Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage.

abstract：:From January 1970 to April 1975, 132 patients underwent surgical repair of aneurysms of the ascending aorta at this institution, 24 of whom had acute dissections. In almost all cases the ascending aorta was replaced with a Dacron tube graft. Aortic valve replacement was performed in 100 patients and 23 patients underw...

journal_title：Circulation

authors： Kidd JN,Ruel GJ Jr,Cooley DA,Sandiford FM,Kyger ER 3rd,Wukasch DC

更新日期：1976-12-01 00:00:00

abstract：:It has been suggested that the beneficial effects of reperfusing ischemic myocardium might be in part reversed by the occurrence of "reperfusion injury." One possible mechanism could be the generation of oxygen free radicals. Superoxide dismutase enzymatically scavenges superoxide radicals by dismutation to hydrogen p...

journal_title：Circulation

authors： Ambrosio G,Weisfeldt ML,Jacobus WE,Flaherty JT

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:HMG CoA reductase inhibitors (or statins), a new class of lipid-lowering compounds, have raised expectations for more widespread use than that of the older lipid-lowering drugs. Not only are they more effective in lowering LDL cholesterol, but they are better tolerated as well. No data exist concerning the e...

journal_title：Circulation

authors： Furberg CD,Adams HP Jr,Applegate WB,Byington RP,Espeland MA,Hartwell T,Hunninghake DB,Lefkowitz DS,Probstfield J,Riley WA

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Beta-blockers improve clinical outcome when administered early after acute myocardial infarction. However, whether beta-blockers actually reduce the myocardial infarction size is still in dispute. Cardiac magnetic resonance imaging can accurately depict the left ventricular (LV) ischemic myocardium at risk (...

journal_title：Circulation

authors： Ibanez B,Prat-González S,Speidl WS,Vilahur G,Pinero A,Cimmino G,García MJ,Fuster V,Sanz J,Badimon JJ

更新日期：2007-06-12 00:00:00

abstract：:Depression is commonly present in patients with coronary heart disease (CHD) and is independently associated with increased cardiovascular morbidity and mortality. Screening tests for depressive symptoms should be applied to identify patients who may require further assessment and treatment. This multispecialty consen...

journal_title：Circulation

authors： Lichtman JH,Bigger JT Jr,Blumenthal JA,Frasure-Smith N,Kaufmann PG,Lespérance F,Mark DB,Sheps DS,Taylor CB,Froelicher ES,American Heart Association Prevention Committee of the Council on Cardiovascular Nursing.,American Heart Assoc

更新日期：2008-10-21 00:00:00

abstract：BACKGROUND:Short-term hibernating myocardium is characterized by a decrease in contractile function in proportion to the reduced myocardial blood flow. Myocardial creatine phosphate content, initially decreased during the first minutes of ischemia, returns to near-control values, the ischemia-induced net lactate produc...

journal_title：Circulation

authors： Schulz R,Rose J,Martin C,Brodde OE,Heusch G

更新日期：1993-08-01 00:00:00

abstract：:The dominance of the coronary arterial system was determined angiographically in 75 adult patients with isolated aortic stenosis with or without insufficiency, 25 adult patients with pure aortic insufficiency, 51 adult patients with combined aortic stenosis and mitral valve disease, and 44 children with bicuspid aorti...

journal_title：Circulation

authors： Higgins CB,Wexler L

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Several authors have reported cases in which 201Tl scintigraphy demonstrated perfusion abnormality in the septum of patients with left bundle branch block (LBBB) and normal coronary arteriogram. The mechanism of this abnormality, however, remains to be clarified. METHODS AND RESULTS:To determine whether LBB...

journal_title：Circulation

authors： Ono S,Nohara R,Kambara H,Okuda K,Kawai C

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Peak early-diastolic mitral annulus velocity (e') by tissue Doppler imaging has been introduced as a clinical marker of diastolic function. This study investigates whether lengthening load (early-diastolic load) and restoring forces are determinants of e' in addition to rate of left ventricular (LV) relaxati...

journal_title：Circulation

authors： Opdahl A,Remme EW,Helle-Valle T,Lyseggen E,Vartdal T,Pettersen E,Edvardsen T,Smiseth OA

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:In patients with acute coronary syndromes and planned percutaneous coronary intervention, the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis in Myocardial Infarction 38 (TRITON-TIMI 38) demonstrated that treatment with prasugrel versus clopid...

journal_title：Circulation

authors： Mahoney EM,Wang K,Arnold SV,Proskorovsky I,Wiviott S,Antman E,Braunwald E,Cohen DJ

更新日期：2010-01-05 00:00:00

abstract：:The left anterior descending coronary artery of four dogs and the right common carotid artery of 15 rabbits were subjected to 40-60% reduction in transluminal diameter for 1 hour by partial ligation with suture thread. Scanning electron microscopic examination of the luminal surface of these vessels revealed endotheli...

journal_title：Circulation

authors： Gertz SD,Uretsky G,Wajnberg RS,Navot N,Gotsman MS

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that bone morphogenetic protein-2 (BMP-2), a transforming growth factor-beta superfamily member cytokine, plays an important role both in vascular development and pathophysiological processes, including endothelial activation that is likely to contribute to the development of coronary ...

journal_title：Circulation

authors： Csiszar A,Smith KE,Koller A,Kaley G,Edwards JG,Ungvari Z

更新日期：2005-05-10 00:00:00

abstract：BACKGROUND:Associations between left ventricular (LV) geometry and the insulin resistance syndrome have been found, mostly in small studies of middle-aged hypertensives. The purpose of this study was to elucidate these associations through the use of a large sample of elderly men. METHODS AND RESULTS:We investigated 4...

journal_title：Circulation

authors： Sundström J,Lind L,Nyström N,Zethelius B,Andrén B,Hales CN,Lithell HO

更新日期：2000-06-06 00:00:00

abstract：:Cardiovascular disease is the number one cause of death for women in the United States. Of the 1.3 million active duty service members, 16.3% are currently women, and the number of women veterans is expected to increase. Women veterans have higher rates of cardiovascular disease than civilian women and present a uniqu...

journal_title：Circulation

authors： Han JK,Yano EM,Watson KE,Ebrahimi R

更新日期：2019-02-19 00:00:00

abstract：BACKGROUND:Symptomatic prolonged sinus pauses on termination of atrial fibrillation (AF) are an indication for pacemaker implantation. We evaluated sinus node function and clinical outcome in patients with prolonged sinus pauses on termination of arrhythmia who underwent ablation of paroxysmal AF. METHODS AND RESULTS:...

journal_title：Circulation

authors： Hocini M,Sanders P,Deisenhofer I,Jaïs P,Hsu LF,Scavée C,Weerasoriya R,Raybaud F,Macle L,Shah DC,Garrigue S,Le Metayer P,Clémenty J,Haïssaguerre M

更新日期：2003-09-09 00:00:00

abstract：BACKGROUND:Autograft reinforcement interventions (R) during the Ross procedure are intended to preserve autograft function and improve durability. The aim of this study is to evaluate this hypothesis. METHODS AND RESULTS:1335 adult patients (mean age:43.5+/-12.0 years) underwent a Ross procedure (subcoronary, SC, n=63...

journal_title：Circulation

authors： Charitos EI,Hanke T,Stierle U,Robinson DR,Bogers AJ,Hemmer W,Bechtel M,Misfeld M,Gorski A,Boehm JO,Rein JG,Botha CA,Lange R,Hoerer J,Moritz A,Wahlers T,Franke UF,Breuer M,Ferrari-Kuehne K,Hetzer R,Huebler M,Ziem

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND:Interleukin-8 (IL-8) secreted from endothelial cells is a powerful neutrophil chemoattractant and activator. We hypothesized that human endothelial cells deprived of oxygen would secrete IL-8, which might translate into elevated IL-8 production after cardiac ischemia. Furthermore, we hypothesized that corona...

journal_title：Circulation

authors： Oz MC,Liao H,Naka Y,Seldomridge A,Becker DN,Michler RE,Smith CR,Rose EA,Stern DM,Pinsky DJ

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Left ventricular (LV) mass is an important predictor of heart failure and cardiovascular mortality, yet determinants of LV mass are incompletely understood. Pulmonary hyperinflation in chronic obstructive pulmonary disease (COPD) may contribute to changes in intrathoracic pressure that increase LV wall stres...

journal_title：Circulation

authors： Smith BM,Kawut SM,Bluemke DA,Basner RC,Gomes AS,Hoffman E,Kalhan R,Lima JA,Liu CY,Michos ED,Prince MR,Rabbani L,Rabinowitz D,Shimbo D,Shea S,Barr RG

更新日期：2013-04-09 00:00:00

abstract：BACKGROUND:In this study, we both investigated coronary flow velocity in hypertrophic obstructive cardiomyopathy (HOCM) and tested the hypothesis of differing coronary flow reserve (CFR) of coronary arteries perfusing left ventricular regions with nonuniform myocardial hypertrophy by measuring the relative CFR. METHOD...

journal_title：Circulation

authors： Kyriakidis MK,Dernellis JM,Androulakis AE,Kelepeshis GA,Barbetseas J,Anastasakis AN,Trikas AG,Tentolouris CA,Gialafos JE,Toutouzas PK

更新日期：1997-08-05 00:00:00

abstract：BACKGROUND:Muscle sympathetic nerve activity (MSNA) is increased in patients with obstructive sleep apnea (OSA). We tested the hypothesis that tonic activation of excitatory chemoreceptor afferents contributes to the elevated sympathetic activity in OSA. METHODS AND RESULTS:Using a double-blind, randomized, vehicle-co...

journal_title：Circulation

authors： Narkiewicz K,van de Borne PJ,Montano N,Dyken ME,Phillips BG,Somers VK

更新日期：1998-03-17 00:00:00

abstract：BACKGROUND:In large mammals and humans, the contribution of IKs to ventricular repolarization is still incompletely understood. METHODS AND RESULTS:In vivo and cellular electrophysiological experiments were conducted to study IKs in canine ventricular repolarization. In conscious dogs, administration of the selective ...

journal_title：Circulation

authors： Volders PG,Stengl M,van Opstal JM,Gerlach U,Spätjens RL,Beekman JD,Sipido KR,Vos MA

更新日期：2003-06-03 00:00:00

abstract：:Recent molecular studies have suggested that viral myocarditis frequently underlies human congestive cardiomyopathy; however, only moderately sensitive and specific techniques were used. Polymerase chain reaction (PCR) gene amplification is a sensitive, specific technique ideally suited for the diagnosis of viral dise...

journal_title：Circulation

authors： Jin O,Sole MJ,Butany JW,Chia WK,McLaughlin PR,Liu P,Liew CC

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Transplantation of ex vivo expanded circulating endothelial progenitor cells (EPCs) from peripheral blood mononuclear cells improves the neovascularization after critical ischemia. However, the origin of the endothelial progenitor lineage and its characteristics have not yet been clearly defined. Therefore, ...

journal_title：Circulation

authors： Urbich C,Heeschen C,Aicher A,Dernbach E,Zeiher AM,Dimmeler S

更新日期：2003-11-18 00:00:00

abstract：BACKGROUND:Diffuse myocardial fibrosis is a final end point in most cardiac diseases. It is missed by the cardiovascular magnetic resonance (CMR) late gadolinium enhancement technique. Currently, quantifying diffuse myocardial fibrosis requires invasive biopsy, with inherent risk and sampling error. We have developed a...

journal_title：Circulation

authors： Flett AS,Hayward MP,Ashworth MT,Hansen MS,Taylor AM,Elliott PM,McGregor C,Moon JC

更新日期：2010-07-13 00:00:00

abstract：BACKGROUND:To further evaluate the mechanism of beta-blocker-induced benefits in heart failure, the relationships between bisoprolol-induced hemodynamic effects and survival were studied during the Cardiac Insufficiency BIsoprolol Study (CIBIS). METHODS AND RESULTS:In 557 patients studied, bisoprolol significantly red...

journal_title：Circulation

authors： Lechat P,Escolano S,Golmard JL,Lardoux H,Witchitz S,Henneman JA,Maisch B,Hetzel M,Jaillon P,Boissel JP,Mallet A

更新日期：1997-10-07 00:00:00

abstract：BACKGROUND:Calcineurin is a calcium-regulated phosphatase that plays a major role in cardiac hypertrophy. We previously described that alternative splicing of the calcineurin Aβ (CnAβ) gene generates the CnAβ1 isoform, with a unique C-terminal region that is different from the autoinhibitory domain present in all other...

journal_title：Circulation

authors： Felkin LE,Narita T,Germack R,Shintani Y,Takahashi K,Sarathchandra P,López-Olañeta MM,Gómez-Salinero JM,Suzuki K,Barton PJ,Rosenthal N,Lara-Pezzi E

更新日期：2011-06-21 00:00:00

abstract：:The effects of verapamil (0.02-0.2 mg/kg) on contractility in normal and partially ischemic myocardium were compared with the changes following propranolol (0.01-1.0 mg/kg). Regional contractile function was studied in open-chest dogs with ultrasonic crystals and ischemia was controlled by graded occlusion of a caroti...

journal_title：Circulation

authors： Smith HJ,Goldstein RA,Griffith JM,Kent KM,Epstein SE

更新日期：1976-10-01 00:00:00

abstract：BACKGROUND:The lysyl oxidases are extracellular copper enzymes that initiate the crosslinking of collagens and elastin, 5 human isoenzymes having been characterized so far. The crosslinks formed provide the tensile strength and elastic properties for various extracellular matrices, including vascular walls. We studied ...

journal_title：Circulation

authors： Mäki JM,Räsänen J,Tikkanen H,Sormunen R,Mäkikallio K,Kivirikko KI,Soininen R

更新日期：2002-11-05 00:00:00

abstract：BACKGROUND:In the past few years, although significant efforts have been made to assess flow distribution during retrograde cerebral perfusion with microspheres, dye, or hydrogen clearance, flow distribution in real time is still undefined. We used MR perfusion imaging to monitor flow distribution in the brain during a...

journal_title：Circulation

authors： Ye J,Ryner LN,Kozlowski P,Yang L,Del Bigio MR,Sun J,Donnelly M,Summers R,Salerno TA,Somorjai RL,Saunders JK,Deslauriers R

更新日期：1998-11-10 00:00:00

abstract：:Vasodilatory or vasoconstrictive renal pharmacoangiography was applied in investigating the significance of 50 renal artery stenoses. The technique involves comparison of selective magnification renal arteriograms before and after intra-arterial injection of epinephrine or acetylcholine, seeking changes in direction o...

journal_title：Circulation

authors： Bookstein JJ,Walter JF,Stanley JC,Fry WJ

更新日期：1976-08-01 00:00:00