Abstract:
:Noninvasive gated cardiac blood pool imaging with technetium-99m autologous erythrocytes was employed to differentiate reversible verus irreversible abnormal ventricular segmental contraction by regional wall and pump responses to sublingual nitroglycerin in 25 patients with chronic coronary heart disease. In 12 patients without ECG infarctions compared to 13 with infarctions, radioisotopic images demonstrated significantly greater percent decreases in end-systolic volumes (33.8 +/- 6.7 SEM vs 187 +/- 4.4; P less than 0.05) without differences in percent reductions in end-diastolicvolumes (13.7 +/- 3.9 vs 11.6 +/- 6.1; NS) and thereby significantly greater percent increases in ejection fractions (9.3 +/- 1.6 vs 4.1 +/- 2.0; P less than 0.05). In the 22 patients with regional dyssynergy, improvement in disordered pattern and extent of localized dyssynergy following antianginal action of nitroglycerin was related to ECG absence of prior infarction. These obsevations demonstrate the clinical accuracy of atraumatic scintigraphy in the detection of reversible localized dyssynergy due to myocardial ischemia in coronary heart disease.
journal_name
Circulationjournal_title
Circulationauthors
Salel AF,Berman DS,DeNardo GL,Mason DTdoi
10.1161/01.cir.53.6.975subject
Has Abstractpub_date
1976-06-01 00:00:00pages
975-82issue
6eissn
0009-7322issn
1524-4539journal_volume
53pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:We have previously shown major differences in beta-adrenergic and muscarinic modulation of L-type calcium currents (ICa) in newborn and adult rabbit heart. However, little is known about developmental changes in modulation of ICa by phosphodiesterases (PDEs), which also regulate intracellular cAMP concentrat...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.90.1.469
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:The mechanisms of thrombosis on plaque erosion are poorly understood. We examined the potential role of endothelial apoptosis in endothelial erosion and vessel thrombosis. METHODS AND RESULTS:Segments of New Zealand White rabbit femoral arteries were temporarily isolated in vivo. One artery was incubated wi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000130172.62481.90
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Patients surviving ventricular fibrillation (VF) or sustained ventricular tachycardia (VT) are at a high risk of death due to a recurrence of arrhythmia. The implantable cardioverter defibrillator (ICD) terminates VT or VF, but it is not known whether this device prolongs life in these patients compared with...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.101.11.1297
更新日期:2000-03-21 00:00:00
abstract::We studied the effects of experimentally induced emotional stress (mental arithmetic) on different hemodynamic parameters, catecholamine levels, and serum and platelet function tests in 25 postinfarction patients and in 10 apparently healthy, age-matched control subjects. Mental stress (10 minutes) induced significant...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:Arterial relaxation is largely regulated by endothelial nitric oxide (NO). Its diminished activity has been associated with incipient atherosclerosis. We investigated the endothelium-dependent relaxation of aorta in apolipoprotein E-knockout (apoE-KO) mice exposed to single or repeated Chlamydia pneumoniae i...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.9.1039
更新日期:2000-08-29 00:00:00
abstract:BACKGROUND:Ventricular tachyarrhythmias are the major clinical manifestation of arrhythmogenic right ventricular disease. Although antiarrhythmic therapy has been widely advocated, there is only limited information available on the efficacy of antiarrhythmic drugs in these patients. METHODS AND RESULTS:The short- and ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.86.1.29
更新日期:1992-07-01 00:00:00
abstract::We performed transventricular pulmonary valvotomy as initial surgery in 22 consecutive patients with pulmonary atresia and intact ventricular septum who had a patent infundibulum. Nineteen patients also had placement of a central aortopulmonary shunt. All patients survived surgery, and 16 patients have had preoperativ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:The mechanisms linking obesity to hypertension have not been established, but sodium retention and excessive sympathetic tone are key contributors. The natriuretic peptides are important regulators of sodium homeostasis and neurohormonal activation, raising the possibility that obese individuals have an impa...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000112582.16683.EA
更新日期:2004-02-10 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated that induction of heat shock protein (HSP) 72 by whole-body hyperthermia reduces infarct size in an in vivo model of ischemia and reperfusion. Furthermore, hearts obtained from transgenic mice that overexpress HSP72 demonstrate improved functional recovery and decreased inf...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.6.1408
更新日期:1996-09-15 00:00:00
abstract:BACKGROUND:The renal actions of brain natriuretic peptide (BNP) in congestive heart failure (CHF) are associated with increased diuresis and natriuresis, preserved glomerular filtration rate (GFR), and lack of activation of the renin-angiotensin-aldosterone system (RAAS). In contrast, diuretic-induced natriuresis may b...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000124064.00494.21
更新日期:2004-04-06 00:00:00
abstract::This review discusses the role of growth factors on the proliferation of smooth muscle cells (SMCs) in injured arteries. We have used a variety of procedures to injure rat carotid arteries and noted that removal of endothelium followed by platelet adherence does not always initiate SMC replication. Furthermore, thromb...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:Pulmonary veno-occlusive disease is caused by excessive cell proliferation and fibrosis, which obliterate the lumen of pulmonary venules, leading to pulmonary hypertension, right ventricular failure, and death. This condition has no effective treatment and a 5-year survival of <5%. Understanding the mechanis...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.007822
更新日期:2014-09-30 00:00:00
abstract::Patency of the femoral artery of infants and children who previously had percutaneous arterial catheterization at a weight of less than 25 kg was studied angiographically. During the study period, 118 patients had repeat arterial catheterization. 48 from the opposite leg. Femoral artery occlusion was found in four pat...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.56.1.102
更新日期:1977-07-01 00:00:00
abstract::To test the hypothesis that an area of slow conduction is present during reentrant ventricular tachycardia in man, and that the earliest activation site during ventricular tachycardia is within or orthodromically just distal to the area of slow conduction in the reentry loop, we studied 12 episodes of ventricular tach...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.75.2.369
更新日期:1987-02-01 00:00:00
abstract:BACKGROUND:CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor for oxidized low-density lipoprotein that is expressed in atherosclerotic lesions. Proteolytic cleavage of membrane-bound CXCL16 releases soluble CXCL16, which may promote migration of effector T cells and augment a proatherogen...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.806877
更新日期:2009-06-30 00:00:00
abstract:BACKGROUND:The purpose of this investigation was to establish normal values of RR variability for middle-aged persons and compare them with values found in patients early and late after myocardial infarction. We hypothesized that presence or absence of coronary heart disease, age, and sex (in this order of importance) ...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/01.cir.91.7.1936
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:Mutations in the ryanodine 2 receptor (RyR2) gene have been identified in patients with catecholaminergic polymorphic ventricular tachycardia. We examined the cellular basis for the ECG features and arrhythmia mechanisms using low-dose caffeine to mimic the defective calcium homeostasis encountered under the...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.104.479295
更新日期:2005-05-31 00:00:00
abstract::The dynamics of acute mitral regurgitation were studied in six open-chest dogs in whom a portion of the anterior leaflet was excised. Phasic mitral and aortic flows were measured electromagnetically and left ventricular filling volume, regurgitant volume (RV) and forward stroke volume (SV) were calculated. The systoli...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.60.1.170
更新日期:1979-07-01 00:00:00
abstract:BACKGROUND:Ischemia-induced electrophysiological changes are more prominent in epicardial cells than in endocardial cells. Epicardial action potentials shorten more than endocardial action potentials during ischemia. Since the L-type Ca2+ current plays an important role in the maintenance of action potential duration, ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.2.768
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:Endothelial nitric oxide (NO)-mediated responses are impaired in arterioles of male spontaneously hypertensive rats (SHR), but they are still present in female SHR. We hypothesized that in vitro incubation of arterioles of male SHR with estrogen will restore NO-mediated responses by upregulation of endotheli...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.1.94
更新日期:2000-01-04 00:00:00
abstract::Experimental studies demonstrate that short-term regional perfusion-contraction matching, in which the energy demands of regional myocardial contraction are reduced to match the diminished myocardial substrate supply, occurs during states of low coronary blood flow under resting conditions and during exercise-induced ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.83.3.1076
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Serum paraoxonase (PON1), an enzyme carried on HDL, inhibits LDL oxidation, and in human population studies, low PON1 activity is associated with atherosclerosis. In addition, PON1 knockout mice are more susceptible to lipoprotein oxidation and atherosclerosis. To evaluate whether PON1 protects against ather...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000023623.87083.4f
更新日期:2002-07-23 00:00:00
abstract::Contrary to opinions generally accepted in the past, CHD is very common in both African-American men and women, with incidence rates approaching those of US Caucasians. Higher prevalence of hypertension, diabetes, cigarette smoking, and obesity all contribute to the high level of CHD in African-Americans. Additional r...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.83.4.1474
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:The outcome of aortic valve replacement in patients with severe aortic stenosis, low transvalvular gradient, and severe left ventricular dysfunction is not well known. METHODS AND RESULTS:Between 1985 and 1995, 52 patients with left ventricular ejection fraction (EF) < or =35% and aortic stenosis with trans...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.16.1940
更新日期:2000-04-25 00:00:00
abstract:BACKGROUND:Repeated brief episodes of myocardial ischemia performed by mechanical clamping of a coronary artery "precondition" the heart and reduce infarct size after a subsequent sustained ischemia. It is not known, however, whether spontaneous episodes of transient ischemia caused by formation of platelet thrombi, wh...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.85.2.779
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:High C-reactive protein (CRP) levels are associated with an increased risk of cardiovascular events, even in apparently healthy individuals. It has not been established whether elevated CRP reflects an increased burden of subclinical coronary atherosclerosis. METHODS AND RESULTS:We studied a stratified rand...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000032135.98011.c4
更新日期:2002-09-03 00:00:00
abstract:BACKGROUND:Postprandial angina pectoris has been recognized for more than two centuries and can be identified in up to 10% of patients with chronic ischemic heart disease. Redistribution of myocardial blood flow, from a region supplied by a severely stenotic coronary artery to those supplied by less diseased or normal ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.97.12.1144
更新日期:1998-03-31 00:00:00
abstract:BACKGROUND:Apoptotic microparticles are responsible for almost all tissue factor activity of the plaque lipid core. We hypothesized that elevated levels of procoagulant microparticles could also circulate in the peripheral blood of patients with recent clinical signs of plaque disruption and thrombosis. METHODS AND RE...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.8.841
更新日期:2000-02-29 00:00:00
abstract::Nineteen patients with chronic low output cardiac failure were studied before, during and after infusion of phentolamine in doses of 10, 20, 30 and 40 microgram/kg/min. Significant reduction of left- and right-sided pressures and increases in cardiac index and heart rate (HR) were present within 15 minutes of starting...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.58.1.157
更新日期:1978-07-01 00:00:00
abstract:BACKGROUND:Previous experimental studies have shown that the effect of serotonin on a coronary stenosis depends on whether that stenosis is compliant or fixed. However, the relation between coronary stenosis morphology and the response to serotonin in patients with angina is not known. METHODS AND RESULTS:Using comput...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.88.4.1518
更新日期:1993-10-01 00:00:00