Outcome and assessment after the modified Fontan procedure for hypoplastic left heart syndrome.

abstract：:We studied regional myocardial perfusion by scintigraphic computer-assisted analysis of initial distribution, washout rates, and residual activity of 133Xe injected into the left coronary artery of four patients with normal arteriograms and 14 patients with coronary stenosis. At rest, residual activity in poststenotic...

journal_title：Circulation

authors： Maseri A,L'Abbate A,Pesola A,Michelassi C,Marzilli M,De Nes M

更新日期：1977-03-01 00:00:00

abstract：BACKGROUND:Coronary heart disease patients with low high-density lipoprotein cholesterol (HDL-C) levels, high triglyceride levels, or both are at an increased risk of cardiovascular events, but the clinical impact of raising HDL-C or decreasing triglycerides remains to be confirmed. METHODS AND RESULTS:In a double-bli...

journal_title：Circulation

authors： Bezafibrate Infarction Prevention (BIP) study.

更新日期：2000-07-04 00:00:00

abstract：:Electrophysiologic studies were performed in 28 patients with documented atrioventricular (AV) nodal reentrant supraventricular tachycardia (SVT) to investigate the presence of AV nodal tissue situated between the tachycardia circuit and both the atrium (upper common pathway, UCP) and the His bundle (lower common path...

journal_title：Circulation

authors： Miller JM,Rosenthal ME,Vassallo JA,Josephson ME

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Orally administered heparin (OHEP) is unreliable because of poor absorption. Sodium N-(8[2-hydroxybenzoyl]amino) caprylate (SNAC) is an amido acid that facilitates the gastrointestinal absorption of heparin. We evaluated the effectiveness of OHEP combined with SNAC (OHEP/SNAC) in the treatment of deep-vein t...

journal_title：Circulation

authors： Gonze MD,Salartash K,Sternbergh WC 3rd,Baughman RA,Leone-Bay A,Money SR

更新日期：2000-06-06 00:00:00

abstract：BACKGROUND:Oxidized low-density lipoprotein plays a key role in the initiation, progression, and destabilization of atherosclerotic plaques and is present in macrophages and the lipid pool. The aim of this study was to assess the feasibility of magnetic resonance imaging of atherosclerotic lesions in mice using micelle...

journal_title：Circulation

authors： Briley-Saebo KC,Shaw PX,Mulder WJ,Choi SH,Vucic E,Aguinaldo JG,Witztum JL,Fuster V,Tsimikas S,Fayad ZA

更新日期：2008-06-24 00:00:00

abstract：BACKGROUND:Vasodilator drugs have variable effects on veins and arteries. However, direct measurements of their effects on the splanchnic veins, perhaps the most important volume reservoir, have not been reported. We assessed the effect of acute heart failure and the subsequent administration of hydralazine, enalaprila...

journal_title：Circulation

authors： Wang SY,Manyari DE,Scott-Douglas N,Smiseth OA,Smith ER,Tyberg JV

更新日期：1995-02-15 00:00:00

abstract：BACKGROUND:Whether the benefit in quality of life (QOL) after percutaneous coronary intervention depends on the severity of the stenosis as determined by fractional flow reserve (FFR) remains unknown. This study sought to investigate the relationship between FFR values and improvement in QOL. METHODS:From the FAME 1 a...

journal_title：Circulation

authors： Nishi T,Piroth Z,De Bruyne B,Jagic N,Möbius-Winkler S,Kobayashi Y,Derimay F,Fournier S,Barbato E,Tonino P,Jüni P,Pijls NHJ,Fearon WF

更新日期：2018-10-23 00:00:00

abstract：:To study the determinants of smooth muscle injury during balloon angioplasty, we conducted a series of experiments to examine the effects of degree of arterial stretching, duration of balloon inflation, and arterial precontraction on smooth muscle injury after balloon angioplasty in isolated, perfused whole-vessel seg...

journal_title：Circulation

authors： Fischell TA,Grant G,Johnson DE

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Small-scale clinical investigations have demonstrated that single doses of beta-blocking agents can improve left ventricular function in heart failure from idiopathic dilated cardiomyopathy (IDC). The purpose of this multicenter clinical trial was to determine the dose-effect characteristics of beta-blockade...

journal_title：Circulation

authors： Bristow MR,O'Connell JB,Gilbert EM,French WJ,Leatherman G,Kantrowitz NE,Orie J,Smucker ML,Marshall G,Kelly P

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:The mechanisms linking obesity to hypertension have not been established, but sodium retention and excessive sympathetic tone are key contributors. The natriuretic peptides are important regulators of sodium homeostasis and neurohormonal activation, raising the possibility that obese individuals have an impa...

journal_title：Circulation

authors： Wang TJ,Larson MG,Levy D,Benjamin EJ,Leip EP,Wilson PW,Vasan RS

更新日期：2004-02-10 00:00:00

abstract：:A 10 mg bolus of the angiotensin blocker saralasin was injected 113 times in 68 subjects with essential or renovascular hypertension. Ninety percent of injections caused a transient increase in blood pressure, which correlated with plasma renin activity (PRA) (r = -0.54); Mean increase at 2 minutes was 21/13.4 mm Hg (...

journal_title：Circulation

authors： Waks UA,Maxwell MH,Marks L,Zawada ET,Kaufman JJ

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND:We examined the association of 3 polymorphisms in the lectin-like oxidized LDL receptor-1 (LOX1 or OLR1) gene with coronary artery disease in the Women's Ischemia Syndrome Evaluation (WISE) study population. METHODS AND RESULTS:The WISE sample comprised 589 white and 122 black women who underwent angiograph...

journal_title：Circulation

authors： Chen Q,Reis SE,Kammerer C,Craig WY,LaPierre SE,Zimmer EL,McNamara DM,Pauly DF,Sharaf B,Holubkov R,Bairey Merz CN,Sopko G,Bontempo F,Kamboh MI

更新日期：2003-07-01 00:00:00

abstract：:We made continuous electrocardiographic recordings on magnetic tape during 15 episodes of ischemia in five patients with variant angina to determine the characteristics of the QRS changes. Orthogonal leads were used and the electrocardiograms were analyzed visually and by digital computer. Changes were quantified by s...

journal_title：Circulation

authors： Barnhill JE,Wikswo JP Jr,Dawson AK,Gundersen S,Robertson RM,Robertson D,Virmani R,Smith RF

更新日期：1985-05-01 00:00:00

abstract：:We evaluated the effects of selective activation of H1 receptors on coronary hemodynamics in 16 patients divided into two groups: group A, 11 patients with atypical angina or valvular heart disease and normal coronary arteries, and group B, five patients with spontaneous angina, four of whom had significant (greater t...

journal_title：Circulation

authors： Vigorito C,Poto S,Picotti GB,Triggiani M,Marone G

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:Inhaled nitric oxide (iNO) has been used to assess the vasodilator capacity of the pulmonary vascular bed in children with congenital heart disease and elevated pulmonary vascular resistance. Inhaled iloprost is a pulmonary vasodilator for the long-term treatment of pulmonary hypertension (PHT). Because thes...

journal_title：Circulation

authors： Rimensberger PC,Spahr-Schopfer I,Berner M,Jaeggi E,Kalangos A,Friedli B,Beghetti M

更新日期：2001-01-30 00:00:00

abstract：BACKGROUND:Heat shock protein (HSP)60 is an abundant protein found primarily in the mitochondria, though 15% to 20% is found in the cytosol. Previously we observed that HSP60 complexes with bax in the cytosol. Reduction in HSP60 precipitates translocation of bax to the mitochondria and apoptosis. We hypothesized that H...

journal_title：Circulation

authors： Gupta S,Knowlton AA

更新日期：2002-11-19 00:00:00

abstract：BACKGROUND:The safety and effectiveness of the MitraClip device (Abbott Vascular, Menlo Park, CA) is being evaluated in the Endovascular Valve Edge-to-Edge Repair Study (EVEREST) clinical studies. The healing response after device implantation has not previously been characterized in humans. METHODS AND RESULTS:A tota...

journal_title：Circulation

authors： Ladich E,Michaels MB,Jones RM,McDermott E,Coleman L,Komtebedde J,Glower D,Argenziano M,Feldman T,Nakano M,Virmani R,Endovascular Valve Edge-to-Edge Repair Study (EVEREST) Investigators.

更新日期：2011-04-05 00:00:00

abstract：BACKGROUND:We measured the content and activities of components of the beta-adrenergic receptor-G protein-adenylate cyclase complex and adrenergic neurotransmitter levels in left and right ventricular myocardial preparations derived from 77 end-stage failing human hearts from patients with idiopathic dilated cardiomyop...

journal_title：Circulation

authors： Bristow MR,Anderson FL,Port JD,Skerl L,Hershberger RE,Larrabee P,O'Connell JB,Renlund DG,Volkman K,Murray J

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Hutchinson-Gilford progeria syndrome is an ultrarare segmental premature aging disease resulting in early death from heart attack or stroke. There is no approved treatment, but starting in 2007, several recent single-arm clinical trials administered inhibitors of protein farnesylation aimed at reducing toxic...

journal_title：Circulation

authors： Gordon LB,Massaro J,D'Agostino RB Sr,Campbell SE,Brazier J,Brown WT,Kleinman ME,Kieran MW,Progeria Clinical Trials Collaborative.

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Recent studies have suggested that endogenous erythropoietin (Epo) plays an important role in the mobilization of bone marrow-derived endothelial progenitor cells (EPCs). However, it remains to be elucidated whether the Epo system exerts protective effects on pulmonary hypertension (PH), a fatal disorder enc...

journal_title：Circulation

authors： Satoh K,Kagaya Y,Nakano M,Ito Y,Ohta J,Tada H,Karibe A,Minegishi N,Suzuki N,Yamamoto M,Ono M,Watanabe J,Shirato K,Ishii N,Sugamura K,Shimokawa H

更新日期：2006-03-21 00:00:00

abstract：BACKGROUND:Conventional x-ray angiography frequently underestimates the true burden of atherosclerosis. Although intravascular ultrasound allows for imaging of coronary plaque, this invasive technique is inappropriate for screening or serial examinations. We therefore sought to develop a noninvasive free-breathing MR t...

journal_title：Circulation

authors： Botnar RM,Stuber M,Kissinger KV,Kim WY,Spuentrup E,Manning WJ

更新日期：2000-11-21 00:00:00

abstract：BACKGROUND:Thioredoxin 2 (Trx2) is a key mitochondrial protein that regulates cellular redox and survival by suppressing mitochondrial reactive oxygen species generation and by inhibiting apoptosis stress kinase-1 (ASK1)-dependent apoptotic signaling. To date, the role of the mitochondrial Trx2 system in heart failure ...

journal_title：Circulation

authors： Huang Q,Zhou HJ,Zhang H,Huang Y,Hinojosa-Kirschenbaum F,Fan P,Yao L,Belardinelli L,Tellides G,Giordano FJ,Budas GR,Min W

更新日期：2015-03-24 00:00:00

abstract：BACKGROUND:We previously reported that administration of elastase inhibitors reverses fatal pulmonary arterial hypertension (PAH) in rats by inducing smooth muscle cell (SMC) apoptosis. We showed in pulmonary artery (PA) organ culture that the mechanism by which elastase inhibitors induce SMC apoptosis involves repress...

journal_title：Circulation

authors： Merklinger SL,Jones PL,Martinez EC,Rabinovitch M

更新日期：2005-07-19 00:00:00

abstract：BACKGROUND:Coronary flow reserve (CFR), an integrated measure of focal, diffuse, and small-vessel coronary artery disease (CAD), identifies patients at risk for cardiac death. We sought to determine the association between CFR, angiographic CAD, and cardiovascular outcomes. METHODS AND RESULTS:Consecutive patients (n=...

journal_title：Circulation

authors： Taqueti VR,Hachamovitch R,Murthy VL,Naya M,Foster CR,Hainer J,Dorbala S,Blankstein R,Di Carli MF

更新日期：2015-01-06 00:00:00

abstract：:Seven of 214 patients (3%) with acute myocardial infarction (120 inferior and 94 anterior) developed atrial fibrillation within 3 hr of the onset of chest pain. All seven patients had an inferior infarction and in all seven the left circumflex artery was occluded proximal to the origin of its left atrial circumflex br...

journal_title：Circulation

authors： Hod H,Lew AS,Keltai M,Cercek B,Geft IL,Shah PK,Ganz W

更新日期：1987-01-01 00:00:00

abstract：:The initial myocardial uptake of thallium-201 depends on myocardial blood flow distribution. The phenomenon of delayed thallium redistribution after transiently or chronically altered myocardial perfusion has been described. The net myocardial accumulation of thallium-201 after injection depends upon the net balance b...

journal_title：Circulation

authors： Grunwald AM,Watson DD,Holzgrefe HH Jr,Irving JF,Beller GA

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND:In patients with acute coronary syndrome (ACS), percutaneous coronary intervention (PCI) may cause thrombus dislodgment followed by reduced flow and impaired microcirculatory function. We prospectively compared conventional PCI to a strategy of additional pretreatment using the X-sizer thrombectomy system. ...

journal_title：Circulation

authors： Beran G,Lang I,Schreiber W,Denk S,Stefenelli T,Syeda B,Maurer G,Glogar D,Siostrzonek P

更新日期：2002-05-21 00:00:00

abstract：OBJECTIVE:Previous studies comparing off-pump coronary artery bypass surgery (OPCABG) to conventional techniques utilizing cardiopulmonary bypass (CABG-CPB) have failed to provide patient selection guidelines. We sought to determine guidelines, attempting to rectify the limitations of previous studies. METHODS AND RES...

journal_title：Circulation

authors： Magee MJ,Coombs LP,Peterson ED,Mack MJ

更新日期：2003-09-09 00:00:00

abstract：BACKGROUND:Although echocardiography is commonly performed before coronary artery bypass surgery, there has yet to be a study examining the incremental prognostic value of a complete echocardiogram. METHODS AND RESULTS:Patients undergoing isolated coronary artery bypass surgery at 2 hospitals were divided into derivat...

journal_title：Circulation

authors： Afilalo J,Flynn AW,Shimony A,Rudski LG,Agnihotri AK,Morin JF,Castrillo C,Shahian DM,Picard MH

更新日期：2013-01-22 00:00:00

abstract：:In this paper we examine the relationship between risk factors and angiographically determined coronary artery disease for blacks and whites enrolled in the Coronary Artery Surgery Study (CASS). Analysis of data from the CASS registry indicated that blacks had a higher incidence of hypertension and current cigarette s...

journal_title：Circulation

authors： Maynard C,Fisher LD,Passamani ER,Pullum T

更新日期：1986-07-01 00:00:00