Interposed abdominal compression-cardiopulmonary resuscitation and resuscitation outcome during asystole and electromechanical dissociation.


BACKGROUND:Coronary perfusion pressure has been shown to be a significant determinant of return of spontaneous circulation from cardiac arrest during asystole and electromechanical dissociation. The addition of interposed abdominal compression to otherwise standard cardiopulmonary resuscitation (CPR) increases coronary perfusion pressure in animal and human models. METHODS AND RESULTS:Accordingly, we conducted a randomized prospective study of 143 consecutive patients experiencing cardiac arrest in a large university-affiliated teaching hospital in whom the initial arrest rhythm was asystole or electromechanical dissociation. Patients were randomized to receive either interposed abdominal compression-CPR or standard CPR. The two end points studied were return of spontaneous circulation and 24-hour survival. In addition, we studied the complications associated with interposed abdominal compression-CPR. Sixty-nine men and 74 women with a mean age of 64 years (range, 19-97 years) were studied. The overall rate of return of spontaneous circulation was 38%. Return of spontaneous circulation was significantly greater in the group receiving interposed abdominal compression-CPR compared with the group receiving standard CPR (49% versus 28%, p = 0.01). At 24 hours, there was a significantly greater number of patients alive in the experimental group than in the control group (33% versus 13%, p = 0.009). We found no complication directly related to the procedure of interposed abdominal compression in a small subset of patients who died and underwent necropsy. CONCLUSIONS:We conclude that the addition of interposed abdominal compression may be a useful adjunct to otherwise standard CPR that can improve resuscitation outcome of patients experiencing in-hospital cardiac arrest from asystole and electromechanical dissociation.






Sack JB,Kesselbrenner MB,Jarrad A




Has Abstract


1992-12-01 00:00:00












  • Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage.

    abstract:BACKGROUND:Aldosterone and angiotensin (Ang) II both may cause organ damage. Circulating aldosterone is produced in the adrenals; however, local cardiac synthesis has been reported. Aldosterone concentrations depend on the activity of aldosterone synthase (CYP11B2). We tested the hypothesis that reducing aldosterone by...


    pub_type: 杂志文章


    authors: Fiebeler A,Nussberger J,Shagdarsuren E,Rong S,Hilfenhaus G,Al-Saadi N,Dechend R,Wellner M,Meiners S,Maser-Gluth C,Jeng AY,Webb RL,Luft FC,Muller DN

    更新日期:2005-06-14 00:00:00

  • Exercise pulmonary hypertension in asymptomatic degenerative mitral regurgitation.

    abstract:BACKGROUND:Current guidelines recommend mitral valve surgery for asymptomatic patients with severe degenerative mitral regurgitation and preserved left ventricular systolic function when exercise pulmonary hypertension (PHT) is present. However, the determinants of exercise PHT have not been evaluated. The aim of this ...


    pub_type: 杂志文章


    authors: Magne J,Lancellotti P,Piérard LA

    更新日期:2010-07-06 00:00:00

  • Gender gap in aortic cholesterol accumulation in cholesterol-clamped rabbits: role of the endothelium and mononuclear-endothelial cell interaction.

    abstract:BACKGROUND:The purpose of the present study was to investigate plasma lipid-independent mechanisms for the sex difference in the development of atherosclerosis. METHODS AND RESULTS:In the first experiment, 20 male and 20 female rabbits were balloon-injured in the middle thoracic aorta and maintained at the same plasma...


    pub_type: 杂志文章


    authors: Holm P,Andersen HL,Arrøe G,Stender S

    更新日期:1998-12-15 00:00:00

  • The pathologic correlates of the electrocardiogram: complete left bundle branch block.

    abstract::To assess whether gross pathologic differences exist between hearts with left bundle branch block (LBBB) and left-axis deviation (LAXD) and those with LBBB and a normal frontal plane axis, we examined 70 hearts with LBBB in a series of 1410 sequential dissections (5%). Thirty-two hearts had LAXD and 34 had normal axes...


    pub_type: 杂志文章


    authors: Havelda CJ,Sohi GS,Flowers NC,Horan LG

    更新日期:1982-03-01 00:00:00

  • Splanchnic venous pressure-volume relation during experimental acute ischemic heart failure. Differential effects of hydralazine, enalaprilat, and nitroglycerin.

    abstract:BACKGROUND:Vasodilator drugs have variable effects on veins and arteries. However, direct measurements of their effects on the splanchnic veins, perhaps the most important volume reservoir, have not been reported. We assessed the effect of acute heart failure and the subsequent administration of hydralazine, enalaprila...


    pub_type: 杂志文章


    authors: Wang SY,Manyari DE,Scott-Douglas N,Smiseth OA,Smith ER,Tyberg JV

    更新日期:1995-02-15 00:00:00

  • Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury.

    abstract:BACKGROUND:Microsomal (m) prostaglandin (PG) E₂ synthase (S)-1 catalyzes the formation of PGE₂ from PGH₂, a cyclooxygenase product that is derived from arachidonic acid. Previous studies in mice suggest that targeting mPGES-1 may be less likely to cause hypertension or thrombosis than cyclooxygenase-2-selective inhibit...


    pub_type: 杂志文章


    authors: Wang M,Ihida-Stansbury K,Kothapalli D,Tamby MC,Yu Z,Chen L,Grant G,Cheng Y,Lawson JA,Assoian RK,Jones PL,Fitzgerald GA

    更新日期:2011-02-15 00:00:00

  • Effects of digitalis on resting and isometric exercise myocardial perfusion in patients with coronary artery disease and left ventricular dysfunction.

    abstract::Digitalis has been shown to improve the impaired ventricular function associated with coronary artery disease as well as to increase myocardial oxygen consumption and produce coronary vasoconstriction. To elucidate the net result of these contrasting effects, six patients with coronary artery disease and left ventricu...


    pub_type: 杂志文章


    authors: Vogel R,Kirch D,LeFree M,Frischknecht J,Steele P

    更新日期:1977-09-01 00:00:00

  • Predictive value of noninvasive measures of atherosclerosis for incident myocardial infarction: the Rotterdam Study.

    abstract:BACKGROUND:Several noninvasive methods are available to investigate the severity of extracoronary atherosclerotic disease. No population-based study has yet examined whether differences exist between these measures with regard to their predictive value for myocardial infarction (MI) or whether a given measure of athero...


    pub_type: 杂志文章


    authors: van der Meer IM,Bots ML,Hofman A,del Sol AI,van der Kuip DA,Witteman JC

    更新日期:2004-03-09 00:00:00

  • HDLs containing apolipoproteins A-I and A-II (LpA-I:A-II) as markers of coronary artery disease in men with non-insulin-dependent diabetes mellitus.

    abstract:BACKGROUND:Abnormalities in HDL and an increased risk of coronary artery disease (CAD) coexist in non-insulin-dependent diabetes mellitus (NIDDM). HDLs can be separated by their apolipoprotein (apo) content into particles containing apoA-I but not apoA-II (LpA-I) and those containing both apoA-I and apoA-II (LpA-I:A-II...


    pub_type: 杂志文章


    authors: Syvänne M,Kahri J,Virtanen KS,Taskinen MR

    更新日期:1995-08-01 00:00:00

  • Noninvasive assessment of left ventricular force-frequency relationships using tissue Doppler-derived isovolumic acceleration: validation in an animal model.

    abstract:BACKGROUND:We have demonstrated that myocardial acceleration during isovolumic contraction (IVA) is a sensitive index of right ventricular contractile function. In this study, we assessed the usefulness of IVA to measure left ventricular (LV) contractile function and force-frequency relationships in an experimental pre...


    pub_type: 杂志文章


    authors: Vogel M,Cheung MM,Li J,Kristiansen SB,Schmidt MR,White PA,Sorensen K,Redington AN

    更新日期:2003-04-01 00:00:00

  • Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy.

    abstract:BACKGROUND:Pulmonary arterial hypertension (PAH) is a life-threatening disease, characterized by vascular smooth muscle cell hyperproliferation. The calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) may play a major role in vascular smooth muscle cell proliferation. METHODS AND RESULTS:We investigated the expres...


    pub_type: 杂志文章


    authors: Schermuly RT,Pullamsetti SS,Kwapiszewska G,Dumitrascu R,Tian X,Weissmann N,Ghofrani HA,Kaulen C,Dunkern T,Schudt C,Voswinckel R,Zhou J,Samidurai A,Klepetko W,Paddenberg R,Kummer W,Seeger W,Grimminger F

    更新日期:2007-05-01 00:00:00

  • Radiofrequency catheter modification of the sinus node for "inappropriate" sinus tachycardia.

    abstract:BACKGROUND:Radiofrequency catheter ablation is the treatment of choice for patients with paroxysmal supraventricular tachycardias refractory to medical therapy. However, in symptomatic patients with inappropriate sinus tachycardia resistant to drug therapy, catheter ablation of the His' bundle with permanent pacemaker ...


    pub_type: 杂志文章


    authors: Lee RJ,Kalman JM,Fitzpatrick AP,Epstein LM,Fisher WG,Olgin JE,Lesh MD,Scheinman MM

    更新日期:1995-11-15 00:00:00

  • Linkage analysis and long QT syndrome. Using genetics to study cardiovascular disease.

    abstract:BACKGROUND:Recombinant DNA technologies have facilitated the development of a set of polymorphic DNA markers covering the human genome. General linkage analysis in families predisposed to inherited disease is now feasible. Linkage analysis can help identify a disease gene even when relatively little is known about the ...


    pub_type: 杂志文章,评审


    authors: Keating M

    更新日期:1992-06-01 00:00:00

  • Effects of nifedipine on systemic and regional oxygen transport and metabolism at rest and during exercise.

    abstract::In a placebo-controlled, randomized, cross-over, double-blind study of 12 patients with stable exertional angina, we measured at rest and during bicycle exercise the effects of 20 mg of nifedipine administered sublingually on hemodynamics and systemic and regional oxygen extraction and metabolism. Nifedipine decreased...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Choong CY,Roubin GS,Shen WF,Harris PJ,Kelly DT

    更新日期:1985-04-01 00:00:00

  • Premature ventricular complexes in the absence of identifiable heart disease.

    abstract::To define the prevalence, frequency and characteristics of premature ventricular complexes (PVCs) in adults free of recognizable heart disease, we performed 24-hour ambulatory electrocardiography on 101 subjects (51 men and 50 women, mean age 48.8 years) in whom physical examination, chest x-ray, ECG, echocardiogram, ...


    pub_type: 杂志文章


    authors: Kostis JB,McCrone K,Moreyra AE,Gotzoyannis S,Aglitz NM,Natarajan N,Kuo PT

    更新日期:1981-06-01 00:00:00

  • Sustained hemodynamic and antianginal effect of high dose oral isosorbide dinitrate.

    abstract::Twenty-one patients with documented coronary atherosclerotic heart disease were studied to determine the effect of high dose oral isosorbide dinitrate (ISDN) on heart rate, blood pressure, and exercise time until angina pectoris. Patients were tested in two phases, initially with 0.4 mg of sublingual nitroglycerin and...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Danahy DT,Burwell DT,Aronow WS,Prakash R

    更新日期:1977-02-01 00:00:00

  • Mechanism of benefit of negative inotropes in obstructive hypertrophic cardiomyopathy.

    abstract:BACKGROUND:Drugs with negative inotropic effect are widely used to decrease obstruction in hypertrophic cardiomyopathy (HCM). However, the mechanism of therapeutic benefit has not been studied. METHODS AND RESULTS:We used M-mode, two-dimensional, and pulsed Doppler echocardiography to study 11 patients with obstructiv...


    pub_type: 杂志文章


    authors: Sherrid MV,Pearle G,Gunsburg DZ

    更新日期:1998-01-06 00:00:00

  • Abnormal norepinephrine clearance and adrenergic receptor sensitivity in idiopathic orthostatic intolerance.

    abstract:BACKGROUND:Chronic orthostatic intolerance (OI) is characterized by symptoms of inadequate cerebral perfusion with standing, in the absence of significant orthostatic hypotension. A heart rate increase of >/=30 bpm is typical. Possible underlying pathophysiologies include hypovolemia, partial dysautonomia, or a primary...


    pub_type: 临床试验,杂志文章


    authors: Jacob G,Shannon JR,Costa F,Furlan R,Biaggioni I,Mosqueda-Garcia R,Robertson RM,Robertson D

    更新日期:1999-04-06 00:00:00

  • The role of nitric oxide in coronary vascular effects of estrogen in postmenopausal women.

    abstract:BACKGROUND:At physiological concentrations, 17beta-estradiol selectively enhances endothelium-dependent coronary vasodilation by an unknown mechanism in postmenopausal women. METHODS AND RESULTS:To assess the contribution of nitric oxide (NO) to the vascular effects of estradiol, we measured coronary epicardial and mi...


    pub_type: 杂志文章


    authors: Guetta V,Quyyumi AA,Prasad A,Panza JA,Waclawiw M,Cannon RO 3rd

    更新日期:1997-11-04 00:00:00

  • Total cavopulmonary connection flow with functional left pulmonary artery stenosis: angioplasty and fenestration in vitro.

    abstract:BACKGROUND:In our multicenter study of the total cavopulmonary connection (TCPC), a cohort of patients with long-segment left pulmonary artery (LPA) stenosis was observed (35%). The clinically recognized detrimental effects of LPA stenosis motivated a computational fluid dynamic simulation study within 3-dimensional pa...


    pub_type: 杂志文章,多中心研究


    authors: Pekkan K,Kitajima HD,de Zelicourt D,Forbess JM,Parks WJ,Fogel MA,Sharma S,Kanter KR,Frakes D,Yoganathan AP

    更新日期:2005-11-22 00:00:00

  • Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure.

    abstract:BACKGROUND:Cardiac growth and function may be modulated in part by trophic effects of neurohormones. Specifically, aldosterone has been shown to stimulate the growth of cardiac myocytes and the accumulation of cardiac extracellular matrix proteins. Moreover, a variant of the aldosterone synthase gene (a cytosine/thymid...


    pub_type: 杂志文章


    authors: Schunkert H,Hengstenberg C,Holmer SR,Broeckel U,Luchner A,Muscholl MW,Kürzinger S,Döring A,Hense HW,Riegger GA

    更新日期:1999-05-04 00:00:00

  • L-4F, an apolipoprotein A-1 mimetic, restores nitric oxide and superoxide anion balance in low-density lipoprotein-treated endothelial cells.

    abstract:BACKGROUND:Low-density lipoprotein (LDL) impairs endothelial cell function by uncoupling endothelial nitric oxide synthase (eNOS) activity, which allows superoxide anion (O2*-)) to be generated rather than nitric oxide (*NO). Recent reports indicate that apolipoprotein (apo) A-1 mimetics inhibit the development of athe...


    pub_type: 杂志文章


    authors: Ou Z,Ou J,Ackerman AW,Oldham KT,Pritchard KA Jr

    更新日期:2003-03-25 00:00:00

  • Detection of enterovirus RNA in myocardial biopsies from patients with myocarditis and cardiomyopathy using gene amplification by polymerase chain reaction.

    abstract::Recent molecular studies have suggested that viral myocarditis frequently underlies human congestive cardiomyopathy; however, only moderately sensitive and specific techniques were used. Polymerase chain reaction (PCR) gene amplification is a sensitive, specific technique ideally suited for the diagnosis of viral dise...


    pub_type: 杂志文章


    authors: Jin O,Sole MJ,Butany JW,Chia WK,McLaughlin PR,Liu P,Liew CC

    更新日期:1990-07-01 00:00:00

  • Epicardial mapping and electrocardiographic models of myocardial ischemic injury.

    abstract::The amplitude and distribution of epicardial ST-segment elevation (ST) were examined for an 8-hour period after coronary occlusion in eight baboons and five pigs. ST was determined from unipolar epicardial electrograms obtained from a high-resolution matrix of fixed electrodes overlying a transmural region of ischemia...


    pub_type: 杂志文章


    authors: Smith GT,Geary G,Ruf W,Roelofs TH,McNamara JJ

    更新日期:1979-10-01 00:00:00

  • Atrial fibrillation after surgical correction of mitral regurgitation in sinus rhythm: incidence, outcome, and determinants.

    abstract:BACKGROUND:The incidence, determinants, and outcome of postoperative atrial fibrillation (AF) after surgery for mitral regurgitation (MR) are poorly defined but may have important implications for timing of mitral valve surgery. METHODS AND RESULTS:In 762 patients in sinus rhythm with no AF history undergoing MR surgi...


    pub_type: 杂志文章


    authors: Kernis SJ,Nkomo VT,Messika-Zeitoun D,Gersh BJ,Sundt TM 3rd,Ballman KV,Scott CG,Schaff HV,Enriquez-Sarano M

    更新日期:2004-10-19 00:00:00

  • Diabetic cardiomyopathy revisited.

    abstract::Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary art...


    pub_type: 杂志文章,评审


    authors: Boudina S,Abel ED

    更新日期:2007-06-26 00:00:00

  • Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy.

    abstract:BACKGROUND:Although beta-adrenergic receptor (AR) blockade therapy is beneficial in the treatment of heart failure, little is known regarding the transcriptional mechanisms underlying this salutary action. METHODS AND RESULTS:In the present study, we screened mice overexpressing Gsalpha, beta1AR, beta2AR, or protein k...


    pub_type: 杂志文章


    authors: Gaussin V,Tomlinson JE,Depre C,Engelhardt S,Antos CL,Takagi G,Hein L,Topper JN,Liggett SB,Olson EN,Lohse MJ,Vatner SF,Vatner DE

    更新日期:2003-12-09 00:00:00

  • Echocardiography in chronic aortic insufficiency. Is valve replacement too late when left ventricular end-systolic dimension reaches 55 mm?

    abstract::To determine whether a ventricular (LV) end-systolic dimension (ESD) greater than or equal to 55 mm and LV left fractional shortening less than 25% are risk factors for aortic valve replacement (AVR) in patients with aortic insufficiency, we analyzed the clinical course and M-mode echocardiograms in 47 consecutive pat...


    pub_type: 杂志文章


    authors: Fioretti P,Roelandt J,Bos RJ,Meltzer RS,van Hoogenhuijze D,Serruys PW,Nauta J,Hugenholtz PG

    更新日期:1983-01-01 00:00:00

  • Significance of adventitial inflammation of the coronary artery in patients with unstable angina: results at autopsy.

    abstract::A quantitative analysis of adventitial inflammation of the coronary artery with intimal lesions is described in 12 patients who suffered coronary death and had had unstable angina (crescendo angina) at rest (group 1). After autopsy in these patients we examined epon-embedded cross sections by light and electron micros...


    pub_type: 杂志文章


    authors: Kohchi K,Takebayashi S,Hiroki T,Nobuyoshi M

    更新日期:1985-04-01 00:00:00

  • Influence of diabetes and mammary artery grafting on survival after coronary bypass.

    abstract::The effect of diabetes on survival after coronary bypass surgery is uncertain. Also, although the overall clinical benefits of internal mammary artery (IMA) grafting are well established, the survival benefit attributable to IMA grafting in diabetics is not well characterized. To determine the influence of diabetes an...


    pub_type: 杂志文章


    authors: Morris JJ,Smith LR,Jones RH,Glower DD,Morris PB,Muhlbaier LH,Reves JG,Rankin JS

    更新日期:1991-11-01 00:00:00