Adenosine primes the opening of mitochondrial ATP-sensitive potassium channels: a key step in ischemic preconditioning?

abstract：BACKGROUND:Ischemic mitral regurgitation (MR) was first ascribed to papillary muscle (PM) contractile dysfunction. Current theories include apical leaflet tethering caused by left ventricular (LV) distortion, but PM dysfunction is still postulated and commonly diagnosed. PM contraction, however, parallels apical tether...

journal_title：Circulation

authors： Messas E,Guerrero JL,Handschumacher MD,Chow CM,Sullivan S,Schwammenthal E,Levine RA

更新日期：2001-10-16 00:00:00

abstract：BACKGROUND:CD4+CD28null T cells are present in increased numbers in the peripheral blood of patients with acute coronary syndrome (ACS) compared with patients with chronic stable angina (CSA). The triggers of activation and expansion of these cells to date remain unclear. METHODS AND RESULTS:Twenty-one patients with A...

journal_title：Circulation

authors： Zal B,Kaski JC,Arno G,Akiyu JP,Xu Q,Cole D,Whelan M,Russell N,Madrigal JA,Dodi IA,Baboonian C

更新日期：2004-03-16 00:00:00

abstract：BACKGROUND:Increased expression of osteopontin (OPN), fibroblast growth factors (FGFs), and their type-1 receptor (FGFR-1) is associated with neointima formation and atherosclerosis. This study tested the hypothesis that ligand activation of FGFR-1 stimulates OPN expression in rat aortic smooth muscle cells (RASMCs), e...

journal_title：Circulation

authors： Li G,Oparil S,Kelpke SS,Chen YF,Thompson JA

更新日期：2002-08-13 00:00:00

abstract：BACKGROUND:Airborne particulate matter has been linked to excess morbidity and mortality. Recent attention has focused on the effects of particulate exposure on cardiac autonomic control. Inhaled particulates may affect the autonomic nervous system either directly, by eliciting a sympathetic stress response, or indirec...

journal_title：Circulation

authors： Magari SR,Hauser R,Schwartz J,Williams PL,Smith TJ,Christiani DC

更新日期：2001-08-28 00:00:00

abstract：BACKGROUND:Atrial fibrillation is common in advanced heart failure, but its prognostic significance is controversial. METHODS AND RESULTS:We evaluated the relation of atrial rhythm to overall survival and sudden death in 390 consecutive advanced heart failure patients. Etiology of heart failure was coronary artery dis...

journal_title：Circulation

authors： Middlekauff HR,Stevenson WG,Stevenson LW

更新日期：1991-07-01 00:00:00

abstract：:Analysis of the external brachial pulse recorded during standard blood pressure cuff deflation with use of a transducer with a wide frequency response has revealed a reproducible pattern with three distinct components that we have labeled K1, K2, and K3. K1 is a low-amplitude, low-frequency signal that is present with...

journal_title：Circulation

authors： Blank SG,West JE,Müller FB,Cody RJ,Harshfield GA,Pecker MS,Laragh JH,Pickering TG

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:Whether cardiac rehabilitation (CR) is effective in patients older than 75 years, who have been excluded from most trials, remains unclear. We enrolled patients 46 to 86 years old in a randomized trial and assessed the effects of 2 months of post-myocardial infarction (MI) CR on total work capacity (TWC, in ...

journal_title：Circulation

authors： Marchionni N,Fattirolli F,Fumagalli S,Oldridge N,Del Lungo F,Morosi L,Burgisser C,Masotti G

更新日期：2003-05-06 00:00:00

abstract：:Patients with aortic stenosis develop widely variable patterns of left ventricular hypertrophy and dysfunction. We postulated that coronary atherosclerosis (CAD) may be associated with impaired left ventricular function and chamber dilatation in patients with aortic stenosis. Left ventricular mass and volumes were qua...

journal_title：Circulation

authors： Vekshtein VI,Alexander RW,Yeung AC,Plappert T,Sutton MG,Ganz P,Selwyn AP,Bittl JA

更新日期：1990-12-01 00:00:00

abstract：:The 21-amino acid peptide endothelin-1 (ET-1) is the predominant isoform of the endothelin peptide family, which includes ET-2, ET-3, and ET-4. It exerts various biological effects, including vasoconstriction and the stimulation of cell proliferation in tissues both within and outside of the cardiovascular system. ET-...

journal_title：Circulation

authors： Lüscher TF,Barton M

更新日期：2000-11-07 00:00:00

abstract：BACKGROUND:Early detection of adverse effects of novel therapies and understanding of their mechanisms could improve the safety and efficiency of drug development. We have retrospectively applied large-scale proteomics to blood samples from ILLUMINATE (Investigation of Lipid Level Management to Understand its Impact in...

journal_title：Circulation

authors： Williams SA,Murthy AC,DeLisle RK,Hyde C,Malarstig A,Ostroff R,Weiss SJ,Segal MR,Ganz P

更新日期：2018-03-06 00:00:00

abstract：BACKGROUND:The mainstay of treatment for atrial fibrillation (AF) remains pharmacological; however, catheter ablation has increasingly been used over the last decade. The relative merits of each strategy have not been extensively studied. METHODS AND RESULTS:We conducted a randomized multicenter comparison of these 2 ...

journal_title：Circulation

authors： Jaïs P,Cauchemez B,Macle L,Daoud E,Khairy P,Subbiah R,Hocini M,Extramiana F,Sacher F,Bordachar P,Klein G,Weerasooriya R,Clémenty J,Haïssaguerre M

更新日期：2008-12-09 00:00:00

abstract：:Patients with systemic morphological right ventricles (RVs), including congenitally corrected transposition of the great arteries and dextro-transposition of the great arteries with a Mustard or Senning atrial baffle repair, have a high likelihood of developing systemic ventricular dysfunction. Unfortunately, there ar...

journal_title：Circulation

authors： Zaragoza-Macias E,Zaidi AN,Dendukuri N,Marelli A

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Memory is a diverse biological phenomenon whose importance in the ventricle has been demonstrated. We hypothesized its occurrence in the atrium, contributing to the modulation of cardiac rhythm. METHODS AND RESULTS:We analyzed P and Ta waves in conscious chronically instrumented dogs with complete heart blo...

journal_title：Circulation

authors： Herweg B,Chang F,Chandra P,Danilo P Jr,Rosen MR

更新日期：2001-01-23 00:00:00

abstract：BACKGROUND:Bartonella species are the only known bacterial pathogens causing vasculoproliferative disorders in humans (bacillary angiomatosis [BA]). Cellular and bacterial pathogenetic mechanisms underlying the induction of BA are largely unknown. METHODS AND RESULTS:Activation of hypoxia-inducible factor-1 (HIF-1), t...

journal_title：Circulation

authors： Kempf VA,Lebiedziejewski M,Alitalo K,Wälzlein JH,Ehehalt U,Fiebig J,Huber S,Schütt B,Sander CA,Müller S,Grassl G,Yazdi AS,Brehm B,Autenrieth IB

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Myocardial infarction (MI) is an ischemic wound that recruits millions of leukocytes. MI-associated blood leukocytosis correlates inversely with patient survival, yet the signals driving heightened leukocyte production after MI remain incompletely understood. METHODS AND RESULTS:With the use of parabiosis s...

journal_title：Circulation

authors： Sager HB,Heidt T,Hulsmans M,Dutta P,Courties G,Sebas M,Wojtkiewicz GR,Tricot B,Iwamoto Y,Sun Y,Weissleder R,Libby P,Swirski FK,Nahrendorf M

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:The purpose of this investigation was to establish normal values of RR variability for middle-aged persons and compare them with values found in patients early and late after myocardial infarction. We hypothesized that presence or absence of coronary heart disease, age, and sex (in this order of importance) ...

journal_title：Circulation

authors： Bigger JT Jr,Fleiss JL,Steinman RC,Rolnitzky LM,Schneider WJ,Stein PK

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Connexin (Cx)40 and Cx45 are the major protein subunits of gap junction channels in the conduction system of mammals. To determine the role of Cx40, we correlated cardiac activation with Connexin distribution in normal and Cx40-deficient mice hearts. METHODS AND RESULTS:Epicardial and septal activation was ...

journal_title：Circulation

authors： van Rijen HV,van Veen TA,van Kempen MJ,Wilms-Schopman FJ,Potse M,Krueger O,Willecke K,Opthof T,Jongsma HJ,de Bakker JM

更新日期：2001-03-20 00:00:00

abstract：:We assessed factors during an initial episode of ventricular fibrillation that may be predictive of recurrence. Of 141 consecutive patients with acute ischemic heart disease who survived an initial episode of ventricular fibrillation, 41 (29%) had recurrent ventricular fibrillation during hospitalization. The incidenc...

journal_title：Circulation

authors： Logan KR,McIlwaine WJ,Adgey AA,Pantridge JF

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:Whether myocardial reperfusion obtained with thrombolysis or primary angioplasty is associated with a similar recovery of function and with the same risk of hemorrhagic infarction is unknown. We evaluated the effects of mechanical and pharmacological reperfusion (with or without a plasma lytic state) on infa...

journal_title：Circulation

authors： Pislaru SV,Barrios L,Stassen T,Jun L,Pislaru C,Van de Werf F

更新日期：1997-07-15 00:00:00

abstract：:One hundred consecutive patients who underwent coronary artery bypass surgery at the Columbia-Presbyterian Medical Center from December 1972 through February 1975 were evaluated at surgery and then followed for as long as 4 1/2 years to study their postoperative psychosocial and behavioral course. One patient died dur...

journal_title：Circulation

authors： Kornfeld DS,Heller SS,Frank KA,Wilson SN,Malm JR

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:The countercurrent arrangement of capillary blood flow in the medulla of mammalian kidneys generates a gradient of oxygen tension between the renal cortex and the papillary tip that results in a state of relative hypoxia within the renal medulla. Exploration of the pathophysiological implications of medullar...

journal_title：Circulation

authors： Prasad PV,Edelman RR,Epstein FH

更新日期：1996-12-15 00:00:00

abstract：:High-density lipoprotein (HDL) cholesterol distributions were compared among 191 black and 1341 white males and 233 black and 1088 white females, ages 5-44 years, examined in five of the Lipid Research Clinic (LRC) population-based surveys. Mean HDL cholesterol was higher in blacks than whites in each 5-year age group...

journal_title：Circulation

authors： Tyroler HA,Glueck CJ,Christensen B,Kwiterovich PO Jr

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND:The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle a...

journal_title：Circulation

authors： Ranchoux B,Antigny F,Rucker-Martin C,Hautefort A,Péchoux C,Bogaard HJ,Dorfmüller P,Remy S,Lecerf F,Planté S,Chat S,Fadel E,Houssaini A,Anegon I,Adnot S,Simonneau G,Humbert M,Cohen-Kaminsky S,Perros F

更新日期：2015-03-17 00:00:00

abstract：BACKGROUND:Sensitivity to apoptotic signals, the clearance rate of apoptosis, and the apoptotic ultrastructure have not been studied in cells of the in vivo adult heart. METHODS AND RESULTS:To minimize the systemic influence, soluble Fas ligand was injected directly into in vivo rat hearts and livers (as the control) ...

journal_title：Circulation

authors： Hayakawa K,Takemura G,Koda M,Kawase Y,Maruyama R,Li Y,Minatoguchi S,Fujiwara T,Fujiwara H

更新日期：2002-06-25 00:00:00

abstract：:Using a mechanical sector-scanner, two-dimensional echocardiograms were obtained from 28 normal subjects, 15 patients with tetralogy of Fallot, 11 patients with complete transposition of the great arteries and six patients with double outlet right ventricle. The image obtained perpendicular to the long axis of the lef...

journal_title：Circulation

authors： Henry WL,Maron BJ,Griffith JM

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND:This study aimed to assess if clampless off-pump coronary artery bypass grafting (CABG) decreases risk-adjusted mortality, stroke rate, and morbidity in unselected patients in comparison to conventional CABG. METHODS AND RESULTS:Between July 2009 and November 2010, data of 1282 consecutive patients undergoi...

journal_title：Circulation

authors： Börgermann J,Hakim K,Renner A,Parsa A,Aboud A,Becker T,Masshoff M,Zittermann A,Gummert JF,Kuss O

更新日期：2012-09-11 00:00:00

abstract：BACKGROUND:Congestive heart failure (CHF) patients with central sleep apnea (CHF-CSA) have elevated plasma norepinephrine (NE) compared with CHF patients without apnea (CHF-N). Patients with CHF-CSA also demonstrate higher mean pulmonary artery pressure (PAP), which is suggestive of worse cardiac function. Whether CSA ...

journal_title：Circulation

authors： Mansfield D,Kaye DM,Brunner La Rocca H,Solin P,Esler MD,Naughton MT

更新日期：2003-03-18 00:00:00

abstract：:To test the hypothesis that an area of slow conduction is present during reentrant ventricular tachycardia in man, and that the earliest activation site during ventricular tachycardia is within or orthodromically just distal to the area of slow conduction in the reentry loop, we studied 12 episodes of ventricular tach...

journal_title：Circulation

authors： Okumura K,Olshansky B,Henthorn RW,Epstein AE,Plumb VJ,Waldo AL

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:Z-Val-Ala-Asp(OMe)-CH2F (ZVAD-fmk), a tripeptide inhibitor of the caspase interleukin-1beta-converting enzyme family of cysteine proteases, may reduce myocardial reperfusion injury in vivo by attenuating cardiomyocyte apoptosis within the ischemic area at risk. METHODS AND RESULTS:Sprague-Dawley rats were s...

journal_title：Circulation

authors： Yaoita H,Ogawa K,Maehara K,Maruyama Y

更新日期：1998-01-27 00:00:00

abstract：BACKGROUND:Systemic markers of inflammation have been found in unstable angina. Disruption of culprit coronary stenoses may cause a greater inflammatory response in patients with unstable than those with stable angina. We assessed the time course of C-reactive protein (CRP), serum amyloid A protein (SAA), and interleuk...

journal_title：Circulation

authors： Liuzzo G,Buffon A,Biasucci LM,Gallimore JR,Caligiuri G,Vitelli A,Altamura S,Ciliberto G,Rebuzzi AG,Crea F,Pepys MB,Maseri A

更新日期：1998-12-01 00:00:00