Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month.

Abstract:

BACKGROUND:Cholesterol-lowering therapy can improve cardiovascular morbidity and mortality in patients with atherosclerosis. Although the mechanisms responsible are unclear, these benefits precede macroscopic changes in the vasculature. Emerging evidence that improvement in endothelial function may occur requires substantiation; in particular, it is unclear how early any such improvement would be detectable after initiation of therapy. METHODS AND RESULTS:This randomized, double-blind, placebo-controlled crossover study evaluated the effect of simvastatin (20 mg daily for 4 weeks) on endothelium-dependent and endothelium-independent vasodilation and on the response to the inhibitor of nitric oxide synthesis, NG-monomethyl-L-arginine (L-NMMA), in the forearm vasculature of subjects with moderate elevation of total serum cholesterol (6.0 to 10.0 mmol/L) by use of strain-gauge plethysmography. Studies were repeated after 3 more months of open therapy. When the results are expressed as percentage changes in flow in the infused arm relative to the noninfused arm, the vasodilator response to acetylcholine was significantly increased after 4 weeks of treatment with simvastatin (P < .0005), and this improvement was further enhanced after 3 months (P < .005). Concurrently, simvastatin augmented the vasoconstrictor response to L-NMMA, an effect that was maintained at 3 months (P < .0005). The response to the endothelium-independent vasodilator sodium nitroprusside was unaltered. CONCLUSIONS:These observations indicate that within 1 month of treatment with simvastatin, both the stimulated and basal nitric oxide dilator functions of the endothelium are augmented, and the benefits of this HMG-coenzyme A reductase inhibitor persist with continued therapy.

journal_name

Circulation

journal_title

Circulation

authors

O'Driscoll G,Green D,Taylor RR

doi

10.1161/01.cir.95.5.1126

subject

Has Abstract

pub_date

1997-03-04 00:00:00

pages

1126-31

issue

5

eissn

0009-7322

issn

1524-4539

journal_volume

95

pub_type

临床试验,杂志文章,随机对照试验
  • Premature pulmonary valve opening.

    abstract::Premature opening of the pulmonary valve (opening independent of atrial or ventricular systole) was originally described in a case of sinus of Valsalva rupture into the right atrium. Since that time we have observed five additional cases in which the pulmonary valve opened prematurely. Entities encountered included: 1...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.55.1.128

    authors: Wann LS,Weyman AE,Dillon JC,Feigenbaum H

    更新日期:1977-01-01 00:00:00

  • Coronary occlusion during coronary angiography.

    abstract::Between January 1, 1970, and December 31, 1974, 2981 patients underwent coronary arteriography. Twelve acute coronary dissections or embolizations occurred, an incidence of 0.4%. The incidences of acute occlusions for the Sones and Judkins techniques were 0.19% (4/2077 studies) and 0.88% (8/940), respectively. No inst...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.52.6.1063

    authors: Guss SB,Zir LM,Garrison HB,Daggett WM,Block PC,Dinsmore RE

    更新日期:1975-12-01 00:00:00

  • Early atrial fibrillation during evolving myocardial infarction: a consequence of impaired left atrial perfusion.

    abstract::Seven of 214 patients (3%) with acute myocardial infarction (120 inferior and 94 anterior) developed atrial fibrillation within 3 hr of the onset of chest pain. All seven patients had an inferior infarction and in all seven the left circumflex artery was occluded proximal to the origin of its left atrial circumflex br...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.75.1.146

    authors: Hod H,Lew AS,Keltai M,Cercek B,Geft IL,Shah PK,Ganz W

    更新日期:1987-01-01 00:00:00

  • The relationship of cardiac output and arterial pressure control.

    abstract::Many basic concepts of cardiac output and arterial pressure control have changed considerably in the past few years. In general, each tissue controls its own local resistance and blood flow regardless of the level of arterial pressure; the sum of the local flows then determines the venous return and cardiac output. Ho...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/01.cir.64.6.1079

    authors: Guyton AC

    更新日期:1981-12-01 00:00:00

  • Aspirin in the treatment of acute myocardial infarction in elderly Medicare beneficiaries. Patterns of use and outcomes.

    abstract:BACKGROUND:Although aspirin is an effective, inexpensive, and safe treatment of acute myocardial infarction, the frequency of use of aspirin in actual medical practice is not known. Elderly patients, a group with low rates of utilization of effective therapies such as thrombolytic therapy, also may be at risk of not re...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.10.2841

    authors: Krumholz HM,Radford MJ,Ellerbeck EF,Hennen J,Meehan TP,Petrillo M,Wang Y,Kresowik TF,Jencks SF

    更新日期:1995-11-15 00:00:00

  • A permanent transvenous lead system for an implantable pacemaker cardioverter-defibrillator. Nonthoracotomy approach to implantation.

    abstract::A transvenous lead system for implantable defibrillators would obviate a surgical thoracotomy and reduce the morbidity and mortality associated with implantation. We evaluated the clinical performance of a new nonthoracotomy lead system that included a defibrillation lead in the coronary sinus. At the time of defibril...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.85.1.196

    authors: Yee R,Klein GJ,Leitch JW,Guiraudon GM,Guiraudon CM,Jones DL,Norris C

    更新日期:1992-01-01 00:00:00

  • Use of a novel endoscopic catheter for direct visualization and ablation in an ovine model of chronic myocardial infarction.

    abstract:BACKGROUND:Defining the arrhythmogenic substrate is essential for successful ablation of scar-related ventricular tachycardia. The visual characteristics of endocardial ischemic scar have not been described in vivo. The goal of this study was (1) to quantify the visual characteristics of normal tissue, scar border zone...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.112.112540

    authors: Betensky BP,Jauregui M,Campos B,Michele J,Marchlinski FE,Oley L,Wylie B,Robinson D,Gerstenfeld EP

    更新日期:2012-10-23 00:00:00

  • Intracellular calcium and vulnerability to fibrillation and defibrillation in Langendorff-perfused rabbit ventricles.

    abstract:BACKGROUND:The role of intracellular calcium (Ca(i)) in defibrillation and vulnerability is unclear. METHODS AND RESULTS:We simultaneously mapped epicardial membrane potential and Ca(i) during shock on T-wave episodes (n=104) and attempted defibrillation episodes (n=173) in 17 Langendorff-perfused rabbit ventricles. U...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.630509

    authors: Hwang GS,Hayashi H,Tang L,Ogawa M,Hernandez H,Tan AY,Li H,Karagueuzian HS,Weiss JN,Lin SF,Chen PS

    更新日期:2006-12-12 00:00:00

  • Comparative accuracy of electrocardiographic and vectorcardiographic criteria for inferior myocardial infarction.

    abstract::Numerous criteria for the diagnosis of inferior wall myocardial infarction by electrocardiogram (ECG) and vectorcardiogram (VCG) have been published, but they have not been subjected to a systematic, independent evaluation. Accordingly, we studied 146 patients undergoing cardiac catheterization; 63 were normal and 83 ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.63.5.1025

    authors: Hurd HP 2nd,Starling MR,Crawford MH,Dlabal PW,O'Rourke RA

    更新日期:1981-05-01 00:00:00

  • Late reperfusion for acute myocardial infarction limits the dilatation of left ventricle without the reduction of infarct size.

    abstract:BACKGROUND:While previous clinical studies have shown a possible beneficial effect of the reperfusion performed at a relatively late phase of acute myocardial infarction ("late reperfusion") in preventing left ventricular enlargement, the mechanism has not been clarified. METHODS AND RESULTS:Of 89 patients with an ini...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.88.6.2565

    authors: Hirayama A,Adachi T,Asada S,Mishima M,Nanto S,Kusuoka H,Yamamoto K,Matsumura Y,Hori M,Inoue M

    更新日期:1993-12-01 00:00:00

  • Myocardial thallium-201 kinetics in normal and ischemic myocardium.

    abstract::The initial myocardial uptake of thallium-201 depends on myocardial blood flow distribution. The phenomenon of delayed thallium redistribution after transiently or chronically altered myocardial perfusion has been described. The net myocardial accumulation of thallium-201 after injection depends upon the net balance b...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.64.3.610

    authors: Grunwald AM,Watson DD,Holzgrefe HH Jr,Irving JF,Beller GA

    更新日期:1981-09-01 00:00:00

  • Effects of volume loading during experimental acute pulmonary embolism.

    abstract::Volume loading is used to treat hemodynamically compromised patients with acute pulmonary embolism despite data to suggest that volume loading after embolism might cause a leftward shift of the ventricular septum with a subsequent decrease in left ventricular (LV) end-diastolic volume and stroke work. We studied 10 cl...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.80.1.178

    authors: Belenkie I,Dani R,Smith ER,Tyberg JV

    更新日期:1989-07-01 00:00:00

  • A reassessment of the echocardiogram in mitral stenosis.

    abstract::Echocardiographic and cardiac catheterization findings were compared in 61 patients with mitral stenosis without other significant lesions in an attempt to determine the clinical usefulness of echocardiography in the assessment of such patients. There was a poor correlation between the E-F slope on the echocardiogram ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.52.4.664

    authors: Cope GD,Kisslo JA,Johnson ML,Behar VS

    更新日期:1975-10-01 00:00:00

  • Dilated cardiomyopathy associated with deficiency of the cytoskeletal protein metavinculin.

    abstract:BACKGROUND:The cytoskeleton plays an important role in maintaining cell structure and integrity. Defects in cytoskeletal proteins can cripple cell strength and may cause cardiomyopathy. We analyzed heart tissues from subjects with dilated cardiomyopathy for abnormalities in the cardiac cytoskeleton. Metavinculin, a car...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.95.1.17

    authors: Maeda M,Holder E,Lowes B,Valent S,Bies RD

    更新日期:1997-01-07 00:00:00

  • Intracoronary beta-irradiation with a liquid (188)re-filled balloon: six-month results from a clinical safety and feasibility study.

    abstract:BACKGROUND:Coronary irradiation is a new concept to reduce restenosis. We evaluated the feasibility and safety of intracoronary irradiation with a balloon catheter filled with (188)Re, a liquid, high-energy beta-emitter. METHODS AND RESULTS:Irradiation with 15 Gy at 0.5-mm tissue depth was performed in 28 lesions afte...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.101.20.2355

    authors: Höher M,Wöhrle J,Wohlfrom M,Hanke H,Voisard R,Osterhues HH,Kochs M,Reske SN,Hombach V,Kotzerke J

    更新日期:2000-05-23 00:00:00

  • Colchicine treatment for recurrent pericarditis. A decade of experience.

    abstract:BACKGROUND:The most troublesome complication of acute pericarditis is recurrent episodes of pericardial inflammation, occurring in 15% to 32% of cases. The cause of the recurrence is usually unknown, although in some cases it may be traced to viral infection or may be a consequence of coronary artery bypass grafting. T...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/01.cir.97.21.2183

    authors: Adler Y,Finkelstein Y,Guindo J,Rodriguez de la Serna A,Shoenfeld Y,Bayes-Genis A,Sagie A,Bayes de Luna A,Spodick DH

    更新日期:1998-06-02 00:00:00

  • Influence of diabetes and mammary artery grafting on survival after coronary bypass.

    abstract::The effect of diabetes on survival after coronary bypass surgery is uncertain. Also, although the overall clinical benefits of internal mammary artery (IMA) grafting are well established, the survival benefit attributable to IMA grafting in diabetics is not well characterized. To determine the influence of diabetes an...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Morris JJ,Smith LR,Jones RH,Glower DD,Morris PB,Muhlbaier LH,Reves JG,Rankin JS

    更新日期:1991-11-01 00:00:00

  • Selective upregulation of endothelin B receptor gene expression in severe pulmonary hypertension.

    abstract:BACKGROUND:The pulmonary circulation is an important site for the production and clearance of endothelin (ET)-1, a potent vasoactive and mitogenic peptide. Increased plasma ET-1 levels are observed in pulmonary arterial hypertension (PHT) and may contribute to the regulation of pulmonary vascular resistance, as well as...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/hc0902.105719

    authors: Bauer M,Wilkens H,Langer F,Schneider SO,Lausberg H,Schäfers HJ

    更新日期:2002-03-05 00:00:00

  • Long-term survival after acute myocardial infarction is lower in more deprived neighborhoods.

    abstract:BACKGROUND:As part of the Worcester Heart Attack Study, a community-wide study examining changes over time in the incidence and long-term case-fatality rates of greater Worcester, Mass, residents hospitalized with confirmed acute myocardial infarction (AMI), we investigated the hypothesis that census tract-level socioe...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.104.496174

    authors: Tonne C,Schwartz J,Mittleman M,Melly S,Suh H,Goldberg R

    更新日期:2005-06-14 00:00:00

  • The effect of acute changes in coronary blood flow on left ventricular end-diastolic wall thickness. An echocardiographic study.

    abstract::The effect of acute alterations in coronary blood flow (CBF) on left ventricular (LV) end-diastolic wall thickness was measured by reflected ultrasound in twelve anesthetized dogs. During five minutes of coronary ligation, wall thickness decreased from a control of 9.0 +/- 0.3 mm to 8.1 +/- 0.3 mm (P less than 0.001);...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.56.4.593

    authors: Gaasch WH,Bernard SA

    更新日期:1977-10-01 00:00:00

  • Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.

    abstract:BACKGROUND:approximately half of patients with heart failure die suddenly as a result of ventricular arrhythmias. Although abnormal Ca(2+) release from the sarcoplasmic reticulum through ryanodine receptors (RyR2) has been linked to arrhythmogenesis, the molecular mechanisms triggering release of arrhythmogenic Ca(2+) ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.110.982298

    authors: van Oort RJ,McCauley MD,Dixit SS,Pereira L,Yang Y,Respress JL,Wang Q,De Almeida AC,Skapura DG,Anderson ME,Bers DM,Wehrens XH

    更新日期:2010-12-21 00:00:00

  • Comparison of high-dose with low-dose aspirin in patients with mechanical heart valve replacement treated with oral anticoagulant.

    abstract:BACKGROUND:There are no reported studies on the safety and efficacy of low-dose aspirin with low-intensity oral anticoagulation in patients with heart valve replacement. In this study, we compared the use of 100 mg/d aspirin with 650 mg/d aspirin in the prevention of systemic embolism and vascular death in patients wit...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.94.9.2113

    authors: Altman R,Rouvier J,Gurfinkel E,Scazziota A,Turpie AG

    更新日期:1996-11-01 00:00:00

  • Measurement of cardioversion/defibrillation thresholds in man by a truncated exponential waveform and an apical patch-superior vena caval spring electrode configuration.

    abstract::Defibrillation/cardioversion thresholds were measured in 33 patients undergoing defibrillator implants. Each patient had a 12 cm2 patch placed near the left ventricular apex via a thoracotomy and a 10 cm2 spring lead placed pervenously at the right atrial-superior vena caval junction. Ventricular tachycardia of stable...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.69.4.766

    authors: Winkle RA,Stinson EB,Bach SM Jr,Echt DS,Oyer P,Armstrong K

    更新日期:1984-04-01 00:00:00

  • Additional lead improves defibrillation efficacy with an abdominal 'hot can' electrode system.

    abstract:BACKGROUND:Although the left prepectoral site is preferred for "hot can" placement, this site is unavailable in some patients. We evaluated the influence of electrode location on defibrillation thresholds with alternative hot can and transvenous lead configurations. METHODS AND RESULTS:Three interrelated studies were ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.96.12.4400

    authors: Yamanouchi Y,Mowrey KA,Niebauer MJ,Tchou PJ,Wilkoff BL

    更新日期:1997-12-16 00:00:00

  • Sudden Cardiac Arrest Survivorship: A Scientific Statement From the American Heart Association.

    abstract::Cardiac arrest systems of care are successfully coordinating community, emergency medical services, and hospital efforts to improve the process of care for patients who have had a cardiac arrest. As a result, the number of people surviving sudden cardiac arrest is increasing. However, physical, cognitive, and emotiona...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIR.0000000000000747

    authors: Sawyer KN,Camp-Rogers TR,Kotini-Shah P,Del Rios M,Gossip MR,Moitra VK,Haywood KL,Dougherty CM,Lubitz SA,Rabinstein AA,Rittenberger JC,Callaway CW,Abella BS,Geocadin RG,Kurz MC,American Heart Association Emergency Cardiovasc

    更新日期:2020-03-24 00:00:00

  • Reduced ventricular volumes and improved systolic function with cardiac resynchronization therapy: a randomized trial comparing simultaneous biventricular pacing, sequential biventricular pacing, and left ventricular pacing.

    abstract:BACKGROUND:Cardiac resynchronization therapy has emerged as an important therapy for advanced systolic heart failure. Among available cardiac resynchronization therapy pacing modes that restore ventricular synchrony, it is uncertain whether simultaneous biventricular (BiV), sequential BiV, or left ventricular (LV) paci...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/CIRCULATIONAHA.106.634444

    authors: Rao RK,Kumar UN,Schafer J,Viloria E,De Lurgio D,Foster E

    更新日期:2007-04-24 00:00:00

  • Electrocardiographic and hemodynamic changes in experimental right ventricular infarction.

    abstract::To investigate the electrocardiographic and hemodynamic changes in isolated right ventricular infarction, 0.25 ml or 0.5 ml of metallic mercury was injected into the right coronary artery of 14 closed-chest dogs. At autopsy, at least 60% of the right ventricle was necrotic in every dog. Hemodynamic observations were m...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.67.6.1258

    authors: Chou TC,Fowler NO,Gabel M,van der Bel-Kahn J,Feltner EJ

    更新日期:1983-06-01 00:00:00

  • Inaccuracy of estimated resting oxygen uptake in the clinical setting.

    abstract:BACKGROUND:The Fick principle (cardiac output = oxygen uptake ( O2)/systemic arterio-venous oxygen difference) is used to determine cardiac output in numerous clinical situations. However, estimated rather than measured O2 is commonly used because of complexities of the measurement, though the accuracy of estimation re...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.113.003334

    authors: Narang N,Thibodeau JT,Levine BD,Gore MO,Ayers CR,Lange RA,Cigarroa JE,Turer AT,de Lemos JA,McGuire DK

    更新日期:2014-01-14 00:00:00

  • Role of functional block extension in lesion-related atrial flutter.

    abstract:BACKGROUND:A line of block in the right atrium (RA) between the venae cavae is necessary to obtain classic atrial flutter (AFL). We tested the hypothesis that the location of that line of block would determine whether the AFL reentrant circuit would be due to single-loop reentry or figure-of-8 reentry. METHODS AND RES...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.103.7.1025

    authors: Tomita Y,Matsuo K,Sahadevan J,Khrestian CM,Waldo AL

    更新日期:2001-02-20 00:00:00

  • Improving blood pressure control through a clinical pharmacist outreach program in patients with diabetes mellitus in 2 high-performing health systems: the adherence and intensification of medications cluster randomized, controlled pragmatic trial.

    abstract:BACKGROUND:Even in high-performing health systems, some patients with diabetes mellitus have poor blood pressure (BP) control because of poor medication adherence and lack of medication intensification. We examined whether the Adherence and Intensification of Medications intervention, a pharmacist-led intervention comb...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/CIRCULATIONAHA.111.089169

    authors: Heisler M,Hofer TP,Schmittdiel JA,Selby JV,Klamerus ML,Bosworth HB,Bermann M,Kerr EA

    更新日期:2012-06-12 00:00:00