Abstract:
:In patients with atrioventricular (A-V) nodal re-entrant paroxysmal supraventricular tachycardia (PSVT), atrial extrastimulus technique frequently reveals discontinuous A1-A2, H1-H2 curves suggestive of dual A-V nodal pathways. To further test the hypothesis that these curves in fact reflect dual A-V nodal pathways, a ventricular extrastimulus (VS) was coupled either to A2 at a fixed A1-A2 interval which reliably produced an A-V nodal re-entrant atrial echo (E) with a constant A2-E interval in two patients, or to QRS complex (V) during sustained PSVT with a constant E-E interval in one patient. Three response zones were defined: at longer A2-VS or V-VS coupling interval, VS manifested no effect on the timing of E (Zone 1). At closer A2-VS or V-VS coupling interval, VS conducted to the atrium, shortening the apparent A2-E or E-E interval (Zone 2). At shortest A2-VS or V-VS coupling interval, VS was blocked retrogradely, and no E was induced (Zone 3). The ability of VS to preempt control of the atria (Zone 2 response) strongly suggests the presence of dual A-V nodal pathways in these PSVT patients. If only a single pathway were present, VS would of necessity collide with the antegrade impulse and could not reach the atria. The Zone 3 response occurs because of retrograde refractoriness of the fast pathway. Failure of the echo during Zone 3 probably reflects concealed conduction to the fast pathway, or possibly interference in the slow pathway.
journal_name
Circulationjournal_title
Circulationauthors
Wu D,Denes P,Wyndham C,Amat-y-Leon F,Dhingra RC,Rosen KMdoi
10.1161/01.cir.52.5.789subject
Has Abstractpub_date
1975-11-01 00:00:00pages
789-98issue
5eissn
0009-7322issn
1524-4539journal_volume
52pub_type
杂志文章相关文献
CIRCULATION文献大全abstract::Integrated ultrasonic backscatter (IB) is a noninvasive measure of the acoustic properties of myocardium. Previous experimental studies have indicated that altered acoustic properties of the myocardium are reflected by the magnitude of variation of IB during the cardiac cycle. In our study, cardiac cycle-dependent var...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.80.4.925
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:Recent data suggest that the Berlin Heart EXCOR Pediatric ventricular assist device is superior to extracorporeal membrane oxygenation for bridge to heart transplantation. Published data are limited to 1 in 4 children who received the device as part of the US clinical trial. We analyzed outcomes for all US c...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.112.000685
更新日期:2013-04-23 00:00:00
abstract:BACKGROUND:We tested the hypothesis that long-term administration of the specific angiotensin II subtype 1 (AT1)-receptor blocker BMS-186295 will regress hypertrophy and modify left ventricular angiotensin converting enzyme (ACE) expression in rats with ascending aortic stenosis. METHODS AND RESULTS:Six weeks after su...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.95.6.1592
更新日期:1997-03-18 00:00:00
abstract:BACKGROUND:Tenascin is a large extracellular matrix glycoprotein generally found in adult tissues undergoing active remodeling such as healing wounds and tumors. To determine the potential role of tenascin-C (TN-C) in the pathophysiology of atherosclerosis, we investigated the pattern of expression of TN-C in human cor...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.10.1284
更新日期:1999-03-16 00:00:00
abstract:BACKGROUND:Interleukin-8 (IL-8) secreted from endothelial cells is a powerful neutrophil chemoattractant and activator. We hypothesized that human endothelial cells deprived of oxygen would secrete IL-8, which might translate into elevated IL-8 production after cardiac ischemia. Furthermore, we hypothesized that corona...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.92.9.428
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Stroke is a leading cause of death and disability. Although clinical trials of the early lipid-lowering therapies did not demonstrate a reduction in the rates of stroke, data from recently completed statin trials strongly suggest benefit. METHODS AND RESULTS:The effect of pravastatin 40 mg/d on stroke event...
journal_title:Circulation
pub_type: 临床试验,杂志文章,meta分析,随机对照试验
doi:10.1161/01.cir.103.3.387
更新日期:2001-01-23 00:00:00
abstract:BACKGROUND:Despite their increasing clinical use and recent evidence that growth hormone (GH) and insulin-like growth factor-1 (IGF-1) target the heart, there has been no systematic investigation of the effects of GH and IGF-1 on the cardiovascular system. METHODS AND RESULTS:Sixty normal but growing adult female rats...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.93.4.800
更新日期:1996-02-15 00:00:00
abstract:BACKGROUND:The overall performance of available mechanical intravascular ultrasound catheters for fetal transesophageal echocardiography during fetoscopic fetal cardiac interventions in sheep has been limited by radioelectronic interference, low system frame rates, and low acoustic outputs. Therefore, a more reliable d...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc4001.097937
更新日期:2001-10-09 00:00:00
abstract::Prospective data was recorded on 217 percutaneous transluminal angioplasty (PTA) procedures performed in the superficial femoral and popliteal arteries over an 8-year period. After the initial procedure, patients were followed with serial noninvasive studies and, in 71 patients, repeat angiography. The mean follow-up ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1991-02-01 00:00:00
abstract::Activation of the sympathetic nervous system is an important factor in the genesis of ventricular arrhythmias in patients with impaired ventricular function. Such patients have an appropriate substrate that is capable of generating rhythm abnormalities, which may be related to enhanced automaticity, triggered automati...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Both thallium imaging and low-dose dobutamine echocardiography have been proposed to predict the reversibility of left ventricular (LV) dysfunction in patients with coronary disease. The present study was designed to evaluate whether the use of these techniques during the preoperative assessment of coronary ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.9.37
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:DC shock catheter ablation for the treatment of ventricular tachycardia (VT) may induce VT episodes that disappear within days. METHODS AND RESULTS:A 30-J cathodal shock was delivered to the endocardial left ventricular wall in 15 closed-chest dogs. All dogs had VT during the first day after ablation. Eleve...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.1.267
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:The beneficial effect of low-dose aspirin in the prevention of coronary vasospasm is well documented. In this study, we investigated the contractile effect of human washed platelets on the human isolated coronary artery. We concentrated on the effect of low-dose aspirin (40 mg/d) taken by the platelet donor ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.89.2.623
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Preconditioning the heart before an ischemic insult has been shown to protect against contractile dysfunction, arrhythmias, and infarction. Pharmacological studies have suggested that fibroblast growth factor-2 (FGF2) is involved in cardioprotection. However, because of the number of FGFs expressed in the he...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000105723.91637.1C
更新日期:2003-12-23 00:00:00
abstract:BACKGROUND:Adrenergic activation is thought to be an important determinant of outcome in subjects with chronic heart failure (CHF), but baseline or serial changes in adrenergic activity have not been previously investigated in a large patient sample treated with a powerful antiadrenergic agent. METHODS AND RESULTS:Sys...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/01.CIR.0000141297.50027.A4
更新日期:2004-09-14 00:00:00
abstract::Experimental studies of animals have previously demonstrated the validity of [1-11C]acetate as a tracer of oxidative metabolism for use with positron emission tomography. The present study was undertaken to define in normal human volunteers the relation between myocardial clearance kinetics of [1-11C]acetate, and the ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.80.4.863
更新日期:1989-10-01 00:00:00
abstract::Medical treatment of heart disease has improved significantly in the past 30 years. The spectacular change in the natural history of rheumatic heart disease is apparent from a 1948 article that reported that 42% of children with rheumatic heart disease died of rheumatic infection or bacterial endocarditis. Antibiotics...
journal_title:Circulation
pub_type: 临床试验,历史文章,杂志文章
doi:10.1161/01.cir.60.7.1609
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:High-pressure distension during harvesting damages the saphenous vein (SV) and may contribute to subsequent coronary artery bypass graft (CABG) occlusion. Application of vasodilator agents to the SV during harvesting may reduce the need for high-pressure distension and improve graft quality. We tested the ef...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.92.9.31
更新日期:1995-11-01 00:00:00
abstract::To assess the results of cardiac repair utilizing a right ventricular to pulmonary artery conduit, we reviewed postoperative hemodynamic data in 16 patients catheterized 0.5 to 5 years after repair. In 12 patients, a Hancock conduit (dacron conduit with porcine valve) was used; the conduit in the remaining four patien...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.54.6.951
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND:The number of CD4(+)CD28(null) (CD28(null)) T cells, a unique subset of T lymphocytes with proinflammatory and cell-lytic phenotype, increases markedly in patients with acute coronary syndrome (ACS). ACS patients harboring high numbers of CD28(null) T cells have increased risk of recurrent severe acute coron...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.114.013710
更新日期:2015-02-24 00:00:00
abstract:BACKGROUND:There is no consensus on how, when, or at what intensity exercise should be performed after heart transplantation (HTx). We have recently shown that high-intensity interval training (HIT) is safe, well tolerated, and efficacious in the maintenance state after HTx, but studies have not investigated HIT effect...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.118.036747
更新日期:2019-05-07 00:00:00
abstract:BACKGROUND:Peroxisome proliferator-activated receptors (PPARs) are transcription factors of the nuclear receptor superfamily. It has been reported that the thiazolidinediones, which are antidiabetic agents and high-affinity ligands for PPARgamma, regulate growth of vascular cells. In the present study, we examined the ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc1002.105225
更新日期:2002-03-12 00:00:00
abstract:BACKGROUND:Ischemia reperfusion injury (IRI) predisposes to the formation of donor-specific antibodies, a factor contributing to chronic rejection and late allograft loss. METHODS:We describe a mechanism underlying the correlative association between IRI and donor-specific antibodies by using humanized models and pati...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.119.042501
更新日期:2020-02-11 00:00:00
abstract:BACKGROUND:The effects of carteolol, a nonselective beta-adrenergic receptor blocker with intrinsic sympathomimetic activity, were compared with those of metoprolol in a murine model of viral myocarditis and dilated cardiomyopathy caused by encephalomyocarditis virus. METHODS AND RESULTS:In the acute experiment, BALB/...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.83.6.2021
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Mitral regurgitation (MR) generally accompanies inferobasal myocardial infarction (MI), with leaflet tethering by displaced papillary muscles. Mitral regurgitation is also reported with anteroapical MI without global dilatation or inferior wall motion abnormalities. We hypothesized that anteroapical MI exten...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.110.977843
更新日期:2011-04-12 00:00:00
abstract:BACKGROUND:A synergistic interaction between the angiotensin II (Ang II) type 1 receptor and alpha1-adrenergic receptors has been described. We hypothesized that the nonselective beta-antagonist carvedilol, through its alpha1-adrenergic blocking properties, may modulate vascular reactivity to Ang II in patients with ch...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.0000045666.04794.14
更新日期:2003-01-21 00:00:00
abstract:BACKGROUND:Arterial relaxation is largely regulated by endothelial nitric oxide (NO). Its diminished activity has been associated with incipient atherosclerosis. We investigated the endothelium-dependent relaxation of aorta in apolipoprotein E-knockout (apoE-KO) mice exposed to single or repeated Chlamydia pneumoniae i...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.9.1039
更新日期:2000-08-29 00:00:00
abstract:BACKGROUND:A key component of reperfusion of myocardial infarction is an immediate inflammatory response, which enhances tissue repair. Matrix turnover is crucial to tissue repair, and matrix metalloproteinases (MMPs) are key enzymes involved in matrix degradation. The hypothesis tested is that one inflammation-based e...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.17.2181
更新日期:2001-05-01 00:00:00
abstract::An isolated perfused working rat heart model was used to investigate the extent to which various protective agents, used either singly or in combination, were able to increase the resistance of the heart to periods of transient ischemia. The aim of the studies was to develop a solution which, if infused into the coron...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.54.2.193
更新日期:1976-08-01 00:00:00
abstract:BACKGROUND:The residual Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) Score is an objective measure of the degree and complexity of residual stenosis after percutaneous coronary intervention (PCI). METHODS AND RESULTS:In the randomized PCI cohort of the SYNTAX Trial (n=903)...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.113.001803
更新日期:2013-07-09 00:00:00