Effects of methylprednisolone on the ischemic damage in patients with acute myocardial infarction.

abstract：BACKGROUND:This study was performed to determine whether antibodies against the amino-terminus of the beta-chain of fibrin (anti-beta) could noninvasively distinguish actively enlarging thrombi from thrombi stabilized with anticoagulants. METHODS AND RESULTS:Dogs with unilateral femoral vein thrombi were allocated int...

journal_title：Circulation

authors： Morris TA,Marsh JJ,Konopka R,Pedersen CA,Chiles PG,Fagnani R,Hagan M,Moser KM

更新日期：1997-11-04 00:00:00

abstract：:In rats, atrial natriuretic factor (ANF) reduces sympathetic nerve activity (SNA) reflexively by sensitizing cardiac mechanoreceptors with inhibitory vagal afferents. We performed three series of experiments in 26 normal young men to document whether ANF inhibits SNA in humans and if so, to determine potential mechani...

journal_title：Circulation

authors： Floras JS

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:During septic shock, the vasoconstrictor response to norepinephrine is seriously blunted. Animal experiments suggest that hyperpolarization of smooth muscle cells by opening of potassium (K) channels underlies this phenomenon. In the present study, we examined whether K-channel blockers and/or nitric oxide (...

journal_title：Circulation

authors： Pickkers P,Dorresteijn MJ,Bouw MP,van der Hoeven JG,Smits P

更新日期：2006-08-01 00:00:00

abstract：:Conventional wall motion analysis of contrast ventriculograms assesses only that part of the wall that is tangential to the x-ray beam. To assess regional left ventricular function in three dimensions, a new computerized method based on densitometric analysis of digital subtraction left ventriculograms was developed a...

journal_title：Circulation

authors： Chappuis F,Widmann T,Guth B,Nicod P,Peterson KL

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:Thirteen of 14 epidemiological studies have shown an increased risk of approximately 20% for coronary heart disease (CHD) for never-smokers exposed to environmental tobacco smoke (ETS), but this association remains controversial. If true, ETS might account for an estimated 35,000 to 40,000 heart disease deat...

journal_title：Circulation

authors： Steenland K,Thun M,Lally C,Heath C Jr

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:Heart failure (HF) is responsible for a huge burden in hospital care. Our goal was to evaluate the value of N-terminal-pro-brain natriuretic peptide (NT-proBNP) in predicting death or hospital readmission after discharge of HF patients. METHODS AND RESULTS:We included 182 patients consecutively admitted to ...

journal_title：Circulation

authors： Bettencourt P,Azevedo A,Pimenta J,Friões F,Ferreira S,Ferreira A

更新日期：2004-10-12 00:00:00

abstract：:Between 1970 and 1987, 112 patients were diagnosed as having thromboangiitis obliterans (TAO). The age was 42 +/- 11 years (mean +/- SD; range, 20-75 years); 23% were women, and 7% were more than 60 years old when they were first diagnosed. Ischemic ulcerations were present in 85 (76%) patients: 24 (28%) patients with...

journal_title：Circulation

authors： Olin JW,Young JR,Graor RA,Ruschhaupt WF,Bartholomew JR

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Brain natriuretic peptide (BNP), as a cardiac hormone, is expressed together with atrial natriuretic peptide (ANP) in the ventricles in congestive heart failure. However, the ventricular expression of BNP in hypertrophic cardiomyopathy (HCM) with normal systolic function is still unclear. METHODS AND RESULT...

journal_title：Circulation

authors： Hasegawa K,Fujiwara H,Doyama K,Miyamae M,Fujiwara T,Suga S,Mukoyama M,Nakao K,Imura H,Sasayama S

更新日期：1993-08-01 00:00:00

abstract：:Accumulating experimental and clinical evidence indicates that a time for reappraisal of therapeutic modalities designed to inhibit the eicosanoid pathway as it may affect vascular disease may be approaching. Pharmacologic agents originally used were chosen because they were capable of suppressing platelet functions s...

journal_title：Circulation

authors： Marcus AJ,Safier LB,Ullman HL,Broekman MJ,Islam N,Oglesby TD,Gorman RR,Ward JW

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Although phase 2 reentry is said to be responsible for initiation of ventricular tachycardia (VT) in Brugada syndrome, information about the activation sequence during VT is limited. METHODS AND RESULTS:We developed an experimental Brugada syndrome model using a canine isolated right ventricular preparation...

journal_title：Circulation

authors： Kimura M,Kobayashi T,Owada S,Ashikaga K,Higuma T,Sasaki S,Iwasa A,Motomura S,Okumura K

更新日期：2004-01-06 00:00:00

abstract：BACKGROUND:In animal models of cardiac arrest, the benefit afforded by hypothermia is closely linked to the rapidity of the decrease in body temperature after resuscitation. Because total liquid ventilation (TLV) with temperature-controlled perfluorocarbons induces a very rapid and generalized cooling, we aimed to dete...

journal_title：Circulation

authors： Chenoune M,Lidouren F,Adam C,Pons S,Darbera L,Bruneval P,Ghaleh B,Zini R,Dubois-Randé JL,Carli P,Vivien B,Ricard JD,Berdeaux A,Tissier R

更新日期：2011-08-23 00:00:00

abstract：BACKGROUND:Current information on the epidemiology and outcomes of hypertrophic cardiomyopathy (HCM) in children is limited by disease diversity and small case series. METHODS AND RESULTS:The Pediatric Cardiomyopathy Registry has collected prospective and retrospective data on children diagnosed with HCM since 1990. W...

journal_title：Circulation

authors： Colan SD,Lipshultz SE,Lowe AM,Sleeper LA,Messere J,Cox GF,Lurie PR,Orav EJ,Towbin JA

更新日期：2007-02-13 00:00:00

abstract：BACKGROUND:Clinical detection of transplant rejection by repeated endomyocardial biopsy requires catheterization and entails risks. Recently developed molecular and cellular imaging techniques that visualize macrophage host responses could provide a noninvasive alternative. Yet, which macrophage functions may provide u...

journal_title：Circulation

authors： Christen T,Nahrendorf M,Wildgruber M,Swirski FK,Aikawa E,Waterman P,Shimizu K,Weissleder R,Libby P

更新日期：2009-04-14 00:00:00

abstract：BACKGROUND:Myocardium irreversibly injured by ischemic stress must be efficiently repaired to maintain tissue integrity and contractile performance. Macrophages play critical roles in this process. These cells transform across a spectrum of phenotypes to accomplish diverse functions ranging from mediating the initial i...

journal_title：Circulation

authors： Cao DJ,Schiattarella GG,Villalobos E,Jiang N,May HI,Li T,Chen ZJ,Gillette TG,Hill JA

更新日期：2018-06-12 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARgamma) activators, such as troglitazone (Tro), not only improve insulin resistance but also suppress the neointimal formation after balloon injury. However, the precise mechanisms have not been determined. Angiotensin II (Ang II) plays crucial roles in th...

journal_title：Circulation

authors： Takeda K,Ichiki T,Tokunou T,Funakoshi Y,Iino N,Hirano K,Kanaide H,Takeshita A

更新日期：2000-10-10 00:00:00

abstract：BACKGROUND:Anisotropy creates nonuniformity in electrical propagation and may contribute to the occurrence of unidirectional conduction block and reentry. We describe the characteristics of reentrant tachycardia in a 2D layer of anisotropic ventricular myocardium. METHODS AND RESULTS:A Langendorff-perfused epicardial ...

journal_title：Circulation

authors： Schalij MJ,Boersma L,Huijberts M,Allessie MA

更新日期：2000-11-21 00:00:00

abstract：BACKGROUND:The purpose of this study was to test the hypothesis that a single meandering functional reentrant wave front can result in rapid and irregular electrogram activity in human atrial tissues. METHODS AND RESULTS:The study used the explanted hearts of five human cardiac transplant recipients. Three right and t...

journal_title：Circulation

authors： Ikeda T,Czer L,Trento A,Hwang C,Ong JJ,Hough D,Fishbein MC,Mandel WJ,Karagueuzian HS,Chen PS

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:High-speed rotational atherectomy uses a diamond-coated, elliptical burr to abrade occlusive atherosclerosis, especially noncompliant calcified plaque. METHODS AND RESULTS:Intravascular ultrasound (IVUS) was used to analyze 28 patients after atherectomy. Arteries treated and imaged were left main (three), l...

journal_title：Circulation

authors： Mintz GS,Potkin BN,Keren G,Satler LF,Pichard AD,Kent KM,Popma JJ,Leon MB

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Cholesterol-lowering therapy can improve cardiovascular morbidity and mortality in patients with atherosclerosis. Although the mechanisms responsible are unclear, these benefits precede macroscopic changes in the vasculature. Emerging evidence that improvement in endothelial function may occur requires subst...

journal_title：Circulation

authors： O'Driscoll G,Green D,Taylor RR

更新日期：1997-03-04 00:00:00

abstract：BACKGROUND:The quantity and intensity of physical activity required for the primary prevention of coronary heart disease (CHD) remain unclear. Therefore, we examined the association of the quantity and intensity of physical activity with CHD risk and the impact of other coronary risk factors. METHODS AND RESULTS:We fo...

journal_title：Circulation

authors： Sesso HD,Paffenbarger RS Jr,Lee IM

更新日期：2000-08-29 00:00:00

abstract：:Congestive heart failure is often preceded by a latent or preclinical phase in which patients are relatively asymptomatic. During this period, there is neuroendocrine activation, left ventricular dysfunction, and remodeling of the heart. The extent to which these activities are interrelated is unclear, but it appears ...

journal_title：Circulation

authors： Francis GS,McDonald KM,Cohn JN

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Heme oxygenase-1 (HO-1) catalyzes the degradation of heme into biliverdin, iron, and carbon monoxide (CO). Although HO-1 is induced in vascular smooth muscle cells (SMCs), the biological role of HO-1 in these cells has not been completely characterized. METHODS AND RESULTS:In the present study, we overexpre...

journal_title：Circulation

authors： Liu XM,Chapman GB,Wang H,Durante W

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Endothelins are recently characterized vasoconstrictor peptides. As chronic heart failure (CHF) is characterized by peripheral arteriolar and renal vasoconstriction, we have measured venous plasma endothelin-like immunoreactivity ("endothelin") in patients with this syndrome. METHODS AND RESULTS:Compared wi...

journal_title：Circulation

authors： McMurray JJ,Ray SG,Abdullah I,Dargie HJ,Morton JJ

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Intentional weight loss is associated with lower risk of heart failure (HF) and atherosclerotic cardiovascular disease among patients with type 2 diabetes. However, the contribution of baseline measures and longitudinal changes in fat mass (FM), lean mass (LM), and waist circumference (WC) to the risk of HF ...

journal_title：Circulation

authors： Patel KV,Bahnson JL,Gaussoin SA,Johnson KC,Pi-Sunyer X,White U,Olson KL,Bertoni AG,Kitzman DW,Berry JD,Pandey A,Look AHEAD Research Group.

更新日期：2020-12-22 00:00:00

abstract：:This review of the clinical studies of thromboxane synthase inhibitors (TXSIs) and thromboxane receptor blocking drugs (TXRBs) covers the years 1981 to the present. Clinical studies on TXSIs include those in normal volunteers as well as those in patients with angina, peripheral vascular disease and Raynaud's syndrome,...

journal_title：Circulation

authors： Fiddler GI,Lumley P

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Previous studies suggest that management of ambulatory hemodynamics may improve outcomes in chronic heart failure. We conducted a prospective, observational, first-in-human study of a physician-directed patient self-management system targeting left atrial pressure. METHODS AND RESULTS:Forty patients with re...

journal_title：Circulation

authors： Ritzema J,Troughton R,Melton I,Crozier I,Doughty R,Krum H,Walton A,Adamson P,Kar S,Shah PK,Richards M,Eigler NL,Whiting JS,Haas GJ,Heywood JT,Frampton CM,Abraham WT,Hemodynamically Guided Home Self-Therapy in Severe Hea

更新日期：2010-03-09 00:00:00

abstract：:The results of coronary bypass 5-10 years after operation at the Baylor College of Medicine are reported. The late results demonstrate that good relief of symptoms of angina pectoris persisted in 89% of patients at 10 years of follow-up. An overall annual attrition rate of 3% has been fairly constant through 10 years ...

journal_title：Circulation

authors： Lawrie GM,Morris GC Jr

更新日期：1982-06-01 00:00:00

abstract：:Two-dimensional suprasternal notch echocardiography was performed in 1033 patients, ages 1 day to 18 years. For the long-axis suprasternal notch view, the transducer was positioned in the suprasternal notch and angled to obtain a plane passing between the right nipple and left scapular tip. In this view, the entire ao...

journal_title：Circulation

authors： Snider AR,Silverman NH

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Pulmonary hypertension (PH) is a life-threatening disorder characterized by increased pulmonary artery pressure, remodeling of the pulmonary vasculature, and right ventricular failure. Loss of endothelium-derived nitric oxide (NO) and prostacyclin contributes to PH pathogenesis, and current therapies are tar...

journal_title：Circulation

authors： Bubb KJ,Trinder SL,Baliga RS,Patel J,Clapp LH,MacAllister RJ,Hobbs AJ

更新日期：2014-08-05 00:00:00

abstract：BACKGROUND:A paucity of literature is available on the effects of age and coronary artery bypass grafting (CABG) on the outcomes of patients undergoing mitral valve (MV) repair versus replacement. METHODS AND RESULTS:A matched study was performed using prospectively collected data from the Emory cardiovascular databas...

journal_title：Circulation

authors： Thourani VH,Weintraub WS,Guyton RA,Jones EL,Williams WH,Elkabbani S,Craver JM

更新日期：2003-07-22 00:00:00