Pulmonary hyperinflation and left ventricular mass: the Multi-Ethnic Study of Atherosclerosis COPD Study.

abstract：BACKGROUND:Optical mapping of cytosolic calcium transients in intact mammalian hearts is now possible using long-wavelength [Ca(2+)](i) indicators. We propose that beat-to-beat [Ca(2+)](i) transient alternans during ischemia may lead to spatial and temporal heterogeneity of calcium-activated membrane currents. METHODS...

journal_title：Circulation

authors： Qian YW,Clusin WT,Lin SF,Han J,Sung RJ

更新日期：2001-10-23 00:00:00

abstract：:Experimental studies have shown that among dogs with a healed myocardial infarction, depressed baroreflex sensitivity (BRS) identifies a subgroup at higher risk for sudden death. We have examined the relation among BRS, several clinical cardiovascular variables, and subsequent mortality in 78 patients below the age of...

journal_title：Circulation

authors： La Rovere MT,Specchia G,Mortara A,Schwartz PJ

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND:Cardiac growth and function may be modulated in part by trophic effects of neurohormones. Specifically, aldosterone has been shown to stimulate the growth of cardiac myocytes and the accumulation of cardiac extracellular matrix proteins. Moreover, a variant of the aldosterone synthase gene (a cytosine/thymid...

journal_title：Circulation

authors： Schunkert H,Hengstenberg C,Holmer SR,Broeckel U,Luchner A,Muscholl MW,Kürzinger S,Döring A,Hense HW,Riegger GA

更新日期：1999-05-04 00:00:00

abstract：:An asymptomatic 14-year-old male was found at cardiac catheterization to have a coronary artery fistula involving a vessel originating from the left main coronary artery and terminating in the right heart. Chest X-ray and electrocardiogram were within normal limits and shunt flow was too small to be detected by oximet...

journal_title：Circulation

authors： Shubrooks SJ Jr,Naggar CZ

更新日期：1978-01-01 00:00:00

abstract：:The thienopyridines ticlopidine and clopidogrel are inhibitors of platelet function in vivo. Their mode of action has not been defined, but it appears that they require conversion to as yet unidentified metabolites that are noncompetitive antagonists of the platelet ADP receptor. Inhibition of platelet aggregation wit...

journal_title：Circulation

authors： Quinn MJ,Fitzgerald DJ

更新日期：1999-10-12 00:00:00

abstract：:In a series of 416 women with congenital heart disease seen in the Royal Brompton National Heart and Lung Hospital, London, and the Hospital Giovanni Bosco, Torino, Italy, there were 822 pregnancies. The outcomes of 96 pregnancies in 44 patients with cyanotic congenital heart disease were studied. Patients with the Ei...

journal_title：Circulation

authors： Presbitero P,Somerville J,Stone S,Aruta E,Spiegelhalter D,Rabajoli F

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:CD4+CD28null T cells are present in increased numbers in the peripheral blood of patients with acute coronary syndrome (ACS) compared with patients with chronic stable angina (CSA). The triggers of activation and expansion of these cells to date remain unclear. METHODS AND RESULTS:Twenty-one patients with A...

journal_title：Circulation

authors： Zal B,Kaski JC,Arno G,Akiyu JP,Xu Q,Cole D,Whelan M,Russell N,Madrigal JA,Dodi IA,Baboonian C

更新日期：2004-03-16 00:00:00

abstract：BACKGROUND:Identification of genes that are specifically activated in restenosis lesions after percutaneous transluminal angioplasty represents a necessary step toward molecular manipulation designed to inhibit cellular proliferation responsible for such lesions. Whereas quiescent smooth muscle cells (contractile pheno...

journal_title：Circulation

authors： Leclerc G,Isner JM,Kearney M,Simons M,Safian RD,Baim DS,Weir L

更新日期：1992-02-01 00:00:00

abstract：:The electrophysiologic mechanisms for the initiation and termination of re-entrant ventricular arrhythmias (RVA) were critically analyzed in dogs 3-7 days following ligation of the anterior descending coronary artery, utilizing direct recordings of the re-entrant pathway (RP) from the epicardial surface of the infarct...

journal_title：Circulation

authors： El-Sherif N,Hope RR,Scherlag BJ,Lazzara R

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:Several centers favor replacing a diseased native heart valve with a tissue rather than a mechanical prosthesis, even in younger adult patients. However, long-term data supporting this approach are lacking. We examined the survival implications of selecting a tissue versus a mechanical prosthesis at initial ...

journal_title：Circulation

authors： Ruel M,Chan V,Bédard P,Kulik A,Ressler L,Lam BK,Rubens FD,Goldstein W,Hendry PJ,Masters RG,Mesana TG

更新日期：2007-09-11 00:00:00

abstract：:The goal of the present study was to demonstrate that intracoronary platelet deposition may trigger intense vasoconstriction of large epicardial coronary arteries in vivo and that this is largely mediated by thromboxane A2 and serotonin released by activated platelets. Cyclic flow variations (progressive declines in b...

journal_title：Circulation

authors： Golino P,Ashton JH,Buja LM,Rosolowsky M,Taylor AL,McNatt J,Campbell WB,Willerson JT

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:The main goal of the initial treatment of ST-segment elevation myocardial infarction is prompt reperfusion of the infarct-related artery. The value of pretreatment with clopidogrel before primary percutaneous coronary intervention is currently unclear. METHODS AND RESULTS:Studies were retrieved through MEDL...

journal_title：Circulation

authors： Vlaar PJ,Svilaas T,Damman K,de Smet BJ,Tijssen JG,Hillege HL,Zijlstra F

更新日期：2008-10-28 00:00:00

abstract：BACKGROUND:Serum paraoxonase (PON1), an enzyme carried on HDL, inhibits LDL oxidation, and in human population studies, low PON1 activity is associated with atherosclerosis. In addition, PON1 knockout mice are more susceptible to lipoprotein oxidation and atherosclerosis. To evaluate whether PON1 protects against ather...

journal_title：Circulation

authors： Tward A,Xia YR,Wang XP,Shi YS,Park C,Castellani LW,Lusis AJ,Shih DM

更新日期：2002-07-23 00:00:00

abstract：:Background-Homozygosity for a relatively common Cys282Tyr mutation of the human hemochromatosis-associated (HFE) gene was recently found to account for most cases of hereditary hemochromatosis. Because excess iron has been postulated to enhance risk of vascular disease, we studied whether occurrence of this mutation w...

journal_title：Circulation

authors： Tuomainen TP,Kontula K,Nyyssönen K,Lakka TA,Heliö T,Salonen JT

更新日期：1999-09-21 00:00:00

abstract：BACKGROUND:Postmortem interrogations of cardiac implantable electronic devices (CIEDs), recommended at autopsy in suspected cases of sudden cardiac death, are rarely performed, and data on systematic postmortem CIED analysis in the forensic pathology are missing. The aim of the study was to determine whether nonselecti...

journal_title：Circulation

authors： Lacour P,Buschmann C,Storm C,Nee J,Parwani AS,Huemer M,Attanasio P,Boldt LH,Rauch G,Kucher A,Pieske B,Haverkamp W,Blaschke F

更新日期：2018-06-19 00:00:00

abstract：BACKGROUND:Together with pulmonary veins, many extrapulmonary vein areas may be the source of initiation and maintenance of atrial fibrillation. The left atrial appendage (LAA) is an underestimated site of initiation of atrial fibrillation. Here, we report the prevalence of triggers from the LAA and the best strategy f...

journal_title：Circulation

authors： Di Biase L,Burkhardt JD,Mohanty P,Sanchez J,Mohanty S,Horton R,Gallinghouse GJ,Bailey SM,Zagrodzky JD,Santangeli P,Hao S,Hongo R,Beheiry S,Themistoclakis S,Bonso A,Rossillo A,Corrado A,Raviele A,Al-Ahmad A,Wang P,

更新日期：2010-07-13 00:00:00

abstract：BACKGROUND:The endocrine-disrupting chemical bisphenol A (BPA) is widely used in food and beverage packaging. Higher urinary BPA concentrations were cross-sectionally associated with heart disease in National Health and Nutrition Examination Survey (NHANES) 2003-2004 and NHANES 2005-2006, independent of traditional ris...

journal_title：Circulation

authors： Melzer D,Osborne NJ,Henley WE,Cipelli R,Young A,Money C,McCormack P,Luben R,Khaw KT,Wareham NJ,Galloway TS

更新日期：2012-03-27 00:00:00

abstract：BACKGROUND:The goal of this study was to assess the clinical value of stress myocardial perfusion scintigraphy (MPS) in elderly patients (> or =75 years of age). METHODS AND RESULTS:We followed up 5200 elderly patients (41% exercise) after dual-isotope MPS over 2.8+/-1.7 years (362 cardiac deaths [CDs], 7.0%, 2.6%/y) ...

journal_title：Circulation

authors： Hachamovitch R,Kang X,Amanullah AM,Abidov A,Hayes SW,Friedman JD,Cohen I,Thomson LE,Germano G,Berman DS

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:prior studies indicated that ablation of the 4 major atrial ganglionated plexi (GP) suppressed atrial fibrillation. METHODS AND RESULTS:superparamagnetic nanoparticles (MNPs) made of Fe(3)O(4) (core), thermoresponsive polymeric hydrogel (shell), and neurotoxic agent (N-isopropylacrylamide monomer [NIPA-M]) ...

journal_title：Circulation

authors： Yu L,Scherlag BJ,Dormer K,Nguyen KT,Pope C,Fung KM,Po SS

更新日期：2010-12-21 00:00:00

abstract：:Vigorous hyperventilation was induced for five minutes immediately after a five-minute infusion of 100 ml of Tris-buffer (pH 10) in nine patients with Prinzmetal's variant angina. In eight of the patients, chest pain with ischemic changes in the electrocardiogram occurred during this procedure or within five minutes a...

journal_title：Circulation

authors： Yasue H,Nagao M,Omote S,Takizawa A,Miwa K,Tanaka S

更新日期：1978-07-01 00:00:00

abstract：:The predictive value of the myocardial scintigraphy with 99mTc-pyrophosphate was studied in 100 patients admitted to the coronary care unit with suspected acute myocardial infarction. None of the 21 patients with normal scintigrams had acute myocardial infraction by other criteria. Fifty-five percent of patients with ...

journal_title：Circulation

authors： Holman BL,Chisholm RJ,Braunwald E

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND:Aging is associated with increased cardiovascular risk and endothelial dysfunction. Since exercise can improve endothelium-dependent vasodilation, in the present study we tested whether long-term physical activity could prevent aging-related endothelial dysfunction. METHODS AND RESULTS:In 12 young and elder...

journal_title：Circulation

authors： Taddei S,Galetta F,Virdis A,Ghiadoni L,Salvetti G,Franzoni F,Giusti C,Salvetti A

更新日期：2000-06-27 00:00:00

abstract：BACKGROUND:Although black cardiac patients receive fewer revascularization procedures than whites, it is unclear whether this has a detrimental impact on outcomes. The objective of our study was to compare 6-month functional status and angina outcomes among blacks and whites with documented coronary disease and to asse...

journal_title：Circulation

authors： Kaul P,Lytle BL,Spertus JA,DeLong ER,Peterson ED

更新日期：2005-03-15 00:00:00

abstract：BACKGROUND:Pulmonary hypertension caused by systolic left ventricular dysfunction is associated with significant morbidity and mortality; however, no treatment is approved for this indication. We hypothesized that riociguat, a novel soluble guanylate cyclase stimulator, would have beneficial hemodynamic effects in pati...

journal_title：Circulation

authors： Bonderman D,Ghio S,Felix SB,Ghofrani HA,Michelakis E,Mitrovic V,Oudiz RJ,Boateng F,Scalise AV,Roessig L,Semigran MJ,Left Ventricular Systolic Dysfunction Associated With Pulmonary Hypertension Riociguat Trial (LEPHT) Study Group.

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Macrophages in human atherosclerotic plaques produce a family of matrix metalloproteinases (MMPs), which may influence vascular remodeling and plaque disruption. Because oxidized LDL (ox-LDL) is implicated in many proatherogenic events, we hypothesized that ox-LDL would regulate expression of MMP-9 and tissu...

journal_title：Circulation

authors： Xu XP,Meisel SR,Ong JM,Kaul S,Cercek B,Rajavashisth TB,Sharifi B,Shah PK

更新日期：1999-03-02 00:00:00

abstract：BACKGROUND:We reviewed the outcome of 76 consecutive patients (age range, 5 months to 6 years; median age, 19 months) who underwent a modified Fontan procedure after initial palliative surgery for hypoplastic left heart syndrome (HLHS) between January 1984 and December 1989. METHODS AND RESULTS:Modifications of the Fo...

journal_title：Circulation

authors： Farrell PE Jr,Chang AC,Murdison KA,Baffa JM,Norwood WI,Murphy JD

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Cerebral protection during surgery for acute aortic dissection type A relies on hypothermic circulatory arrest, either alone or in conjunction with cerebral perfusion. METHODS AND RESULTS:The perioperative and intraoperative conditions of 1558 patients submitted from 44 cardiac surgery centers in German-spe...

journal_title：Circulation

authors： Krüger T,Weigang E,Hoffmann I,Blettner M,Aebert H,GERAADA Investigators.

更新日期：2011-07-26 00:00:00

abstract：BACKGROUND:Although the left prepectoral site is preferred for "hot can" placement, this site is unavailable in some patients. We evaluated the influence of electrode location on defibrillation thresholds with alternative hot can and transvenous lead configurations. METHODS AND RESULTS:Three interrelated studies were ...

journal_title：Circulation

authors： Yamanouchi Y,Mowrey KA,Niebauer MJ,Tchou PJ,Wilkoff BL

更新日期：1997-12-16 00:00:00

abstract：:A patient who had disabling supraventricular tachycardia showed electrophysiologic evidence of coexistent right and left Kent bundles. The supraventricular tachycardia was accelerated by sequential antegrade and retrograde conduction over the right and left Kent bundles, respectively. Spontaneous blocking of the condu...

journal_title：Circulation

authors： Cinca J,Valle V,Gutierrez L,Figueras J,Rius J

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND:Aprotinin was a commonly used pharmacological agent for homeostasis in cardiac surgery but was discontinued, resulting in the extensive use of lysine analogues. This study tested the hypothesis that early postoperative adverse events and blood product utilization would affected in this post-aprotinin era. M...

journal_title：Circulation

authors： DeSantis SM,Toole JM,Kratz JM,Uber WE,Wheat MJ,Stroud MR,Ikonomidis JS,Spinale FG

更新日期：2011-09-13 00:00:00