Vitamins C and E inhibit O2- production in the pig coronary artery.

abstract：BACKGROUND:The incidence and cause of sudden cardiac death (SCD) in athletes is debated with hypertrophic cardiomyopathy often reported as the most common cause. METHODS AND RESULTS:A database of all National Collegiate Athletic Association deaths (2003-2013) was developed. Additional information and autopsy reports w...

journal_title：Circulation

authors： Harmon KG,Asif IM,Maleszewski JJ,Owens DS,Prutkin JM,Salerno JC,Zigman ML,Ellenbogen R,Rao AL,Ackerman MJ,Drezner JA

更新日期：2015-07-07 00:00:00

abstract：BACKGROUND:The relations of plasma activated factor XII (FXIIa) concentration and a common polymorphism (C46T) of the factor XII gene with hemostatic status and risk of coronary heart disease (CHD) were examined by prospective surveillance. METHODS AND RESULTS:Genotyping for the C46T variant was performed in 2624 men ...

journal_title：Circulation

authors： Zito F,Drummond F,Bujac SR,Esnouf MP,Morrissey JH,Humphries SE,Miller GJ

更新日期：2000-10-24 00:00:00

abstract：BACKGROUND:Mild and moderate functional ischemic mitral insufficiency present at the time of surgical revascularization present clinical uncertainty. It is unclear whether the relatively poor outcomes in this cohort are dependent on valvular function or related to left ventricular dysfunction. The purpose of this study...

journal_title：Circulation

authors： Grossi EA,Crooke GA,DiGiorgi PL,Schwartz CF,Jorde U,Applebaum RM,Ribakove GH,Galloway AC,Grau JB,Colvin SB

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:Current consensus statements maintain that endoscopic vein harvesting (EVH) should be standard care in coronary artery bypass graft surgery, but vein quality and clinical outcomes have been questioned. The VICO trial (Vein Integrity and Clinical Outcomes) was designed to assess the impact of different vein h...

journal_title：Circulation

authors： Krishnamoorthy B,Critchley WR,Thompson AJ,Payne K,Morris J,Venkateswaran RV,Caress AL,Fildes JE,Yonan N

更新日期：2017-10-31 00:00:00

abstract：BACKGROUND:Both glucose-insulin-potassium (GIK) and tri-iodothyronine (T3) may improve cardiovascular performance after coronary artery surgery (CABG) but their effects have not been directly compared and the effects of combined treatment are unknown. METHODS AND RESULTS:In 2 consecutive randomized double-blind placeb...

journal_title：Circulation

authors： Ranasinghe AM,Quinn DW,Pagano D,Edwards N,Faroqui M,Graham TR,Keogh BE,Mascaro J,Riddington DW,Rooney SJ,Townend JN,Wilson IC,Bonser RS

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:Risk factors for obstructive sleep apnea (OSA) and the development of subsequent cardiovascular (CV) complications differ by sex. We hypothesize that the relationship between OSA and high-sensitivity troponin T (hs-TnT), cardiac structure, and CV outcomes differs by sex. METHODS AND RESULTS:Seven hundred fi...

journal_title：Circulation

authors： Roca GQ,Redline S,Claggett B,Bello N,Ballantyne CM,Solomon SD,Shah AM

更新日期：2015-10-06 00:00:00

abstract：BACKGROUND:Because acute exercise increases systemic catecholamines, we sought to determine whether exercise training would alter daily or exercise-related catecholamine release and inactivation. METHODS AND RESULTS:In 24-hour urine collections, catecholamines and metabolites provided indexes of overall oxidative deam...

journal_title：Circulation

authors： Rogers PJ,Tyce GM,Weinshilboum RM,O'Connor DT,Bailey KR,Bove AA

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Associations between left ventricular (LV) geometry and the insulin resistance syndrome have been found, mostly in small studies of middle-aged hypertensives. The purpose of this study was to elucidate these associations through the use of a large sample of elderly men. METHODS AND RESULTS:We investigated 4...

journal_title：Circulation

authors： Sundström J,Lind L,Nyström N,Zethelius B,Andrén B,Hales CN,Lithell HO

更新日期：2000-06-06 00:00:00

abstract：BACKGROUND:Disintegrin metalloproteinases (ADAMs) may contribute to structural cardiac remodeling by altering cell-surface matrix receptors (integrins) and activating potent biomolecules. We compared expression of ADAMs, their endogenous inhibitor tissue inhibitor of metalloproteinases (TIMP)-3, and integrins in human ...

journal_title：Circulation

authors： Fedak PW,Moravec CS,McCarthy PM,Altamentova SM,Wong AP,Skrtic M,Verma S,Weisel RD,Li RK

更新日期：2006-01-17 00:00:00

abstract：BACKGROUND:Fortilin, a recently characterized nuclear antiapoptotic factor structurally distinct from inhibitor of apoptosis proteins (IAPs) and Bcl-2 family member proteins, has been suggested to be involved in cell survival and regulation of apoptosis within the cardiovascular system. In this continued investigation,...

journal_title：Circulation

authors： Tulis DA,Mnjoyan ZH,Schiesser RL,Shelat HS,Evans AJ,Zoldhelyi P,Fujise K

更新日期：2003-01-07 00:00:00

abstract：BACKGROUND:PCTP (phosphatidylcholine transfer protein) regulates the intermembrane transfer of phosphatidylcholine. Higher platelet PCTP expression is associated with increased platelet responses on activation of protease-activated receptor 4 thrombin receptors noted in black subjects compared with white subjects. Litt...

journal_title：Circulation

authors： Mao G,Songdej N,Voora D,Goldfinger LE,Del Carpio-Cano FE,Myers RA,Rao AK

更新日期：2017-09-05 00:00:00

abstract：:The echocardiograms of 46 patients with aortic insufficiency which manifested typical high frequency vibrations of the anterior mitral valve leaflet were reviewed. All patients had overt clinical evidence of aortic insufficiency which was confirmed by angiography in 17 cases. In 17 cases (eight of whom underwent cat...

journal_title：Circulation

authors： Cope GD,Kisslo JA,Johnson ML,Myers S

更新日期：1975-04-01 00:00:00

abstract：BACKGROUND:Patients with acute ischemic right ventricular dysfunction often develop hemodynamic compromise, yet most manifest spontaneous early clinical improvement and later recovery of global right ventricular performance. This study was designed to delineate the determinants of right ventricular performance followin...

journal_title：Circulation

authors： Laster SB,Shelton TJ,Barzilai B,Goldstein JA

更新日期：1993-08-01 00:00:00

abstract：:Twenty-six major cardiovascular centers participated in a cooperative study of all cases of infective endocarditis occurring during a single calendar year to obtain an overview of infective endocarditis. The study was designed to learn which patients appear to be at highest risk to develop this infection after palliat...

journal_title：Circulation

authors： Kaplan EL,Rich H,Gersony W,Manning J

更新日期：1979-02-01 00:00:00

abstract：:The first stage of a repair of pulmonary atresia with intact ventricular septum (type I) was attempted in a 2-day-old infant. At surgery, decompression of the hypertensive small right ventricle was followed by a sudden loss of myocardial contractility and death. Postmortem examination revealed a fistula with a large o...

journal_title：Circulation

authors： O'Connor WN,Cottrill CM,Johnson GL,Noonan JA,Todd EP

更新日期：1982-04-01 00:00:00

abstract：:Disorders associated with the overproduction or delayed clearance of beta-very low density lipoprotein and low density lipoprotein (LDL) are strikingly related to premature coronary artery disease. There are five recognized classes of LDL-lowering drugs, each acting through different basic mechanisms. The increased pr...

journal_title：Circulation

authors： Levy RI,Troendle AJ,Fattu JM

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Endogenous nitric oxide (NO) has been reported to inhibit oxygen consumption in the normal heart, so that nonselective inhibition of NO synthase (NOS) caused an increase of myocardial oxygen consumption (MVO2). Although endothelial NOS responses are depressed in congestive heart failure (CHF), inducible NOS ...

journal_title：Circulation

authors： Chen Y,Traverse JH,Du R,Hou M,Bache RJ

更新日期：2002-07-09 00:00:00

abstract：BACKGROUND:Ventricular tachyarrhythmias are the major clinical manifestation of arrhythmogenic right ventricular disease. Although antiarrhythmic therapy has been widely advocated, there is only limited information available on the efficacy of antiarrhythmic drugs in these patients. METHODS AND RESULTS:The short- and ...

journal_title：Circulation

authors： Wichter T,Borggrefe M,Haverkamp W,Chen X,Breithardt G

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Endocarditis related to pacemaker (PM)-lead infection is a rare but serious complication of permanent transvenous pacing. To determine in which situations the diagnosis should be evoked and to determine optimal management, we reviewed our experience with endocarditis related to PM-lead infection. METHODS AN...

journal_title：Circulation

authors： Klug D,Lacroix D,Savoye C,Goullard L,Grandmougin D,Hennequin JL,Kacet S,Lekieffre J

更新日期：1997-04-15 00:00:00

abstract：BACKGROUND:Patients with advanced heart failure have bioenergetic abnormalities of skeletal muscle metabolism during exercise. Using 31P magnetic resonance spectroscopy, we sought to determine whether skeletal metabolic responses to exercise are normalized by orthotopic cardiac transplantation. METHODS AND RESULTS:Fou...

journal_title：Circulation

authors： Stratton JR,Kemp GJ,Daly RC,Yacoub M,Rajagopalan B

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:Patients with prior atherosclerosis in 1 or more vascular territories (coronary, cerebrovascular, or peripheral arterial) who present with acute coronary syndromes have high cardiovascular risk and may benefit significantly from evidence-based therapies, yet whether these are used consistently is unknown. M...

journal_title：Circulation

authors： Brilakis ES,Hernandez AF,Dai D,Peterson ED,Banerjee S,Fonarow GC,Cannon CP,Bhatt DL

更新日期：2009-08-18 00:00:00

abstract：BACKGROUND:Anthracyclines are the most effective drugs available in the treatment of neoplastic diseases; however, they have profound consequences on the structure and function of the heart, which over time cause a cardiomyopathy that leads to congestive heart failure. METHODS AND RESULTS:Administration of doxorubicin...

journal_title：Circulation

authors： De Angelis A,Piegari E,Cappetta D,Marino L,Filippelli A,Berrino L,Ferreira-Martins J,Zheng H,Hosoda T,Rota M,Urbanek K,Kajstura J,Leri A,Rossi F,Anversa P

更新日期：2010-01-19 00:00:00

abstract：:This review discusses the role of growth factors on the proliferation of smooth muscle cells (SMCs) in injured arteries. We have used a variety of procedures to injure rat carotid arteries and noted that removal of endothelium followed by platelet adherence does not always initiate SMC replication. Furthermore, thromb...

journal_title：Circulation

authors： Reidy MA,Fingerle J,Lindner V

更新日期：1992-12-01 00:00:00

abstract：:In patients with atrioventricular (A-V) nodal re-entrant paroxysmal supraventricular tachycardia (PSVT), atrial extrastimulus technique frequently reveals discontinuous A1-A2, H1-H2 curves suggestive of dual A-V nodal pathways. To further test the hypothesis that these curves in fact reflect dual A-V nodal pathways, a...

journal_title：Circulation

authors： Wu D,Denes P,Wyndham C,Amat-y-Leon F,Dhingra RC,Rosen KM

更新日期：1975-11-01 00:00:00

abstract：BACKGROUND:Monitoring implantable cardiac device function and patient condition is important. The Lumos-T Safely Reduces Routine Office Device Follow-Up (TRUST) trial tested the hypothesis that remote home monitoring with automatic daily surveillance (HM) is safe and effective for implantable cardioverter-defibrillator...

journal_title：Circulation

authors： Varma N,Epstein AE,Irimpen A,Schweikert R,Love C,TRUST Investigators.

更新日期：2010-07-27 00:00:00

abstract：BACKGROUND:Development of left ventricular hypertrophy in aortic stenosis (AS) is accompanied by coronary microcirculatory dysfunction, demonstrated by an impaired coronary vasodilator reserve (CVR). However, evidence for regional abnormalities in myocardial blood flow (MBF) and the potential mechanisms is limited. The...

journal_title：Circulation

authors： Rajappan K,Rimoldi OE,Dutka DP,Ariff B,Pennell DJ,Sheridan DJ,Camici PG

更新日期：2002-01-29 00:00:00

abstract：BACKGROUND:The individual makeup of atherosclerotic plaque has been identified as a dominant prognostic factor. With the use of an intravascular magnetic resonance (MR) catheter coil, we evaluated the effectiveness of high-resolution MR in the study of the development of atherosclerotic lesions in heritable hyperlipide...

journal_title：Circulation

authors： Zimmermann-Paul GG,Quick HH,Vogt P,von Schulthess GK,Kling D,Debatin JF

更新日期：1999-03-02 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) remains a concern in patients with β-thalassemia major (TM) and intermedia (TI); however, studies evaluating its prevalence and risk factors using systematic confirmation on right heart catheterization are lacking. METHODS AND RESULTS:This was a multicenter cross-sectio...

journal_title：Circulation

authors： Derchi G,Galanello R,Bina P,Cappellini MD,Piga A,Lai ME,Quarta A,Casu G,Perrotta S,Pinto V,Musallam KM,Forni GL,Webthal Pulmonary Arterial Hypertension Group*.

更新日期：2014-01-21 00:00:00

abstract：BACKGROUND:Administration of aprotinin during extracorporeal circulation reduces blood loss and improves platelet function. METHODS AND RESULTS:To evaluate the protective effect of aprotinin on platelets, 50 patients undergoing cardiopulmonary bypass were randomized before surgery to one of three groups. Seventeen pat...

journal_title：Circulation

authors： Mohr R,Goor DA,Lusky A,Lavee J

更新日期：1992-11-01 00:00:00

abstract：:Balloon dilation angioplasty was attempted in 10 infants and children with severe congenital or operative "venous" obstructions. In five children the obstructions were "vena caval" and followed repair for transposition of the great vessels (four patients) or orthotopic liver transplantation (one patient). In the four ...

journal_title：Circulation

authors： Lock JE,Bass JL,Castaneda-Zuniga W,Fuhrman BP,Rashkind WJ,Lucas RV Jr

更新日期：1984-09-01 00:00:00