Effects of the beta 1-adrenergic receptor partial agonist xamoterol on left ventricular diastolic function. An evaluation after 1-6 years of oral therapy.

abstract：:The formula for survival in resuscitation describes educational efficiency and local implementation as key determinants in survival after cardiac arrest. Current educational offerings in the form of standardized online and face-to-face courses are falling short, with providers demonstrating a decay of skills over time...

journal_title：Circulation

authors： Cheng A,Nadkarni VM,Mancini MB,Hunt EA,Sinz EH,Merchant RM,Donoghue A,Duff JP,Eppich W,Auerbach M,Bigham BL,Blewer AL,Chan PS,Bhanji F,American Heart Association Education Science Investigators; and on behalf of the American

更新日期：2018-08-07 00:00:00

abstract：BACKGROUND:The extent of the peri-infarct zone by magnetic resonance imaging (MRI) has been related to all-cause mortality in patients with coronary artery disease. This relationship may result from arrhythmogenesis in the infarct border. However, the relationship between tissue heterogeneity in the infarct periphery a...

journal_title：Circulation

authors： Schmidt A,Azevedo CF,Cheng A,Gupta SN,Bluemke DA,Foo TK,Gerstenblith G,Weiss RG,Marbán E,Tomaselli GF,Lima JA,Wu KC

更新日期：2007-04-17 00:00:00

abstract：:The cause and associated pathophysiology of precordial ST-segment depression (ST decreases) during acute inferior myocardial infarction (IMI) are controversial. To investigate this problem, electrocardiographic findings in 48 consecutive patients with acute IMI were prospectively compared with results of coronary angi...

journal_title：Circulation

authors： Gibson RS,Crampton RS,Watson DD,Taylor GJ,Carabello BA,Holt ND,Beller GA

更新日期：1982-10-01 00:00:00

abstract：:Cardiac events of early diastole were studied in 50 normal subjects and 46 patients with mitral stenosis (MS) by simultaneous recordings of the mitral valve echogram (MVE), phonocardiogram, and apexcardiogram (ACG). Left ventricular isovolumic relaxation time (IRT), measured between A2 and onset of the MVE opening mot...

journal_title：Circulation

authors： Toutouzas P,Velimezis A,Castellanos S,Avgoustakis D

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND:Coconut oil is high in saturated fat and may, therefore, raise serum cholesterol concentrations, but beneficial effects on other cardiovascular risk factors have also been suggested. Therefore, we conducted a systematic review of the effect of coconut oil consumption on blood lipids and other cardiovascular ...

journal_title：Circulation

authors： Neelakantan N,Seah JYH,van Dam RM

更新日期：2020-03-10 00:00:00

abstract：BACKGROUND:Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results in low plasma LDL cholesterol and protection against coronary heart disease. Recent evidence indicates that PCSK9 also modulates the metabo...

journal_title：Circulation

authors： Rashid S,Tavori H,Brown PE,Linton MF,He J,Giunzioni I,Fazio S

更新日期：2014-07-29 00:00:00

abstract：BACKGROUND:Short-term hibernating myocardium is characterized by a decrease in contractile function in proportion to the reduced myocardial blood flow. Myocardial creatine phosphate content, initially decreased during the first minutes of ischemia, returns to near-control values, the ischemia-induced net lactate produc...

journal_title：Circulation

authors： Schulz R,Rose J,Martin C,Brodde OE,Heusch G

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:The positions, sizes, and shapes of ventricular septal defects (VSDs) can be difficult to assess by 2-dimensional echocardiography (2DE). Volume-rendered 3-dimensional echocardiography (3DE) can provide unique views of VSDs from the left ventricular (LV) side, allowing complete assessment of their circumfere...

journal_title：Circulation

authors： Kardon RE,Cao QL,Masani N,Sugeng L,Supran S,Warner KG,Pandian NG,Marx GR

更新日期：1998-09-29 00:00:00

abstract：BACKGROUND:There is no published randomized study comparing amiodarone therapy and radiofrequency catheter ablation (RFA) after only 1 episode of symptomatic atrial flutter (AFL). The aim of the Loire-Ardèche-Drôme-Isère-Puy-de-Dôme (LADIP) Trial of Atrial Flutter was 2-fold: (1) to prospectively compare first-line RFA...

journal_title：Circulation

authors： Da Costa A,Thévenin J,Roche F,Romeyer-Bouchard C,Abdellaoui L,Messier M,Denis L,Faure E,Gonthier R,Kruszynski G,Pages JM,Bonijoly S,Lamaison D,Defaye P,Barthélemy JC,Gouttard T,Isaaz K,Loire-Ardèche-Drôme-Isère-Puy-de-D

更新日期：2006-10-17 00:00:00

abstract：BACKGROUND:The roles of Purkinje fibers (PFs) and focal wave fronts, if any, in the maintenance of ventricular fibrillation (VF) are unknown. If PFs are involved in VF maintenance, it should be possible to map wave fronts propagating from PFs into the working ventricular myocardium during VF. If wave fronts ever arise ...

journal_title：Circulation

authors： Tabereaux PB,Walcott GP,Rogers JM,Kim J,Dosdall DJ,Robertson PG,Killingsworth CR,Smith WM,Ideker RE

更新日期：2007-09-04 00:00:00

abstract：:We used a canine preparation of experimental infarction to study the natural course of echocardiographically defined regional wall motion abnormalities in the 6 weeks after acute coronary ligation. Eight dogs underwent serial short-axis echocardiographic evaluation and microsphere blood flow determinations at control,...

journal_title：Circulation

authors： Gibbons EF,Hogan RD,Franklin TD,Nolting M,Weyman AE

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease is the leading cause of death for both men and women in the United States and the world. A profound pattern exists in the time of day at which the death occurs; it is in the morning, when the endothelium is most vulnerable and blood pressure surges, that stroke and heart attack most fr...

journal_title：Circulation

authors： Anea CB,Zhang M,Stepp DW,Simkins GB,Reed G,Fulton DJ,Rudic RD

更新日期：2009-03-24 00:00:00

abstract：BACKGROUND:Exposure to risk factors such as hypertension or hypercholesterolemia decreases the bioavailability of endothelium-derived nitric oxide (NO) and impairs endothelium-dependent vasodilation. Recently, a circulating endogenous NO synthase inhibitor, asymmetric dimethylarginine (ADMA), has been detected in human...

journal_title：Circulation

authors： Miyazaki H,Matsuoka H,Cooke JP,Usui M,Ueda S,Okuda S,Imaizumi T

更新日期：1999-03-09 00:00:00

abstract：:To investigate whether ergonovine acts directly on coronary arteries or via remote neurohumoral reflexes, we administered small titrated increments of intracoronary ergonovine up to a maximum cumulative dose of 50 micrograms to 15 patients. In six patients with variant angina (group 1), ischemic electrocardiographic S...

journal_title：Circulation

authors： Hackett D,Larkin S,Chierchia S,Davies G,Kaski JC,Maseri A

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that hypertrophy of surviving myocytes after myocardial infarction (MI) is limited. Progressive ventricular dilatation after MI may occur when compensatory hypertrophy cannot restore left ventricular (LV) wall stress to normal. METHODS AND RESULTS:To test whether induction of add...

journal_title：Circulation

authors： Litwin SE,Raya TE,Anderson PG,Litwin CM,Bressler R,Goldman S

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes is associated with accelerated atherosclerosis. Because cell-derived microparticles support coagulation and inflammation, they may be involved in atherogenesis. We characterized circulating microparticles both in patients with uncomplicated, well-regulated type 2 diabetes and in healthy subje...

journal_title：Circulation

authors： Diamant M,Nieuwland R,Pablo RF,Sturk A,Smit JW,Radder JK

更新日期：2002-11-05 00:00:00

abstract：BACKGROUND:Although the left prepectoral site is preferred for "hot can" placement, this site is unavailable in some patients. We evaluated the influence of electrode location on defibrillation thresholds with alternative hot can and transvenous lead configurations. METHODS AND RESULTS:Three interrelated studies were ...

journal_title：Circulation

authors： Yamanouchi Y,Mowrey KA,Niebauer MJ,Tchou PJ,Wilkoff BL

更新日期：1997-12-16 00:00:00

abstract：:Power outputs that are below the anaerobic threshold (theta an) may be sustained for prolonged durations, whereas power outputs that are greater than theta an result in a significant reduction in the tolerable duration to fatigue. The theta an may therefore be considered to demarcate exercise intensity into moderate (...

journal_title：Circulation

authors： Whipp BJ

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Aging results in vascular stiffening and an increase in the velocity of the pressure wave as it travels down the aorta. Increased aortic pulse wave velocity (aPWV) has been associated with mortality in clinical but not general populations. The objective of this investigation was to determine whether aPWV is ...

journal_title：Circulation

authors： Sutton-Tyrrell K,Najjar SS,Boudreau RM,Venkitachalam L,Kupelian V,Simonsick EM,Havlik R,Lakatta EG,Spurgeon H,Kritchevsky S,Pahor M,Bauer D,Newman A,Health ABC Study.

更新日期：2005-06-28 00:00:00

abstract：:Three patients developed late pulmonary vein obstruction (PVO) following Mustard's operation for transposition of the great arteries. In all three the absence of PVO had been documented by an earlier postoperative cardiac catheterization. At reoperation shrinkage and kinking of the dacron baffle was evident. After Mus...

journal_title：Circulation

authors： Driscoll DJ,Nihill MR,Vargo TA,Mullins CE,McNamara DG

更新日期：1977-03-01 00:00:00

abstract：BACKGROUND:In patients with coronary artery disease (CAD), acute thrombosis frequently occurs in coronary arteries with only mild or moderate stenoses. Obesity increases the risk of atherosclerosis, but it is not known whether it also increases the risk of coronary thrombosis. We hypothesized that body mass index (BMI)...

journal_title：Circulation

authors： Wolk R,Berger P,Lennon RJ,Brilakis ES,Somers VK

更新日期：2003-11-04 00:00:00

abstract：BACKGROUND:Fortilin, a recently characterized nuclear antiapoptotic factor structurally distinct from inhibitor of apoptosis proteins (IAPs) and Bcl-2 family member proteins, has been suggested to be involved in cell survival and regulation of apoptosis within the cardiovascular system. In this continued investigation,...

journal_title：Circulation

authors： Tulis DA,Mnjoyan ZH,Schiesser RL,Shelat HS,Evans AJ,Zoldhelyi P,Fujise K

更新日期：2003-01-07 00:00:00

abstract：BACKGROUND:In the congenital long-QT syndrome (LQTS), there can be a marked phenotypic heterogeneity. Founder effects, by which many individuals share a mutation identical by descent, represent a powerful tool to further understand the underlying mechanisms and to predict the natural history of mutation-associated effe...

journal_title：Circulation

authors： Brink PA,Crotti L,Corfield V,Goosen A,Durrheim G,Hedley P,Heradien M,Geldenhuys G,Vanoli E,Bacchini S,Spazzolini C,Lundquist AL,Roden DM,George AL Jr,Schwartz PJ

更新日期：2005-10-25 00:00:00

abstract：BACKGROUND:Enteroviridae such as coxsackievirus B3 (CVB3) are important infectious agents involved in viral heart disease, hepatitis, and pancreatitis, but no specific antiviral therapy is available. METHODS AND RESULTS:The aim of the present study was to evaluate the impact of RNA interference on viral replication, c...

journal_title：Circulation

authors： Merl S,Michaelis C,Jaschke B,Vorpahl M,Seidl S,Wessely R

更新日期：2005-04-05 00:00:00

abstract：BACKGROUND:A paucity of literature is available on the effects of age and coronary artery bypass grafting (CABG) on the outcomes of patients undergoing mitral valve (MV) repair versus replacement. METHODS AND RESULTS:A matched study was performed using prospectively collected data from the Emory cardiovascular databas...

journal_title：Circulation

authors： Thourani VH,Weintraub WS,Guyton RA,Jones EL,Williams WH,Elkabbani S,Craver JM

更新日期：2003-07-22 00:00:00

abstract：:Studies of the correlation of aortic valve gradient determined by continuous-wave Doppler echocardiography and that determined at catheterization have, to date, involved young patients and nonsimultaneous measurements. We therefore obtained simultaneous Doppler echocardiographic and catheter measurements of pressure g...

journal_title：Circulation

authors： Currie PJ,Seward JB,Reeder GS,Vlietstra RE,Bresnahan DR,Bresnahan JF,Smith HC,Hagler DJ,Tajik AJ

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND:Factors leading differentially to the development of isolated diastolic (IDH), systolic-diastolic (SDH), and isolated systolic (ISH) hypertension are poorly understood. We examined the relations of blood pressure (BP) and clinical risk factors to the new onset of the 3 forms of hypertension. METHODS AND RES...

journal_title：Circulation

authors： Franklin SS,Pio JR,Wong ND,Larson MG,Leip EP,Vasan RS,Levy D

更新日期：2005-03-08 00:00:00

abstract：:Optimal electrode position for long-term transvenous cardiac pacing is in the apex of the right ventricle. Intracardiac electrograms, surface electrocardiograms, frontal fluoroscopy, lateral roentgenograms, and pacing threshold levels were studied in two groups of patients: One group was comprised of five patients wit...

journal_title：Circulation

authors： Gulotta SJ

更新日期：1970-10-01 00:00:00

abstract：BACKGROUND:Iron overload has an increasing worldwide prevalence and is associated with significant cardiovascular morbidity and mortality. Elevated iron levels in the myocardium lead to impaired systolic and diastolic function and elevated oxidative stress. Taurine accounts for 25% to 50% of the amino acid pool in myoc...

journal_title：Circulation

authors： Oudit GY,Trivieri MG,Khaper N,Husain T,Wilson GJ,Liu P,Sole MJ,Backx PH

更新日期：2004-04-20 00:00:00

abstract：BACKGROUND:In vivo testing of novel antiplatelet agents requires informative biomarkers. By genetically modifying mouse von Willebrand factor (VWF(R1326H)), we have developed a small animal model that supports human but not mouse platelet-mediated thrombosis. Here, we evaluate the use of this biological platform as a p...

journal_title：Circulation

authors： Magallon J,Chen J,Rabbani L,Dangas G,Yang J,Bussel J,Diacovo T

更新日期：2011-01-25 00:00:00