Syncope while driving: clinical characteristics, causes, and prognosis.

abstract：BACKGROUND:Dynamic intraventricular flow velocities after valve replacement for aortic stenosis have been associated with high in-hospital morbidity and mortality. The aims of the present study were to determine the mechanisms and preoperative predictors of abnormal flow velocity (AFV) after valve replacement for aorti...

journal_title：Circulation

authors： Bartunek J,Sys SU,Rodrigues AC,van Schuerbeeck E,Mortier L,de Bruyne B

更新日期：1996-02-15 00:00:00

abstract：BACKGROUND:A synergistic interaction between the angiotensin II (Ang II) type 1 receptor and alpha1-adrenergic receptors has been described. We hypothesized that the nonselective beta-antagonist carvedilol, through its alpha1-adrenergic blocking properties, may modulate vascular reactivity to Ang II in patients with ch...

journal_title：Circulation

authors： Vittorio TJ,Lang CC,Katz SD,Packer M,Mancini DM,Jorde UP

更新日期：2003-01-21 00:00:00

abstract：BACKGROUND:The regional wall motion impairment and predisposition to arrhythmias in human ventricular hibernation may plausibly result from abnormal intercellular propagation of the depolarizing wave front. This study investigated the hypothesis that altered patterns of expression of connexin43, the principal gap junct...

journal_title：Circulation

authors： Kaprielian RR,Gunning M,Dupont E,Sheppard MN,Rothery SM,Underwood R,Pennell DJ,Fox K,Pepper J,Poole-Wilson PA,Severs NJ

更新日期：1998-02-24 00:00:00

abstract：:Power outputs that are below the anaerobic threshold (theta an) may be sustained for prolonged durations, whereas power outputs that are greater than theta an result in a significant reduction in the tolerable duration to fatigue. The theta an may therefore be considered to demarcate exercise intensity into moderate (...

journal_title：Circulation

authors： Whipp BJ

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:High-mobility group box-1 (HMGB1) is a nuclear factor released by necrotic cells and by activated immune cells. HMGB1 signals via members of the toll-like receptor family and the receptor for advanced glycation end products (RAGE). Although HMGB1 has been implicated in ischemia/reperfusion (I/R) injury of th...

journal_title：Circulation

authors： Andrassy M,Volz HC,Igwe JC,Funke B,Eichberger SN,Kaya Z,Buss S,Autschbach F,Pleger ST,Lukic IK,Bea F,Hardt SE,Humpert PM,Bianchi ME,Mairbäurl H,Nawroth PP,Remppis A,Katus HA,Bierhaus A

更新日期：2008-06-24 00:00:00

abstract：BACKGROUND:The individual makeup of atherosclerotic plaque has been identified as a dominant prognostic factor. With the use of an intravascular magnetic resonance (MR) catheter coil, we evaluated the effectiveness of high-resolution MR in the study of the development of atherosclerotic lesions in heritable hyperlipide...

journal_title：Circulation

authors： Zimmermann-Paul GG,Quick HH,Vogt P,von Schulthess GK,Kling D,Debatin JF

更新日期：1999-03-02 00:00:00

abstract：:Recent molecular studies have suggested that viral myocarditis frequently underlies human congestive cardiomyopathy; however, only moderately sensitive and specific techniques were used. Polymerase chain reaction (PCR) gene amplification is a sensitive, specific technique ideally suited for the diagnosis of viral dise...

journal_title：Circulation

authors： Jin O,Sole MJ,Butany JW,Chia WK,McLaughlin PR,Liu P,Liew CC

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Mechanisms favoring the occurrence of paroxysmal atrial fibrillation (PAF) are complex and poorly defined. This study was designed to analyze dynamic changes in autonomic tone preceding the onset of PAF in a large group of patients. METHODS AND RESULTS:Holter tapes from 77 unselected consecutive patients (6...

journal_title：Circulation

authors： Bettoni M,Zimmermann M

更新日期：2002-06-11 00:00:00

abstract：BACKGROUND:Ibutilide is an action potential-prolonging antiarrhythmic currently in clinical trials. The drug shares structural similarities with E-4031 and dofetilide, specific blockers of the rapidly activating delayed rectifier K+ current (IKr). However, previous in vitro studies in guinea pig myocytes have indicated...

journal_title：Circulation

authors： Yang T,Snyders DJ,Roden DM

更新日期：1995-03-15 00:00:00

abstract：BACKGROUND:Endocardial mapping using standard electrode catheters is often technically limited in ventricular tachycardia and constitutes a major obstacle to successful ablation. We wished to examine the utility of a basket-shaped multielectrode mapping catheter (MMC) in the mapping and ablation of ventricular tachycar...

journal_title：Circulation

authors： Eldar M,Ohad DG,Goldberger JJ,Rotstein Z,Hsu S,Swanson DK,Greenspon AJ

更新日期：1997-10-07 00:00:00

abstract：BACKGROUND:Heat shock protein (HSP)60 is an abundant protein found primarily in the mitochondria, though 15% to 20% is found in the cytosol. Previously we observed that HSP60 complexes with bax in the cytosol. Reduction in HSP60 precipitates translocation of bax to the mitochondria and apoptosis. We hypothesized that H...

journal_title：Circulation

authors： Gupta S,Knowlton AA

更新日期：2002-11-19 00:00:00

abstract：BACKGROUND:Although several prospective cohort studies have found an inverse association between fish consumption and risk of coronary heart disease (CHD) or sudden cardiac death in the general population, limited data are available among diabetic patients. METHODS AND RESULTS:We examined prospectively the association...

journal_title：Circulation

authors： Hu FB,Cho E,Rexrode KM,Albert CM,Manson JE

更新日期：2003-04-15 00:00:00

abstract：BACKGROUND:Left ventricular (LV) mass is an important predictor of heart failure and cardiovascular mortality, yet determinants of LV mass are incompletely understood. Pulmonary hyperinflation in chronic obstructive pulmonary disease (COPD) may contribute to changes in intrathoracic pressure that increase LV wall stres...

journal_title：Circulation

authors： Smith BM,Kawut SM,Bluemke DA,Basner RC,Gomes AS,Hoffman E,Kalhan R,Lima JA,Liu CY,Michos ED,Prince MR,Rabbani L,Rabinowitz D,Shimbo D,Shea S,Barr RG

更新日期：2013-04-09 00:00:00

abstract：:R-wave synchronous equilbrium radionuclide angiography (RNA) is a noninvasive method that provides time-activity curve count information proportional to ventricular volumes and is used for relative volume comparisons within the left or right ventricle to derive the ejection fraction. Comparison of the ventricular coun...

journal_title：Circulation

authors： Sorensen SG,O'Rourke RA,Chaudhuri TK

更新日期：1980-11-01 00:00:00

abstract：:The healthcare system is undergoing a transition from paying for volume to paying for value. Clinicians, as well as public and private payers, are beginning to implement alternative delivery and payment models, such as the patient-centered medical home, accountable care organizations, and bundled payment arrangements....

journal_title：Circulation

authors： Bufalino VJ,Berkowitz SA,Gardner TJ,Piña IL,Konig M,AHA Expert Panel on Payment and Delivery System Reform.

更新日期：2017-08-15 00:00:00

abstract：BACKGROUND AND PURPOSE:The guidelines presented in this consensus statement are intended to serve researchers, clinicians, reviewers, and regulators in the selection of the most appropriate primary outcome for a clinical trial of cardiac arrest therapies. The American Heart Association guidelines for the treatment of c...

journal_title：Circulation

authors： Becker LB,Aufderheide TP,Geocadin RG,Callaway CW,Lazar RM,Donnino MW,Nadkarni VM,Abella BS,Adrie C,Berg RA,Merchant RM,O'Connor RE,Meltzer DO,Holm MB,Longstreth WT,Halperin HR,American Heart Association Emergency Cardiova

更新日期：2011-11-08 00:00:00

abstract：BACKGROUND:High-altitude pulmonary edema (HAPE) is characterized by pulmonary hypertension, increased pulmonary capillary permeability, and hypoxemia. Treatment is limited to descent to lower altitude and administration of oxygen. METHODS AND RESULTS:We studied the acute effects of inhaled nitric oxide (NO), 50% oxyge...

journal_title：Circulation

authors： Anand IS,Prasad BA,Chugh SS,Rao KR,Cornfield DN,Milla CE,Singh N,Singh S,Selvamurthy W

更新日期：1998-12-01 00:00:00

abstract：:Mapping of blood velocities across the lumen of the ascending aorta was performed in eight patients during open-heart surgery. A Doppler ultrasound probe was constructed to measure velocities in 2 mm steps from the maximum convexity to the maximum concavity of aorta, 6 to 7 cm above the aortic valve. In five patients ...

journal_title：Circulation

authors： Segadal L,Matre K

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:Current methods of signal-averaged ECG analysis interrogate the terminal 40 msec of the QRS complex and/or the ST segment and have a low positive-predictive accuracy for detecting vulnerability to sustained ventricular tachycardia (VT). The extent to which abnormalities detected during these ECG intervals ar...

journal_title：Circulation

authors： Hood MA,Pogwizd SM,Peirick J,Cain ME

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Calcineurin is a calcium-regulated phosphatase that plays a major role in cardiac hypertrophy. We previously described that alternative splicing of the calcineurin Aβ (CnAβ) gene generates the CnAβ1 isoform, with a unique C-terminal region that is different from the autoinhibitory domain present in all other...

journal_title：Circulation

authors： Felkin LE,Narita T,Germack R,Shintani Y,Takahashi K,Sarathchandra P,López-Olañeta MM,Gómez-Salinero JM,Suzuki K,Barton PJ,Rosenthal N,Lara-Pezzi E

更新日期：2011-06-21 00:00:00

abstract：BACKGROUND:Television viewing time, the predominant leisure-time sedentary behavior, is associated with biomarkers of cardiometabolic risk, but its relationship with mortality has not been studied. We examined the associations of prolonged television viewing time with all-cause, cardiovascular disease (CVD), cancer, an...

journal_title：Circulation

authors： Dunstan DW,Barr EL,Healy GN,Salmon J,Shaw JE,Balkau B,Magliano DJ,Cameron AJ,Zimmet PZ,Owen N

更新日期：2010-01-26 00:00:00

abstract：:An isolated perfused working rat heart model was used to investigate the extent to which various protective agents, used either singly or in combination, were able to increase the resistance of the heart to periods of transient ischemia. The aim of the studies was to develop a solution which, if infused into the coron...

journal_title：Circulation

authors： Hearse DJ,Stewart DA,Braimbridge MV

更新日期：1976-08-01 00:00:00

abstract：BACKGROUND:The treatment of unstable angina targets the specific pathophysiological thrombotic process at the site of the active culprit lesion. In unstable angina due to a restenotic lesion, smooth muscle cell proliferation and increased vasoreactivity may play a more important role than thrombus formation. Therefore,...

journal_title：Circulation

authors： Doucet S,Malekianpour M,Théroux P,Bilodeau L,Côté G,de Guise P,Dupuis J,Joyal M,Gosselin G,Tanguay JF,Juneau M,Harel F,Nattel S,Tardif JC,Lespérance J

更新日期：2000-03-07 00:00:00

abstract：BACKGROUND:Right ventricular (RV) function is the major determinant for both functional capacity and survival in patients with pulmonary arterial hypertension (PAH). Despite the recognized clinical importance of preserving RV function, the subcellular mechanisms that govern the transition from a compensated to a decomp...

journal_title：Circulation

authors： Omura J,Habbout K,Shimauchi T,Wu WH,Breuils-Bonnet S,Tremblay E,Martineau S,Nadeau V,Gagnon K,Mazoyer F,Perron J,Potus F,Lin JH,Zafar H,Kiely DG,Lawrie A,Archer SL,Paulin R,Provencher S,Boucherat O,Bonnet S

更新日期：2020-10-13 00:00:00

abstract：BACKGROUND:Despite a recent American Heart Association (AHA) consensus statement emphasizing the importance of resistant hypertension, the incidence and prognosis of this condition are largely unknown. METHODS AND RESULTS:This retrospective cohort study in 2 integrated health plans included patients with incident hype...

journal_title：Circulation

authors： Daugherty SL,Powers JD,Magid DJ,Tavel HM,Masoudi FA,Margolis KL,O'Connor PJ,Selby JV,Ho PM

更新日期：2012-04-03 00:00:00

abstract：:Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiova...

journal_title：Circulation

authors： Tian R,Colucci WS,Arany Z,Bachschmid MM,Ballinger SW,Boudina S,Bruce JE,Busija DW,Dikalov S,Dorn GW II,Galis ZS,Gottlieb RA,Kelly DP,Kitsis RN,Kohr MJ,Levy D,Lewandowski ED,McClung JM,Mochly-Rosen D,O'Brien KD,O'R

更新日期：2019-10-01 00:00:00

abstract：:The quantitative approaches to the assessment of regional left ventricular (LV) function described in the preceding paper were applied in a well-defined population of patients with coronary artery disease. Two groups were chosen by electrocardiographic and angiographic criteria: group 1 had infarction and regional wal...

journal_title：Circulation

authors： Parisi AF,Moynihan PF,Folland ED,Feldman CL

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND:Fluid energy loss across stenotic aortic valves is influenced by factors other than the valve effective orifice area (EOA). We propose a new index that will provide a more accurate estimate of this energy loss. METHODS AND RESULTS:An experimental model was designed to measure EOA and energy loss in 2 fixed ...

journal_title：Circulation

authors： Garcia D,Pibarot P,Dumesnil JG,Sakr F,Durand LG

更新日期：2000-02-22 00:00:00

abstract：BACKGROUND:The Jun family of activator protein 1 (AP-1) transcription factors (c-Jun, JunB, and JunD) is involved in fundamental biological processes such as proliferation, apoptosis, tumor angiogenesis, and hypertrophy. The role of individual AP-1 transcription factors in the stressed heart is not clear. In the presen...

journal_title：Circulation

authors： Hilfiker-Kleiner D,Hilfiker A,Kaminski K,Schaefer A,Park JK,Michel K,Quint A,Yaniv M,Weitzman JB,Drexler H

更新日期：2005-09-06 00:00:00

abstract：:D8/17, a B cell alloantigen, and its occurrence with DR/DQ antigens was examined in 54 patients with rheumatic heart disease and matched North Indian controls. Thirty-four patients (62.9%) carried D8/17 as compared with a frequency of 12.5% in controls (chi 2 by Yates', 18.75; p less than 0.0001). A marginally increas...

journal_title：Circulation

authors： Taneja V,Mehra NK,Reddy KS,Narula J,Tandon R,Vaidya MC,Bhatia ML

更新日期：1989-08-01 00:00:00