Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells.

abstract：:Fifty patients who presented with angina pectoris were studied to examine the disturbances of regional myocardial perfusion during stress. Each patient underwent 16-point precordial mapping of the ECG during an exercise test, and coronary and left ventricular angiography. Regional myocardial perfusion was assessed usi...

journal_title：Circulation

authors： Selwyn AP,Forse G,Fox K,Jonathan A,Steiner R

更新日期：1981-07-01 00:00:00

abstract：BACKGROUND:Direct thrombin inhibitors are a new class of drugs that may offer a more effective and potentially simpler alternative to heparin. Hirulog is a synthetic peptide based on the leech-derived compound hirudin and, like hirudin, is a highly specific, direct inhibitor of free and clot-bound thrombin. METHODS AN...

journal_title：Circulation

authors： Fuchs J,Cannon CP

更新日期：1995-08-15 00:00:00

abstract：:Body surface isochrone mapping was performed in 36 normal subjects and in 85 patients with previous myocardial infarction. Eighty-seven unipolar electrocardiograms distributed over the anterior chest and the back were recorded simultaneously. For each lead, activation time was measured as the time from the onset of QR...

journal_title：Circulation

authors： Ikeda K,Kubota I,Igarashi A,Yamaki M,Tsuiki K,Yasui S

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Albuminuria is an established risk marker for both cardiovascular and renal outcomes. Albuminuria can be reduced with drugs that block the renin-angiotensin system (RAS). We questioned whether the short-term drug-induced change in albuminuria would predict the long-term cardioprotective efficacy of RAS inter...

journal_title：Circulation

authors： de Zeeuw D,Remuzzi G,Parving HH,Keane WF,Zhang Z,Shahinfar S,Snapinn S,Cooper ME,Mitch WE,Brenner BM

更新日期：2004-08-24 00:00:00

abstract：BACKGROUND:Chronic, complete AV block (CAVB) in the dog leads to ventricular hypertrophy, which has been described as an independent risk factor for arrhythmias. In this model, we examined (1) whether the short- and long-term electrical adaptations predispose to acquired torsade de pointes arrhythmias (TdP) and (2) the...

journal_title：Circulation

authors： Vos MA,de Groot SH,Verduyn SC,van der Zande J,Leunissen HD,Cleutjens JP,van Bilsen M,Daemen MJ,Schreuder JJ,Allessie MA,Wellens HJ

更新日期：1998-09-15 00:00:00

abstract：BACKGROUND:Despite improvements in management, infective endocarditis remains associated with high mortality and morbidity. We describe temporal changes in the incidence, microbiology, and outcomes of infective endocarditis and the effect of changes in national antibiotic prophylaxis guidelines on incident infective en...

journal_title：Circulation

authors： Shah ASV,McAllister DA,Gallacher P,Astengo F,Rodríguez Pérez JA,Hall J,Lee KK,Bing R,Anand A,Nathwani D,Mills NL,Newby DE,Marwick C,Cruden NL

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND:Automatic implantable cardioverter-defibrillator therapy is considered the only effective treatment for high-risk patients with Brugada syndrome. Quinidine depresses I(to) current, which may play an important role in the arrhythmogenesis of this disease. METHODS AND RESULTS:The effects of quinidine bisulfat...

journal_title：Circulation

authors： Belhassen B,Glick A,Viskin S

更新日期：2004-09-28 00:00:00

abstract：:We made continuous electrocardiographic recordings on magnetic tape during 15 episodes of ischemia in five patients with variant angina to determine the characteristics of the QRS changes. Orthogonal leads were used and the electrocardiograms were analyzed visually and by digital computer. Changes were quantified by s...

journal_title：Circulation

authors： Barnhill JE,Wikswo JP Jr,Dawson AK,Gundersen S,Robertson RM,Robertson D,Virmani R,Smith RF

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Hypertension is a major modifiable cardiovascular risk factor. The present longitudinal study aimed to examine the best combination of childhood physical and environmental factors to predict adult hypertension and furthermore whether newly identified genetic variants for blood pressure increase the predictio...

journal_title：Circulation

authors： Juhola J,Oikonen M,Magnussen CG,Mikkilä V,Siitonen N,Jokinen E,Laitinen T,Würtz P,Gidding SS,Taittonen L,Seppälä I,Jula A,Kähönen M,Hutri-Kähönen N,Lehtimäki T,Viikari JS,Juonala M,Raitakari OT

更新日期：2012-07-24 00:00:00

abstract：BACKGROUND:High-density lipoproteins have antidiabetic properties in vitro. Furthermore, elevated high-density lipoprotein levels accompanying a genetic deficiency of cholesteryl ester transfer protein are associated with decreased levels of plasma glucose. We now investigate effects on glucose homeostasis of inhibitin...

journal_title：Circulation

authors： Barter PJ,Rye KA,Tardif JC,Waters DD,Boekholdt SM,Breazna A,Kastelein JJ

更新日期：2011-08-02 00:00:00

abstract：BACKGROUND:Myocardial infarction, stroke, and sudden death undergo diurnal variation. Although genes relevant to hemostasis and vascular integrity undergo circadian oscillation, the role of the molecular clock in thrombotic events remains to be established. METHODS AND RESULTS:A diurnal variation in the time to thromb...

journal_title：Circulation

authors： Westgate EJ,Cheng Y,Reilly DF,Price TS,Walisser JA,Bradfield CA,FitzGerald GA

更新日期：2008-04-22 00:00:00

abstract：BACKGROUND:In patients with severe congestive heart failure (CHF), short-term administration of dobutamine exerts sustained clinical benefits that are partially mediated by a training-like effect on skeletal muscle. Recently, physical training has been shown to enhance endothelial function in the skeletal muscle vascul...

journal_title：Circulation

authors： Patel MB,Kaplan IV,Patni RN,Levy D,Strom JA,Shirani J,LeJemtel TH

更新日期：1999-01-05 00:00:00

abstract：BACKGROUND:Intracoronary stents may be effective when used as "bail-out" devices for acute complications after percutaneous transluminal coronary angioplasty. Furthermore, preliminary reports have demonstrated some promising results with stents with regard to the reduction of restenosis. Several stent devices are avail...

journal_title：Circulation

authors： van der Giessen WJ,Serruys PW,van Beusekom HM,van Woerkens LJ,van Loon H,Soei LK,Strauss BH,Beatt KJ,Verdouw PD

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Less invasive methods are replacing traditional invasive means of measuring coronary flow reserve (CFR). Transesophageal echocardiography (TEE) is becoming a useful tool for evaluation of coronary artery disease and has recently been used to measure CFR. This has always been done using dipyridamole, but aden...

journal_title：Circulation

authors： Redberg RF,Sobol Y,Chou TM,Malloy M,Kumar S,Botvinick E,Kane J

更新日期：1995-07-15 00:00:00

abstract：BACKGROUND:Hypothermic hyperkalemic cardioplegia results in significant myocyte swelling and impaired contractility. These detrimental effects may be eliminated by the addition of an adenosine triphosphate-sensitive potassium (KATP) channel opener. This study evaluated the hypothesis that a KATP channel opener (diazoxi...

journal_title：Circulation

authors： Mizutani S,Prasad SM,Sellitto AD,Schuessler RB,Damiano RJ Jr,Lawton JS

更新日期：2005-08-30 00:00:00

abstract：BACKGROUND:Transfer of the coronary arteries is a crucial step during the arterial switch operation (ASO) for transposition of the great arteries. This retrospective study aims to assess the incidence and risk factors of coronary events after ASO and sensitivity of noninvasive tests in the diagnosis of the coronary obs...

journal_title：Circulation

authors： Legendre A,Losay J,Touchot-Koné A,Serraf A,Belli E,Piot JD,Lambert V,Capderou A,Planche C

更新日期：2003-09-09 00:00:00

abstract：:High-density lipoprotein (HDL) cholesterol distributions were compared among 191 black and 1341 white males and 233 black and 1088 white females, ages 5-44 years, examined in five of the Lipid Research Clinic (LRC) population-based surveys. Mean HDL cholesterol was higher in blacks than whites in each 5-year age group...

journal_title：Circulation

authors： Tyroler HA,Glueck CJ,Christensen B,Kwiterovich PO Jr

更新日期：1980-11-01 00:00:00

abstract：:Ventricular tachycardia is unusual in infancy. Three infants are described in whom this arrhythmia was documented by electrophysiologic studies. The ability to start and terminate this rhythm by critically timed premature ventricular stimulation suggests a reentrant mechanism. All three patients have remained free of ...

journal_title：Circulation

authors： Gaum WE,Schwartz DC,Kaplan S

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:Ischemic mitral regurgitation (MR) was first ascribed to papillary muscle (PM) contractile dysfunction. Current theories include apical leaflet tethering caused by left ventricular (LV) distortion, but PM dysfunction is still postulated and commonly diagnosed. PM contraction, however, parallels apical tether...

journal_title：Circulation

authors： Messas E,Guerrero JL,Handschumacher MD,Chow CM,Sullivan S,Schwammenthal E,Levine RA

更新日期：2001-10-16 00:00:00

abstract：BACKGROUND:Autopsy studies in children have shown that atherosclerotic lesions begin to develop first in the intima of the aorta. Recent developments in ultrasound techniques have made it possible to visualize the intima-medial thickness of the abdominal aorta directly (aIMT). Therefore, we examined the feasibility of ...

journal_title：Circulation

authors： Järvisalo MJ,Jartti L,Näntö-Salonen K,Irjala K,Rönnemaa T,Hartiala JJ,Celermajer DS,Raitakari OT

更新日期：2001-12-11 00:00:00

abstract：BACKGROUND:Coronary perfusion pressure has been shown to be a significant determinant of return of spontaneous circulation from cardiac arrest during asystole and electromechanical dissociation. The addition of interposed abdominal compression to otherwise standard cardiopulmonary resuscitation (CPR) increases coronary...

journal_title：Circulation

authors： Sack JB,Kesselbrenner MB,Jarrad A

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Oxidized LDLs (oxLDLs) and matrix metalloproteinases (MMPs) are present in atherosclerotic lesions. OxLDLs activate various signaling pathways potentially involved in atherogenesis. OxLDLs induce smooth muscle cell (SMC) proliferation mediated by the activation of the sphingomyelin/ceramide pathway and tyros...

journal_title：Circulation

authors： Augé N,Maupas-Schwalm F,Elbaz M,Thiers JC,Waysbort A,Itohara S,Krell HW,Salvayre R,Nègre-Salvayre A

更新日期：2004-08-03 00:00:00

abstract：:Patients undergoing carotid endarterectomy were pretreated with low-dose, oral beta carotene to determine whether the carotenoid content of plaque could be increased in vivo. Beta carotene-treated patients had a 50-fold increase in their plaque beta carotene level from 0.066 to 3.3 micrograms beta carotene/g plaque. M...

journal_title：Circulation

authors： Prince MR,LaMuraglia GM,MacNichol EF Jr

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND:Angiotensin II (ATII), a potent vasoconstrictor, causes hypertension, promotes infiltration of myelomonocytic cells into the vessel wall, and stimulates both vascular and inflammatory cell NADPH oxidases. The predominant source of reactive oxygen species, eg, vascular (endothelial, smooth muscle, adventitial...

journal_title：Circulation

authors： Wenzel P,Knorr M,Kossmann S,Stratmann J,Hausding M,Schuhmacher S,Karbach SH,Schwenk M,Yogev N,Schulz E,Oelze M,Grabbe S,Jonuleit H,Becker C,Daiber A,Waisman A,Münzel T

更新日期：2011-09-20 00:00:00

abstract：BACKGROUND:Inflammatory vasculopathies, ranging from the vasculitides (Takayasu arteritis, giant cell arteritis, and polyarteritis nodosa) to atherosclerosis, display remarkable target tissue tropisms for selected vascular beds. Molecular mechanisms directing wall inflammation to restricted anatomic sites within the va...

journal_title：Circulation

authors： Pryshchep O,Ma-Krupa W,Younge BR,Goronzy JJ,Weyand CM

更新日期：2008-09-16 00:00:00

abstract：BACKGROUND:In subjects of all ages, those who weigh the most often have the highest blood pressure. Thus, in epidemiological studies, weight is the most important correlate of blood pressure. Using the data from the Medical College of Virginia Twin Study, we asked these questions: 1) Do the same genetic paths that regu...

journal_title：Circulation

authors： Schieken RM,Mosteller M,Goble MM,Moskowitz WB,Hewitt JK,Eaves LJ,Nance WE

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Orally administered heparin (OHEP) is unreliable because of poor absorption. Sodium N-(8[2-hydroxybenzoyl]amino) caprylate (SNAC) is an amido acid that facilitates the gastrointestinal absorption of heparin. We evaluated the effectiveness of OHEP combined with SNAC (OHEP/SNAC) in the treatment of deep-vein t...

journal_title：Circulation

authors： Gonze MD,Salartash K,Sternbergh WC 3rd,Baughman RA,Leone-Bay A,Money SR

更新日期：2000-06-06 00:00:00

abstract：:The effect of the ouabain-quinidine interaction was examined in 10 conscious dogs. Left ventricular (LV) pressure, LV dP/dt, LV diameter and left atrial (LA) diameter were measured with high-fidelity micromanometers and sonomicrometer crystals. Ouabain, 0.025 mg/kg, significantly (p less than 0.05) increased LV dP/dt,...

journal_title：Circulation

authors： Goldman S,Hager WD,Olajos M,Perrier D,Mayersohn M

更新日期：1983-05-01 00:00:00

abstract：:Nine patients (eight males) are reported with one or more episodes of circulatory collapse in the absence of overt heart disease or other known causes of arrhythmias; sudden arrhythmic death occurred in one of these patients. Age at first episode ranged from 16 to 41 (mean, 28) years. In seven patients, ventricular fi...

journal_title：Circulation

authors： Wellens HJ,Lemery R,Smeets JL,Brugada P,Gorgels AP,Cheriex EC,de Zwaan C

更新日期：1992-01-01 00:00:00

abstract：:Despite the clinical prevalence of paradoxic interventricular septal (IVS) motion, its pathogenesis remains unclear. To assess the influence of the end-diastolic transseptal pressure gradient, we studied eight open-chest dogs during right ventricular (RV) volume loading (induced by opening a Dacron shunt between the p...

journal_title：Circulation

authors： Kingma I,Tyberg JV,Smith ER

更新日期：1983-12-01 00:00:00