Abstract:
BACKGROUND:Several nonatherosclerotic animal models of restenosis exist and are used for the evaluation of the vascular response to angioplasty-induced injury. However, few studies have evaluated the response of an atherosclerotic vessel to angioplasty. The present study examined the radiographic, histological, immunohistochemical, and morphometric responses over time of atherosclerotic rabbit femoral arteries after percutaneous transluminal angioplasty (PTA). METHODS AND RESULTS:Rabbits (n = 94) underwent arterial dissection and were fed a hypercholesterolemic diet for 3 weeks, and then PTA was performed. Arteries were obtained before PTA and 1, 3, 5, 7, 14, and 28 days after PTA. PTA caused radial stretching of the artery, medial compression, intramural hemorrhage, injury to normal arterial segments, and dissection within the intima and media. Thrombus filled and cellular accumulation repaired the dissection. Peak smooth muscle cell and macrophage DNA synthesis was noted at 3 to 5 days after angioplasty, generally at the dissection but also in normal sections of the artery. Adventitial injury and subsequent adventitial cellular proliferation and collagen production were observed. A rapid decrease in the radiographic minimal luminal diameter was noted at 3 days, resulting from vascular recoil or thrombus filling the dissection. At 7 to 14 days, only 24% to 33% of the luminal loss was accounted for by an increase in the intimal area, and 22% to 28% of the intima was neointima. CONCLUSIONS:Restenosis in an atherosclerotic artery results from a variable combination of intimal proliferation, vascular remodeling/wound contraction, and recoil of the normal section of the artery. The variability of an atherosclerotic artery to PTA injury results from variable dissection, thrombus formation, and cellular response to injury as well as variable scar contraction and elastic recoil.
journal_name
Circulationjournal_title
Circulationauthors
Wilensky RL,March KL,Gradus-Pizlo I,Sandusky G,Fineberg N,Hathaway DRdoi
10.1161/01.cir.92.10.2995subject
Has Abstractpub_date
1995-11-15 00:00:00pages
2995-3005issue
10eissn
0009-7322issn
1524-4539journal_volume
92pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:Beneficial effects of exercise training on cardiovascular function in chronic heart failure (CHF) have been suggested previously, but the underlying mechanisms are unknown. We tested whether daily exercise training improves systemic hemodynamics and preserves endothelium-mediated vasodilator function during ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.8.2683
更新日期:1997-10-21 00:00:00
abstract::A 28-year-old female undergoing elective total hip replacement experienced an anaphylactic reaction to succinylcholine. Hemodynamics, plasma histamine and catecholamines were measured. The tachycardia experienced during the reaction appeared to be secondary to the sympathoadrenal response rather than a direct chronotr...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.63.1.210
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Some clinical data suggest that atrial-based pacing prevents paroxysmal atrial fibrillation (AF). This study tested the hypothesis that DDDR pacing compared with VDD pacing prevents AF after atrioventricular (AV) junction ablation. METHODS AND RESULTS:Patients were randomized to DDDR pacing (n=33) or to VDD...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.102.7.736
更新日期:2000-08-15 00:00:00
abstract:BACKGROUND:Heat shock protein (HSP)60 is an abundant protein found primarily in the mitochondria, though 15% to 20% is found in the cytosol. Previously we observed that HSP60 complexes with bax in the cytosol. Reduction in HSP60 precipitates translocation of bax to the mitochondria and apoptosis. We hypothesized that H...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000038112.64503.6e
更新日期:2002-11-19 00:00:00
abstract:BACKGROUND:It is not clear why some plaque ruptures lead to acute coronary syndromes (ACS) but others do not. METHODS AND RESULTS:We analyzed 80 plaque ruptures in 74 patients and compared culprit lesions of ACS patients with nonculprit lesions of ACS patients and lesions of non-ACS patients; both culprit and nonculpr...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.CIR.0000097121.95451.39
更新日期:2003-11-18 00:00:00
abstract::Multiple areas of concealed intraventricular conduction are deduced on the basis of aftereffects observed in His bundle recordings. Electrocardiograms and His bundle recordings are presented from two patients with unstable bilateral bundle branch block, the instability of which depended on the interval at which ventri...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.53.5.776
更新日期:1976-05-01 00:00:00
abstract:BACKGROUND:In previous studies comparing regional 201Tl (201Tl) and 18fluorodeoxyglucose (FDG) activity in patients with chronic coronary artery disease and left ventricular dysfunction, we hypothesized that regions with mild-to-moderate reduction in FDG activity and regions with mild-to-moderate irreversible 201Tl def...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.86.4.1125
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:In this study we tested the hypothesis that atrial fibrillation (AF) causes electrophysiological changes of the atrial myocardium which might explain the progressive nature of the arrhythmia. METHODS AND RESULTS:Twelve goats were chronically instrumented with multiple electrodes sutured to the epicardium of...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.7.1954
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:In recent clinical trials, glycoprotein IIb/IIIa blockers have demonstrated effectiveness in preventing adverse events after angioplasty in high-risk patients. However, uncertainty exists regarding the cost-effective selection of patients to receive antiplatelet therapy. METHODS AND RESULTS:All 4962 patient...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.4.392
更新日期:2000-07-25 00:00:00
abstract:BACKGROUND:Recently, it has been shown that stem/progenitor cells may repair damaged/lost endothelial cells in vein grafts and wire-injured arteries. In the present study, we investigated endothelial cell turnover and regeneration in apolipoprotein E (apoE)(-/-)/transgenic mice carrying LacZ genes driven by an endothel...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.746008
更新日期:2008-04-08 00:00:00
abstract::Of 22 children with congenital complete heart block (CCHB) available for study, 14 (63.6%) were born to 11 mothers with clinical or laboratory evidence of connective tissue disease, primarily lupus erythematosus (LE). Seven mothers had both clinical and laboratory evidence of disease while four had only positive labor...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.56.1.82
更新日期:1977-07-01 00:00:00
abstract:BACKGROUND:Evidence suggests that the vessel wall contains an oxidase similar, if not identical, to phagocytic NADPH oxidase. We tested the contribution of this specific oxidase to the progression of atherosclerosis and the regulation of blood pressure. METHODS AND RESULTS:An examination of aortic rings from wild-type...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.11.1234
更新日期:2000-03-21 00:00:00
abstract::Forty-four patients with acute transmural myocardial infarction underwent cardiac catheterization 4.7 +/- 1.3 hours (+/- SD) after the onset of persistent chest discomfort. Thirty-nine patients had total occlusion of infarct-related vessels; 27 of these 39 had successful intracoronary thrombolysis. Twenty of these 27 ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00
abstract:BACKGROUND:Leptin has been implicated in cardiovascular disease. A diet rich in fish has been associated with decreased cardiac and vascular risk. METHODS AND RESULTS:We examined the relationship between diet and leptin in 2 related homogeneous African tribal populations of Tanzania. One tribe consumes freshwater fish...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000025241.01418.4d
更新日期:2002-07-16 00:00:00
abstract::Hemodynamic effects of dobutamine and dopamine (both 5, 10, 15 microgram/kg/min) and epinephrine (0.04 microgram/kg/min) were studied immediately following cessation of cardiopulmonary bypass in 34 patients with preoperative evidence of left ventricular dysfunction. Significant increases in mean cardiac index were see...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.57.2.378
更新日期:1978-02-01 00:00:00
abstract:BACKGROUND:A synergistic interaction between the angiotensin II (Ang II) type 1 receptor and alpha1-adrenergic receptors has been described. We hypothesized that the nonselective beta-antagonist carvedilol, through its alpha1-adrenergic blocking properties, may modulate vascular reactivity to Ang II in patients with ch...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.0000045666.04794.14
更新日期:2003-01-21 00:00:00
abstract:BACKGROUND:The clinical significance of minor elevations in creatine kinase-myocardial band isoenzyme (CK-MB) after coronary interventions has not been systematically evaluated. METHODS AND RESULTS:We examined 4484 patients who underwent successful percutaneous transluminal coronary angioplasty or directional coronary...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.7.1528
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Although long-term lipid-lowering therapy improves endothelium-dependent vasodilatation in humans, it remains unknown whether the short-term removal of LDL per se ameliorates endothelial dysfunction. METHODS AND RESULTS:To examine the effects of a single session of LDL apheresis on endothelial function in p...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.95.1.76
更新日期:1997-01-07 00:00:00
abstract:BACKGROUND:Abciximab is very effective in reducing major cardiac events in patients undergoing interventional procedures. Its antithrombotic effect is primarily attributable to the blocking of platelet glycoprotein IIb/IIIa receptors, but recent evidence suggests that it may have a direct antithrombin effect. No data a...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/hc0802.104456
更新日期:2002-02-26 00:00:00
abstract::The endothelin (ET) system is comprised of 4 active ETs, with ET-1 being the predominant isoform in the cardiovascular system. Because of the potent vasoconstricting and mitogenic effects of ET-1 and its involvement in various cardiovascular diseases, blockade of the ET receptor has received considerable attention. ET...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.CIR.0000094397.19932.78
更新日期:2003-11-04 00:00:00
abstract:BACKGROUND:The endocrine-disrupting chemical bisphenol A (BPA) is widely used in food and beverage packaging. Higher urinary BPA concentrations were cross-sectionally associated with heart disease in National Health and Nutrition Examination Survey (NHANES) 2003-2004 and NHANES 2005-2006, independent of traditional ris...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.111.069153
更新日期:2012-03-27 00:00:00
abstract:BACKGROUND:Apoptotic microparticles are responsible for almost all tissue factor activity of the plaque lipid core. We hypothesized that elevated levels of procoagulant microparticles could also circulate in the peripheral blood of patients with recent clinical signs of plaque disruption and thrombosis. METHODS AND RE...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.8.841
更新日期:2000-02-29 00:00:00
abstract::The effectiveness of intra-aortic balloon pumping in augmenting ventricular performance during acute myocardial ischemic syndromes was determined by noninvasive multigated cardiac blood pool imaging. Nine patients with unstable angina refractory to medical therapy and nine patients with acute myocardial infarction com...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1978-09-01 00:00:00
abstract:BACKGROUND:Catheter-based intrapericardial (IPC) delivery of therapeutic agents has recently been demonstrated. Paclitaxel is known to inhibit vascular smooth muscle cell proliferation. This study examined the effect of IPC instillation of paclitaxel on neointimal proliferation after balloon overstretch of porcine coro...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.13.1575
更新日期:2000-09-26 00:00:00
abstract:BACKGROUND:Angiogenesis is a critical feature of plaque development in atherosclerosis and might play a key role in both the initiation and later rupture of plaques that lead to myocardial infarction and stroke. The precursory molecular or cellular events that initiate plaque growth and that ultimately contribute to pl...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000093185.16083.95
更新日期:2003-11-04 00:00:00
abstract:BACKGROUND:Chagas heart disease is a frequent cause of morbidity and mortality in Latin America. Echocardiography provides useful diagnostic and prognostic information and is an important tool in the management of patients with Chagas disease. METHODS AND RESULTS:A search for relevant publications was obtained from ME...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/CIRCULATIONAHA.106.627323
更新日期:2007-03-06 00:00:00
abstract::Twenty-one reoperations for relief of angina have been performed at Stanford Medical Center in patients who had had previously unsuccessful direct coronary artery surgery. Complete releif of angina was obtained in seven (33%), improvement of angina in six (29%), and no change in angina in eight (38%) after these opera...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1975-08-01 00:00:00
abstract::The capability of a pulsed Doppler flowmeter combined with a phased-array imaging system to measure volume flow was tested in vitro and in patients undergoing cardiac catheterization. The Doppler-phased-array system (DPA) was used to determine vessel diameter and a superimposed cursor was used to locate the range and ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.63.2.388
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in the United States and is responsible for 17% of national health expenditures. As the population ages, these costs are expected to increase substantially. METHODS AND RESULTS:To prepare for future cardiovascular care needs, the American Heart Asso...
journal_title:Circulation
pub_type: 共识发展会议,杂志文章
doi:10.1161/CIR.0b013e31820a55f5
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Although the American Heart Association/American College of Sports Medicine's Preparticipation Questionnaire (AAPQ) is a recommended preexercise cardiovascular screening tool, it has never been systematically evaluated. The purpose of this research is to provide preliminary evidence of its effectiveness amon...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.004160
更新日期:2014-03-11 00:00:00