Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice.

Abstract:

BACKGROUND:Vascular inflammation and lipid deposition are prominent features of atherosclerotic lesion formation. We have shown previously that the dithiol compound alpha-lipoic acid (LA) exerts antiinflammatory effects by inhibiting tumor necrosis factor-alpha- and lipopolysaccharide-induced endothelial and monocyte activation in vitro and lipopolysaccharide-induced acute inflammatory responses in vivo. Here, we investigated whether LA inhibits atherosclerosis in apolipoprotein E-deficient (apoE-/-) and apoE/low-density lipoprotein receptor-deficient mice, 2 well-established animal models of human atherosclerosis. METHODS AND RESULTS:Four-week-old female apoE-/- mice (n=20 per group) or apoE/low-density lipoprotein receptor-deficient mice (n=21 per group) were fed for 10 weeks a Western-type chow diet containing 15% fat and 0.125% cholesterol without or with 0.2% (wt/wt) R,S-LA or a normal chow diet containing 4% fat without or with 0.2% (wt/wt) R-LA, respectively. Supplementation with LA significantly reduced atherosclerotic lesion formation in the aortic sinus of both mouse models by approximately 20% and in the aortic arch and thoracic aorta of apoE-/- and apoE/low-density lipoprotein receptor-deficient mice by approximately 55% and 40%, respectively. This strong antiatherogenic effect of LA was associated with almost 40% less body weight gain and lower serum and very low-density lipoprotein levels of triglycerides but not cholesterol. In addition, LA supplementation reduced aortic expression of adhesion molecules and proinflammatory cytokines and aortic macrophage accumulation. These antiinflammatory effects of LA were more pronounced in the aortic arch and the thoracic aorta than in the aortic sinus, reflecting the corresponding reductions in atherosclerosis. CONCLUSIONS:Our study shows that dietary LA supplementation inhibits atherosclerotic lesion formation in 2 mouse models of human atherosclerosis, an inhibition that appears to be due to the "antiobesity," antihypertriglyceridemic, and antiinflammatory effects of LA. LA may be a useful adjunct in the prevention and treatment of atherosclerotic vascular diseases.

journal_name

Circulation

journal_title

Circulation

authors

Zhang WJ,Bird KE,McMillen TS,LeBoeuf RC,Hagen TM,Frei B

doi

10.1161/CIRCULATIONAHA.107.725275

subject

Has Abstract

pub_date

2008-01-22 00:00:00

pages

421-8

issue

3

eissn

0009-7322

issn

1524-4539

pii

CIRCULATIONAHA.107.725275

journal_volume

117

pub_type

杂志文章
  • Cardiac beta-adrenergic neuroeffector systems in acute myocardial dysfunction related to brain injury. Evidence for catecholamine-mediated myocardial damage.

    abstract:BACKGROUND:Ten percent to 20% of potential cardiac donors with brain injury and no previous cardiac history have myocardial dysfunction. We assessed components of the beta-receptor-G-protein-adenylyl cyclase complex as well as the contractile response in 10 explanted acutely failing human hearts (donor heart dysfunctio...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.8.2183

    authors: White M,Wiechmann RJ,Roden RL,Hagan MB,Wollmering MM,Port JD,Hammond E,Abraham WT,Wolfel EE,Lindenfeld J

    更新日期:1995-10-15 00:00:00

  • Natural history and classification of occlusive thromboaortopathy (Takayasu's disease).

    abstract::Fifty-four Japanese patients with occlusive thromboaortopathy (OTAP), including four males, were classified according to evidence of complications attributed to OTAP at the time when the diagnosis was established: Group I, uncomplicated OTAP with or without the involvement of the pulmonary artery. Group II, mono-compl...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.57.1.27

    authors: Ishikawa K

    更新日期:1978-01-01 00:00:00

  • Regional myocardial oxygen consumption determined noninvasively in humans with [1-11C]acetate and dynamic positron tomography.

    abstract::Experimental studies of animals have previously demonstrated the validity of [1-11C]acetate as a tracer of oxidative metabolism for use with positron emission tomography. The present study was undertaken to define in normal human volunteers the relation between myocardial clearance kinetics of [1-11C]acetate, and the ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.80.4.863

    authors: Armbrecht JJ,Buxton DB,Brunken RC,Phelps ME,Schelbert HR

    更新日期:1989-10-01 00:00:00

  • Adenovirus-mediated VEGF(121) gene transfer stimulates angiogenesis in normoperfused skeletal muscle and preserves tissue perfusion after induction of ischemia.

    abstract:BACKGROUND:Administration of angiogenic factors stimulates neovascularization in ischemic tissues. However, there is no evidence that angiogenesis can be induced in normoperfused skeletal muscles. We tested the hypothesis that adenovirus-mediated intramuscular (IM) gene transfer of the 121-amino-acid form of vascular e...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.102.5.565

    authors: Gowdak LH,Poliakova L,Wang X,Kovesdi I,Fishbein KW,Zacheo A,Palumbo R,Straino S,Emanueli C,Marrocco-Trischitta M,Lakatta EG,Anversa P,Spencer RG,Talan M,Capogrossi MC

    更新日期:2000-08-01 00:00:00

  • Correlation between left ventricular hypertrophy and GAA trinucleotide repeat length in Friedreich's ataxia.

    abstract:BACKGROUND:Friedreich's ataxia (FA), the most common inherited ataxia, is associated frequently with cardiac hypertrophy, and death is often cardiac related. Recently, the disease has been associated with a mutation that consists of an unstable expansion of GAA repeats in the first intron of the gene encoding frataxin ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.95.9.2247

    authors: Isnard R,Kalotka H,Dürr A,Cossée M,Schmitt M,Pousset F,Thomas D,Brice A,Koenig M,Komajda M

    更新日期:1997-05-06 00:00:00

  • Long-Term Survival and Freedom From Reintervention After Off-Pump Coronary Artery Bypass Grafting: A Propensity-Matched Study.

    abstract:BACKGROUND:The long-term outcomes of off-pump coronary artery bypass grafting (CABG) are the subject of speculation. Our institution has >15 years of experience performing CABG both off-pump (OPCAB) and on cardiopulmonary bypass (CPB). Our null hypothesis was that there would be no difference in a long-term composite o...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.116.021933

    authors: Kirmani BH,Holmes MV,Muir AD

    更新日期:2016-10-25 00:00:00

  • Bone marrow derived mesenchymal cell mobilization by granulocyte-colony stimulating factor after acute myocardial infarction: results from the Stem Cells in Myocardial Infarction (STEMMI) trial.

    abstract:BACKGROUND:Granulocyte-colony stimulating factor (G-CSF) after myocardial infarction does not affect systolic function when compared with placebo. In contrast, intracoronary infusion of bone marrow cells appears to improve ejection fraction. We aimed to evaluate the G-CSF mobilization of subsets of stem cells. METHODS...

    journal_title:Circulation

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/CIRCULATIONAHA.106.678649

    authors: Ripa RS,Haack-Sørensen M,Wang Y,Jørgensen E,Mortensen S,Bindslev L,Friis T,Kastrup J

    更新日期:2007-09-11 00:00:00

  • Infantile dilated cardiomyopathy. Relation of outcome to left ventricular mechanics, hemodynamics, and histology at the time of presentation.

    abstract:BACKGROUND:For patients with acute dilated cardiomyopathy, definition of prognosis and of clinical features predictive of outcome is particularly important due to the availability of cardiac transplantation and other innovative treatment strategies. METHODS AND RESULTS:We reviewed our experience with 24 children under...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.90.3.1310

    authors: Matitiau A,Perez-Atayde A,Sanders SP,Sluysmans T,Parness IA,Spevak PJ,Colan SD

    更新日期:1994-09-01 00:00:00

  • Enhanced expression of β3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase.

    abstract:BACKGROUND:β1-2-adrenergic receptors (AR) are key regulators of cardiac contractility and remodeling in response to catecholamines. β3-AR expression is enhanced in diseased human myocardium, but its impact on remodeling is unknown. METHODS AND RESULTS:Mice with cardiac myocyte-specific expression of human β3-AR (β3-TG...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.113.004940

    authors: Belge C,Hammond J,Dubois-Deruy E,Manoury B,Hamelet J,Beauloye C,Markl A,Pouleur AC,Bertrand L,Esfahani H,Jnaoui K,Götz KR,Nikolaev VO,Vanderper A,Herijgers P,Lobysheva I,Iaccarino G,Hilfiker-Kleiner D,Tavernier G,La

    更新日期:2014-01-28 00:00:00

  • Outcome of the Fontan procedure in patients with tricuspid atresia.

    abstract::Between 1973 and 1983, 90 patients with tricuspid atresia underwent the Fontan operation at the Mayo Clinic. Operative mortality was 12% overall and decreased to 7% during the second 5 year period. At postoperative follow-up of 65 patients (1 to 10 years, mean 4), 50 (86%) of 58 present survivors were in excellent con...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Mair DD,Rice MJ,Hagler DJ,Puga FJ,McGoon DC,Danielson GK

    更新日期:1985-09-01 00:00:00

  • Metalloproteinase inhibition reduces constrictive arterial remodeling after balloon angioplasty: a study in the atherosclerotic Yucatan micropig.

    abstract:BACKGROUND:Arterial remodeling after balloon angioplasty has been recognized as a major determinant of restenosis. Perturbation of collagen metabolism might be important. After balloon injury, matrix metalloproteinase (MMP) expression is upregulated. We investigated the effect of Batimastat, a nonspecific MMP inhibitor...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.101.25.2962

    authors: de Smet BJ,de Kleijn D,Hanemaaijer R,Verheijen JH,Robertus L,van Der Helm YJ,Borst C,Post MJ

    更新日期:2000-06-27 00:00:00

  • Identification of acute myocardial infarction patients suitable for early hospital discharge after aggressive interventional therapy. Results from the Thrombolysis and Angioplasty in Acute Myocardial Infarction Registry.

    abstract:BACKGROUND:Very early (day 4) hospital discharge has recently been proposed for selected patients with acute myocardial infarction (MI). The purpose of this study was to determine the most useful factors for identifying acute MI patients treated with aggressive interventional therapy who could be safely discharged on d...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.83.4.1186

    authors: Mark DB,Sigmon K,Topol EJ,Kereiakes DJ,Pryor DB,Candela RJ,Califf RM

    更新日期:1991-04-01 00:00:00

  • Antiviral treatment with WIN 54 954 reduces mortality in murine coxsackievirus B3 myocarditis.

    abstract:BACKGROUND:Coxsackieviruses B (CBVs) are dominant causative agents in myocarditis and are associated with pathogenesis is some cases of dilated cardiomyopathy, a clinical entity with a poor survival without heart transplantation. METHODS AND RESULTS:In vitro, the antiviral agent WIN 54 954 was shown to inhibit replica...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.94.9.2254

    authors: Fohlman J,Pauksen K,Hyypiä T,Eggertsen G,Ehrnst A,Ilbäck NG,Friman G

    更新日期:1996-11-01 00:00:00

  • Inhibition of intimal hyperplasia after balloon injury by antibodies to intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1.

    abstract:BACKGROUND:Although intercellular adhesion molecule-1 (ICAM-1) is known to be expressed in balloon-injured arteries, it remains unknown whether ICAM-1 plays a role in the progression of intimal hyperplasia (IH) induced by balloon injury. METHODS AND RESULTS:We examined the ICAM-1 expression in rat carotid arteries at ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.95.6.1515

    authors: Yasukawa H,Imaizumi T,Matsuoka H,Nakashima A,Morimatsu M

    更新日期:1997-03-18 00:00:00

  • Antithrombotic effects of thrombolytic agents in a platelet-rich femoral vein thrombosis model in the hamster.

    abstract:BACKGROUND:The extent and mechanism of the antithrombotic properties of fibrin-selective and non-fibrin-selective thrombolytic agents have not yet been established. METHODS AND RESULTS:The antithrombotic, thrombolytic, fibrinogenolytic, and pharmacokinetic properties of the following substances were determined in hams...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.91.5.1330

    authors: Stassen JM,Nyström A,Hoylaerts M,Collen D

    更新日期:1995-03-01 00:00:00

  • Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib.

    abstract:BACKGROUND:Early detection of adverse effects of novel therapies and understanding of their mechanisms could improve the safety and efficiency of drug development. We have retrospectively applied large-scale proteomics to blood samples from ILLUMINATE (Investigation of Lipid Level Management to Understand its Impact in...

    journal_title:Circulation

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/CIRCULATIONAHA.117.028213

    authors: Williams SA,Murthy AC,DeLisle RK,Hyde C,Malarstig A,Ostroff R,Weiss SJ,Segal MR,Ganz P

    更新日期:2018-03-06 00:00:00

  • Congenital heart block in newborns of mothers with connective tissue disease.

    abstract::Of 22 children with congenital complete heart block (CCHB) available for study, 14 (63.6%) were born to 11 mothers with clinical or laboratory evidence of connective tissue disease, primarily lupus erythematosus (LE). Seven mothers had both clinical and laboratory evidence of disease while four had only positive labor...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.56.1.82

    authors: McCue CM,Mantakas ME,Tingelstad JB,Ruddy S

    更新日期:1977-07-01 00:00:00

  • Coronary collateral function in patients without occlusive coronary artery disease.

    abstract::Little is known of the functional capacity of coronary collaterals in humans without occlusive coronary artery disease. We, therefore, measured peripheral coronary pressure (PCP) and retrograde flow (RF) from coronary arteries at aortic valve replacement in seven patients without occlusive coronary artery disease. Usi...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.51.1.118

    authors: Goldstein RE,Michaelis LL,Morrow AG,Epstein SE

    更新日期:1975-01-01 00:00:00

  • The interaction of verapamil and norverapamil with beta-adrenergic receptors.

    abstract::To determine the effect of calcium-channel blockers on beta-adrenergic receptors, we studied the interactions of verapamil, diltiazem, and nifedipine with both human lymphocyte beta 2-adrenergic receptors and rat myocardial beta 1-adrenergic receptors by means of radioligand binding assays. We also determined the func...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.72.3.547

    authors: Feldman RD,Park GD,Lai CY

    更新日期:1985-09-01 00:00:00

  • Open-Label Randomized Trial Comparing Oral Anticoagulation With and Without Single Antiplatelet Therapy in Patients With Atrial Fibrillation and Stable Coronary Artery Disease Beyond 1 Year After Coronary Stent Implantation.

    abstract:BACKGROUND:Despite recommendations in the guidelines and consensus documents, there has been no randomized controlled trial evaluating oral anticoagulation (OAC) alone without antiplatelet therapy (APT) in patients with atrial fibrillation and stable coronary artery disease beyond 1 year after coronary stenting. METHO...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.118.036768

    authors: Matsumura-Nakano Y,Shizuta S,Komasa A,Morimoto T,Masuda H,Shiomi H,Goto K,Nakai K,Ogawa H,Kobori A,Kono Y,Kaitani K,Suwa S,Aoyama T,Takahashi M,Sasaki Y,Onishi Y,Mano T,Matsuda M,Motooka M,Tomita H,Inoko M,Wak

    更新日期:2019-01-29 00:00:00

  • Exploration of the precision of classifying sudden cardiac death. Implications for the interpretation of clinical trials.

    abstract:BACKGROUND:As cardiovascular clinical trials improve in sophistication and therapies target specific cardiac mechanisms of death, a more objective and precise system to identify specific cause of death is needed. Ideally, sudden cardiac death would describe patients dying of ventricular tachycardia and ventricular fibr...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.93.3.519

    authors: Pratt CM,Greenway PS,Schoenfeld MH,Hibben ML,Reiffel JA

    更新日期:1996-02-01 00:00:00

  • Reentry within the atrioventricular node: surgical cure with preservation of atrioventricular conduction.

    abstract::Paroxysmal supraventricular tachycardia (PSVT) is commonly caused by reentry within the atrioventricular (AV) node. This arrhythmia was abolished by operative dissection of the AV junction in a patient with disabling tachycardia that was not controlled by drugs. The operation was intended to create complete AV block, ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.60.2.440

    authors: Pritchett EL,Anderson RW,Benditt DG,Kasell J,Harrison L,Wallace AG,Sealy WC,Gallagher JJ

    更新日期:1979-08-01 00:00:00

  • Nitroglycerin improves functional recovery of neonatal lamb hearts after 2 hours of cold ischemia.

    abstract:BACKGROUND:Vascular events during initial reperfusion after a period of hypothermic cardioplegic ischemia may play an important role in the recovery of mechanical function. Prior studies have shown (1) that dysfunction of the postischemic myocardium after normothermic ischemia can be ameliorated by vasodilation and (2)...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Kawata H,Aoki M,Mayer JE Jr

    更新日期:1993-11-01 00:00:00

  • Acute rheumatic fever and rheumatic heart disease: incidence and progression in the Northern Territory of Australia, 1997 to 2010.

    abstract:BACKGROUND:Although acute rheumatic fever (ARF) and its sequel, rheumatic heart disease (RHD), continue to cause a large burden of morbidity and mortality in disadvantaged populations, most studies investigating the effectiveness of control programs date from the 1950s. A control program, including a disease register, ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.113.001477

    authors: Lawrence JG,Carapetis JR,Griffiths K,Edwards K,Condon JR

    更新日期:2013-07-30 00:00:00

  • Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white males.

    abstract:BACKGROUND:The renin-angiotensin system regulates blood pressure through its effects on vascular tone, renal hemodynamics, and renal sodium and fluid balance. METHODS AND RESULTS:Using data from a large population-based sample of 1488 siblings having a mean age of 14.8 years and belonging to the youngest generation of...

    journal_title:Circulation

    pub_type: 评论,杂志文章

    doi:10.1161/01.cir.97.18.1773

    authors: Fornage M,Amos CI,Kardia S,Sing CF,Turner ST,Boerwinkle E

    更新日期:1998-05-12 00:00:00

  • Effects of combination of ACE inhibitor and angiotensin receptor blocker on cardiac remodeling, cardiac function, and survival in rat heart failure.

    abstract:BACKGROUND:The mechanism and treatment of diastolic heart failure are poorly understood. We compared the effects of an ACE inhibitor, an angiotensin receptor blocker (ARB), and their combination on diastolic heart failure in Dahl salt-sensitive (DS) rats. METHODS AND RESULTS:DS rats fed an 8% NaCl diet from 7 weeks of...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.103.1.148

    authors: Kim S,Yoshiyama M,Izumi Y,Kawano H,Kimoto M,Zhan Y,Iwao H

    更新日期:2001-01-02 00:00:00

  • Limited exercise capacity in heterozygous manganese superoxide dismutase gene-knockout mice: roles of superoxide anion and nitric oxide.

    abstract:BACKGROUND:We have reported that there is a limitation of exercise capacity in mice with defects in the expression of endothelial nitric oxide (NO) synthase, which is associated with a greater increase in whole-body oxygen consumption (VO2). We hypothesized that in states in which superoxide anion (O2-) is increased, e...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000159261.11520.63

    authors: Kinugawa S,Wang Z,Kaminski PM,Wolin MS,Edwards JG,Kaley G,Hintze TH

    更新日期:2005-03-29 00:00:00

  • Bone Morphogenetic Protein 9 Reduces Cardiac Fibrosis and Improves Cardiac Function in Heart Failure.

    abstract:BACKGROUND:Heart failure is a growing cause of morbidity and mortality worldwide. Transforming growth factor beta (TGF-β1) promotes cardiac fibrosis, but also activates counterregulatory pathways that serve to regulate TGF-β1 activity in heart failure. Bone morphogenetic protein 9 (BMP9) is a member of the TGFβ family ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.117.031635

    authors: Morine KJ,Qiao X,York S,Natov PS,Paruchuri V,Zhang Y,Aronovitz MJ,Karas RH,Kapur NK

    更新日期:2018-07-31 00:00:00

  • Prognostic value of N-terminal pro-brain natriuretic peptide in patients with chronic stable angina.

    abstract:BACKGROUND:Patients with chronic stable angina are poorly characterized in terms of biomarkers that help in the assessment of prognosis. We investigated whether plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) may be used as a prognostic marker in patients with chronic stable angina treated with co...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.550715

    authors: Ndrepepa G,Braun S,Niemöller K,Mehilli J,von Beckerath N,von Beckerath O,Vogt W,Schömig A,Kastrati A

    更新日期:2005-10-04 00:00:00

  • Role and results of surgery in acute type B aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD).

    abstract:BACKGROUND:The clinical profiles and outcomes of patients treated surgically for acute type B aortic dissection (ABAD) are often reported for those in small series or for those cared for at a single institution over a long time period, during which a continuous evolution in techniques has occurred. Accordingly, we soug...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.000620

    authors: Trimarchi S,Nienaber CA,Rampoldi V,Myrmel T,Suzuki T,Bossone E,Tolva V,Deeb MG,Upchurch GR Jr,Cooper JV,Fang J,Isselbacher EM,Sundt TM 3rd,Eagle KA,IRAD Investigators.

    更新日期:2006-07-04 00:00:00