Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes.

Abstract:

BACKGROUND:Oxidized low-density lipoprotein plays a key role in the initiation, progression, and destabilization of atherosclerotic plaques and is present in macrophages and the lipid pool. The aim of this study was to assess the feasibility of magnetic resonance imaging of atherosclerotic lesions in mice using micelles containing gadolinium and murine (MDA2 and E06) or human (IK17) antibodies that bind unique oxidation-specific epitopes. METHODS AND RESULTS:MDA2 micelles, E06 micelles, IK17 micelles, nonspecific IgG micelles, and untargeted micelles (no antibody) were prepared and characterized with respect to pharmacokinetics and biodistribution in wild-type and atherosclerotic apolipoprotein E-deficient (apoE(-/-)) mice. Magnetic resonance imaging was performed at 9.4 T over a 96-hour time interval after the administration of 0.075-mmol Gd/kg micelles. MDA2, E06, and IK17 micelles exhibited a longer plasma half-life than IgG or untargeted micelles in apoE(-/-) but not wild-type mice. In apoE(-/-) mice, MDA2 and IK17 micelles showed maximal arterial wall uptake at 72 hours and E06 micelles at 96 hours, manifested by 125% to 231% enhancement in magnetic resonance signal compared with adjacent muscle. Confocal microscopy revealed that MDA2, IK17, and E06 micelles accumulated within atherosclerotic lesions and specifically within macrophages. Intravenous injection of free MDA2 before imaging with MDA2 micelles resulted in significantly diminished magnetic resonance signal enhancement. IgG micelles and untargeted micelles showed minimal enhancement in apoE(-/-) mice. There was no significant signal enhancement with all micelles in wild-type mice. CONCLUSIONS:Magnetic resonance imaging with micelles containing gadolinium and oxidation-specific antibodies demonstrates specific targeting and excellent image quality of oxidation-rich atherosclerotic lesions.

journal_name

Circulation

journal_title

Circulation

authors

Briley-Saebo KC,Shaw PX,Mulder WJ,Choi SH,Vucic E,Aguinaldo JG,Witztum JL,Fuster V,Tsimikas S,Fayad ZA

doi

10.1161/CIRCULATIONAHA.107.757120

subject

Has Abstract

pub_date

2008-06-24 00:00:00

pages

3206-15

issue

25

eissn

0009-7322

issn

1524-4539

pii

CIRCULATIONAHA.107.757120

journal_volume

117

pub_type

杂志文章
  • Introduction to the Analysis of Survival Data in the Presence of Competing Risks.

    abstract::Competing risks occur frequently in the analysis of survival data. A competing risk is an event whose occurrence precludes the occurrence of the primary event of interest. In a study examining time to death attributable to cardiovascular causes, death attributable to noncardiovascular causes is a competing risk. When ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.115.017719

    authors: Austin PC,Lee DS,Fine JP

    更新日期:2016-02-09 00:00:00

  • Comparison of myocardial preservation with hypothermic potassium and nifedipine arrest.

    abstract::Preservation of regional myocardial function, high-energy phosphate stores and ultrastructure were assessed in 28 canine hearts subjected to 2 hours of global ischemia at either 12 degrees C or 21 degrees C. The preservation achieved with a potassium arrest solution was simultaneously compared in the same heart with e...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Johnson RG,Jacocks MA,Aretz TH,Geffin GA,O'Keefe DD,DeBoer LW,Guyton RA,Fallon JT,Daggett WM

    更新日期:1982-08-01 00:00:00

  • Survival after coronary artery bypass surgery in specific patient groups.

    abstract::The results of coronary bypass 5-10 years after operation at the Baylor College of Medicine are reported. The late results demonstrate that good relief of symptoms of angina pectoris persisted in 89% of patients at 10 years of follow-up. An overall annual attrition rate of 3% has been fairly constant through 10 years ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.65.7.43

    authors: Lawrie GM,Morris GC Jr

    更新日期:1982-06-01 00:00:00

  • Body fat distribution and risk of coronary heart disease in men and women in the European Prospective Investigation Into Cancer and Nutrition in Norfolk cohort: a population-based prospective study.

    abstract:BACKGROUND:Body fat distribution has been cross-sectionally associated with atherosclerotic disease risk factors, but the prospective relation with coronary heart disease remains uncertain. METHODS AND RESULTS:We examined the prospective relation between fat distribution indices and coronary heart disease among 24,508...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.673756

    authors: Canoy D,Boekholdt SM,Wareham N,Luben R,Welch A,Bingham S,Buchan I,Day N,Khaw KT

    更新日期:2007-12-18 00:00:00

  • Evidence for microvascular dysfunction in hypertrophic cardiomyopathy: new insights from multiparametric magnetic resonance imaging.

    abstract:BACKGROUND:Microvascular dysfunction in hypertrophic cardiomyopathy (HCM) may create an ischemic substrate conducive to sudden death, but it remains unknown whether the extent of hypertrophy is associated with proportionally poorer perfusion reserve. Comparisons between magnitude of hypertrophy, impairment of perfusion...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.657023

    authors: Petersen SE,Jerosch-Herold M,Hudsmith LE,Robson MD,Francis JM,Doll HA,Selvanayagam JB,Neubauer S,Watkins H

    更新日期:2007-05-08 00:00:00

  • Trans-fatty acids intake and risk of myocardial infarction.

    abstract:BACKGROUND:Concern that trans-fatty acids formed in the partial hydrogenation of vegetable oils may increase the risk of coronary disease has existed for several decades, but direct evidence on this relation in humans is limited. METHODS AND RESULTS:With a case-control design, we studied the association between intake...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.89.1.94

    authors: Ascherio A,Hennekens CH,Buring JE,Master C,Stampfer MJ,Willett WC

    更新日期:1994-01-01 00:00:00

  • Indium-111 platelet scintigraphy for the diagnosis of acute venous thrombosis.

    abstract::Platelets labeled with indium-111 have been used successfully as a marker of active thrombosis in man. To establish the diagnostic accuracy of platelet scintigraphy in comparison to contrast venography in the diagnosis of acute lower limb venous thrombosis, we evaluated 103 consecutive patients divided into two groups...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.73.4.668

    authors: Ezekowitz MD,Pope CF,Sostman HD,Smith EO,Glickman M,Rapoport S,Sniderman KW,Friedlaender G,Pelker RR,Taylor FB

    更新日期:1986-04-01 00:00:00

  • Effect of the ouabain-quinidine interaction on left ventricular and left atrial function in conscious dogs.

    abstract::The effect of the ouabain-quinidine interaction was examined in 10 conscious dogs. Left ventricular (LV) pressure, LV dP/dt, LV diameter and left atrial (LA) diameter were measured with high-fidelity micromanometers and sonomicrometer crystals. Ouabain, 0.025 mg/kg, significantly (p less than 0.05) increased LV dP/dt,...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.67.5.1054

    authors: Goldman S,Hager WD,Olajos M,Perrier D,Mayersohn M

    更新日期:1983-05-01 00:00:00

  • Women have higher left ventricular ejection fractions than men independent of differences in left ventricular volume: the Dallas Heart Study.

    abstract:BACKGROUND:Although gender-specific criteria are common for defining cardiac traits such as left ventricular hypertrophy, left ventricular ejection fraction (LVEF) thresholds widely used in clinical practice have traditionally been the same for women and men, perhaps because it remains uncertain whether there is a syst...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.574400

    authors: Chung AK,Das SR,Leonard D,Peshock RM,Kazi F,Abdullah SM,Canham RM,Levine BD,Drazner MH

    更新日期:2006-03-28 00:00:00

  • Radiofrequency catheter ablation of atrial flutter. Further insights into the various types of isthmus block: application to ablation during sinus rhythm.

    abstract:BACKGROUND:Radiofrequency ablation of type 1 atrial flutter (AF1) has recently evolved toward an anatomically guided procedure directed to isthmuses at the lower part of the right atrium (RA). However, different types of block at these isthmuses may be observed and potentially correlated with different late outcomes. I...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.94.12.3204

    authors: Poty H,Saoudi N,Nair M,Anselme F,Letac B

    更新日期:1996-12-15 00:00:00

  • Paclitaxel-Coated Balloons and Eluting Stents: Is There a Mortality Risk in Patients With Peripheral Artery Disease?

    abstract::Paclitaxel drug-coated balloons and drug-eluting stents became commercially available for the treatment of intermittent claudication in 2015 and 2012, respectively. Both devices demonstrated superiority in limb revascularization compared with non-paclitaxel-coated devices and were rapidly accepted into clinical practi...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.041099

    authors: Beckman JA,White CJ

    更新日期:2019-10-15 00:00:00

  • Renal function and urate metabolism in late survivors with cyanotic congenital heart disease.

    abstract::Diminished glomerular filtration rate, proteinuria, and large hypercellular congested glomeruli with segmental sclerosis are found in late survivors with cyanotic congenital heart disease (CCHD). Hyperuricemia is common, acute gouty arthritis is less common than uric acid levels would predict, and overt tophaceous dep...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.73.3.396

    authors: Ross EA,Perloff JK,Danovitch GM,Child JS,Canobbio MM

    更新日期:1986-03-01 00:00:00

  • Prediction of improvement of regional left ventricular function after surgical revascularization. A comparison of low-dose dobutamine echocardiography with 201Tl single-photon emission computed tomography.

    abstract:BACKGROUND:Although both 201Tl scintigraphy and low-dose dobutamine echocardiography (LDDE) have been proposed as effective methods of assessing myocardial viability, their relative efficacies are unknown. The aim of the present study was to compare the two imaging techniques in the prediction of improvement of regiona...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.91.11.2748

    authors: Arnese M,Cornel JH,Salustri A,Maat A,Elhendy A,Reijs AE,Ten Cate FJ,Keane D,Balk AH,Roelandt JR

    更新日期:1995-06-01 00:00:00

  • Metabolic Predictors of Incident Coronary Heart Disease in Women.

    abstract:BACKGROUND:Although metabolomic profiling offers promise for the prediction of coronary heart disease (CHD), and metabolic risk factors are more strongly associated with CHD in women than men, limited data are available for women. METHODS:We applied a liquid chromatography-tandem mass spectrometry metabolomics platfor...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.117.029468

    authors: Paynter NP,Balasubramanian R,Giulianini F,Wang DD,Tinker LF,Gopal S,Deik AA,Bullock K,Pierce KA,Scott J,Martínez-González MA,Estruch R,Manson JE,Cook NR,Albert CM,Clish CB,Rexrode KM

    更新日期:2018-02-20 00:00:00

  • Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia.

    abstract:BACKGROUND:The release of endothelium-derived relaxing factors has been shown experimentally to be of pivotal importance for the maintenance of coronary blood flow during increased demand. In humans with coronary atherosclerosis, endothelial vasodilator dysfunction is not confined only to epicardial conductance vessels...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.91.9.2345

    authors: Zeiher AM,Krause T,Schächinger V,Minners J,Moser E

    更新日期:1995-05-01 00:00:00

  • Observational comparison of event-free survival with medical and surgical therapy in patients with coronary artery disease. 20 years of follow-up.

    abstract:BACKGROUND:The purpose of this study was to describe the long-term event-free survival patterns of patients with significant coronary artery disease treated medically versus patterns of those treated surgically and to evaluate the factors associated with improved event-free survival. METHODS AND RESULTS:We studied the...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Muhlbaier LH,Pryor DB,Rankin JS,Smith LR,Mark DB,Jones RH,Glower DD,Harrell FE Jr,Lee KL,Califf RM

    更新日期:1992-11-01 00:00:00

  • Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study.

    abstract:BACKGROUND:Biomarkers that predict response to cardiac resynchronization therapy (CRT) in heart failure patients with dyssynchrony (HFDYS) would be clinically important. Circulating extracellular microRNAs (miRNAs) have emerged as novel biomarkers that may also play important functional roles, but their relevance as ma...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.114.013220

    authors: Melman YF,Shah R,Danielson K,Xiao J,Simonson B,Barth A,Chakir K,Lewis GD,Lavender Z,Truong QA,Kleber A,Das R,Rosenzweig A,Wang Y,Kass D,Singh JP,Das S

    更新日期:2015-06-23 00:00:00

  • The cellular electrophysiologic changes induced by ablation: comparison between argon laser photoablation and high-energy electrical ablation.

    abstract::The cellular electrophysiologic effects of myocardial ablation performed in vitro with argon laser energy were compared with those of high-energy electrical shocks. A border zone of injured but nonnecrotic tissue surrounding the site of energy delivery was present after tissue ablation by both energy modalities. A dec...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.76.1.217

    authors: Levine JH,Merillat JC,Stern M,Weisman HF,Kadish AH,Moore EN,Spear JF,Fonger J,Guarnieri T

    更新日期:1987-07-01 00:00:00

  • Role of the sympathetic nervous system in the genesis of ventricular arrhythmia.

    abstract::Activation of the sympathetic nervous system is an important factor in the genesis of ventricular arrhythmias in patients with impaired ventricular function. Such patients have an appropriate substrate that is capable of generating rhythm abnormalities, which may be related to enhanced automaticity, triggered automati...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:

    authors: Podrid PJ,Fuchs T,Candinas R

    更新日期:1990-08-01 00:00:00

  • Increased diastolic chamber stiffness during demand ischemia: response to quick length change differentiates rigor-activated from calcium-activated tension.

    abstract:BACKGROUND:Increased diastolic chamber stiffness (increased DCS) during angina (demand ischemia) has been postulated to be generated by increased diastolic myocyte calcium concentration. METHODS AND RESULTS:We reproduced demand ischemia in isolated isovolumically contracting red-cell-perfused rabbit hearts by imposing...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.101.18.2185

    authors: Varma N,Eberli FR,Apstein CS

    更新日期:2000-05-09 00:00:00

  • Role of endogenous atrial natriuretic peptide in DOCA-salt hypertensive rats. Effects of a novel nonpeptide antagonist for atrial natriuretic peptide receptor.

    abstract:BACKGROUND:To explore roles of endogenous atrial natriuretic peptide (ANP) in blood pressure and volume regulation, we examined the effects of a newly developed ANP antagonist, HS-142-1 (HS) in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. METHODS AND RESULTS:We examined 1) the effects of HS on ANP- or br...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.87.2.554

    authors: Hirata Y,Matsuoka H,Suzuki E,Hayakawa H,Sugimoto T,Matsuda Y,Morishita Y,Kangawa K,Minamino N,Matsuo H

    更新日期:1993-02-01 00:00:00

  • The role of right and left ventricular function in the ventilatory response to exercise in chronic heart failure.

    abstract:BACKGROUND:Right ventricular function may be an important determinant of exercise capacity, peak oxygen consumption (VO2), and the ventilatory response to carbon dioxide production (VE/VCO2 relation) in patients with chronic heart failure (CHF). METHODS AND RESULTS:We studied the role of right ventricular function in ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.89.5.2062

    authors: Clark AL,Swan JW,Laney R,Connelly M,Somerville J,Coats AJ

    更新日期:1994-05-01 00:00:00

  • Regulation of shear stress in the canine coronary microcirculation.

    abstract:BACKGROUND:Physical forces, such as pressure and flow, are well known to affect vascular function in the coronary circulation. Increases in shear stress produce vasodilation in coronary arterioles in vitro, and constant-flow preparations suggest a role for shear stress-induced vasodilation during adjustments to metabol...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.100.14.1555

    authors: Stepp DW,Nishikawa Y,Chilian WM

    更新日期:1999-10-05 00:00:00

  • The effect of L-arginine on myocardial recovery after cardioplegic arrest and ischemia under moderate and deep hypothermia.

    abstract:BACKGROUND:Depletion of L-arginine (L-arg), the substrate for nitric oxide (NO) synthesis, could be one of the mechanisms responsible for the reduced production of NO and decreased coronary flow (CF) during reperfusion. This, in turn, may adversely affect mechanical function. We aimed to study the benefits of exogenous...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Amrani M,Gray CC,Smolenski RT,Goodwin AT,London A,Yacoub MH

    更新日期:1997-11-04 00:00:00

  • Overexpression of heat shock protein 72 in transgenic mice decreases infarct size in vivo.

    abstract:BACKGROUND:Previous studies have demonstrated that induction of heat shock protein (HSP) 72 by whole-body hyperthermia reduces infarct size in an in vivo model of ischemia and reperfusion. Furthermore, hearts obtained from transgenic mice that overexpress HSP72 demonstrate improved functional recovery and decreased inf...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.94.6.1408

    authors: Hutter JJ,Mestril R,Tam EK,Sievers RE,Dillmann WH,Wolfe CL

    更新日期:1996-09-15 00:00:00

  • Efficacy and Safety of a Pharmaco-Invasive Strategy With Half-Dose Alteplase Versus Primary Angioplasty in ST-Segment-Elevation Myocardial Infarction: EARLY-MYO Trial (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI in Acute

    abstract:BACKGROUND:Timely primary percutaneous coronary intervention (PPCI) cannot be offered to all patients with ST-segment-elevation myocardial infarction (STEMI). Pharmaco-invasive (PhI) strategy has been proposed as a valuable alternative for eligible patients with STEMI. We conducted a randomized study to compare the eff...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/CIRCULATIONAHA.117.030582

    authors: Pu J,Ding S,Ge H,Han Y,Guo J,Lin R,Su X,Zhang H,Chen L,He B,EARLY-MYO Investigators.

    更新日期:2017-10-17 00:00:00

  • Novel associations between bioavailable estradiol and adipokines in elderly women with different phenotypes of obesity: implications for atherogenesis.

    abstract:BACKGROUND:Peripheral adiposity confers protection against diabetes and atherosclerosis in elderly women. The underlying mechanisms, however, remain to be elucidated. METHODS AND RESULTS:On the basis on dual-energy X-ray absorptiometry measurements of central fat mass (CFM) and peripheral fat mass (PFM), we identified...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000144470.55149.E5

    authors: Tankó LB,Bruun JM,Alexandersen P,Bagger YZ,Richelsen B,Christiansen C,Larsen PJ

    更新日期:2004-10-12 00:00:00

  • Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age: The Muscatine Study.

    abstract:BACKGROUND:Higher carotid intimal-medial thickness (IMT) is associated with cardiovascular risk factors and is predictive of coronary artery disease and stroke in older adults. Carotid IMT was measured in young and middle-aged adults to determine its relationship with risk factors measured (1) in childhood, (2) current...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/hc4601.099486

    authors: Davis PH,Dawson JD,Riley WA,Lauer RM

    更新日期:2001-12-04 00:00:00

  • Cumulative Blood Pressure Exposure During Young Adulthood and Mobility and Cognitive Function in Midlife.

    abstract:BACKGROUND:High blood pressure (BP) is a known risk factor for mobility and cognitive impairment in older adults. This study tested the association of cumulative BP exposure from young adulthood to midlife with gait and cognitive function in midlife. Furthermore, we tested whether these associations were modified by ce...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.119.042502

    authors: Mahinrad S,Kurian S,Garner CR,Sedaghat S,Nemeth AJ,Moscufo N,Higgins JP,Jacobs DR Jr,Hausdorff JM,Lloyd-Jones DM,Sorond FA

    更新日期:2020-03-03 00:00:00

  • Effects on coagulation and fibrinolysis with reduced versus full systemic heparinization and heparin-coated cardiopulmonary bypass.

    abstract:BACKGROUND:Extracorporeal circulation with circuits coated with surface-bound heparin has allowed reduced levels of systemic heparinization. Clinical benefits have included reduced postoperative bleeding and less homologous blood usage. However, the effects on the hemostatic and fibrinolytic systems have remained in pa...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.92.9.2579

    authors: Ovrum E,Brosstad F,Am Holen E,Tangen G,Abdelnoor M

    更新日期:1995-11-01 00:00:00