Abstract:
BACKGROUND:Angiography of the coronary arteries reflects only changes in luminal dimensions. With intravascular ultrasound, cross-sectional images can be obtained and area measurements can be added to calculate volumes of the external elastic membrane (EEM), plaque plus media (P+M), and lumen. The aim of this study was to investigate the effect of lipid lowering by simvastatin on coronary atherosclerotic P+M as changes in volumes of EEM, P+M, and lumen. METHODS AND RESULTS:In 40 male patients with hypercholesterolemia, ischemic heart disease, and a nonsignificant coronary artery lesion in a not previously revascularized coronary artery, serial intravascular ultrasound studies with an ECG-triggered pullback were performed at baseline, after 3 months on a lipid-lowering diet, and after another 12 months on simvastatin 40 mg/d. Mean length of the analyzed atherosclerotic segments was 5.9+/-3.3 mm. After 12 months on simvastatin, a significant reduction in P+M volume of 6.3% (P=0.002) was observed, whereas only a nonsignificant reduction in EEM volume of 1.8% was seen without any concomitant change in lumen volume. A significant reduction in total cholesterol of 31.0% (6.1+/-0.8 versus 4.2+/-0.7 mmol/L, P<0.001) and LDL cholesterol of 42.6% (4.0+/-0.8 versus 2.2+/-0.6 mmol/L, P<0.001) was obtained. CONCLUSIONS:Lipid-lowering therapy with simvastatin for 12 months is associated with a significant P+M regression in coronary arteries measured as reduction in P+M and EEM volumes without any concomitant change in lumen volume.
journal_name
Circulationjournal_title
Circulationauthors
Jensen LO,Thayssen P,Pedersen KE,Stender S,Haghfelt Tdoi
10.1161/01.CIR.0000135215.75876.41subject
Has Abstractpub_date
2004-07-20 00:00:00pages
265-70issue
3eissn
0009-7322issn
1524-4539pii
01.CIR.0000135215.75876.41journal_volume
110pub_type
临床试验,杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:The overall performance of available mechanical intravascular ultrasound catheters for fetal transesophageal echocardiography during fetoscopic fetal cardiac interventions in sheep has been limited by radioelectronic interference, low system frame rates, and low acoustic outputs. Therefore, a more reliable d...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc4001.097937
更新日期:2001-10-09 00:00:00
abstract:BACKGROUND:Angiotensin-converting enzyme (ACE) inhibition potentiates the tissue-type plasminogen activator (t-PA) response to exogenous bradykinin. This study tested the hypothesis that ACE inhibition increases endothelial t-PA release through endogenous bradykinin. METHODS AND RESULTS:We measured the effect of intra...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.0000046268.59922.a4
更新日期:2003-02-04 00:00:00
abstract:BACKGROUND:Sustained shortening of the atrial effective refractory period (AERP), probably due to reduction in the L-type calcium current, is a major factor in the initiation and maintenance of atrial fibrillation (AF). We investigated underlying molecular changes by studying the relation between gene expression of the...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.5.684
更新日期:2001-02-06 00:00:00
abstract:BACKGROUND:Experimental studies suggest that arterial injury and inflammation lead to increased neointimal growth after stenting. Despite the increased use of coronary stents in humans, there are only limited pathological data on the morphological features of in-stent restenosis. METHODS AND RESULTS:Detailed histology...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000019071.72887.bd
更新日期:2002-06-25 00:00:00
abstract::These types of studies lay the foundation for understanding the human apolipoproteins at the genetic level. In addition, through a few specific examples, we have already shown evidence at the DNA level that lesions in apolipoprotein genes can play a role in human atherosclerosis. This work is in its infancy, but we ho...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.69.6.1190
更新日期:1984-06-01 00:00:00
abstract:BACKGROUND:In the preterm newborn, a patent ductus arteriosus is in large part a result of the increased sensitivity of the immature ductus to prostaglandin E2 (PGE2). PGE2 acts through 3 G protein-coupled receptors (EP2, EP3, and EP4) that activate both adenyl cyclase and K(ATP) channels. We explored these pathways to...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000145159.16637.5D
更新日期:2004-10-19 00:00:00
abstract:BACKGROUND:The outcome of aortic valve replacement in patients with severe aortic stenosis, low transvalvular gradient, and severe left ventricular dysfunction is not well known. METHODS AND RESULTS:Between 1985 and 1995, 52 patients with left ventricular ejection fraction (EF) < or =35% and aortic stenosis with trans...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.16.1940
更新日期:2000-04-25 00:00:00
abstract:BACKGROUND:We measured cardiovagal baroreflex gain and its vascular mechanical and neural components during dynamic baroreflex engagement in 10 young untrained men, 6 older untrained men, and 12 older, physically active men. METHODS AND RESULTS:Our newly developed assessment of beat-to-beat carotid diameters during ba...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.20.2424
更新日期:2001-05-22 00:00:00
abstract::Two hundred-three patients had -echnetium 99m (stannous) pyrophosphate myocardial scintigrams for the evaluation of chest pain and suspected acute myocardial infarction. In addition to routine imaging at 60--90 minutes after injection of the radio-pharmaceutical, the blood pool was imaged immediately in each patient f...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.56.2.192
更新日期:1977-08-01 00:00:00
abstract::This review discusses the role of growth factors on the proliferation of smooth muscle cells (SMCs) in injured arteries. We have used a variety of procedures to injure rat carotid arteries and noted that removal of endothelium followed by platelet adherence does not always initiate SMC replication. Furthermore, thromb...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1992-12-01 00:00:00
abstract::This two-part article provides an overview of the global burden of atherothrombotic cardiovascular disease. Part I initially discusses the epidemiologic transition which has resulted in a decrease in deaths in childhood due to infections, with a concomitant increase in cardiovascular and other chronic diseases; and th...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/hc4601.099487
更新日期:2001-11-27 00:00:00
abstract:BACKGROUND:Vascular inflammatory lesions from patients with giant-cell arteritis show a remarkable amount of neovascularization, but its clinical implications have never been investigated. METHODS AND RESULTS:To assess the clinical relevance of neovascularization in giant-cell arteritis, angiogenesis was measured in t...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.0000030185.67510.c0
更新日期:2002-09-24 00:00:00
abstract::Vigorous hyperventilation was induced for five minutes immediately after a five-minute infusion of 100 ml of Tris-buffer (pH 10) in nine patients with Prinzmetal's variant angina. In eight of the patients, chest pain with ischemic changes in the electrocardiogram occurred during this procedure or within five minutes a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.58.1.56
更新日期:1978-07-01 00:00:00
abstract::Separate effects of perfusion hypothermia, potassium arrest, and procaine arrest were studied in 150 hearts using the isolated rat heart preparation. Aortic flow rate (AFR), coronary flow rate (CFR), and heart rate (HR) were measured before and after ischemic periods of 90 to 300 min. Prior to the ischemic period, the...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1978-09-01 00:00:00
abstract:BACKGROUND:Left ventricular (LV) reconstruction surgery leads to early improvement in LV function in ischemic cardiomyopathy (ICM) patients. This study was designed to evaluate the impact of mitral valve (MV) repair associated with LV reconstruction on LV function 1-year after surgery in ICM patients assessed by real-t...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.0000087653.99527.50
更新日期:2003-09-09 00:00:00
abstract::Guiding surgical therapy of ventricular tachycardia by preoperative endocardial catheter mapping necessitates improvement of the accuracy of localization of the arrhythmogenic site. We therefore used a new mathematical cineradiographic method during catheter mapping to compute the position of left ventricular arrhythm...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.74.6.1346
更新日期:1986-12-01 00:00:00
abstract:OBJECTIVE:To assess the outcome of 3 different surgical approaches for treatment of acute aortic dissection type A (AADA). METHODS AND RESULTS:Between October 1990 and October 2003, we operated on 295 patients (pts) for AADA. Follow-up was complete for 257 pts (87%). Supracommissural replacement (SCR) of the ascending...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000138948.14144.d6
更新日期:2004-09-14 00:00:00
abstract::Factors related to late narrowing of aortocoronary vein grafts are poorly understood. Repeat aortocoronary bypass graft angiography was performed in 34 patients at 13 +/- 5 months and 61 +/- 13 months after surgery. In these patients, 61 of 65 grafts (94%) were patent at 1 year; at 5 years, 39 of these patent grafts (...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1982-08-01 00:00:00
abstract:BACKGROUND:Up to 50% of patients fail to meet ST-segment-elevation myocardial infarction (STEMI) guideline goals recommending a first medical contact-to-device time of <90 minutes for patients directly presenting to percutaneous coronary intervention-capable hospitals and <120 minutes for transferred patients. We sough...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.115.019474
更新日期:2016-08-02 00:00:00
abstract:BACKGROUND:Oxidative stress activates endothelial innate immunity and disrupts endothelial functions, including endothelial nitric oxide synthase-derived nitric oxide bioavailability. Here, we postulated that oxidative stress induces sterol regulatory element-binding protein 2 (SREBP2) and microRNA-92a (miR-92a), which...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.114.013675
更新日期:2015-03-03 00:00:00
abstract:BACKGROUND:Cystic kidneys and vascular aneurysms are clinical manifestations seen in patients with polycystic kidney disease, a cilia-associated pathology (ciliopathy). Survivin overexpression is associated with cancer, but the clinical pathology associated with survivin downregulation or knockout has never been studie...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.005746
更新日期:2014-02-11 00:00:00
abstract:BACKGROUND:Tenascin is a large extracellular matrix glycoprotein generally found in adult tissues undergoing active remodeling such as healing wounds and tumors. To determine the potential role of tenascin-C (TN-C) in the pathophysiology of atherosclerosis, we investigated the pattern of expression of TN-C in human cor...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.10.1284
更新日期:1999-03-16 00:00:00
abstract:BACKGROUND:The influence of changes in heart rate on myocardial contractility (the force-frequency effect) differs under various experimental conditions, including the anesthetized versus the conscious state. METHODS AND RESULTS:To assess the influence of beta-adrenergic stimulation on force-frequency effects on myoca...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.86.2.572
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Our aim was to compare the electron-beam CT (EBCT) features of coronary arteries in heart transplant recipients with those of biplane coronary angiography and intracoronary ultrasound (ICUS). METHODS AND RESULTS:We examined 112 heart transplant recipients (25 female; age, 17 to 69 years; median, 52 years) 1...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.101.17.2078
更新日期:2000-05-02 00:00:00
abstract::To examine whether nicardipine, a dihydropyridine derivative, limits size of myocardial infarction, and to compare the protective effects of nicardipine administered before and early and late after coronary artery occlusion, 99mTc-labeled albumin microspheres were injected into the left atrium during 5 min temporary c...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.74.2.420
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:Albumin microbubbles that are used for contrast echocardiography persist within the myocardial microcirculation after ischemia/reperfusion (I-R). The mechanism responsible for this phenomenon is unknown. METHODS AND RESULTS:Intravital microscopy of the microcirculation of exteriorized cremaster muscle was p...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.6.668
更新日期:2000-02-15 00:00:00
abstract:BACKGROUND:Flowing erythrocytes and platelets are separated from the luminal endothelial cell (EC) surface by a 0.5-microm-wide space named the endothelial surface layer. We hypothesized that the disruption of the endothelial surface layer by oxidized low-density lipoproteins (Ox-LDL) contributes to atherogenic increas...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.13.1500
更新日期:2000-04-04 00:00:00
abstract:BACKGROUND:This study was performed to determine whether chronic cocaine abuse is associated with left ventricular hypertrophy in humans. METHODS AND RESULTS:A consecutive series of 40 chronic cocaine abusers 23-44 years old who were enrolled in an inpatient drug rehabilitation program were considered for the study. S...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.3.1130
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:The cardiovascular adaptation to bed rest leads to orthostatic intolerance, characterized by an excessive fall in stroke volume (SV) in the upright position. We hypothesized that this large fall in SV is due to a change in cardiac mechanics. METHODS AND RESULTS:We measured pulmonary capillary wedge pressure...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.2.517
更新日期:1997-07-15 00:00:00
abstract:BACKGROUND:It is unknown whether adenosine can precondition human myocardium against ischemia in vivo. METHODS AND RESULTS:Thirty patients were randomized to receive a 10-minute intracoronary infusion of adenosine (2 mg/min) or normal saline; 10 minutes later, they underwent percutaneous transluminal coronary angiopla...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.95.11.2500
更新日期:1997-06-03 00:00:00