Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects.

abstract：:This study examined quantitative regional myocardial perfusion (RMP) measured by the washout of 133Xe at rest and after an isoproterenol challenge in 50 patients (group I) studied 8 to 14 days after they underwent saphenous vein bypass grafting to the left coronary artery, and compared this with RMP measured in the na...

journal_title：Circulation

authors： Schmidt DH,Blau FM,Hendrix LJ,Kamath ML,Ray G

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Arterial remodeling after balloon angioplasty has been recognized as a major determinant of restenosis. Perturbation of collagen metabolism might be important. After balloon injury, matrix metalloproteinase (MMP) expression is upregulated. We investigated the effect of Batimastat, a nonspecific MMP inhibitor...

journal_title：Circulation

authors： de Smet BJ,de Kleijn D,Hanemaaijer R,Verheijen JH,Robertus L,van Der Helm YJ,Borst C,Post MJ

更新日期：2000-06-27 00:00:00

abstract：BACKGROUND:Whether the benefit in quality of life (QOL) after percutaneous coronary intervention depends on the severity of the stenosis as determined by fractional flow reserve (FFR) remains unknown. This study sought to investigate the relationship between FFR values and improvement in QOL. METHODS:From the FAME 1 a...

journal_title：Circulation

authors： Nishi T,Piroth Z,De Bruyne B,Jagic N,Möbius-Winkler S,Kobayashi Y,Derimay F,Fournier S,Barbato E,Tonino P,Jüni P,Pijls NHJ,Fearon WF

更新日期：2018-10-23 00:00:00

abstract：:This study was undertaken to provide a better anatomic description of the location and course of the left coronary artery within a commonly used ultrasonic tomographic plane. Twenty-three hearts were excised at autopsy and scanned in vitro. The locations of the left main (LMCA), left anterior descending (LAD), and lef...

journal_title：Circulation

authors： Rogers EW,Feigenbaum H,Weyman AE,Godley RW,Vakili ST

更新日期：1980-10-01 00:00:00

abstract：:A Y-shaped lesion in the right atrium allows induction of atrial flutter in dogs. We recorded the activation sequence during this tachycardia from 96 endocardial bipolar electrodes using intracavitary electrode arrays during 12 separate episodes in three isolated perfused hearts. In each case a reentrant impulse circu...

journal_title：Circulation

authors： Frame LH,Page RL,Boyden PA,Fenoglio JJ Jr,Hoffman BF

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:Randomized trials that studied clinical outcomes after percutaneous coronary intervention (PCI) with bare metal stenting versus coronary artery bypass grafting (CABG) are underpowered to properly assess safety end points like death, stroke, and myocardial infarction. Pooling data from randomized controlled t...

journal_title：Circulation

authors： Daemen J,Boersma E,Flather M,Booth J,Stables R,Rodriguez A,Rodriguez-Granillo G,Hueb WA,Lemos PA,Serruys PW

更新日期：2008-09-09 00:00:00

abstract：:Acute myocardial ischemia leads to a gradual increase in beta-adrenergic receptors at the cell surface. This increase occurs rapidly after onset of global ischemia (15 minutes) and persists even after prolonged periods of global ischemia. This alteration can be observed both in vivo and in vitro in isolated perfused h...

journal_title：Circulation

authors： Strasser RH,Marquetant R,Kübler W

更新日期：1990-09-01 00:00:00

abstract：:Data from 981 patients evaluated for ischemic heart disease with coronary angiography were reviewed to identify variables predictive of sudden death and duration from onset of symptoms to death. During the period of follow-up, 113 patients died. Of these deaths, 99 were classified as cardiovascular. Forty percent occu...

journal_title：Circulation

authors： Oberman A,Ray M,Turner ME,Barnes G,Grooms C

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Fe2+ released from tissue iron stores may accelerate lipid peroxidation by virtue of its pro-oxidant properties and thus promote early atherogenesis. METHODS AND RESULTS:The present prospective survey addresses the potential association between serum ferritin concentrations and the 5-year progression of car...

journal_title：Circulation

authors： Kiechl S,Willeit J,Egger G,Poewe W,Oberhollenzer F

更新日期：1997-11-18 00:00:00

abstract：BACKGROUND:C-kit is a receptor tyrosine kinase family member expressed in hematopoietic stem cells. C-kit is also transiently expressed in cardiomyocyte precursors during development and in a rare cell population in the normal adult heart. In the present study, the cardiomyogenic potential of c-kit(+) cells isolated fr...

journal_title：Circulation

authors： Zaruba MM,Soonpaa M,Reuter S,Field LJ

更新日期：2010-05-11 00:00:00

abstract：BACKGROUND:Analyses from randomized controlled trials suggest that bleeding in patients with acute myocardial infarction is associated with poor outcomes. Because these data are not generalizable to all patients with acute myocardial infarction, we sought to better understand the scope of this problem in a "real-world"...

journal_title：Circulation

authors： Spencer FA,Moscucci M,Granger CB,Gore JM,Goldberg RJ,Steg PG,Goodman SG,Budaj A,FitzGerald G,Fox KA,GRACE Investigators.

更新日期：2007-12-11 00:00:00

abstract：BACKGROUND:Transplant-associated coronary artery disease (TxCAD) is the manifestation of chronic rejection in the cardiac allograft. Both immunological and nonimmunological factors contribute to its development. Stratification by the time of development of TxCAD has not been considered previously for an extensive trans...

journal_title：Circulation

authors： Hornick P,Smith J,Pomerance A,Mitchell A,Banner N,Rose M,Yacoub M

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:Inhibition of fibrinolysis attributable to elevated concentrations of plasminogen activator inhibitor type 1 (PAI-1) in blood is associated with insulin resistance, hyperinsulinemia, and type 2 diabetes mellitus. Because we have shown that insulin can stimulate PAI-1 synthesis in vivo and because accelerated...

journal_title：Circulation

authors： Sobel BE,Woodcock-Mitchell J,Schneider DJ,Holt RE,Marutsuka K,Gold H

更新日期：1998-06-09 00:00:00

abstract：BACKGROUND:Both glucose-insulin-potassium (GIK) and tri-iodothyronine (T3) may improve cardiovascular performance after coronary artery surgery (CABG) but their effects have not been directly compared and the effects of combined treatment are unknown. METHODS AND RESULTS:In 2 consecutive randomized double-blind placeb...

journal_title：Circulation

authors： Ranasinghe AM,Quinn DW,Pagano D,Edwards N,Faroqui M,Graham TR,Keogh BE,Mascaro J,Riddington DW,Rooney SJ,Townend JN,Wilson IC,Bonser RS

更新日期：2006-07-04 00:00:00

abstract：:The ability of 67Ga citrate and 99mTc pyrophosphate cardiac imaging to detect myocarditis was assessed in an experimental rabbit model. Twenty-three rabbits were imaged approximately 72 hours after infusion of i.v. norepinephrine. Diffuse cardiac uptake was found in 13 of 15 rabbits scanned with 67Ga. Tissue distribut...

journal_title：Circulation

authors： Reeves WC,Jackson GL,Flickinger FW,Kwee HG,Schwiter EJ,Werner J,Whitesell L,Biddle MA,Copenhaver G,Shaikh BS,Zelis R

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND:The relationship between intake of fruits and vegetables (F/V) during young adulthood and coronary atherosclerosis later in life is unclear. METHODS AND RESULTS:We studied participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study, a cohort of young, healthy black and white individu...

journal_title：Circulation

authors： Miedema MD,Petrone A,Shikany JM,Greenland P,Lewis CE,Pletcher MJ,Gaziano JM,Djousse L

更新日期：2015-11-24 00:00:00

abstract：BACKGROUND:It is not known whether subspecialty care by cardiologists improves outcomes in heart failure patients from the community over care by other physicians. METHODS AND RESULTS:Using administrative data, we monitored 38 702 consecutive patients with first-time hospitalization for heart failure in Ontario, Canad...

journal_title：Circulation

authors： Jong P,Gong Y,Liu PP,Austin PC,Lee DS,Tu JV

更新日期：2003-07-15 00:00:00

abstract：:Previous studies in patients with sustained ventricular tachycardia (VT) have demonstrated the efficacy of surgical and catheter-mediated ablative procedures based on activation mapping during VT. Since extensive preoperative or intraoperative mapping may be impractical due to time constraints or patient intolerance, ...

journal_title：Circulation

authors： Miller JM,Marchlinski FE,Buxton AE,Josephson ME

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Previous studies have reported an association between chronic Helicobacter pylori infection and ischemic heart disease. However, it is not clear whether this association is really due to the virulence of the bacterium or is merely the result of confounding factors (in particular, age and social class). METH...

journal_title：Circulation

authors： Pasceri V,Cammarota G,Patti G,Cuoco L,Gasbarrini A,Grillo RL,Fedeli G,Gasbarrini G,Maseri A

更新日期：1998-05-05 00:00:00

abstract：BACKGROUND:The mechanistic target of rapamycin (mTOR) comprises 2 structurally distinct multiprotein complexes, mTOR complexes 1 and 2 (mTORC1 and mTORC2). Deregulation of mTOR signaling occurs during and contributes to the severity of myocardial damage from ischemic heart disease. However, the relative roles of mTORC1...

journal_title：Circulation

authors： Völkers M,Konstandin MH,Doroudgar S,Toko H,Quijada P,Din S,Joyo A,Ornelas L,Samse K,Thuerauf DJ,Gude N,Glembotski CC,Sussman MA

更新日期：2013-11-05 00:00:00

abstract：:While the steady-state effects of positive pleural pressure on the circulation have been extensively studied, less is known about the immediate effects of positive intrathoracic pressure on cardiac dynamics. Therefore, we performed electrocardiographically gated radionuclide ventriculography with a respiratory gating ...

journal_title：Circulation

authors： Natarajan TK,Wise RA,Karam M,Permutt S,Wagner HN Jr

更新日期：1987-01-01 00:00:00

abstract：:Twenty-three children with valvar or discrete subvalvar aortic stenosis underwent a controlled, progressive bicycle exercise test within 6 months before and 3-30 months after surgery for left ventricular outflow tract obstruction. The patients were divided into three groups according to the preoperative resting gradie...

journal_title：Circulation

authors： Whitmer JT,James FW,Kaplan S,Schwartz DC,Knight MJ

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:Drugs that simultaneously decrease platelet function and inflammation may improve the treatment of cardiovascular disorders. Here, we determined whether dipyridamole and aspirin, a combination therapy used to prevent recurrent stroke, regulates gene expression in platelet-monocyte inflammatory model systems....

journal_title：Circulation

authors： Weyrich AS,Denis MM,Kuhlmann-Eyre JR,Spencer ED,Dixon DA,Marathe GK,McIntyre TM,Zimmerman GA,Prescott SM

更新日期：2005-02-08 00:00:00

abstract：BACKGROUND:Systemic administration of heparin can decrease mortality and morbidity of acute ischemic coronary syndromes such as unstable angina and myocardial infarction. Hemorrhage is the major limiting factor in the clinical use of systemic heparin. The objective of the present study was to determine whether local de...

journal_title：Circulation

authors： Nunes GL,Thomas CN,Hanson SR,Barry JJ,King SB 3rd,Scott NA

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Tetralogy of Fallot is the most common form of congenital heart disease in implantable cardioverter-defibrillator (ICD) recipients, yet little is known about the value of ICDs in this patient population. METHODS AND RESULTS:We conducted a multicenter cohort study in high-risk patients with Tetralogy of Fall...

journal_title：Circulation

authors： Khairy P,Harris L,Landzberg MJ,Viswanathan S,Barlow A,Gatzoulis MA,Fernandes SM,Beauchesne L,Therrien J,Chetaille P,Gordon E,Vonder Muhll I,Cecchin F

更新日期：2008-01-22 00:00:00

abstract：BACKGROUND:Heart failure treatment depends partly on the underlying cause of the disease. We evaluated cardiovascular magnetic resonance (CMR) for the problem of differentiating dilated cardiomyopathy (DCM) from left ventricular (LV) dysfunction caused by coronary artery disease (CAD). METHODS AND RESULTS:Late gadolin...

journal_title：Circulation

authors： McCrohon JA,Moon JC,Prasad SK,McKenna WJ,Lorenz CH,Coats AJ,Pennell DJ

更新日期：2003-07-08 00:00:00

abstract：:We performed a 15 year follow-up of 748 patients undergoing bypass surgery, comparing 532 patients with one or two internal mammary artery grafts with or without additional saphenous vein grafts to 216 patients with saphenous vein grafts alone. During the 15 years of follow-up the 532 patients with at least one intern...

journal_title：Circulation

authors： Cameron A,Kemp HG Jr,Green GE

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:Macrophage migration inhibitory factor (MIF), a cytokine that controls cell-mediated inflammatory responses, is upregulated in atherogenesis; however, its functional contribution to lesion development has not been evaluated. METHODS AND RESULTS:We studied the role of MIF on neointima lesion formation after ...

journal_title：Circulation

authors： Schober A,Bernhagen J,Thiele M,Zeiffer U,Knarren S,Roller M,Bucala R,Weber C

更新日期：2004-01-27 00:00:00

abstract：:One thousand four Medtronic Hall valves (601 mitral, 398 aortic, and five tricuspid) were implanted in 847 patients between December 1979 and June 1987. Total experience at the end of June 1987 was 2,640 patient-years of follow-up. Prothrombin time ratios were reviewed for all patients (16,866 observations), and these...

journal_title：Circulation

authors： Butchart EG,Lewis PA,Grunkemeier GL,Kulatilake N,Breckenridge IM

更新日期：1988-09-01 00:00:00

abstract：:A group of 916 apparently healthy men between the ages of 27 and 55 years (mean 37) were followed up with serial medical and exercise test evaluations for a period of 8 to 15 years (mean 12.7) to determine (1) the prevalence and specific types of new coronary events observed in subjects with and without abnormal ST se...

journal_title：Circulation

authors： McHenry PL,O'Donnell J,Morris SN,Jordan JJ

更新日期：1984-10-01 00:00:00