Left atrial appendage: an underrecognized trigger site of atrial fibrillation.

abstract：:Twelve healthy men were studied by M mode echocardiography during exercise to investigate the effect of afterload reduction on left ventricular function at maximal exertion. They performed two maximal exercise bicycle tests 4 hr apart while in the semisupine position and were given 20 mg nifedipine sublingually 30 min...

journal_title：Circulation

authors： Andersen K,Vik-Mo H

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND:The pathophysiological mechanisms leading to acceleration of ventricular tachycardia (VT) are still unclear. METHODS AND RESULTS:High-resolution epicardial mapping was used to study the mechanisms of VT acceleration by programmed electrical stimulation (PES) in a model of sustained reentrant VT in Langendor...

journal_title：Circulation

authors： Brugada J,Brugada P,Boersma L,Mont L,Kirchhof C,Wellens HJ,Allessie MA

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Cardiac allograft arteriosclerosis is a complex process of alloimmune response, chronic inflammation, and smooth muscle cell proliferation that includes cross talk between cytokines and growth factors. METHODS AND RESULTS:Our results in rat cardiac allografts established alloimmune response as an alternativ...

journal_title：Circulation

authors： Lemström KB,Krebs R,Nykänen AI,Tikkanen JM,Sihvola RK,Aaltola EM,Häyry PJ,Wood J,Alitalo K,Ylä-Herttuala S,Koskinen PK

更新日期：2002-05-28 00:00:00

abstract：:From November 1981 to November 1982, intra-aortic balloon pumping (IABP) was used after surgery in eight patients who were from 6 weeks to 6 years old and who weighed from 4.2 to 16.2 kg. In seven patients, specially constructed intra-aortic balloons with 2.5 and 5.0 ml volumes mounted on No. 5F catheters were used. I...

journal_title：Circulation

authors： Veasy LG,Blalock RC,Orth JL,Boucek MM

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Most survival prediction models for coronary artery bypass grafting surgery are limited to in-hospital or 30-day end points. We estimate a long-term survival model using data from the Society of Thoracic Surgeons Adult Cardiac Surgery Database and Centers for Medicare and Medicaid Services. METHODS AND RESU...

journal_title：Circulation

authors： Shahian DM,O'Brien SM,Sheng S,Grover FL,Mayer JE,Jacobs JP,Weiss JM,Delong ER,Peterson ED,Weintraub WS,Grau-Sepulveda MV,Klein LW,Shaw RE,Garratt KN,Moussa ID,Shewan CM,Dangas GD,Edwards FH

更新日期：2012-03-27 00:00:00

abstract：:Studies of the correlation of aortic valve gradient determined by continuous-wave Doppler echocardiography and that determined at catheterization have, to date, involved young patients and nonsimultaneous measurements. We therefore obtained simultaneous Doppler echocardiographic and catheter measurements of pressure g...

journal_title：Circulation

authors： Currie PJ,Seward JB,Reeder GS,Vlietstra RE,Bresnahan DR,Bresnahan JF,Smith HC,Hagler DJ,Tajik AJ

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND:Insulin sensitivity varies up to threefold in apparently healthy individuals, but the mechanism for this is unknown. We have examined the hypothesis that vascular endothelial nitric oxide production and insulin sensitivity are directly related in humans. METHODS AND RESULTS:Nineteen healthy male subjects we...

journal_title：Circulation

authors： Petrie JR,Ueda S,Webb DJ,Elliott HL,Connell JM

更新日期：1996-04-01 00:00:00

abstract：:We examined the influence of left ventricular end-diastolic pressure (LVEDP) on the mechanical interaction between ischemic and nonischemic areas during acute myocardial ischemia. Circumferentially oriented ultrasonic segment gauges were implanted in the midwall of the anterior apex and posterior apex of the left vent...

journal_title：Circulation

authors： Lew WY,Ban-Hayashi E

更新日期：1985-11-01 00:00:00

abstract：:Labetalol was administered to six hypertensive subjects in increasing doses for seven days. A decrease in both supine and standing arterial pressure and heart rate was observed with no change in cardiac output and few side effects. Exercise tolerance was unaltered by the drug, but the heart rate and arterial pressure ...

journal_title：Circulation

authors： Mehta J,Cohn JN

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:The ability of apolipoprotein (apo)A-I to induce regression of preexisting atherosclerotic lesions has not been determined, and a mouse model of atherosclerosis regression has not yet been reported. METHODS AND RESULTS:LDL receptor-deficient mice were fed a western-type diet for 5 weeks to induce atheroscle...

journal_title：Circulation

authors： Tangirala RK,Tsukamoto K,Chun SH,Usher D,Puré E,Rader DJ

更新日期：1999-10-26 00:00:00

abstract：BACKGROUND:Fibrinogen has been identified as an independent risk factor for cardiovascular disease and associated with traditional cardiovascular risk factors. Also, the role of elevated fibrinogen in thrombosis suggests that it may be on the causal pathway for certain risk factors to exert their effect. These associat...

journal_title：Circulation

authors： Stec JJ,Silbershatz H,Tofler GH,Matheney TH,Sutherland P,Lipinska I,Massaro JM,Wilson PF,Muller JE,D'Agostino RB Sr

更新日期：2000-10-03 00:00:00

abstract：BACKGROUND:Although phase 2 reentry is said to be responsible for initiation of ventricular tachycardia (VT) in Brugada syndrome, information about the activation sequence during VT is limited. METHODS AND RESULTS:We developed an experimental Brugada syndrome model using a canine isolated right ventricular preparation...

journal_title：Circulation

authors： Kimura M,Kobayashi T,Owada S,Ashikaga K,Higuma T,Sasaki S,Iwasa A,Motomura S,Okumura K

更新日期：2004-01-06 00:00:00

abstract：BACKGROUND:We previously found in a pig coronary balloon injury model that vitamins C and E as well as probucol had beneficial effects on the vessel response to injury measured by morphometry These effects correlated with an inhibition in the ability to oxidize LDLs ex vivo, suggesting that the morphological response w...

journal_title：Circulation

authors： Nunes GL,Robinson K,Kalynych A,King SB 3rd,Sgoutas DS,Berk BC

更新日期：1997-11-18 00:00:00

abstract：:All physicians increasingly will encounter patients who have implanted cardioverter-defibrillators (ICDs) for protection from ventricular arrhythmias. This advisory provides a concise summary relevant to the assessment and management of patients with ICDs, including those who present to primary care or emergency depar...

journal_title：Circulation

authors： Stevenson WG,Chaitman BR,Ellenbogen KA,Epstein AE,Gross WL,Hayes DL,Strickberger SA,Sweeney MO,Subcommittee on Electrocardiography and Arrhythmias of the American Heart Association Council on Clinical Cardiology.,Heart Rhythm Society.

更新日期：2004-12-21 00:00:00

abstract：BACKGROUND:Pharmacological evidence has implicated ATP-sensitive K(+) (K(ATP)) channels as the effectors of cardioprotection, but the relative roles of mitochondrial (mitoK(ATP)) and sarcolemmal (surfaceK(ATP)) channels remain controversial. METHODS AND RESULTS:We examined the effects of the K(ATP) channel blocker HMR...

journal_title：Circulation

authors： Sato T,Sasaki N,Seharaseyon J,O'Rourke B,Marbán E

更新日期：2000-05-23 00:00:00

abstract：BACKGROUND:In patients with acute coronary syndromes and planned percutaneous coronary intervention, the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis in Myocardial Infarction 38 (TRITON-TIMI 38) demonstrated that treatment with prasugrel versus clopid...

journal_title：Circulation

authors： Mahoney EM,Wang K,Arnold SV,Proskorovsky I,Wiviott S,Antman E,Braunwald E,Cohen DJ

更新日期：2010-01-05 00:00:00

abstract：BACKGROUND:Body fat distribution has been cross-sectionally associated with atherosclerotic disease risk factors, but the prospective relation with coronary heart disease remains uncertain. METHODS AND RESULTS:We examined the prospective relation between fat distribution indices and coronary heart disease among 24,508...

journal_title：Circulation

authors： Canoy D,Boekholdt SM,Wareham N,Luben R,Welch A,Bingham S,Buchan I,Day N,Khaw KT

更新日期：2007-12-18 00:00:00

abstract：:Coronary artery bypass surgery with or without aneurysmectomy has been used to treat patients with angiographically defined left ventricular aneurysm. To evaluate whether surgery benefits such patients, we analyzed the data from 1131 patients who were enrolled in the registry of the Coronary Artery Surgery Study. Four...

journal_title：Circulation

authors： Faxon DP,Myers WO,McCabe CH,Davis KB,Schaff HV,Wilson JW,Ryan TJ

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:The electrocardiographic short QT-interval syndrome forms a distinct clinical entity presenting with a high rate of sudden death and exceptionally short QT intervals. The disorder has recently been linked to gain-of-function mutation in KCNH2. The present study demonstrates that this disorder is genetically ...

journal_title：Circulation

authors： Bellocq C,van Ginneken AC,Bezzina CR,Alders M,Escande D,Mannens MM,Baró I,Wilde AA

更新日期：2004-05-25 00:00:00

abstract：BACKGROUND:Circulatory arrest (CA), which provides a bloodless field and good visualization without the need of aortic cross-clamp, is commonly used to facilitate repair of aortic lesions. However, extended periods of CA may impair cerebral metabolism and cause ischemic injury. Studies were performed to evaluate the ef...

journal_title：Circulation

authors： Lin PJ,Chang CH,Tan PP,Chang CN,Lee ST,Wang CC,Chang JP,Liu DW,Chu JJ,Tsai KT,Kao CL,Hsieh MJ,Hua MS

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Endothelin (ET)-1 and norepinephrine (NE) are involved in myocardial ischemia/reperfusion injury. We investigated the role of ET-1 in ischemia/reperfusion-induced NE overflow and cardiac dysfunction using a selective ET(A) receptor antagonist (ABT-627), a selective ET(B) receptor antagonist (A-192621), and t...

journal_title：Circulation

authors： Yamamoto S,Matsumoto N,Kanazawa M,Fujita M,Takaoka M,Gariepy CE,Yanagisawa M,Matsumura Y

更新日期：2005-01-25 00:00:00

abstract：BACKGROUND:Unlike the Western world, valvular disease ranks among the major cardiovascular afflictions in Africa. Acute rheumatic fever and chronic rheumatic valvular disease in their most virulent form are still commonly encountered and impose a huge burden on limited healthcare resources. METHODS AND RESULTS:We perf...

journal_title：Circulation

authors： Essop MR,Nkomo VT

更新日期：2005-12-06 00:00:00

abstract：BACKGROUND:Signaling through protein tyrosine kinases (PTKs) is a major contributor to the transmission of mitogenic stimuli to the interior of the cell and nucleus. The present study was designed to determine the effect of the tyrphostin AG1295, a selective blocker of PDGF-receptor PTK, on the growth of porcine and hu...

journal_title：Circulation

authors： Banai S,Wolf Y,Golomb G,Pearle A,Waltenberger J,Fishbein I,Schneider A,Gazit A,Perez L,Huber R,Lazarovichi G,Rabinovich L,Levitzki A,Gertz SD

更新日期：1998-05-19 00:00:00

abstract：BACKGROUND:The long-term success of coronary bypass surgery is dependent on graft patency after surgery. This trial was designed to determine if aspirin improved saphenous vein graft or internal mammary artery (IMA) graft patency between 1 and 3 years after coronary artery bypass grafting (CABG). METHODS AND RESULTS:A...

journal_title：Circulation

authors： Goldman S,Copeland J,Moritz T,Henderson W,Zadina K,Ovitt T,Kern KB,Sethi G,Sharma GV,Khuri S

更新日期：1994-03-01 00:00:00

abstract：:The effects of encainide on ventricular arrhythmia and left ventricular function were studied in 21 patients with chronic, high-grade ventricular arrhythmia using a prospective, 3-month, placebo-controlled, single-blind trial design. Encainide caused a 96% decrease in the average hourly frequency of ventricular premat...

journal_title：Circulation

authors： DiBianco R,Fletcher RD,Cohen AI,Gottdiener JS,Singh SN,Katz RJ,Bates HR,Sauerbrunn B

更新日期：1982-06-01 00:00:00

abstract：:Little is known of the functional capacity of coronary collaterals in humans without occlusive coronary artery disease. We, therefore, measured peripheral coronary pressure (PCP) and retrograde flow (RF) from coronary arteries at aortic valve replacement in seven patients without occlusive coronary artery disease. Usi...

journal_title：Circulation

authors： Goldstein RE,Michaelis LL,Morrow AG,Epstein SE

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:Genetic polymorphisms at codons 16 and 27 of the beta2-adrenergic receptor have been associated with altered response to sympathetic stimulation. We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study. METHODS AND RESULTS:A total of 808 black and 4441 whi...

journal_title：Circulation

authors： Heckbert SR,Hindorff LA,Edwards KL,Psaty BM,Lumley T,Siscovick DS,Tang Z,Durda JP,Kronmal RA,Tracy RP

更新日期：2003-04-22 00:00:00

abstract：BACKGROUND:Mildly oxidized LDL (moxLDL) is thought to play a role in atherogenesis. MoxLDL induces derivatization of cell proteins and triggers a variety of intracellular signaling. We aimed to investigate whether moxLDL-induced protein derivatization may influence the activity of platelet-derived growth factor recepto...

journal_title：Circulation

authors： Escargueil-Blanc I,Salvayre R,Vacaresse N,Jürgens G,Darblade B,Arnal JF,Parthasarathy S,Nègre-Salvayre A

更新日期：2001-10-09 00:00:00

abstract：:We examined the cardiopulmonary effects of maximum bicycle ergometer exercise in seven patients with implanted Intermedics Nova MR pacemakers for three types of pacing in a randomized sequence: VVI or AAI at 70 beats/min (SSI 70), rate-adaptive temperature-controlled pacing with the implanted Nova MR, and rate-adaptiv...

journal_title：Circulation

authors： Alt E,Völker R,Högl B,MacCarter D

更新日期：1988-11-01 00:00:00

abstract：:For patients with stenotic native valves, the modified Bernoulli equation (delta P = 4V2) may be applied to Doppler-measured transvalvular velocities to yield an accurate estimate of transvalvular gradients. Although it would be useful if the same approach could be used for those with stenotic prosthetic valves, no pr...

journal_title：Circulation

authors： Wilkins GT,Gillam LD,Kritzer GL,Levine RA,Palacios IF,Weyman AE

更新日期：1986-10-01 00:00:00