Beta-blocker treatment of dilated cardiomyopathy. Beneficial effect of carteolol in mice.


BACKGROUND:The effects of carteolol, a nonselective beta-adrenergic receptor blocker with intrinsic sympathomimetic activity, were compared with those of metoprolol in a murine model of viral myocarditis and dilated cardiomyopathy caused by encephalomyocarditis virus. METHODS AND RESULTS:In the acute experiment, BALB/c and DBA/2 mice were inoculated with encephalomyocarditis virus. BALB/c mice were then given carteolol at 1 (n = 10), 10 (n = 10), 30 (n = 11), or 100 mg/kg (n = 9) daily, and DBA/2 mice were given carteolol at 1 (n = 9) or 10 mg/kg (n = 9) daily starting the day of inoculation. Controls were given distilled water (n = 23 for BALB/c mice and n = 8 for DBA/2 mice). BALB/c mice were killed on day 7, and DBA/2 mice were killed on day 14. In the subacute experiment, DBA/2 mice were inoculated with the virus and then given carteolol at 1 (n = 12) or 10 mg/kg (n = 16), or distilled water (n = 27) daily, starting on day 14. Mice were killed on day 28. Virus replication, murine survival, heart weight to body weight ratio, and histopathological findings were similar in each group in the acute and subacute experiments. In the chronic experiment, DBA/2 mice were inoculated with the virus and were then given carteolol at 1 (n = 13) or 10 mg/kg (n = 9), metoprolol at 30 mg/kg (n = 9), or distilled water (n = 31) daily, starting on day 14. Mice were killed on day 104. Heart weight to body weight ratio and histopathological scores were significantly lower in mice given carteolol than in the infected control group. Furthermore, left ventricular cavity dimension, left ventricular wall thickness, and myocardial fiber diameter of the left ventricle were significantly reduced in mice given carteolol compared with the control group. Metoprolol did not cause any significant changes compared with the control group. CONCLUSIONS:This study suggests that carteolol prevents the development of myocardial lesions similar to those in dilated cardiomyopathy after myocarditis in the chronic stage.






Tominaga M,Matsumori A,Okada I,Yamada T,Kawai C




Has Abstract


1991-06-01 00:00:00












  • Epinephrine increases the severity of postresuscitation myocardial dysfunction.

    abstract:BACKGROUND:Epinephrine has been the mainstay for cardiac resuscitation for more than 30 years. Its vasopressor effect by which it increases coronary perfusion pressure is likely to favor initial resuscitation. Its beta-adrenergic action, however, may have detrimental effects on postresuscitation myocardial function whe...


    pub_type: 杂志文章


    authors: Tang W,Weil MH,Sun S,Noc M,Yang L,Gazmuri RJ

    更新日期:1995-11-15 00:00:00

  • Effects of balloon injury on neointimal hyperplasia in streptozotocin-induced diabetes and in hyperinsulinemic nondiabetic pancreatic islet-transplanted rats.

    abstract:BACKGROUND:The mechanisms of increased neointimal hyperplasia after coronary interventions in diabetic patients are still unknown. METHODS AND RESULTS:Glucose and insulin effects on in vitro vascular smooth muscle cell (VSMC) proliferation and migration were assessed. The effect of balloon injury on neointimal hyperpl...


    pub_type: 杂志文章


    authors: Indolfi C,Torella D,Cavuto L,Davalli AM,Coppola C,Esposito G,Carriero MV,Rapacciuolo A,Di Lorenzo E,Stabile E,Perrino C,Chieffo A,Pardo F,Chiariello M

    更新日期:2001-06-19 00:00:00

  • Instant power spectrum analysis of heart rate variability during orthostatic tilt using a time-/frequency-domain method.

    abstract:BACKGROUND:Spectral analysis of heart rate (HR) variability (HRV) requires, as a rule, some level of stationarity and, as a result, is inadequate to quantify biological transients. A time-/frequency-domain method (TF) was developed to obtain an instant spectral power (SP) of HRV during tilt. METHODS AND RESULTS:HR was...


    pub_type: 临床试验,杂志文章


    authors: Jasson S,Médigue C,Maison-Blanche P,Montano N,Meyer L,Vermeiren C,Mansier P,Coumel P,Malliani A,Swynghedauw B

    更新日期:1997-11-18 00:00:00

  • Population characteristics according to recruitment source.

    abstract::Considerable variability was observed among recruitment sources and centers in the proportion of first protocol visits proceeding to entry. Some of the reasons for these differences are explored. Several characteristics of the participants were also analyzed to determine whether significant variability existed among r...


    pub_type: 杂志文章


    authors: Hunninghake DB,Knoke J,LaDouceur M,Peterson F

    更新日期:1982-12-01 00:00:00

  • Multitargeted effects of statin-enhanced thrombolytic therapy for stroke with recombinant human tissue-type plasminogen activator in the rat.

    abstract:BACKGROUND:Microvascular dysfunction posttreatment of stroke with recombinant human tissue-type plasminogen activator (rht-PA) constrains the therapeutic window to 3 hours. Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) promote vascular thrombolysis and reduce the inflammation response. We therefo...


    pub_type: 杂志文章


    authors: Zhang L,Zhang ZG,Ding GL,Jiang Q,Liu X,Meng H,Hozeska A,Zhang C,Li L,Morris D,Zhang RL,Lu M,Chopp M

    更新日期:2005-11-29 00:00:00

  • Vasodilation to bradykinin is mediated by an ouabain-sensitive pathway as a compensatory mechanism for impaired nitric oxide availability in essential hypertensive patients.

    abstract:BACKGROUND:In essential hypertension, endothelium-dependent vasodilation is impaired because of reduced nitric oxide (NO) availability, which is mainly caused by oxidative stress. The present study was designed to identify the mechanism(s) responsible for NO-independent vasodilation to bradykinin in patients with essen...


    pub_type: 杂志文章


    authors: Taddei S,Ghiadoni L,Virdis A,Buralli S,Salvetti A

    更新日期:1999-09-28 00:00:00

  • Severe pulmonary hypertension associated with a small ventricular septal defect.

    abstract::A case of progressive pulmonary hypertension in a child with a small ventricular septal defect is presented. Natural history studies have indicated that children with small ventricular septal defects can be followed conservatively. This case represents a contradiction to that rule and suggests that further study must ...


    pub_type: 杂志文章


    authors: Bisset GS 3rd,Hirschfeld SS

    更新日期:1983-02-01 00:00:00

  • Psychosocial precursors of hypertension: a review of the epidemiologic evidence.

    abstract::This article provides a selective overview of epidemiologic studies on the relationship between psychosocial factors and blood pressure elevation. The review focuses on English-language reports published since 1975 and emphasizes two broad areas of research: changes in mean blood pressures of third world populations u...


    pub_type: 杂志文章,评审


    authors: James SA

    更新日期:1987-07-01 00:00:00

  • Magnetic resonance and echocardiographic imaging of pulmonary artery size throughout stages of Fontan reconstruction.

    abstract:BACKGROUND:Because pulmonary artery size is considered by most investigators to be a major prognosticator of outcome in patients undergoing staged Fontan reconstruction, the objective of the present study was to determine the efficacy of noninvasive measures in determining pulmonary artery size. METHODS AND RESULTS:Th...


    pub_type: 杂志文章


    authors: Fogel MA,Donofrio MT,Ramaciotti C,Hubbard AM,Weinberg PM

    更新日期:1994-12-01 00:00:00

  • C-reactive protein is associated with subclinical epicardial coronary calcification in men and women: the Framingham Heart Study.

    abstract:BACKGROUND:High C-reactive protein (CRP) levels are associated with an increased risk of cardiovascular events, even in apparently healthy individuals. It has not been established whether elevated CRP reflects an increased burden of subclinical coronary atherosclerosis. METHODS AND RESULTS:We studied a stratified rand...


    pub_type: 杂志文章


    authors: Wang TJ,Larson MG,Levy D,Benjamin EJ,Kupka MJ,Manning WJ,Clouse ME,D'Agostino RB,Wilson PW,O'Donnell CJ

    更新日期:2002-09-03 00:00:00

  • SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy.

    abstract:BACKGROUND:Pathological cardiac hypertrophy induced by stresses such as aging and neurohumoral activation is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown. We aimed to...


    pub_type: 杂志文章


    authors: Tang X,Chen XF,Wang NY,Wang XM,Liang ST,Zheng W,Lu YB,Zhao X,Hao DL,Zhang ZQ,Zou MH,Liu DP,Chen HZ

    更新日期:2017-11-21 00:00:00

  • Near drowning.

    abstract::Several conditions that contribute to drowning and near drowning must be considered in the treatment of near-drowned victims. Regardless of the cause, mechanical ventilation should begin as soon as possible and closed-chest cardiac massage should be administered when there is any question about the adequacy of cardiac...


    pub_type: 杂志文章


    authors: Modell JH

    更新日期:1986-12-01 00:00:00

  • Overexpression of heat shock protein 72 in transgenic mice decreases infarct size in vivo.

    abstract:BACKGROUND:Previous studies have demonstrated that induction of heat shock protein (HSP) 72 by whole-body hyperthermia reduces infarct size in an in vivo model of ischemia and reperfusion. Furthermore, hearts obtained from transgenic mice that overexpress HSP72 demonstrate improved functional recovery and decreased inf...


    pub_type: 杂志文章


    authors: Hutter JJ,Mestril R,Tam EK,Sievers RE,Dillmann WH,Wolfe CL

    更新日期:1996-09-15 00:00:00

  • Inhibition of intimal hyperplasia after balloon injury by antibodies to intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1.

    abstract:BACKGROUND:Although intercellular adhesion molecule-1 (ICAM-1) is known to be expressed in balloon-injured arteries, it remains unknown whether ICAM-1 plays a role in the progression of intimal hyperplasia (IH) induced by balloon injury. METHODS AND RESULTS:We examined the ICAM-1 expression in rat carotid arteries at ...


    pub_type: 杂志文章


    authors: Yasukawa H,Imaizumi T,Matsuoka H,Nakashima A,Morimatsu M

    更新日期:1997-03-18 00:00:00

  • Echophonocardiographic studies of the contribution of the atrioventricular valves to the first heart sound.

    abstract::The movements of the mitral, tricuspid and aortic valves have been recorded echocardiographically and related to the first heart sound (S1) in patients with various hemodynamic and conduction abnormalities. Closure of the mitral and tricuspid valves has been studied with respect to the corresponding atrioventricular p...


    pub_type: 杂志文章


    authors: Mills PG,Chamusco RF,Moos S,Craige E

    更新日期:1976-12-01 00:00:00

  • Premature ventricular complexes in the absence of identifiable heart disease.

    abstract::To define the prevalence, frequency and characteristics of premature ventricular complexes (PVCs) in adults free of recognizable heart disease, we performed 24-hour ambulatory electrocardiography on 101 subjects (51 men and 50 women, mean age 48.8 years) in whom physical examination, chest x-ray, ECG, echocardiogram, ...


    pub_type: 杂志文章


    authors: Kostis JB,McCrone K,Moreyra AE,Gotzoyannis S,Aglitz NM,Natarajan N,Kuo PT

    更新日期:1981-06-01 00:00:00

  • Regression of coronary atherosclerosis by simvastatin: a serial intravascular ultrasound study.

    abstract:BACKGROUND:Angiography of the coronary arteries reflects only changes in luminal dimensions. With intravascular ultrasound, cross-sectional images can be obtained and area measurements can be added to calculate volumes of the external elastic membrane (EEM), plaque plus media (P+M), and lumen. The aim of this study was...


    pub_type: 临床试验,杂志文章


    authors: Jensen LO,Thayssen P,Pedersen KE,Stender S,Haghfelt T

    更新日期:2004-07-20 00:00:00

  • Metabolic Predictors of Incident Coronary Heart Disease in Women.

    abstract:BACKGROUND:Although metabolomic profiling offers promise for the prediction of coronary heart disease (CHD), and metabolic risk factors are more strongly associated with CHD in women than men, limited data are available for women. METHODS:We applied a liquid chromatography-tandem mass spectrometry metabolomics platfor...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Paynter NP,Balasubramanian R,Giulianini F,Wang DD,Tinker LF,Gopal S,Deik AA,Bullock K,Pierce KA,Scott J,Martínez-González MA,Estruch R,Manson JE,Cook NR,Albert CM,Clish CB,Rexrode KM

    更新日期:2018-02-20 00:00:00

  • Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability.

    abstract:BACKGROUND:Growth of atherosclerotic plaques is accompanied by neovascularization from vasa vasorum microvessels extending through the tunica media into the base of the plaque and by lumen-derived microvessels through the fibrous cap. Microvessels are associated with plaque hemorrhage and may play a role in plaque rupt...


    pub_type: 杂志文章


    authors: Moreno PR,Purushothaman KR,Fuster V,Echeverri D,Truszczynska H,Sharma SK,Badimon JJ,O'Connor WN

    更新日期:2004-10-05 00:00:00

  • Excess mortality due to coronary artery disease after valve surgery. Secular trends in valvular regurgitation and effect of internal mammary artery bypass.

    abstract:BACKGROUND:During the 1980s, mortality from coronary artery disease (CAD) decreased markedly in the United States. This raises the question of whether a parallel decrease occurred in excess mortality due to CAD in patients undergoing surgical correction of valvular regurgitation. METHODS AND RESULTS:Survival of 752 pa...


    pub_type: 杂志文章


    authors: Tribouilloy CM,Enriquez-Sarano M,Schaff HV,Orszulak TA,Fett SL,Bailey KR,Tajik AJ,Frye RL

    更新日期:1998-11-10 00:00:00

  • Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery.

    abstract:BACKGROUND:The efficacy of bypass surgery in patients with ischemic cardiomyopathy is not easily predictable; preoperative clinical conditions may be similar, but the outcome may differ significantly. We hypothesized that the growth reserve of cardiac stem cells (CSCs) and circulating cytokines promoting CSC activation...


    pub_type: 杂志文章,收录出版


    authors: D'Amario D,Leone AM,Iaconelli A,Luciani N,Gaudino M,Kannappan R,Manchi M,Severino A,Shin SH,Graziani F,Biasillo G,Macchione A,Smaldone C,De Maria GL,Cellini C,Siracusano A,Ottaviani L,Massetti M,Goichberg P,Leri A,

    更新日期:2014-01-14 00:00:00

  • Electrode system influence on biphasic waveform defibrillation efficacy in humans.

    abstract:BACKGROUND:Several clinical studies have demonstrated a general superiority of biphasic waveform defibrillation compared with monophasic waveform defibrillation using epicardial lead systems. To test the breadth of utility of biphasic waveforms in humans, a prospective, randomized evaluation of defibrillation efficacy ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bardy GH,Troutman C,Johnson G,Mehra R,Poole JE,Dolack GL,Kudenchuk PJ,Gartman DM

    更新日期:1991-08-01 00:00:00

  • Angina symptoms are associated with mortality in older women with ischemic heart disease.

    abstract:BACKGROUND:Angina symptoms have been reported to predict mortality in men. The aim of this study was to investigate the association between angina symptoms and mortality in women. METHODS AND RESULTS:In 2004, 873 older participants in the Australian Longitudinal Study on Women's Health with self-reported ischemic hear...


    pub_type: 杂志文章,随机对照试验


    authors: Berecki-Gisolf J,Humphreyes-Reid L,Wilson A,Dobson A

    更新日期:2009-12-08 00:00:00

  • Detection of local abnormalities in ventricular activation sequence by body surface isochrone mapping in patients with previous myocardial infarction.

    abstract::Body surface isochrone mapping was performed in 36 normal subjects and in 85 patients with previous myocardial infarction. Eighty-seven unipolar electrocardiograms distributed over the anterior chest and the back were recorded simultaneously. For each lead, activation time was measured as the time from the onset of QR...


    pub_type: 杂志文章


    authors: Ikeda K,Kubota I,Igarashi A,Yamaki M,Tsuiki K,Yasui S

    更新日期:1985-10-01 00:00:00

  • Spectral energy of the first heart sound in acute myocardial ischemia. A correlation with electrocardiographic, hemodynamic, and wall motion abnormalities.

    abstract::First heart sound (S1) energy spectra in isovolumic systole, hemodynamics, and angiographic left ventricular wall motion (LVWM) at rest and with atrial pacing were compared in 27 patients who underwent diagnostic cardiac catheterization and angiography because of chest pain. Eighteen patients were found to have corona...


    pub_type: 杂志文章


    authors: Clarke WB,Austin SM,Shah PM,Griffin PM,Dove JT,McCullough J,Schreiner BF

    更新日期:1978-03-01 00:00:00

  • Comparison of lifestyle-based and traditional cardiovascular disease prediction in a multiethnic cohort of nonsmoking women.

    abstract:BACKGROUND:Healthy levels of lifestyle factors can reduce the risk of cardiovascular disease. However, except for smoking status, often considered a traditional risk factor, their effect on cardiovascular risk prediction is unclear. METHODS AND RESULTS:We used a case-cohort design of postmenopausal nonsmokers in the m...


    pub_type: 杂志文章


    authors: Paynter NP,LaMonte MJ,Manson JE,Martin LW,Phillips LS,Ridker PM,Robinson JG,Cook NR

    更新日期:2014-10-21 00:00:00

  • Intracoronary application of C1 esterase inhibitor improves cardiac function and reduces myocardial necrosis in an experimental model of ischemia and reperfusion.

    abstract:BACKGROUND:Myocardial injury from ischemia can be aggravated by reperfusion of the jeopardized area. The precise underlying mechanisms have not been clearly defined, but proinflammatory events, including complement activation, leukocyte adhesion, and infiltration and release of diverse mediators, probably play importan...


    pub_type: 杂志文章


    authors: Horstick G,Heimann A,Götze O,Hafner G,Berg O,Böhmer P,Becker P,Darius H,Rupprecht HJ,Loos M,Bhakdi S,Meyer J,Kempski O

    更新日期:1997-02-04 00:00:00

  • Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.

    abstract:BACKGROUND:Pulmonary hypertension is a fatal disease characterized by vasoconstriction and vascular remodeling. Loss of endothelial nitric oxide bioavailability is implicated in pulmonary hypertension pathogenesis. Recent evidence suggests that the cofactor tetrahydrobiopterin (BH4) is an important regulator of nitric ...


    pub_type: 杂志文章


    authors: Khoo JP,Zhao L,Alp NJ,Bendall JK,Nicoli T,Rockett K,Wilkins MR,Channon KM

    更新日期:2005-04-26 00:00:00

  • Achievements in congenital heart defect surgery: a prospective, 40-year study of 7038 patients.

    abstract:BACKGROUND:This article presents an update of the results achieved by modern surgery in congenital heart defects (CHDs) over the past 40 years regarding survival and the need for reoperations, especially focusing on the results from the past 2 decades. METHODS AND RESULTS:From 1971 to 2011, all 7038 patients <16 years...


    pub_type: 杂志文章


    authors: Erikssen G,Liestøl K,Seem E,Birkeland S,Saatvedt KJ,Hoel TN,Døhlen G,Skulstad H,Svennevig JL,Thaulow E,Lindberg HL

    更新日期:2015-01-27 00:00:00

  • Angiotensin II increases plasminogen activator inhibitor type 1 and tissue-type plasminogen activator messenger RNA in cultured rat aortic smooth muscle cells.

    abstract:BACKGROUND:The role of angiotensin as a vasoconstrictor is well established. Lately, several other actions of this hormone on vascular smooth muscle (VSM) cells have been recognized including the induction of hypertrophy and/or DNA synthesis. Platelet-derived growth factor (PDGF), a mitogen recently shown to increase p...


    pub_type: 杂志文章


    authors: van Leeuwen RT,Kol A,Andreotti F,Kluft C,Maseri A,Sperti G

    更新日期:1994-07-01 00:00:00