and its outcomes.

    abstract:BACKGROUND:We examined the associations of a range of parental and early life characteristics with systolic blood pressure at 5 years of age. METHODS AND RESULTS:Information from 3864 children who were followed up prospectively from their mother's first antenatal clinic assessment was used. Maternal age, body mass ind...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000145165.80130.B5

    authors: Lawlor DA,Najman JM,Sterne J,Williams GM,Ebrahim S,Davey Smith G

    更新日期:2004-10-19 00:00:00

  • Psychosocial precursors of hypertension: a review of the epidemiologic evidence.

    abstract::This article provides a selective overview of epidemiologic studies on the relationship between psychosocial factors and blood pressure elevation. The review focuses on English-language reports published since 1975 and emphasizes two broad areas of research: changes in mean blood pressures of third world populations u...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:

    authors: James SA

    更新日期:1987-07-01 00:00:00

  • High-mobility group box-1 in ischemia-reperfusion injury of the heart.

    abstract:BACKGROUND:High-mobility group box-1 (HMGB1) is a nuclear factor released by necrotic cells and by activated immune cells. HMGB1 signals via members of the toll-like receptor family and the receptor for advanced glycation end products (RAGE). Although HMGB1 has been implicated in ischemia/reperfusion (I/R) injury of th...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.108.769331

    authors: Andrassy M,Volz HC,Igwe JC,Funke B,Eichberger SN,Kaya Z,Buss S,Autschbach F,Pleger ST,Lukic IK,Bea F,Hardt SE,Humpert PM,Bianchi ME,Mairbäurl H,Nawroth PP,Remppis A,Katus HA,Bierhaus A

    更新日期:2008-06-24 00:00:00

  • Incidence, predictors, and significance of abnormal cardiac enzyme rise in patients treated with bypass surgery in the arterial revascularization therapies study (ARTS).

    abstract:BACKGROUND:Although it has been suggested that elevation of CK-MB after percutaneous coronary intervention is associated with adverse clinical outcomes, limited data are available in the setting of coronary bypass grafting. The aim of the present study was to determine the incidence, predictors, and prognostic signific...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/hc4701.099789

    authors: Costa MA,Carere RG,Lichtenstein SV,Foley DP,de Valk V,Lindenboom W,Roose PC,van Geldorp TR,Macaya C,Castanon JL,Fernandez-Avilèz F,Gonzáles JH,Heyer G,Unger F,Serruys PW

    更新日期:2001-11-27 00:00:00

  • Premature pulmonary valve opening.

    abstract::Premature opening of the pulmonary valve (opening independent of atrial or ventricular systole) was originally described in a case of sinus of Valsalva rupture into the right atrium. Since that time we have observed five additional cases in which the pulmonary valve opened prematurely. Entities encountered included: 1...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.55.1.128

    authors: Wann LS,Weyman AE,Dillon JC,Feigenbaum H

    更新日期:1977-01-01 00:00:00

  • Mechanisms of ischemic preconditioning in rat hearts. Involvement of alpha 1B-adrenoceptors, pertussis toxin-sensitive G proteins, and protein kinase C.

    abstract:BACKGROUND:Ischemic preconditioning attenuates the effects of subsequent sustained ischemia by a mechanism involving adenosine and G proteins in several species. Adenosine is not involved in ischemic preconditioning of rat hearts, the mechanisms of which are poorly understood. METHODS AND RESULTS:Reduction of isometri...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.8.2259

    authors: Hu K,Nattel S

    更新日期:1995-10-15 00:00:00

  • Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure.

    abstract:BACKGROUND:Cardiac growth and function may be modulated in part by trophic effects of neurohormones. Specifically, aldosterone has been shown to stimulate the growth of cardiac myocytes and the accumulation of cardiac extracellular matrix proteins. Moreover, a variant of the aldosterone synthase gene (a cytosine/thymid...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.99.17.2255

    authors: Schunkert H,Hengstenberg C,Holmer SR,Broeckel U,Luchner A,Muscholl MW,Kürzinger S,Döring A,Hense HW,Riegger GA

    更新日期:1999-05-04 00:00:00

  • Atrioventricular sequential pacing: differential effect on retrograde conduction related to level of impulse collision.

    abstract::Patients with DDD pacemakers who have intact retrograde conduction are known to be at risk of developing ventricular and "endless loop" tachycardia. To address this problem, a pacing protocol was designed in which V2A2 conduction was assessed in 16 patients during ventricular pacing alone (standard method) and during ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.68.1.23

    authors: Mahmud R,Lehmann M,Denker S,Gilbert CJ,Akhtar M

    更新日期:1983-07-01 00:00:00

  • Association of Baseline and Longitudinal Changes in Body Composition Measures With Risk of Heart Failure and Myocardial Infarction in Type 2 Diabetes: Findings From the Look AHEAD Trial.

    abstract:BACKGROUND:Intentional weight loss is associated with lower risk of heart failure (HF) and atherosclerotic cardiovascular disease among patients with type 2 diabetes. However, the contribution of baseline measures and longitudinal changes in fat mass (FM), lean mass (LM), and waist circumference (WC) to the risk of HF ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.120.050941

    authors: Patel KV,Bahnson JL,Gaussoin SA,Johnson KC,Pi-Sunyer X,White U,Olson KL,Bertoni AG,Kitzman DW,Berry JD,Pandey A,Look AHEAD Research Group.

    更新日期:2020-12-22 00:00:00

  • Targeted deletion of Fgl-2/fibroleukin in the donor modulates immunologic response and acute vascular rejection in cardiac xenografts.

    abstract:BACKGROUND:Xenografts ultimately fail as a result of acute vascular rejection (AVR), a process characterized by intravascular thrombosis, fibrin deposition, and endothelial cell activation. METHODS AND RESULTS:We studied whether targeted deletion of Fgl-2, an inducible endothelial cell procoagulant, (Fgl-2-/-) in the ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.534271

    authors: Mendicino M,Liu M,Ghanekar A,He W,Koscik C,Shalev I,Javadi M,Turnbull J,Chen W,Fung L,Sakamoto S,Marsden P,Waddell TK,Phillips MJ,Gorczynski R,Levy GA,Grant D

    更新日期:2005-07-12 00:00:00

  • Effects of volume loading during experimental acute pulmonary embolism.

    abstract::Volume loading is used to treat hemodynamically compromised patients with acute pulmonary embolism despite data to suggest that volume loading after embolism might cause a leftward shift of the ventricular septum with a subsequent decrease in left ventricular (LV) end-diastolic volume and stroke work. We studied 10 cl...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.80.1.178

    authors: Belenkie I,Dani R,Smith ER,Tyberg JV

    更新日期:1989-07-01 00:00:00

  • Sternotomy approach for the modified Blalock-Taussig shunt.

    abstract:BACKGROUND:Since 1990, sternotomy has been the preferred approach for construction of a modified Blalock-Taussig shunt (MBTS) at Children's Hospital, Boston, Mass. In retrospect, we sought to test the hypothesis that this approach yields less mortality and morbidity than the traditional thoracotomy approach. METHODS A...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.9.256

    authors: Odim J,Portzky M,Zurakowski D,Wernovsky G,Burke RP,Mayer JE Jr,Castaneda AR,Jonas RA

    更新日期:1995-11-01 00:00:00