Tenascin-C is expressed in macrophage-rich human coronary atherosclerotic plaque.

abstract：BACKGROUND:The risk of syncope occurring while driving has obvious implications for personal and public safety. We aimed to define the clinical characteristics, causes, and prognosis of syncope while driving. METHODS AND RESULTS:In this case-control study of consecutive patients evaluated for syncope from 1996 through...

journal_title：Circulation

authors： Sorajja D,Nesbitt GC,Hodge DO,Low PA,Hammill SC,Gersh BJ,Shen WK

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND:Mutations in the ryanodine 2 receptor (RyR2) gene have been identified in patients with catecholaminergic polymorphic ventricular tachycardia. We examined the cellular basis for the ECG features and arrhythmia mechanisms using low-dose caffeine to mimic the defective calcium homeostasis encountered under the...

journal_title：Circulation

authors： Nam GB,Burashnikov A,Antzelevitch C

更新日期：2005-05-31 00:00:00

abstract：BACKGROUND:Several centers favor replacing a diseased native heart valve with a tissue rather than a mechanical prosthesis, even in younger adult patients. However, long-term data supporting this approach are lacking. We examined the survival implications of selecting a tissue versus a mechanical prosthesis at initial ...

journal_title：Circulation

authors： Ruel M,Chan V,Bédard P,Kulik A,Ressler L,Lam BK,Rubens FD,Goldstein W,Hendry PJ,Masters RG,Mesana TG

更新日期：2007-09-11 00:00:00

abstract：:These types of studies lay the foundation for understanding the human apolipoproteins at the genetic level. In addition, through a few specific examples, we have already shown evidence at the DNA level that lesions in apolipoprotein genes can play a role in human atherosclerosis. This work is in its infancy, but we ho...

journal_title：Circulation

authors： Breslow JL

更新日期：1984-06-01 00:00:00

abstract：:Early afterdepolarizations (EADs) are depolarizing potentials that occur before complete repolarization. They may be important in the acquired and possibly the idiopathic long QT syndrome and associated ventricular tachycardia (VT). The purpose of these experiments was to study in 20 open-chest dogs the effects of sym...

journal_title：Circulation

authors： Ben-David J,Zipes DP

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Endogenous adenosine can protect the overloaded heart against the development of hypertrophy and heart failure, but the contribution of A(1) receptors (A(1)R) and A(3) receptors (A(3)R) is not known. METHODS AND RESULTS:To test the hypothesis that A(1)R and A(3)R can protect the heart against systolic overl...

journal_title：Circulation

authors： Lu Z,Fassett J,Xu X,Hu X,Zhu G,French J,Zhang P,Schnermann J,Bache RJ,Chen Y

更新日期：2008-10-21 00:00:00

abstract：BACKGROUND:In the Myocardial Infarction, Triage, and Intervention (MITI) registry of acute myocardial infarction, 441 (12%) of 3750 patients had direct angioplasty as initial treatment. Approximately half (233) were performed in hospitals with no on-site surgery. METHODS AND RESULTS:Procedure success rates, use of eme...

journal_title：Circulation

authors： Weaver WD,Litwin PE,Martin JS

更新日期：1993-11-01 00:00:00

abstract：:Volume loading is used to treat hemodynamically compromised patients with acute pulmonary embolism despite data to suggest that volume loading after embolism might cause a leftward shift of the ventricular septum with a subsequent decrease in left ventricular (LV) end-diastolic volume and stroke work. We studied 10 cl...

journal_title：Circulation

authors： Belenkie I,Dani R,Smith ER,Tyberg JV

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to test the hypothesis that a single meandering functional reentrant wave front can result in rapid and irregular electrogram activity in human atrial tissues. METHODS AND RESULTS:The study used the explanted hearts of five human cardiac transplant recipients. Three right and t...

journal_title：Circulation

authors： Ikeda T,Czer L,Trento A,Hwang C,Ong JJ,Hough D,Fishbein MC,Mandel WJ,Karagueuzian HS,Chen PS

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:Some clinical data suggest that atrial-based pacing prevents paroxysmal atrial fibrillation (AF). This study tested the hypothesis that DDDR pacing compared with VDD pacing prevents AF after atrioventricular (AV) junction ablation. METHODS AND RESULTS:Patients were randomized to DDDR pacing (n=33) or to VDD...

journal_title：Circulation

authors： Gillis AM,Connolly SJ,Lacombe P,Philippon F,Dubuc M,Kerr CR,Yee R,Rose MS,Newman D,Kavanagh KM,Gardner MJ,Kus T,Wyse DG

更新日期：2000-08-15 00:00:00

abstract：:Since the discovery that neuregulin-1 (NRG-1)/ErbB signaling is indispensable in cardiac development, evidence has shown that this system also plays a crucial role in the adult heart. In patients, an inhibitory ErbB2 antibody, trastuzumab, used in the treatment of mammary carcinomas, increases the risk for the develop...

journal_title：Circulation

authors： Lemmens K,Doggen K,De Keulenaer GW

更新日期：2007-08-21 00:00:00

abstract：BACKGROUND:Accessory pathways originating at the tricuspid annulus that exhibit decremental antegrade conduction properties (Mahaim-type preexcitation) are amenable to radiofrequency (RF) current catheter ablation. However, a reliable and reproducible strategy for mapping and ablation of these fibers is lacking. METHO...

journal_title：Circulation

authors： Cappato R,Schlüter M,Weiss C,Siebels J,Hebe J,Duckeck W,Mletzko RU,Kuck KH

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Several nonatherosclerotic animal models of restenosis exist and are used for the evaluation of the vascular response to angioplasty-induced injury. However, few studies have evaluated the response of an atherosclerotic vessel to angioplasty. The present study examined the radiographic, histological, immunoh...

journal_title：Circulation

authors： Wilensky RL,March KL,Gradus-Pizlo I,Sandusky G,Fineberg N,Hathaway DR

更新日期：1995-11-15 00:00:00

abstract：BACKGROUND:For patients with in-hospital cardiac arrests attributable to nonshockable rhythms, delays in epinephrine administration beyond 5 minutes is associated with worse survival. However, the extent of hospital variation in delayed epinephrine administration and its effect on hospital-level outcomes is unknown. M...

journal_title：Circulation

authors： Khera R,Chan PS,Donnino M,Girotra S,American Heart Association’s Get With The Guidelines-Resuscitation Investigators.

更新日期：2016-12-20 00:00:00

abstract：BACKGROUND:Friedreich's ataxia (FA), the most common inherited ataxia, is associated frequently with cardiac hypertrophy, and death is often cardiac related. Recently, the disease has been associated with a mutation that consists of an unstable expansion of GAA repeats in the first intron of the gene encoding frataxin ...

journal_title：Circulation

authors： Isnard R,Kalotka H,Dürr A,Cossée M,Schmitt M,Pousset F,Thomas D,Brice A,Koenig M,Komajda M

更新日期：1997-05-06 00:00:00

abstract：BACKGROUND:The safety and efficacy of percutaneous coronary intervention of de novo lesions in unprotected left main coronary arteries remains an unresolved issue. METHODS AND RESULTS:We analyzed 67 consecutive patients treated with the following devices: 39 with stents, 12 with rotational atherectomy plus stents, 13 ...

journal_title：Circulation

authors： Takagi T,Stankovic G,Finci L,Toutouzas K,Chieffo A,Spanos V,Liistro F,Briguori C,Corvaja N,Albero R,Sivieri G,Paloschi R,Di Mario C,Colombo A

更新日期：2002-08-06 00:00:00

abstract：BACKGROUND:Mitral regurgitation (MR) generally accompanies inferobasal myocardial infarction (MI), with leaflet tethering by displaced papillary muscles. Mitral regurgitation is also reported with anteroapical MI without global dilatation or inferior wall motion abnormalities. We hypothesized that anteroapical MI exten...

journal_title：Circulation

authors： Yosefy C,Beeri R,Guerrero JL,Vaturi M,Scherrer-Crosbie M,Handschumacher MD,Levine RA

更新日期：2011-04-12 00:00:00

abstract：BACKGROUND:We tested the hypothesis that real-time magnetic resonance imaging (MRI) can guide coronary artery catheterization in swine via a percutaneous femoral artery approach. METHODS AND RESULTS:In 12 pigs, we accessed femoral arteries percutaneously. We used 6- or 7-French coronary Judkins catheters filled with d...

journal_title：Circulation

authors： Omary RA,Green JD,Schirf BE,Li Y,Finn JP,Li D

更新日期：2003-06-03 00:00:00

abstract：:We reviewed 35 patients undergoing resection of a chronic postinfarction left ventricular aneurysm. There was 5.7% operative mortality. Of the long-term survivors, 80% are functional class I or II. Ten patients had postoperative left ventriculograms studied by means of a computerized analysis of endocardial motion usi...

journal_title：Circulation

authors： Shaw RC,Connors JP,Hieb BR,Ludbrook PA,Krone R,Kleiger RE,Ferguson TB,Weldon CS

更新日期：1977-09-01 00:00:00

abstract：:The effects of encainide on ventricular arrhythmia and left ventricular function were studied in 21 patients with chronic, high-grade ventricular arrhythmia using a prospective, 3-month, placebo-controlled, single-blind trial design. Encainide caused a 96% decrease in the average hourly frequency of ventricular premat...

journal_title：Circulation

authors： DiBianco R,Fletcher RD,Cohen AI,Gottdiener JS,Singh SN,Katz RJ,Bates HR,Sauerbrunn B

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Increasingly, the diagnostic codes from administrative claims data are being used as clinical outcomes. METHODS AND RESULTS:Data from the Cardiovascular Health Study (CHS) were used to compare event rates and risk factor associations between adjudicated hospitalized cardiovascular events and claims-based me...

journal_title：Circulation

authors： Psaty BM,Delaney JA,Arnold AM,Curtis LH,Fitzpatrick AL,Heckbert SR,McKnight B,Ives D,Gottdiener JS,Kuller LH,Longstreth WT Jr

更新日期：2016-01-12 00:00:00

abstract：:A reduced rate of diastolic closure of the anterior mitral leaflet has been shown to occur in mitral stenosis, primary pulmonary hypertension, and in cases with reduced left ventricular compliance. Posterior notion of the posterior mitral leaflet in diastole has been the distinguishing feature to rule out the diagnosi...

journal_title：Circulation

authors： Levisman JA,Abbasi AS,Pearce ML

更新日期：1975-03-01 00:00:00

abstract：BACKGROUND:Experimental studies revealed proinflammatory properties of angiotensin II. We evaluated antiinflammatory effects of the angiotensin II subtype 1 receptor antagonist olmesartan medoxomil alone and in cotherapy with the HMG-CoA reductase inhibitor pravastatin in patients with essential hypertension and microi...

journal_title：Circulation

authors： Fliser D,Buchholz K,Haller H,EUropean Trial on Olmesartan and Pravastatin in Inflammation and Atherosclerosis (EUTOPIA) Investigators.

更新日期：2004-08-31 00:00:00

abstract：BACKGROUND:Gaps of sufficient cross-sectional dimensions within linear radiofrequency (RF) lesions may allow conduction through the lesion. The purpose of this study was to examine the effects of different gap geometries on conduction through discontinuous RF lesions. METHODS AND RESULTS:Radiofrequency lesions were cr...

journal_title：Circulation

authors： Pérez FJ,Wood MA,Schubert CM

更新日期：2006-04-11 00:00:00

abstract：BACKGROUND:Matricellular proteins are extracellular matrix proteins that do not contribute directly to tissue integrity but are capable of modulating cell function. We hypothesized that the matricellular protein thrombospondin (TSP)-1, a potent inhibitor of angiogenesis and activator of transforming growth factor (TGF-...

journal_title：Circulation

authors： Frangogiannis NG,Ren G,Dewald O,Zymek P,Haudek S,Koerting A,Winkelmann K,Michael LH,Lawler J,Entman ML

更新日期：2005-06-07 00:00:00

abstract：BACKGROUND:Heart failure (HF) is responsible for a huge burden in hospital care. Our goal was to evaluate the value of N-terminal-pro-brain natriuretic peptide (NT-proBNP) in predicting death or hospital readmission after discharge of HF patients. METHODS AND RESULTS:We included 182 patients consecutively admitted to ...

journal_title：Circulation

authors： Bettencourt P,Azevedo A,Pimenta J,Friões F,Ferreira S,Ferreira A

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:It was the aim of this study to assess the long-term effects of physical exercise and low-fat diet on the progression of coronary artery disease. At the beginning of the study, 113 male patients with coronary artery disease were randomized to an intervention group (n=56) or a control group (n=57); 90 patient...

journal_title：Circulation

authors： Niebauer J,Hambrecht R,Velich T,Hauer K,Marburger C,Kälberer B,Weiss C,von Hodenberg E,Schlierf G,Schuler G,Zimmermann R,Kübler W

更新日期：1997-10-21 00:00:00

abstract：BACKGROUND:Despite successful repair of coarctation of the aorta in childhood, adult survivors often have hypertension at rest or on exercise, and their life expectancy is shorter than normal because of premature coronary and cerebrovascular disease. This may be related to persistent structural and functional arterial ...

journal_title：Circulation

authors： Gardiner HM,Celermajer DS,Sorensen KE,Georgakopoulos D,Robinson J,Thomas O,Deanfield JE

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:The myocardial protective role of heat shock protein (HSP) has been demonstrated, and there has been increasing interest in stress response in the heart. We examined the DNA-binding activity of heat shock transcription factor (HSF), by which the transcription of heat shock genes is mainly regulated, during h...

journal_title：Circulation

authors： Nishizawa J,Nakai A,Higashi T,Tanabe M,Nomoto S,Matsuda K,Ban T,Nagata K

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Smoking is a major risk factor for cardiovascular events. One of the potential mechanisms may be related to both coronary endothelial dysfunction and increased inflammatory response. The present study was designed to test the hypothesis that smoking is associated with epicardial coronary endothelial dysfunct...

journal_title：Circulation

authors： Lavi S,Prasad A,Yang EH,Mathew V,Simari RD,Rihal CS,Lerman LO,Lerman A

更新日期：2007-05-22 00:00:00