Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age: The Muscatine Study.

abstract：BACKGROUND:Cardiac dyssynchrony in the failing heart worsens global function and efficiency and generates regional loading disparities that may exacerbate stress-response molecular signaling and worsen cell survival. We hypothesized that cardiac resynchronization (CRT) from biventricular stimulation reverses such molec...

journal_title：Circulation

authors： Chakir K,Daya SK,Tunin RS,Helm RH,Byrne MJ,Dimaano VL,Lardo AC,Abraham TP,Tomaselli GF,Kass DA

更新日期：2008-03-18 00:00:00

abstract：BACKGROUND:Red blood cell transfusion can both benefit and harm. To inform decisions about transfusion, we aimed to quantify associations of transfusion with clinical outcomes and cost in patients having cardiac surgery. METHODS AND RESULTS:Clinical, hematology, and blood transfusion databases were linked with the UK ...

journal_title：Circulation

authors： Murphy GJ,Reeves BC,Rogers CA,Rizvi SI,Culliford L,Angelini GD

更新日期：2007-11-27 00:00:00

abstract：BACKGROUND:In the Basel Antiarrhythmic Study of Infarct Survival trial, low-dose amiodarone improved 1-year survival in patients with asymptomatic complex ventricular arrhythmias persisting 2 weeks after myocardial infarction. To assess whether this beneficial effect persisted despite discontinuation of amiodarone afte...

journal_title：Circulation

authors： Pfisterer ME,Kiowski W,Brunner H,Burckhardt D,Burkart F

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Adenosine can initiate ischemic preconditioning, and mitochondrial ATP-sensitive potassium (K(ATP)) channels have emerged as the likely effectors. We sought to determine the mechanistic interactions between these 2 observations. METHODS AND RESULTS:The mitochondrial flavoprotein oxidation induced by diazoxi...

journal_title：Circulation

authors： Sato T,Sasaki N,O'Rourke B,Marbán E

更新日期：2000-08-15 00:00:00

abstract：BACKGROUND:The release of endothelium-derived relaxing factors has been shown experimentally to be of pivotal importance for the maintenance of coronary blood flow during increased demand. In humans with coronary atherosclerosis, endothelial vasodilator dysfunction is not confined only to epicardial conductance vessels...

journal_title：Circulation

authors： Zeiher AM,Krause T,Schächinger V,Minners J,Moser E

更新日期：1995-05-01 00:00:00

abstract：:Since platelet accumulation may be an important determinant of restenosis after angioplasty, the time course of 51Cr-labeled platelet accumulation after experimental angioplasty was evaluated in a deendothelialized, hypercholesterolemic rabbit preparation of atherosclerosis. Marked platelet accumulation (39.5 +/- 8.7 ...

journal_title：Circulation

authors： Wilentz JR,Sanborn TA,Haudenschild CC,Valeri CR,Ryan TJ,Faxon DP

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:-Recent studies have suggested that testosterone has a protective effect in the arterial vascular system. However, little is known about the molecular aspects of the mechanism(s) involved in these processes. The aim of the present study was to investigate the effect of testosterone on neointimal plaque devel...

journal_title：Circulation

authors： Hanke H,Lenz C,Hess B,Spindler KD,Weidemann W

更新日期：2001-03-13 00:00:00

abstract：:While the steady-state effects of positive pleural pressure on the circulation have been extensively studied, less is known about the immediate effects of positive intrathoracic pressure on cardiac dynamics. Therefore, we performed electrocardiographically gated radionuclide ventriculography with a respiratory gating ...

journal_title：Circulation

authors： Natarajan TK,Wise RA,Karam M,Permutt S,Wagner HN Jr

更新日期：1987-01-01 00:00:00

abstract：:Mitral valve closure during cardiopulmonary resuscitation may result from direct cardiac compression. An alternative hypothesis is that with a rise in intrathoracic pressure, mitral valve closure can occur but may be influenced by whether the lungs are inflated or deflated. To test this hypothesis, we placed a large-b...

journal_title：Circulation

authors： Halperin HR,Weiss JL,Guerci AD,Chandra N,Tsitlik JE,Brower R,Beattie C,Wurmb E,Cadden J,Weisfeldt ML

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle a...

journal_title：Circulation

authors： Ranchoux B,Antigny F,Rucker-Martin C,Hautefort A,Péchoux C,Bogaard HJ,Dorfmüller P,Remy S,Lecerf F,Planté S,Chat S,Fadel E,Houssaini A,Anegon I,Adnot S,Simonneau G,Humbert M,Cohen-Kaminsky S,Perros F

更新日期：2015-03-17 00:00:00

abstract：BACKGROUND:The relations of plasma activated factor XII (FXIIa) concentration and a common polymorphism (C46T) of the factor XII gene with hemostatic status and risk of coronary heart disease (CHD) were examined by prospective surveillance. METHODS AND RESULTS:Genotyping for the C46T variant was performed in 2624 men ...

journal_title：Circulation

authors： Zito F,Drummond F,Bujac SR,Esnouf MP,Morrissey JH,Humphries SE,Miller GJ

更新日期：2000-10-24 00:00:00

abstract：BACKGROUND:Phosphatidylserine-expressing microparticles circulate in blood with a short half-life of <10 minutes. We tested the role of an endothelium-derived phosphatidylserine-binding opsonin, developmental endothelial locus-1 (Del-1), in the uptake of platelet microparticles. METHODS AND RESULTS:Cultured human umbi...

journal_title：Circulation

authors： Dasgupta SK,Le A,Chavakis T,Rumbaut RE,Thiagarajan P

更新日期：2012-04-03 00:00:00

abstract：:Between 1976 and 1982, 413 consecutive patients underwent valvular replacement with a bioprosthesis. Aortic valve replacement was performed in 240 patients, mitral valve replacement in 132, and multiple-valve replacement in 41. Four prostheses were employed: Carpentier-Edwards porcine (n = 336), Angel-Shiley porcine (...

journal_title：Circulation

authors： Teoh KH,Ivanov J,Weisel RD,Darcel IC,Rakowski H

更新日期：1989-09-01 00:00:00

abstract：:We tested the hypothesis that different subsets of ischemia-induced wall motion disorders are characterized by specific patterns of abnormal regional left ventricular systolic function. Regional contraction was quantitatively assessed from two-dimensional echocardiograms by an automated integrative analysis considerin...

journal_title：Circulation

authors： Zeiher AM,Wollschlaeger H,Bonzel T,Kasper W,Just H

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:Laminins are major components of basement membranes, well located to interact with platelets upon vascular injury. Laminin-111 (α1β1γ1) is known to support platelet adhesion but is absent from most blood vessels, which contain isoforms with the α2, α4, or α5 chain. Whether vascular laminins support platelet ...

journal_title：Circulation

authors： Schaff M,Tang C,Maurer E,Bourdon C,Receveur N,Eckly A,Hechler B,Arnold C,de Arcangelis A,Nieswandt B,Denis CV,Lefebvre O,Georges-Labouesse E,Gachet C,Lanza F,Mangin PH

更新日期：2013-07-30 00:00:00

abstract：:To describe the coronary arteriographic findings during early transmural myocardial infarction and to define the prevalence of coronary thrombosis by arteriography, we performed coronary arteriography and left ventriculography within 24 hours from symptom onset of transmural myocardial infarction in 517 patients. The ...

journal_title：Circulation

authors： DeWood MA,Spores J,Hensley GR,Simpson CS,Eugster GS,Sutherland KI,Grunwald RP,Shields JP

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that the oxygen-sensing pathway consisting of transcription factor hypoxia-inducible factor and prolyl hydroxylase domain proteins (PHDs) plays a critical role in glucose metabolism. However, the role of adipocyte PHD in the development of obesity has not been clarified. We examined wh...

journal_title：Circulation

authors： Matsuura H,Ichiki T,Inoue E,Nomura M,Miyazaki R,Hashimoto T,Ikeda J,Takayanagi R,Fong GH,Sunagawa K

更新日期：2013-05-28 00:00:00

abstract：BACKGROUND:Exercise echocardiography (digital cine-loop technique) and 201Tl single-photon emission computed tomography (SPECT) were performed simultaneously in 292 patients being evaluated for coronary artery disease. METHODS AND RESULTS:Pretreadmill and posttreadmill echocardiographic images of diagnostic quality we...

journal_title：Circulation

authors： Quiñones MA,Verani MS,Haichin RM,Mahmarian JJ,Suarez J,Zoghbi WA

更新日期：1992-03-01 00:00:00

abstract：:The nature, prevalence, functional significance, and indeed existence of myocardial disease in progressive systemic sclerosis (PSS) has been debated. In this study the clinical and pathological features of 52 autopsied patients were analyzed in an attempt to resolve these questions. A distinctive focal myocardial lesi...

journal_title：Circulation

authors： Bulkley BH,Ridolfi RL,Salyer WR,Hutchins GM

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:The physiological effects of ACE inhibitors may act in part through a kinin-dependent mechanism. We investigated the effect of chronic ACE-inhibitor treatment on functional kinin B(1)- and B(2)-receptor expression, which are the molecular entities responsible for the biological effects of kinins. METHODS AN...

journal_title：Circulation

authors： Marin-Castaño ME,Schanstra JP,Neau E,Praddaude F,Pecher C,Ader JL,Girolami JP,Bascands JL

更新日期：2002-02-05 00:00:00

abstract：BACKGROUND:Oxidative stress has been implicated in vascular injury and atherogenesis, and antioxidant treatment has shown favorable results in preclinical studies. Despite this, antioxidant therapy has failed to show benefit in clinical trials. Failure of antioxidants in clinical trials may be partly because such thera...

journal_title：Circulation

authors： Chyu KY,Babbidge SM,Zhao X,Dandillaya R,Rietveld AG,Yano J,Dimayuga P,Cercek B,Shah PK

更新日期：2004-05-25 00:00:00

abstract：BACKGROUND:Although molecular biological studies suggest a pathogenic link between enterovirus infection and dilated cardiomyopathy (DCM), the frequency of detection of enteroviral RNA is not consistently high in myocardial tissue from patients with DCM. A recent study has suggested that hepatitis C virus (HCV) may als...

journal_title：Circulation

authors： Okabe M,Fukuda K,Arakawa K,Kikuchi M

更新日期：1997-07-01 00:00:00

abstract：:Eighty-six of 452 patients (19%) with chronic bifascicular block were found to have no clinically apparent associated organic heart disease (OHD) and were defined as having primary conduction disease (PCD). Comparison of patients with PCD and OHD revealed a significantly lower incidence of the following clinical varia...

journal_title：Circulation

authors： Dhingra RC,Wyndham C,Bauernfeind R,Denes P,Wu D,Swiryn S,Rosen KM

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND:Plaque disruption and exposure of subendothelial procoagulants such as tissue factor (TF) to circulating factor VII/VIIa (FVII/VIIa) lead to intravascular thrombosis. Tissue factor pathway inhibitor (TFPI) is an endogenous inhibitor of TF-induced coagulation that binds to factor Xa and the TF-FVIIa catalytic...

journal_title：Circulation

authors： Caplice NM,Mueske CS,Kleppe LS,Simari RD

更新日期：1998-09-15 00:00:00

abstract：BACKGROUND:Although type B aortic dissection has been treated with beta blockers to lower the arterial blood pressure (BP), there has been little evidences about reduction in heart rate (HR). We assessed whether tight HR control improved the outcome of medical treatment in patients with aortic dissection. METHODS AND ...

journal_title：Circulation

authors： Kodama K,Nishigami K,Sakamoto T,Sawamura T,Hirayama T,Misumi H,Nakao K

更新日期：2008-09-30 00:00:00

abstract：BACKGROUND:Previous studies suggested that blockade of RAGE in diabetic apolipoprotein (apo) E-null mice suppressed early acceleration of atherosclerosis. A critical test of the potential applicability of RAGE blockade to clinical settings was its ability to impact established vascular disease. In this study, we tested...

journal_title：Circulation

authors： Bucciarelli LG,Wendt T,Qu W,Lu Y,Lalla E,Rong LL,Goova MT,Moser B,Kislinger T,Lee DC,Kashyap Y,Stern DM,Schmidt AM

更新日期：2002-11-26 00:00:00

abstract：BACKGROUND:Accumulating evidence suggests that several subsets of regulatory T cells that actively mediate immunologic tolerance play crucial roles in atherogenesis. Recently, orally administered anti-CD3 monoclonal antibody has been shown as an inducer of novel regulatory T cells expressing latency-associated peptide ...

journal_title：Circulation

authors： Sasaki N,Yamashita T,Takeda M,Shinohara M,Nakajima K,Tawa H,Usui T,Hirata K

更新日期：2009-11-17 00:00:00

abstract：BACKGROUND:Studies have consistently shown that ventricular tachycardia (VT) and sudden cardiac death (SCD) complicate the long-term outcome after tetralogy of Fallot repair, yet the diagnostic and predictive value of electrophysiological testing in this population is uncertain. METHODS AND RESULTS:A multicenter cohor...

journal_title：Circulation

authors： Khairy P,Landzberg MJ,Gatzoulis MA,Lucron H,Lambert J,Marçon F,Alexander ME,Walsh EP

更新日期：2004-04-27 00:00:00

abstract：:Noninvasive gated cardiac blood pool imaging with technetium-99m autologous erythrocytes was employed to differentiate reversible verus irreversible abnormal ventricular segmental contraction by regional wall and pump responses to sublingual nitroglycerin in 25 patients with chronic coronary heart disease. In 12 patie...

journal_title：Circulation

authors： Salel AF,Berman DS,DeNardo GL,Mason DT

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Hemodynamic efficiency of Fontan circulation is believed to be a major determinant of outcome. Prior research on flow dynamics in different modifications of Fontan circulation used in vitro models and computer-based simulation. This study was designed to compare in vivo flow dynamics in the systemic venous p...

journal_title：Circulation

authors： Be'eri E,Maier SE,Landzberg MJ,Chung T,Geva T

更新日期：1998-12-22 00:00:00