Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia.

abstract：BACKGROUND:We hypothesized that cytomegalovirus (CMV) may contribute to the vasculopathy observed in cardiac allograft recipients by impairing the endothelial nitric oxide synthase pathway. We focused on asymmetric dimethylarginine (ADMA, the endogenous inhibitor of nitric oxide synthase) as a potential mediator of the...

journal_title：Circulation

authors： Weis M,Kledal TN,Lin KY,Panchal SN,Gao SZ,Valantine HA,Mocarski ES,Cooke JP

更新日期：2004-02-03 00:00:00

abstract：BACKGROUND:Cholesterol-lowering therapy can improve cardiovascular morbidity and mortality in patients with atherosclerosis. Although the mechanisms responsible are unclear, these benefits precede macroscopic changes in the vasculature. Emerging evidence that improvement in endothelial function may occur requires subst...

journal_title：Circulation

authors： O'Driscoll G,Green D,Taylor RR

更新日期：1997-03-04 00:00:00

abstract：:Patients with lower-extremity peripheral artery disease (PAD) have greater functional impairment, faster functional decline, increased rates of mobility loss, and poorer quality of life than people without PAD. Supervised exercise therapy (SET) improves walking ability, overall functional status, and health-related qu...

journal_title：Circulation

authors： Treat-Jacobson D,McDermott MM,Beckman JA,Burt MA,Creager MA,Ehrman JK,Gardner AW,Mays RJ,Regensteiner JG,Salisbury DL,Schorr EN,Walsh ME,American Heart Association Council on Peripheral Vascular Disease; Council on Cardiovascular

更新日期：2019-09-24 00:00:00

abstract：:The clinical significance of perioperative myocardial infarction (MI) after coronary artery bypass surgery is not known. Therefore, strategies for the risk stratification of these patients do not exist. This study was undertaken to define the effect of perioperative MI on prognosis after discharge from the hospital an...

journal_title：Circulation

authors： Force T,Hibberd P,Weeks G,Kemper AJ,Bloomfield P,Tow D,Josa M,Khuri S,Parisi AF

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Recent failures of drugs that raised high-density lipoprotein (HDL) cholesterol levels to reduce cardiovascular events in clinical trials have led to increased interest in alternative indices of HDL quality, such as cholesterol efflux capacity, and HDL quantity, such as HDL particle number. However, no studi...

journal_title：Circulation

authors： Khera AV,Demler OV,Adelman SJ,Collins HL,Glynn RJ,Ridker PM,Rader DJ,Mora S

更新日期：2017-06-20 00:00:00

abstract：:Since the discovery that neuregulin-1 (NRG-1)/ErbB signaling is indispensable in cardiac development, evidence has shown that this system also plays a crucial role in the adult heart. In patients, an inhibitory ErbB2 antibody, trastuzumab, used in the treatment of mammary carcinomas, increases the risk for the develop...

journal_title：Circulation

authors： Lemmens K,Doggen K,De Keulenaer GW

更新日期：2007-08-21 00:00:00

abstract：BACKGROUND:Despite successful surgical correction, morbidity of patients with coarctation of the aorta is increased. It is well known that these patients have impaired elastic properties of the prestenotic arteries. To find out whether these abnormalities are primarily present or develop later, we studied 17 newborns b...

journal_title：Circulation

authors： Vogt M,Kühn A,Baumgartner D,Baumgartner C,Busch R,Kostolny M,Hess J

更新日期：2005-06-21 00:00:00

abstract：BACKGROUND:Inflammatory vasculopathies, ranging from the vasculitides (Takayasu arteritis, giant cell arteritis, and polyarteritis nodosa) to atherosclerosis, display remarkable target tissue tropisms for selected vascular beds. Molecular mechanisms directing wall inflammation to restricted anatomic sites within the va...

journal_title：Circulation

authors： Pryshchep O,Ma-Krupa W,Younge BR,Goronzy JJ,Weyand CM

更新日期：2008-09-16 00:00:00

abstract：BACKGROUND:The Doppler Substudy of the randomized, double-blind, placebo-controlled Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) trial aimed to investigate the effects of intracoronary infusion of bone marrow-derived progenitor cells (BMCs) on coronary blood...

journal_title：Circulation

authors： Erbs S,Linke A,Schächinger V,Assmus B,Thiele H,Diederich KW,Hoffmann C,Dimmeler S,Tonn T,Hambrecht R,Zeiher AM,Schuler G

更新日期：2007-07-24 00:00:00

abstract：BACKGROUND:Cardiac troponin I (cTnI), a sensitive and specific marker of myocardial cell injury, is useful in diagnosing and assessing prognosis in acute coronary syndromes. Small studies report that cTnI is elevated in severe heart failure (HF) and may predict adverse outcomes. METHODS AND RESULTS:The present study e...

journal_title：Circulation

authors： Horwich TB,Patel J,MacLellan WR,Fonarow GC

更新日期：2003-08-19 00:00:00

abstract：BACKGROUND:Paraplegia remains a devastating complication of thoracic aortic surgery. The mechanism of the antecedent spinal cord ischemia and reperfusion injury (IR) remains poorly described. IR involves 2 injuries, an initial ischemic insult and subsequent inflammatory amplification of the injury. This mechanism is co...

journal_title：Circulation

authors： Smith PD,Puskas F,Meng X,Lee JH,Cleveland JC Jr,Weyant MJ,Fullerton DA,Reece TB

更新日期：2012-09-11 00:00:00

abstract：BACKGROUND:Research published in Circulation has shown that cardiac mortality is highest during December and January. We investigated whether some of this spike could be ascribed to the Christmas/New Year's holidays rather than to climatic factors. METHODS AND RESULTS:We fitted a locally weighted polynomial regression...

journal_title：Circulation

authors： Phillips DP,Jarvinen JR,Abramson IS,Phillips RR

更新日期：2004-12-21 00:00:00

abstract：:In patients with atrioventricular (A-V) nodal re-entrant paroxysmal supraventricular tachycardia (PSVT), atrial extrastimulus technique frequently reveals discontinuous A1-A2, H1-H2 curves suggestive of dual A-V nodal pathways. To further test the hypothesis that these curves in fact reflect dual A-V nodal pathways, a...

journal_title：Circulation

authors： Wu D,Denes P,Wyndham C,Amat-y-Leon F,Dhingra RC,Rosen KM

更新日期：1975-11-01 00:00:00

abstract：:In this double-blind randomized study, 19 patients with acute transmural myocardial infarction were treated with methylprednisolone administered 4.4 +/- 0.7 hours (+/- SEM) after the onset of chest pain, and were compared with 21 patients who received placebo 4.5 +/- 0.4 hours after the start of clinical symptoms. The...

journal_title：Circulation

authors： Madias JE,Hood WB Jr

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Proposed advantages to the Ross procedure included presumed increased freedom from reoperation and simpler reoperation for pulmonary conduit replacement if needed. It is increasingly apparent, however, that reoperations are frequent after the Ross procedure and that when required, they may be more complex th...

journal_title：Circulation

authors： Stulak JM,Burkhart HM,Sundt TM 3rd,Connolly HM,Suri RM,Schaff HV,Dearani JA

更新日期：2010-09-21 00:00:00

abstract：BACKGROUND:Cardiopulmonary resuscitation (CPR) is initiated in hospitalized children with bradycardia and poor perfusion. However, their rate of progression to pulseless cardiac arrest despite CPR and the differences in survival compared with initially pulseless arrest are unknown. We examined the prevalence and predic...

journal_title：Circulation

authors： Khera R,Tang Y,Girotra S,Nadkarni VM,Link MS,Raymond TT,Guerguerian AM,Berg RA,Chan PS,American Heart Association’s Get With the Guidelines-Resuscitation Investigators.

更新日期：2019-07-30 00:00:00

abstract：BACKGROUND:We tested the hypothesis that real-time magnetic resonance imaging (MRI) can guide coronary artery catheterization in swine via a percutaneous femoral artery approach. METHODS AND RESULTS:In 12 pigs, we accessed femoral arteries percutaneously. We used 6- or 7-French coronary Judkins catheters filled with d...

journal_title：Circulation

authors： Omary RA,Green JD,Schirf BE,Li Y,Finn JP,Li D

更新日期：2003-06-03 00:00:00

abstract：BACKGROUND:Exertional fatigue, which frequently limits exercise in patients with chronic heart failure, is associated with early anaerobic metabolism in skeletal muscle. The present study was designed to examine the skeletal muscle metabolic response to exercise in this disorder and determine the relation of reduced mu...

journal_title：Circulation

authors： Sullivan MJ,Green HJ,Cobb FR

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Myocardial ischemia is considered to be a possible stimulus for development of the coronary collateral circulation. We therefore hypothesized that chronic reduction of myocardial oxygen demand to lessen ischemia would attenuate coronary collateral development over an 8-week period using left circumflex coron...

journal_title：Circulation

authors： Symons JD,Pitsillides KF,Longhurst JC

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is the most common sustained arrhythmia; however, little is known about patients in a primary care setting from high-, middle-, and low-income countries. METHODS AND RESULTS:This prospective registry enrolled patients presenting to an emergency department with AF at 164 sites in 46 ...

journal_title：Circulation

authors： Oldgren J,Healey JS,Ezekowitz M,Commerford P,Avezum A,Pais P,Zhu J,Jansky P,Sigamani A,Morillo CA,Liu L,Damasceno A,Grinvalds A,Nakamya J,Reilly PA,Keltai K,Van Gelder IC,Yusufali AH,Watanabe E,Wallentin L,Connoll

更新日期：2014-04-15 00:00:00

abstract：BACKGROUND:The contractile dysfunction observed in end-stage myocardial hypertrophy has at its base an abnormality in myocyte function. However, whether depressed contractile function is related to an alteration in contractile protein function is presently unknown. METHODS AND RESULTS:Contractile force, tension, and c...

journal_title：Circulation

authors： Fan D,Wannenburg T,de Tombe PP

更新日期：1997-05-06 00:00:00

abstract：:To estimate the extent of myocardial infarction after coronary artery reperfusion, serum levels of cardiac myosin light chain (LC) I and creatine kinase (CK) were determined serially in 49 patients with acute myocardial infarction. Intracoronary thrombolysis was successful in 25 patients (reperfusion group), and 24 pa...

journal_title：Circulation

authors： Isobe M,Nagai R,Ueda S,Tsuchimochi H,Nakaoka H,Takaku F,Yamaguchi T,Machii K,Nobuyoshi M,Yazaki Y

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:We hypothesized that during demand ischemia, abnormal perfusion will precede abnormal function, the spatial extent of perfusion abnormality will be greater than that of functional abnormality, and the spatiotemporal disparity between abnormal perfusion and abnormal function will be more marked in the presenc...

journal_title：Circulation

authors： Leong-Poi H,Rim SJ,Le DE,Fisher NG,Wei K,Kaul S

更新日期：2002-02-26 00:00:00

abstract：BACKGROUND:Vasoplegic syndrome is a form of vasodilatory shock that can occur after cardiopulmonary bypass (CPB). We hypothesized that the severity and duration of the decline in mean arterial pressure immediately after CPB is begun can be used as a predictor of patients will develop vasoplegia in the immediate post-CP...

journal_title：Circulation

authors： Levin MA,Lin HM,Castillo JG,Adams DH,Reich DL,Fischer GW

更新日期：2009-10-27 00:00:00

abstract：:The effects of therapeutic levels of quinidine were studied in an ischemic gap preparation of reflected reentry. The preparation consisted of a Purkinje fiber mounted in a three-compartment chamber. A narrow central compartment was perfused with a solution prepared to mimic the extracellular milieu at a site of ischem...

journal_title：Circulation

authors： Shen XT,Antzelevitch C

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:ε protein kinase C (εPKC) is involved in vascular smooth muscle cell (VSMC) activation, but little is known about its function in vascular pathology. We aimed at assessing the role of εPKC in the development of restenosis. METHODS AND RESULTS:Rat models of aortic balloon injury with or without subsequent st...

journal_title：Circulation

authors： Deuse T,Koyanagi T,Erben RG,Hua X,Velden J,Ikeno F,Reichenspurner H,Robbins RC,Mochly-Rosen D,Schrepfer S

更新日期：2010-09-14 00:00:00

abstract：BACKGROUND:Higher carotid intimal-medial thickness (IMT) is associated with cardiovascular risk factors and is predictive of coronary artery disease and stroke in older adults. Carotid IMT was measured in young and middle-aged adults to determine its relationship with risk factors measured (1) in childhood, (2) current...

journal_title：Circulation

authors： Davis PH,Dawson JD,Riley WA,Lauer RM

更新日期：2001-12-04 00:00:00

abstract：BACKGROUND:Sudden Unexplained Death Syndrome (SUDS) is the leading cause of death in young, healthy, Southeast Asian men. The role of an implantable cardioverter defibrillator (ICD) for mortality reduction in these patients remains unclear. METHODS AND RESULTS:The Defibrillator Versus beta-Blockers for Unexplained Dea...

journal_title：Circulation

authors： Nademanee K,Veerakul G,Mower M,Likittanasombat K,Krittayapong R,Bhuripanyo K,Sitthisook S,Chaothawee L,Lai MY,Azen SP

更新日期：2003-05-06 00:00:00

abstract：BACKGROUND:The individual makeup of atherosclerotic plaque has been identified as a dominant prognostic factor. With the use of an intravascular magnetic resonance (MR) catheter coil, we evaluated the effectiveness of high-resolution MR in the study of the development of atherosclerotic lesions in heritable hyperlipide...

journal_title：Circulation

authors： Zimmermann-Paul GG,Quick HH,Vogt P,von Schulthess GK,Kling D,Debatin JF

更新日期：1999-03-02 00:00:00

abstract：BACKGROUND:Biomarkers that predict response to cardiac resynchronization therapy (CRT) in heart failure patients with dyssynchrony (HFDYS) would be clinically important. Circulating extracellular microRNAs (miRNAs) have emerged as novel biomarkers that may also play important functional roles, but their relevance as ma...

journal_title：Circulation

authors： Melman YF,Shah R,Danielson K,Xiao J,Simonson B,Barth A,Chakir K,Lewis GD,Lavender Z,Truong QA,Kleber A,Das R,Rosenzweig A,Wang Y,Kass D,Singh JP,Das S

更新日期：2015-06-23 00:00:00