Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans.

abstract：BACKGROUND:Atherosclerosis is complicated by cardiovascular events such as myocardial infarction, stroke, or peripheral arterial occlusive disease. Inflammation and pathological neovascularization are thought to precipitate plaque rupture or erosion, both causes of arterial thrombosis and cardiovascular events. We test...

journal_title：Circulation

authors： Fleiner M,Kummer M,Mirlacher M,Sauter G,Cathomas G,Krapf R,Biedermann BC

更新日期：2004-11-02 00:00:00

abstract：BACKGROUND:Biventricular direct cardiac compression (DCC) can potentially support the failing heart without the complications associated with a blood/device interface. The effect of uniform DCC on left and right ventricular performance was evaluated in 7 isolated canine heart preparations. METHODS AND RESULTS:A comput...

journal_title：Circulation

authors： Artrip JH,Wang J,Leventhal AR,Tsitlik JE,Levin HR,Burkhoff D

更新日期：1999-04-27 00:00:00

abstract：BACKGROUND:Doppler echocardiography is frequently used to predict filling pressures in normal sinus rhythm, but it is unknown whether it can be applied in sinus tachycardia, with merging of E and A velocities. Tissue Doppler imaging (TDI) can record the mitral annular velocity. The early diastolic velocity (Ea) behaves...

journal_title：Circulation

authors： Nagueh SF,Mikati I,Kopelen HA,Middleton KJ,Quiñones MA,Zoghbi WA

更新日期：1998-10-20 00:00:00

abstract：BACKGROUND:Chemokines play an essential role in regulating the infiltration of leukocytes into allografts in experimental models. Little is known of their expression or function after human cardiac transplantation. METHODS AND RESULTS:We analyzed 169 sequential human endomyocardial biopsies by immunocytochemistry for ...

journal_title：Circulation

authors： Melter M,Exeni A,Reinders ME,Fang JC,McMahon G,Ganz P,Hancock WW,Briscoe DM

更新日期：2001-11-20 00:00:00

abstract：BACKGROUND:Administration of protease inhibitors (PIs) to HIV-infected individuals has been associated with hyperlipidemia. In this study, we characterized the lipoprotein profile in subjects receiving ritonavir, indinavir, or nelfinavir, alone or in combination with saquinavir. METHODS AND RESULTS:Plasma lipoprotein ...

journal_title：Circulation

authors： Périard D,Telenti A,Sudre P,Cheseaux JJ,Halfon P,Reymond MJ,Marcovina SM,Glauser MP,Nicod P,Darioli R,Mooser V

更新日期：1999-08-17 00:00:00

abstract：BACKGROUND:Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. METHODS:ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcom...

journal_title：Circulation

authors： Steg PG,Szarek M,Bhatt DL,Bittner VA,Brégeault MF,Dalby AJ,Diaz R,Edelberg JM,Goodman SG,Hanotin C,Harrington RA,Jukema JW,Lecorps G,Mahaffey KW,Moryusef A,Ostadal P,Parkhomenko A,Pordy R,Roe MT,Tricoci P,Vogel R

更新日期：2019-07-09 00:00:00

abstract：:The modulated receptor hypothesis states that sodium channels have a specific receptor for antiarrhythmic drugs. Therefore, two agents that block sodium channels by binding to this receptor are expected to compete for occupancy. Glycylxylidide (GX) is a deethylated metabolite of lidocaine that accumulates in patients ...

journal_title：Circulation

authors： Bennett PB,Woosley RL,Hondeghem LM

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Higher levels of physical activity are associated with fewer cardiovascular disease (CVD) events. Although the precise mechanisms underlying this inverse association are unclear, differences in several cardiovascular risk factors may mediate this effect. METHODS AND RESULTS:In a prospective study of 27,055 ...

journal_title：Circulation

authors： Mora S,Cook N,Buring JE,Ridker PM,Lee IM

更新日期：2007-11-06 00:00:00

abstract：:In rats, atrial natriuretic factor (ANF) reduces sympathetic nerve activity (SNA) reflexively by sensitizing cardiac mechanoreceptors with inhibitory vagal afferents. We performed three series of experiments in 26 normal young men to document whether ANF inhibits SNA in humans and if so, to determine potential mechani...

journal_title：Circulation

authors： Floras JS

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle a...

journal_title：Circulation

authors： Ranchoux B,Antigny F,Rucker-Martin C,Hautefort A,Péchoux C,Bogaard HJ,Dorfmüller P,Remy S,Lecerf F,Planté S,Chat S,Fadel E,Houssaini A,Anegon I,Adnot S,Simonneau G,Humbert M,Cohen-Kaminsky S,Perros F

更新日期：2015-03-17 00:00:00

abstract：:Many basic concepts of cardiac output and arterial pressure control have changed considerably in the past few years. In general, each tissue controls its own local resistance and blood flow regardless of the level of arterial pressure; the sum of the local flows then determines the venous return and cardiac output. Ho...

journal_title：Circulation

authors： Guyton AC

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:Chronic orthostatic intolerance (OI) is characterized by symptoms of inadequate cerebral perfusion with standing, in the absence of significant orthostatic hypotension. A heart rate increase of >/=30 bpm is typical. Possible underlying pathophysiologies include hypovolemia, partial dysautonomia, or a primary...

journal_title：Circulation

authors： Jacob G,Shannon JR,Costa F,Furlan R,Biaggioni I,Mosqueda-Garcia R,Robertson RM,Robertson D

更新日期：1999-04-06 00:00:00

abstract：:A clinical study was conducted to evaluate the efficacy and safety of percutaneous coronary excimer laser angioplasty in 60 patients with coronary artery disease. Forty-nine patients had stable exertional angina, and 11 patients had unstable angina despite medical therapy. A novel 1.4-mm diameter catheter with 20 quar...

journal_title：Circulation

authors： Karsch KR,Haase KK,Voelker W,Baumbach A,Mauser M,Seipel L

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Oxidized low-density lipoprotein plays a key role in the initiation, progression, and destabilization of atherosclerotic plaques and is present in macrophages and the lipid pool. The aim of this study was to assess the feasibility of magnetic resonance imaging of atherosclerotic lesions in mice using micelle...

journal_title：Circulation

authors： Briley-Saebo KC,Shaw PX,Mulder WJ,Choi SH,Vucic E,Aguinaldo JG,Witztum JL,Fuster V,Tsimikas S,Fayad ZA

更新日期：2008-06-24 00:00:00

abstract：BACKGROUND:Angiography of the coronary arteries reflects only changes in luminal dimensions. With intravascular ultrasound, cross-sectional images can be obtained and area measurements can be added to calculate volumes of the external elastic membrane (EEM), plaque plus media (P+M), and lumen. The aim of this study was...

journal_title：Circulation

authors： Jensen LO,Thayssen P,Pedersen KE,Stender S,Haghfelt T

更新日期：2004-07-20 00:00:00

abstract：BACKGROUND:Ghrelin is a novel growth hormone-releasing peptide that has been shown to improve cachexia in heart failure and cancer and to ameliorate the hemodynamic and metabolic disturbances in septic shock. Because cytokine-induced inflammation is critical in these pathological states and because the growth hormone s...

journal_title：Circulation

authors： Li WG,Gavrila D,Liu X,Wang L,Gunnlaugsson S,Stoll LL,McCormick ML,Sigmund CD,Tang C,Weintraub NL

更新日期：2004-05-11 00:00:00

abstract：:Depression of myocardial conduction velocity can be an important mechanism of action of antiarrhythmic drugs but it can also facilitate arrhythmogenesis. We used lidocaine in an anesthetized canine preparation to address the hypothesis that drug-induced rate-dependent conduction velocity depression causes ventricular ...

journal_title：Circulation

authors： Anderson KP,Walker R,Lux RL,Ershler PR,Menlove R,Williams MR,Krall R,Moddrelle D

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:The clinical significance and pathophysiological mechanisms of reverse redistribution on stress-redistribution thallium-201 myocardial scintigraphy in patients with chronic coronary artery disease are unclear. Recent studies have shown that thallium-201 reinjection is a useful technique for the detection of ...

journal_title：Circulation

authors： Marin-Neto JA,Dilsizian V,Arrighi JA,Freedman NM,Perrone-Filardi P,Bacharach SL,Bonow RO

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Sympathetic activation and respiratory abnormalities may each be implicated in the pathophysiology of congestive heart failure (CHF). Chemoreflexes are an important mechanism regulating both sympathetic drive and breathing. We therefore tested the hypothesis that chemoreflex function is altered in CHF. METH...

journal_title：Circulation

authors： Narkiewicz K,Pesek CA,van de Borne PJ,Kato M,Somers VK

更新日期：1999-07-20 00:00:00

abstract：BACKGROUND:It has been proposed that bone marrow-derived cells infiltrate the neointima, where they differentiate into smooth muscle (SM) cells; however, technical limitations have hindered clear identification of the lineages of bone marrow-derived "SM cell-like" cells. METHODS AND RESULTS:Using a specific antibody a...

journal_title：Circulation

authors： Iwata H,Manabe I,Fujiu K,Yamamoto T,Takeda N,Eguchi K,Furuya A,Kuro-o M,Sata M,Nagai R

更新日期：2010-11-16 00:00:00

abstract：BACKGROUND:Aspirin is effective for the primary prevention of cardiovascular events, but it remains unclear for which subgroups of individuals aspirin is beneficial. We assessed the cost-effectiveness of aspirin separately for men and women of different ages with various levels of cardiovascular disease risk. METHODS ...

journal_title：Circulation

authors： Greving JP,Buskens E,Koffijberg H,Algra A

更新日期：2008-06-03 00:00:00

abstract：BACKGROUND:We tested the hypothesis that real-time magnetic resonance imaging (MRI) can guide coronary artery catheterization in swine via a percutaneous femoral artery approach. METHODS AND RESULTS:In 12 pigs, we accessed femoral arteries percutaneously. We used 6- or 7-French coronary Judkins catheters filled with d...

journal_title：Circulation

authors： Omary RA,Green JD,Schirf BE,Li Y,Finn JP,Li D

更新日期：2003-06-03 00:00:00

abstract：:The endogenous opioid system includes three major families of peptides: dynorphins (derived from pre-proenkephalin B), endorphins (derived from pre-proopiomelanocortin), and enkephalins (derived from pre-proenkephalin A). Multiple species of opioid peptides are derived from these major precursors and many of them poss...

journal_title：Circulation

authors： Feuerstein G,Sirén AL

更新日期：1987-01-01 00:00:00

abstract：:The effect of bretylium tosylate (BT) was determined in 27 consecutive cases of resistant ventricular fibrillation (VF) encountered by a hospital cardiac arrest team. The VF was sustained and completely resistant to multiple injections of lidocaine, sequential DC shocks at 400 watt-sec and one or a combination of intr...

journal_title：Circulation

authors： Holder DA,Sniderman AD,Fraser G,Fallen EL

更新日期：1977-03-01 00:00:00

abstract：BACKGROUND:Thirteen of 14 epidemiological studies have shown an increased risk of approximately 20% for coronary heart disease (CHD) for never-smokers exposed to environmental tobacco smoke (ETS), but this association remains controversial. If true, ETS might account for an estimated 35,000 to 40,000 heart disease deat...

journal_title：Circulation

authors： Steenland K,Thun M,Lally C,Heath C Jr

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:Factors predicting the occurrence of premature coronary artery disease (CAD) may not be quantitatively the same as those predicting CAD severity, particularly in women, in whom there have been few studies. METHODS AND RESULTS:To determine factors predictive of severity of CAD and of angina pectoris, we docu...

journal_title：Circulation

authors： Wang XL,Tam C,McCredie RM,Wilcken DE

更新日期：1994-05-01 00:00:00

abstract：:Coronary occlusion in the dog results in irreversible myocardial cell injury which develops first in subendocardial areas of severe ischemica and subsequently spreads into mid and subepicardial areas of moderate ischemia. The effect of propranolol on this progression of ischemic injury was evaluated. Three groups of d...

journal_title：Circulation

authors： Rasmussen MM,Reimer KA,Kloner RA,Jennings RB

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:The impact of cyclooxygenase (COX)-2 antagonist treatment on acute coronary risk is controversial. We investigated the effect of prolonged COX-2 inhibition on inflammatory profile and endothelial function in patients with ischemic heart disease and high serum C-reactive protein (CRP) values. METHODS AND RES...

journal_title：Circulation

authors： Bogaty P,Brophy JM,Noel M,Boyer L,Simard S,Bertrand F,Dagenais GR

更新日期：2004-08-24 00:00:00

abstract：BACKGROUND:Ischemic preconditioning attenuates the effects of subsequent sustained ischemia by a mechanism involving adenosine and G proteins in several species. Adenosine is not involved in ischemic preconditioning of rat hearts, the mechanisms of which are poorly understood. METHODS AND RESULTS:Reduction of isometri...

journal_title：Circulation

authors： Hu K,Nattel S

更新日期：1995-10-15 00:00:00

abstract：:To determine how survival and clinical status were related to left ventricular (LV) size and systolic function after mitral valve replacement, 104 patients (48 mitral regurgitation [MR], 33 mitral stenosis [MS], and 23 MS/MR) with isolated mitral valve replacement were evaluated before and after surgery. Preoperative ...

journal_title：Circulation

authors： Crawford MH,Souchek J,Oprian CA,Miller DC,Rahimtoola S,Giacomini JC,Sethi G,Hammermeister KE

更新日期：1990-04-01 00:00:00