Developmental endothelial locus-1 (Del-1) mediates clearance of platelet microparticles by the endothelium.

abstract：:The dynamics between mitral anulus motion, and, thus, motion of the base of the heart, and filling of the left atrium and ventricle were studied by Doppler echocardiography in 12 normal subjects and 28 patients with dilated cardiomyopathy. The normal motion of the mitral anulus is associated with two phases of inflow ...

journal_title：Circulation

authors： Keren G,Sonnenblick EH,LeJemtel TH

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Posteroseptal ablation of the atrioventricular node (AVN) has been proposed as a means to slow the ventricular rate during atrial fibrillation (AF). The suggested mechanism is elimination of the AVN "slow pathway." On the basis of the unpredictable success of the procedure, we hypothesize that, in fact, the ...

journal_title：Circulation

authors： Garrigue S,Mowrey KA,Fahy G,Tchou PJ,Mazgalev TN

更新日期：1999-05-04 00:00:00

abstract：BACKGROUND:The role of a cluster of risk factors characteristic for the insulin resistance syndrome as a predictor for coronary heart disease (CHD) has not been studied previously. METHODS AND RESULTS:Clustering of cardiovascular risk factors was analyzed by factor analysis to investigate whether these clusters (facto...

journal_title：Circulation

authors： Lempiäinen P,Mykkänen L,Pyörälä K,Laakso M,Kuusisto J

更新日期：1999-07-13 00:00:00

abstract：BACKGROUND:Erosion and rupture of coronary atheromas are the events preceding the vast majority of acute coronary syndromes. The shoulder regions of atheromas, the sites at which erosion or rupture is most likely to occur, are the sites at which mast cells accumulate. These cells are filled with neutral proteases capab...

journal_title：Circulation

authors： Kovanen PT,Kaartinen M,Paavonen T

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:There is no published randomized study comparing amiodarone therapy and radiofrequency catheter ablation (RFA) after only 1 episode of symptomatic atrial flutter (AFL). The aim of the Loire-Ardèche-Drôme-Isère-Puy-de-Dôme (LADIP) Trial of Atrial Flutter was 2-fold: (1) to prospectively compare first-line RFA...

journal_title：Circulation

authors： Da Costa A,Thévenin J,Roche F,Romeyer-Bouchard C,Abdellaoui L,Messier M,Denis L,Faure E,Gonthier R,Kruszynski G,Pages JM,Bonijoly S,Lamaison D,Defaye P,Barthélemy JC,Gouttard T,Isaaz K,Loire-Ardèche-Drôme-Isère-Puy-de-D

更新日期：2006-10-17 00:00:00

abstract：BACKGROUND:Recently, it was shown that intraindividual variation in low-density lipoprotein cholesterol (LDL-C) predicts both cerebrovascular and cardiovascular events. We aimed to examine whether this extends to cognitive function and examined possible pathways using a magnetic resonance imaging substudy. METHODS:We ...

journal_title：Circulation

authors： Smit RA,Trompet S,Sabayan B,le Cessie S,van der Grond J,van Buchem MA,de Craen AJ,Jukema JW

更新日期：2016-07-19 00:00:00

abstract：BACKGROUND:Catheter-based ultrasound is a new imaging modality to examine endovascular detail in the coronary circulation. This technique requires direct placement of the catheter in the arterial segment of interest. METHODS AND RESULTS:We examined the feasibility of a less invasive approach by imaging the coronary ar...

journal_title：Circulation

authors： Sudhir K,Fitzgerald PJ,MacGregor JS,DeMarco T,Ports TA,Chatterjee K,Yock PG

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Metformin is first-line therapy for type 2 diabetes mellitus, although its effects on the cardiovascular system are unproved. METHODS:In this post hoc analysis, patients in SAVOR-TIMI 53 (Saxagliptin and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus) with baseline biomarker samples (n=12...

journal_title：Circulation

authors： Bergmark BA,Bhatt DL,McGuire DK,Cahn A,Mosenzon O,Steg PG,Im K,Kanevsky E,Gurmu Y,Raz I,Braunwald E,Scirica BM,SAVOR-TIMI 53 Steering Committee and Investigators.

更新日期：2019-09-17 00:00:00

abstract：BACKGROUND:Mutations in the ryanodine 2 receptor (RyR2) gene have been identified in patients with catecholaminergic polymorphic ventricular tachycardia. We examined the cellular basis for the ECG features and arrhythmia mechanisms using low-dose caffeine to mimic the defective calcium homeostasis encountered under the...

journal_title：Circulation

authors： Nam GB,Burashnikov A,Antzelevitch C

更新日期：2005-05-31 00:00:00

abstract：BACKGROUND:Vascular endothelial cell growth factor plays a pivotal role in angiogenesis via regulating endothelial cell proliferation. The X-box binding protein 1 (XBP1) is believed to be a signal transducer in the endoplasmic reticulum stress response. It is unknown whether there is crosstalk between vascular endothel...

journal_title：Circulation

authors： Zeng L,Xiao Q,Chen M,Margariti A,Martin D,Ivetic A,Xu H,Mason J,Wang W,Cockerill G,Mori K,Li JY,Chien S,Hu Y,Xu Q

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:The mechanisms by which ACE inhibitors produce a sustained clinical benefit are not entirely clear but may involve the sympathetic nervous system. We compared the effect of local brachial artery infusions of an ACE inhibitor (perindoprilat) with the effect of placebo (0.9% NaCl) on endogenously mediated (low...

journal_title：Circulation

authors： Lyons D,Roy S,O'Byrne S,Swift CG

更新日期：1997-08-05 00:00:00

abstract：:A genetic-epidemiologic study was undertaken of a white Colorado population of 207 patients who had a myocardial infarction before age 55 years. Nineteen independent variables were compared between the 207 cases and 621 controls, matched 3:1. The highest risk ratios were associated with a positive family history for i...

journal_title：Circulation

authors： Nora JJ,Lortscher RH,Spangler RD,Nora AH,Kimberling WJ

更新日期：1980-03-01 00:00:00

abstract：:Two-dimensional echocardiography can provide serial cross-sectional images of the left ventricular cavity. We examined whether such serial images from steady-state ejecting hearts would allow three-dimensional reconstruction and accurate volume estimation without major geometric assumptions. Cross-circulated, paced do...

journal_title：Circulation

authors： Eaton LW,Maughan WL,Shoukas AA,Weiss JL

更新日期：1979-08-01 00:00:00

abstract：:The prognostic significance of a preoperative echocardiographic left ventricular end-systolic dimension (ESD) greater than 55 mm and/or fractional shortening (FS) of 25% or less was evaluated retrospectively in 84 patients who had undergone aortic valve replacement for isolated chronic aortic regurgitation due to vari...

journal_title：Circulation

authors： Daniel WG,Hood WP Jr,Siart A,Hausmann D,Nellessen U,Oelert H,Lichtlen PR

更新日期：1985-04-01 00:00:00

abstract：:Background: In ISCHEMIA, an initial invasive strategy did not significantly reduce rates of cardiovascular events or all-cause mortality compared with a conservative strategy in patients with stable ischemic heart disease and moderate/severe myocardial ischemia. The most frequent component of composite cardiovascular ...

journal_title：Circulation

authors： Chaitman BR,Alexander KP,Cyr DD,Berger JS,Reynolds HR,Bangalore S,Boden WE,Lopes RD,Demkow M,Perna GP,Riezebos RK,McFalls EO,Banerjee S,Bagai A,Gosselin G,O'Brien SM,Rockhold FW,Waters DD,Thygesen KA,Stone GW,Whit

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:We wished to test previous hypotheses that sex-related differences in mortality and morbidity may be due to differences in the cause of heart failure or in left ventricular ejection fraction (LVEF) by comparing fatal and nonfatal outcomes in women and men with heart failure and a broad spectrum of left ventr...

journal_title：Circulation

authors： O'Meara E,Clayton T,McEntegart MB,McMurray JJ,Piña IL,Granger CB,Ostergren J,Michelson EL,Solomon SD,Pocock S,Yusuf S,Swedberg K,Pfeffer MA,CHARM Investigators.

更新日期：2007-06-19 00:00:00

abstract：:Acute intravenous administration of the new beta 1-adrenergic receptor partial agonist xamoterol lowers left ventricular end-diastolic pressure and improves the isovolumic indexes of inotropic state and relaxation. To determine if these hemodynamic changes were maintained after prolonged administration, the dose-respo...

journal_title：Circulation

authors： Pouleur H,Etienne J,Van Mechelen H,Gurné O,Rousseau MF

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Surviving cells in the postinfarction border zone are subjected to intense fluctuations of their microenvironment. Recently, border zone cardiomyocytes have been specifically implicated in cardiac regeneration. Here, we defined their unique transcriptional and regulatory properties, and comprehensively valid...

journal_title：Circulation

authors： van Duijvenboden K,de Bakker DEM,Man JCK,Janssen R,Günthel M,Hill MC,Hooijkaas IB,van der Made I,van der Kraak PH,Vink A,Creemers EE,Martin JF,Barnett P,Bakkers J,Christoffels VM

更新日期：2019-09-09 00:00:00

abstract：:Despite the clinical prevalence of paradoxic interventricular septal (IVS) motion, its pathogenesis remains unclear. To assess the influence of the end-diastolic transseptal pressure gradient, we studied eight open-chest dogs during right ventricular (RV) volume loading (induced by opening a Dacron shunt between the p...

journal_title：Circulation

authors： Kingma I,Tyberg JV,Smith ER

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND:Several of the theories on the pathogenesis of atherosclerosis may be integrated into a single multifactorial one. According to this theory, the most likely sequence of events involved in early atherosclerosis is vascular dysfunction and/or injury, monocyte recruitment and macrophage formation, lipid deposit...

journal_title：Circulation

authors： Badimon JJ,Fuster V,Chesebro JH,Badimon L

更新日期：1993-03-01 00:00:00

abstract：:Nineteen patients with chronic low output cardiac failure were studied before, during and after infusion of phentolamine in doses of 10, 20, 30 and 40 microgram/kg/min. Significant reduction of left- and right-sided pressures and increases in cardiac index and heart rate (HR) were present within 15 minutes of starting...

journal_title：Circulation

authors： Stern MA,Gohlke HK,Loeb HS,Croke RP,Gunnar RM

更新日期：1978-07-01 00:00:00

abstract：:The echocardiograms of 46 patients with aortic insufficiency which manifested typical high frequency vibrations of the anterior mitral valve leaflet were reviewed. All patients had overt clinical evidence of aortic insufficiency which was confirmed by angiography in 17 cases. In 17 cases (eight of whom underwent cat...

journal_title：Circulation

authors： Cope GD,Kisslo JA,Johnson ML,Myers S

更新日期：1975-04-01 00:00:00

abstract：BACKGROUND:Regular exercise in patients with stable coronary artery disease has been shown to improve myocardial perfusion and to retard disease progression. We therefore conducted a randomized study to compare the effects of exercise training versus standard percutaneous coronary intervention (PCI) with stenting on cl...

journal_title：Circulation

authors： Hambrecht R,Walther C,Möbius-Winkler S,Gielen S,Linke A,Conradi K,Erbs S,Kluge R,Kendziorra K,Sabri O,Sick P,Schuler G

更新日期：2004-03-23 00:00:00

abstract：BACKGROUND:Nafamostat mesilate (FUT-175) is a protease inhibitor inactivating coagulation, fibrinolysis, and platelet aggregation. A prospective, randomized trial was performed to assess the efficacy of FUT-175 in the reduction of postoperative bleeding tendency. METHODS AND RESULTS:FUT-175 was infused at a rate of 40...

journal_title：Circulation

authors： Murase M,Usui A,Tomita Y,Maeda M,Koyama T,Abe T

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Preconditioning the heart before an ischemic insult has been shown to protect against contractile dysfunction, arrhythmias, and infarction. Pharmacological studies have suggested that fibroblast growth factor-2 (FGF2) is involved in cardioprotection. However, because of the number of FGFs expressed in the he...

journal_title：Circulation

authors： House SL,Bolte C,Zhou M,Doetschman T,Klevitsky R,Newman G,Schultz Jel J

更新日期：2003-12-23 00:00:00

abstract：:It has been suggested that the rate of left ventricular (LV) relaxation is related to the inotropic state, end-systolic fiber length and peak LV pressure, but little information is available regarding the rate of LV relaxation in patients with coronary artery disease (CAD) and LV dysfunction. To assess the rate of LV ...

journal_title：Circulation

authors： Papapietro SE,Coghlan HC,Zissermann D,Russell RO Jr,Rackley CE,Rogers WJ

更新日期：1979-05-01 00:00:00

abstract：:The myocardial uptake of 125I- and 131I-antimyosin monoclonal antibody Fab in experimental myocarditis in BALB/c mice induced by encephalomyocarditis virus was studied. The biodistribution of 125I-antimyosin demonstrated that the highest ratio of radioactivity appears in the heart of infected mice on day 14 (the ratio...

journal_title：Circulation

authors： Matsumori A,Ohkusa T,Matoba Y,Okada I,Yamada T,Kawai C,Tamaki N,Watanabe Y,Yonekura Y,Endo K

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:We tested the hypothesis that intracoronary delivery of an adenovirus encoding adenylyl cyclase type VI (Ad.AC(VI)) would be associated with increased left ventricular (LV) function in pigs with congestive heart failure. METHODS AND RESULTS:Pigs (52+/-6 kg; n=16) underwent placement of pacemakers, LV pressu...

journal_title：Circulation

authors： Lai NC,Roth DM,Gao MH,Tang T,Dalton N,Lai YY,Spellman M,Clopton P,Hammond HK

更新日期：2004-07-20 00:00:00

abstract：BACKGROUND:We have previously demonstrated vasculoprotective effects after repeated intravenous administration of recombinant apolipoprotein A-IMilano (apoA-Im)/phospholipid complex. In this study, we sought to determine the effects of local recombinant apoA-Im/1-palmitoyl,2-oleoyl phosphatidylcholine complex (ETC-216)...

journal_title：Circulation

authors： Kaul S,Rukshin V,Santos R,Azarbal B,Bisgaier CL,Johansson J,Tsang VT,Chyu KY,Cercek B,Mirocha J,Shah PK

更新日期：2003-05-27 00:00:00

abstract：BACKGROUND:Isomerism is associated with a complex spectrum of anomalies. There is paucity of data on prenatally detected cases. METHODS AND RESULTS:Between January 1990 and February 2004, 83 of 166 cases (50%) had a prenatal diagnosis of left isomerism (LAI; 52 of 97) or right isomerism (RAI; 31 of 69) at our institut...

journal_title：Circulation

authors： Lim JS,McCrindle BW,Smallhorn JF,Golding F,Caldarone CA,Taketazu M,Jaeggi ET

更新日期：2005-10-18 00:00:00