Beta-blocker treatment of dilated cardiomyopathy. Beneficial effect of carteolol in mice.

abstract：BACKGROUND:Previous studies have shown that pericytes can differentiate into osteoblasts and form bone. This study investigated whether pericytes can also differentiate into chondrocytes and adipocytes. METHODS AND RESULTS:Reverse transcription-polymerase chain reaction demonstrated that pericytes express mRNA for the...

journal_title：Circulation

authors： Farrington-Rock C,Crofts NJ,Doherty MJ,Ashton BA,Griffin-Jones C,Canfield AE

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:Myocardial injury from ischemia can be aggravated by reperfusion of the jeopardized area. The precise underlying mechanisms have not been clearly defined, but proinflammatory events, including complement activation, leukocyte adhesion, and infiltration and release of diverse mediators, probably play importan...

journal_title：Circulation

authors： Horstick G,Heimann A,Götze O,Hafner G,Berg O,Böhmer P,Becker P,Darius H,Rupprecht HJ,Loos M,Bhakdi S,Meyer J,Kempski O

更新日期：1997-02-04 00:00:00

abstract：:Diagnosis of rejection after cardiac transplantation is currently made by right ventricular endomyocardial biopsy. To evaluate antimyosin imaging as a noninvasive means of detecting human cardiac rejection, the Fab fragment of murine monoclonal antimyosin antibodies was labeled with indium-111 and given intravenously ...

journal_title：Circulation

authors： Frist W,Yasuda T,Segall G,Khaw BA,Strauss HW,Gold H,Stinson E,Oyer P,Baldwin J,Billingham M

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:Noninvasively assessed pulmonary pressure elevations and left ventricular (LV) diastolic dysfunction are associated with increased mortality in adults with sickle cell disease, but their relationship to exercise intolerance has not been evaluated prospectively. METHODS AND RESULTS:Echocardiography, 6-minute...

journal_title：Circulation

authors： Sachdev V,Kato GJ,Gibbs JS,Barst RJ,Machado RF,Nouraie M,Hassell KL,Little JA,Schraufnagel DE,Krishnamurti L,Novelli EM,Girgis RE,Morris CR,Rosenzweig EB,Badesch DB,Lanzkron S,Castro OL,Taylor JG 6th,Hannoush H,Gold

更新日期：2011-09-27 00:00:00

abstract：BACKGROUND:Diffuse myocardial fibrosis is a final end point in most cardiac diseases. It is missed by the cardiovascular magnetic resonance (CMR) late gadolinium enhancement technique. Currently, quantifying diffuse myocardial fibrosis requires invasive biopsy, with inherent risk and sampling error. We have developed a...

journal_title：Circulation

authors： Flett AS,Hayward MP,Ashworth MT,Hansen MS,Taylor AM,Elliott PM,McGregor C,Moon JC

更新日期：2010-07-13 00:00:00

abstract：BACKGROUND:Thiazolidinediones have been reported to protect against ischemia-reperfusion injury. Their protective actions are considered to be peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-dependent; however, it is unclear how PPAR-gamma activation confers resistance to ischemia-reperfusion injury. MET...

journal_title：Circulation

authors： Wu JS,Cheung WM,Tsai YS,Chen YT,Fong WH,Tsai HD,Chen YC,Liou JY,Shyue SK,Chen JJ,Chen YE,Maeda N,Wu KK,Lin TN

更新日期：2009-03-03 00:00:00

abstract：BACKGROUND:Pulmonary hypertension caused by systolic left ventricular dysfunction is associated with significant morbidity and mortality; however, no treatment is approved for this indication. We hypothesized that riociguat, a novel soluble guanylate cyclase stimulator, would have beneficial hemodynamic effects in pati...

journal_title：Circulation

authors： Bonderman D,Ghio S,Felix SB,Ghofrani HA,Michelakis E,Mitrovic V,Oudiz RJ,Boateng F,Scalise AV,Roessig L,Semigran MJ,Left Ventricular Systolic Dysfunction Associated With Pulmonary Hypertension Riociguat Trial (LEPHT) Study Group.

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:The safety and efficacy of percutaneous coronary intervention of de novo lesions in unprotected left main coronary arteries remains an unresolved issue. METHODS AND RESULTS:We analyzed 67 consecutive patients treated with the following devices: 39 with stents, 12 with rotational atherectomy plus stents, 13 ...

journal_title：Circulation

authors： Takagi T,Stankovic G,Finci L,Toutouzas K,Chieffo A,Spanos V,Liistro F,Briguori C,Corvaja N,Albero R,Sivieri G,Paloschi R,Di Mario C,Colombo A

更新日期：2002-08-06 00:00:00

abstract：:Knowledge of the potential gradient field created by defibrillation electrodes is important for the understanding and improvement of defibrillation. To obtain this knowledge by direct measurements, potentials were recorded from 60 epicardial, eight septal, and 36 right ventricular transmural electrodes in six open-che...

journal_title：Circulation

authors： Chen PS,Wolf PD,Claydon FJ,Dixon EG,Vidaillet HJ Jr,Danieley ND,Pilkington TC,Ideker RE

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Selection of treatment in vasovagal syndrome should be guided by the mechanism of symptoms. This study determined whether a simple drug test may assess one mechanism. METHODS AND RESULTS:To identify patients at risk of severe cardioinhibitory response of vagal origin, we infused 20 mg ATP into 316 patients ...

journal_title：Circulation

authors： Flammang D,Church T,Waynberger M,Chassing A,Antiel M

更新日期：1997-08-19 00:00:00

abstract：:Diffuse coronary artery disease is frequently untreatable by coronary artery bypass or angioplasty. Many such "no-option" patients have been subjects for trials of angiogenesis using growth factor manipulation or laser injury. We think these novel revascularization strategies are limited by insufficient inflow to puta...

journal_title：Circulation

authors： Oesterle SN,Reifart N,Hauptmann E,Hayase M,Yeung AC

更新日期：2001-05-29 00:00:00

abstract：BACKGROUND:The individual makeup of atherosclerotic plaque has been identified as a dominant prognostic factor. With the use of an intravascular magnetic resonance (MR) catheter coil, we evaluated the effectiveness of high-resolution MR in the study of the development of atherosclerotic lesions in heritable hyperlipide...

journal_title：Circulation

authors： Zimmermann-Paul GG,Quick HH,Vogt P,von Schulthess GK,Kling D,Debatin JF

更新日期：1999-03-02 00:00:00

abstract：BACKGROUND:The patency of AV expanded polytetrafluoroethylene (ePTFE) grafts for hemodialysis is impaired by intimal hyperplasia (IH) at the venous outflow tract. The absence of a functional endothelial monolayer on the prosthetic grafts is an important stimulus for IH. In the present study, we evaluated the feasibilit...

journal_title：Circulation

authors： Rotmans JI,Heyligers JM,Verhagen HJ,Velema E,Nagtegaal MM,de Kleijn DP,de Groot FG,Stroes ES,Pasterkamp G

更新日期：2005-07-05 00:00:00

abstract：BACKGROUND:The time constant of truncated exponential pulses used with implantable defibrillators is determined by the output capacitor size and defibrillation pathway resistance. The optimal capacitor size is unknown. METHODS AND RESULTS:This study compared defibrillation threshold (DFT) for standard 120-microF capac...

journal_title：Circulation

authors： Swerdlow CD,Kass RM,Chen PS,Hwang C,Raissi S

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Receptor-mediated activation of myocardial Gq signaling is postulated as a biochemical mechanism transducing pressure-overload hypertrophy. The specific effects of Gq activation on the functional and morphological adaptations to pressure overload are not known. METHODS AND RESULTS:To determine the effects o...

journal_title：Circulation

authors： Sakata Y,Hoit BD,Liggett SB,Walsh RA,Dorn GW 2nd

更新日期：1998-04-21 00:00:00

abstract：:Eight cases of ventricular parasystole are reported. In all these cases, regardless of whether parasystole seems intermittent or "continuous," the presence of second degree entrance block of the Mobitz type I was suggested. Parasystole alternated with concealed extrasystolic bigeminy showing occasional reentrant extra...

journal_title：Circulation

authors： Kinoshita S

更新日期：1978-10-01 00:00:00

abstract：BACKGROUND:Several echocardiographic dyssynchrony indexes have been proposed to identify responders to cardiac resynchronization therapy using tissue velocity and strain. The present study aimed to compare tissue velocity-derived and strain-derived dyssynchrony indexes in patients with or without systolic dysfunction a...

journal_title：Circulation

authors： Miyazaki C,Powell BD,Bruce CJ,Espinosa RE,Redfield MM,Miller FA,Hayes DL,Cha YM,Oh JK

更新日期：2008-05-20 00:00:00

abstract：BACKGROUND:We tested the hypothesis that long-term administration of the specific angiotensin II subtype 1 (AT1)-receptor blocker BMS-186295 will regress hypertrophy and modify left ventricular angiotensin converting enzyme (ACE) expression in rats with ascending aortic stenosis. METHODS AND RESULTS:Six weeks after su...

journal_title：Circulation

authors： Weinberg EO,Lee MA,Weigner M,Lindpaintner K,Bishop SP,Benedict CR,Ho KK,Douglas PS,Chafizadeh E,Lorell BH

更新日期：1997-03-18 00:00:00

abstract：BACKGROUND:Current guidelines recommend mitral valve surgery for asymptomatic patients with severe degenerative mitral regurgitation and preserved left ventricular systolic function when exercise pulmonary hypertension (PHT) is present. However, the determinants of exercise PHT have not been evaluated. The aim of this ...

journal_title：Circulation

authors： Magne J,Lancellotti P,Piérard LA

更新日期：2010-07-06 00:00:00

abstract：:Premature escape beats induced in conscious dogs with chronic complete atrioventricular block have been defined as escape beats occurring on cessation of overdrive pacing and having a coupling interval to the last paced beat shorter than the coupling interval between the premature escape beat and the second postpacing...

journal_title：Circulation

authors： Viamonte VA,Rosen MR

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Experimental studies revealed proinflammatory properties of angiotensin II. We evaluated antiinflammatory effects of the angiotensin II subtype 1 receptor antagonist olmesartan medoxomil alone and in cotherapy with the HMG-CoA reductase inhibitor pravastatin in patients with essential hypertension and microi...

journal_title：Circulation

authors： Fliser D,Buchholz K,Haller H,EUropean Trial on Olmesartan and Pravastatin in Inflammation and Atherosclerosis (EUTOPIA) Investigators.

更新日期：2004-08-31 00:00:00

abstract：:The dynamics between mitral anulus motion, and, thus, motion of the base of the heart, and filling of the left atrium and ventricle were studied by Doppler echocardiography in 12 normal subjects and 28 patients with dilated cardiomyopathy. The normal motion of the mitral anulus is associated with two phases of inflow ...

journal_title：Circulation

authors： Keren G,Sonnenblick EH,LeJemtel TH

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Memory is a diverse biological phenomenon whose importance in the ventricle has been demonstrated. We hypothesized its occurrence in the atrium, contributing to the modulation of cardiac rhythm. METHODS AND RESULTS:We analyzed P and Ta waves in conscious chronically instrumented dogs with complete heart blo...

journal_title：Circulation

authors： Herweg B,Chang F,Chandra P,Danilo P Jr,Rosen MR

更新日期：2001-01-23 00:00:00

abstract：BACKGROUND:Smooth muscle cells (SMCs) play a key role in intimal thickening in atherosclerosis and restenosis. The precise signaling pathways by which the proliferation of SMCs is regulated are largely unknown. The TR3 orphan receptor, the mitogen-induced nuclear orphan receptor (MINOR), and the nuclear receptor of T c...

journal_title：Circulation

authors： Arkenbout EK,de Waard V,van Bragt M,van Achterberg TA,Grimbergen JM,Pichon B,Pannekoek H,de Vries CJ

更新日期：2002-09-17 00:00:00

abstract：BACKGROUND:Pulmonary hypertension (PH) is a life-threatening disease. Bone marrow cell transplantation is reported to reduce the development of PH by increasing vascular beds in pulmonary circulation. However, adenoviral overexpression of endothelial nitric oxide synthase (eNOS) in the lung is also known to reduce PH. ...

journal_title：Circulation

authors： Kanki-Horimoto S,Horimoto H,Mieno S,Kishida K,Watanabe F,Furuya E,Katsumata T

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:The safety of drug-eluting stents in ST-segment elevation myocardial infarction (STEMI) continues to be debated. Pathological studies have demonstrated an association between uncovered struts and subsequent stent thrombosis. Optical coherence tomography can detect stent strut coverage in vivo on a micron-sca...

journal_title：Circulation

authors： Guagliumi G,Costa MA,Sirbu V,Musumeci G,Bezerra HG,Suzuki N,Matiashvili A,Lortkipanidze N,Mihalcsik L,Trivisonno A,Valsecchi O,Mintz GS,Dressler O,Parise H,Maehara A,Cristea E,Lansky AJ,Mehran R,Stone GW

更新日期：2011-01-25 00:00:00

abstract：BACKGROUND:Patients with repaired coarctation are at increased risk of hypertension and cardiovascular disease despite successful repair. We studied the function of conduit arteries in upper and lower limbs of patients late after successful coarctation repair and its relation to age at surgery. METHODS AND RESULTS:Flo...

journal_title：Circulation

authors： de Divitiis M,Pilla C,Kattenhorn M,Zadinello M,Donald A,Leeson P,Wallace S,Redington A,Deanfield JE

更新日期：2001-09-18 00:00:00

abstract：:To assess the effects of angioplasty (PTCA) and intracoronary streptokinase (ICSK) on relative myocardial perfusion, we administered 99mTc-macroaggregated albumin (MAA) to the uninvolved coronary artery before successful PTCA in 33 patients and before successful infusion of ICSK in eight patients and of 111In-MAA into...

journal_title：Circulation

authors： Wahr DW,Ports TA,Botvinick EH,Dae M,Schechtmann N,Huberty J,Hattner RS,O'Connell JW,Turley K

更新日期：1985-08-01 00:00:00

abstract：:For half a century the systolic click and late systolic murmur lay dormant as innocent auscultatory curiosities. The thirteen years since Barlow related these phenomena to mitral leaflet prolapse have witnessed an astonishing information explosion. We have sought to bring together the accumulated data in this review. ...

journal_title：Circulation

authors： Devereux RB,Perloff JK,Reichek N,Josephson ME

更新日期：1976-07-01 00:00:00

abstract：:A significant fraction of patients in whom mechanical left ventricular assist devices are implanted for refractory cardiac failure after open heart surgery have had the complication of right heart failure. To evaluate the effects of left ventricular assistance and pressure unloading on right ventricular function, we p...

journal_title：Circulation

authors： Farrar DJ,Compton PG,Dajee H,Fonger JD,Hill JD

更新日期：1984-10-01 00:00:00