Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting.

abstract：BACKGROUND:Aortic valve calcification is an actively regulated process that displays hallmarks of atherosclerosis. Natriuretic peptides (A-, B-, and C-type natriuretic peptides [ANP, BNP, and CNP]) have been reported to have a role in the pathogenesis of vascular atherosclerosis, but their expression in aortic valves i...

journal_title：Circulation

authors： Peltonen TO,Taskinen P,Soini Y,Rysä J,Ronkainen J,Ohtonen P,Satta J,Juvonen T,Ruskoaho H,Leskinen H

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:Chronic heart failure remains a major cause of mortality and morbidity. The role of antithrombotic therapy in patients with chronic heart failure has long been debated. The objective of this study was to determine the optimal antithrombotic agent for heart failure patients with reduced ejection fractions who...

journal_title：Circulation

authors： Massie BM,Collins JF,Ammon SE,Armstrong PW,Cleland JG,Ezekowitz M,Jafri SM,Krol WF,O'Connor CM,Schulman KA,Teo K,Warren SR,WATCH Trial Investigators.

更新日期：2009-03-31 00:00:00

abstract：:Peripheral arterial disease is one manifestation of systemic atherosclerosis. The prevalence of peripheral arterial disease increases with the age of the population. It is important to remember the significant association of coincident coronary artery disease, which is the major cause of mortality in these patients. R...

journal_title：Circulation

authors： White CJ,Gray WA

更新日期：2007-11-06 00:00:00

abstract：:The acute coronary hemodynamic and metabolic effects of intravenous dipyridamole were studied in 13 patients. Total left ventricular (LV), anterior (supplied by the left anterior descending coronary artery) and inferior (supplied by circumflex and right coronary arteries) regional flows and metabolic responses were as...

journal_title：Circulation

authors： Feldman RL,Nichols WW,Pepine CJ,Conti CR

更新日期：1981-08-01 00:00:00

abstract：OBJECTIVE:Previous studies comparing off-pump coronary artery bypass surgery (OPCABG) to conventional techniques utilizing cardiopulmonary bypass (CABG-CPB) have failed to provide patient selection guidelines. We sought to determine guidelines, attempting to rectify the limitations of previous studies. METHODS AND RES...

journal_title：Circulation

authors： Magee MJ,Coombs LP,Peterson ED,Mack MJ

更新日期：2003-09-09 00:00:00

abstract：:Thirty patients with triple-vessel coronary artery disease proven by angiography, symptomatic angina and a positive ECG stress test were evaluated with thallium-201 (201TI) scintigraphy. Twenty patients also had aortocoronary saphenous vein bypass surgery; 15 of them had repeat noninvasive evaluation. Seventy percent ...

journal_title：Circulation

authors： Leppo J,Yipintsoi T,Blankstein R,Bontemps R,Freeman LM,Zohman L,Scheuer J

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:Myocardial infarction, stroke, and sudden death undergo diurnal variation. Although genes relevant to hemostasis and vascular integrity undergo circadian oscillation, the role of the molecular clock in thrombotic events remains to be established. METHODS AND RESULTS:A diurnal variation in the time to thromb...

journal_title：Circulation

authors： Westgate EJ,Cheng Y,Reilly DF,Price TS,Walisser JA,Bradfield CA,FitzGerald GA

更新日期：2008-04-22 00:00:00

abstract：BACKGROUND:Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. Phenotyping patients into pathophysiologically homogeneous groups may enable better targeting of treatment. Obesity is common in HFpEF and has many cardiovascular effects, suggesting that it may be a viable candidate for...

journal_title：Circulation

authors： Obokata M,Reddy YNV,Pislaru SV,Melenovsky V,Borlaug BA

更新日期：2017-07-04 00:00:00

abstract：:Ventilation with positive end-expiratory pressure (PEEP) is associated with reduced cardiac output, but the mechanisms involved are controversial. Possible explanations include increased intrathoracic pressure, reflex changes in myocardial inotropism, pulmonary vascular obstruction and abnormal ventricular interaction...

journal_title：Circulation

authors： Rankin JS,Olsen CO,Arentzen CE,Tyson GS,Maier G,Smith PK,Hammon JW Jr,Davis JW,McHale PA,Anderson RW,Sabiston DC Jr

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND:Recent studies indicate that serotonin (5-HT) has a growth-promoting effect on several different cell types, including smooth muscle cells. After percutaneous transluminal coronary angioplasty, there is damage and denudation of vascular endothelial cells, which promotes platelet aggregation at the site of in...

journal_title：Circulation

authors： Pakala R,Willerson JT,Benedict CR

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The guidelines presented in this consensus statement are intended to serve researchers, clinicians, reviewers, and regulators in the selection of the most appropriate primary outcome for a clinical trial of cardiac arrest therapies. The American Heart Association guidelines for the treatment of c...

journal_title：Circulation

authors： Becker LB,Aufderheide TP,Geocadin RG,Callaway CW,Lazar RM,Donnino MW,Nadkarni VM,Abella BS,Adrie C,Berg RA,Merchant RM,O'Connor RE,Meltzer DO,Holm MB,Longstreth WT,Halperin HR,American Heart Association Emergency Cardiova

更新日期：2011-11-08 00:00:00

abstract：BACKGROUND:A mortality follow-up of 12,866 men was conducted 16 years after randomization to special intervention (SI) or usual care (UC) groups of the Multiple Risk Factor Intervention Trial to assess the long-term effect of cardiovascular risk factor intervention on coronary heart disease (CHD), cardiovascular death ...

journal_title：Circulation

authors：

更新日期：1996-09-01 00:00:00

abstract：:Analysis of the Framingham Heart Study experience between 1958 and 1970 showed a progressive increase in the rate of treatment and control of hypertension. With cross-sectional criteria to define diastolic hypertension, the treatment rate rose from 35% in 1958 through 1960 to 69% in 1968 through 1970 (p less than .001...

journal_title：Circulation

authors： Shea S,Cook EF,Kannel WB,Goldman L

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Previous studies found that percutaneous coronary intervention (PCI) does not improve outcome compared with medical therapy (MT) in patients with stable coronary artery disease, but PCI was guided by angiography alone. FAME 2 trial (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) compa...

journal_title：Circulation

authors： Fearon WF,Nishi T,De Bruyne B,Boothroyd DB,Barbato E,Tonino P,Jüni P,Pijls NHJ,Hlatky MA,FAME 2 Trial Investigators.

更新日期：2018-01-30 00:00:00

abstract：:To investigate the effects of verapamil on left ventricular systolic and diastolic function in patients with hypertrophic cardiomyopathy, we studied 14 patients at catheterization with a nonimaging scintillation probe before and after serial intravenous infusions of low-, medium-, and high-dose verapamil (total dose 0...

journal_title：Circulation

authors： Bonow RO,Ostrow HG,Rosing DR,Cannon RO 3rd,Lipson LC,Maron BJ,Kent KM,Bacharach SL,Green MV

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:There are no reported studies on the safety and efficacy of low-dose aspirin with low-intensity oral anticoagulation in patients with heart valve replacement. In this study, we compared the use of 100 mg/d aspirin with 650 mg/d aspirin in the prevention of systemic embolism and vascular death in patients wit...

journal_title：Circulation

authors： Altman R,Rouvier J,Gurfinkel E,Scazziota A,Turpie AG

更新日期：1996-11-01 00:00:00

abstract：:Background: Vascular smooth muscle cells (VSMCs) show a remarkable phenotypic plasticity allowing acquisition of contractile or synthetic states but critical information is missing about the physiological signals, promoting formation and maintenance of contractile VSMCs in vivo. BMP9 and BMP10 are known to regulate en...

journal_title：Circulation

authors： Wang L,Rice M,Swist S,Kubin T,Wu F,Wang S,Kraut S,Weissmann N,Böttger T,Wheeler M,Schneider A,Braun T

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND:Hypercholesterolemia causes an upregulation of vascular angiotensin II type 1 (AT1) receptor expression in cell culture and animal models. The presented studies were undertaken to examine AT1 receptor overexpression in hypercholesterolemic men and therapeutic interventions thereof by HMG CoA reductase inhibi...

journal_title：Circulation

authors： Nickenig G,Bäumer AT,Temur Y,Kebben D,Jockenhövel F,Böhm M

更新日期：1999-11-23 00:00:00

abstract：BACKGROUND:Systemic administration of heparin can decrease mortality and morbidity of acute ischemic coronary syndromes such as unstable angina and myocardial infarction. Hemorrhage is the major limiting factor in the clinical use of systemic heparin. The objective of the present study was to determine whether local de...

journal_title：Circulation

authors： Nunes GL,Thomas CN,Hanson SR,Barry JJ,King SB 3rd,Scott NA

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Heart rate (HR) variability is a marker of tonic cardiac autonomic activity and contributes in assessing risk for sudden death after myocardial infarction. Recent clinical observations have indicated that attenuation of HR variability, which occurs after myocardial infarction, may be transient. This study ad...

journal_title：Circulation

authors： Adamson PB,Huang MH,Vanoli E,Foreman RD,Schwartz PJ,Hull SS Jr

更新日期：1994-08-01 00:00:00

abstract：:The automatic implantable cardioverter-defibrillator (ICD) is highly effective in reducing sudden death rates in patients with life-threatening ventricular tachyarrhythmias. However, the magnitude of the ability of the ICD to improve overall survival is less certain. Data supporting the contention that the ICD prolong...

journal_title：Circulation

authors： Sweeney MO,Ruskin JN

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:By the formation of cGMP, nitric oxide (NO)-sensitive guanylyl cyclase (GC) acts as the effector for the signaling molecule NO and mediates the relaxation of vascular smooth muscle and the inhibition of platelet aggregation. The compounds YC-1 and BAY 41-2272 are regarded as NO-independent activators and sen...

journal_title：Circulation

authors： Mullershausen F,Russwurm M,Friebe A,Koesling D

更新日期：2004-04-13 00:00:00

abstract：BACKGROUND:Interleukin-8 (IL-8) secreted from endothelial cells is a powerful neutrophil chemoattractant and activator. We hypothesized that human endothelial cells deprived of oxygen would secrete IL-8, which might translate into elevated IL-8 production after cardiac ischemia. Furthermore, we hypothesized that corona...

journal_title：Circulation

authors： Oz MC,Liao H,Naka Y,Seldomridge A,Becker DN,Michler RE,Smith CR,Rose EA,Stern DM,Pinsky DJ

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Few data exist regarding the effects of angiotensin converting enzyme inhibitors in patients with regurgitant valvular lesions. We postulated an immediate improvement in cardiac performance with captopril in mitral regurgitation, which, in a hemodynamically compensated group of patients, might be mediated th...

journal_title：Circulation

authors： Wisenbaugh T,Essop R,Sareli P

更新日期：1991-11-01 00:00:00

abstract：:The initial appearance and continuous development of a coronary plaque depends on a combination of hemodynamic trauma, deposition of excess cholesterol, and accretion and incorporation of thrombogenic elements as well as fully formed mural thrombi. Plaques become life-threatening when rupture of their intimal surface ...

journal_title：Circulation

authors： Friedman M

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Intravascular ultrasound imaging was performed in 27 patients after coronary balloon angioplasty to quantify the lumen and atheroma cross-sectional areas. METHODS AND RESULTS:A 20-MHz ultrasound catheter was inserted through a 1.6-mm plastic introducer sheath across the dilated area to obtain real-time imag...

journal_title：Circulation

authors： Tobis JM,Mallery J,Mahon D,Lehmann K,Zalesky P,Griffith J,Gessert J,Moriuchi M,McRae M,Dwyer ML

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:In an open-label blinded study, we compared intracoronary and transendocardial CD34(+) cell transplantation in patients with nonischemic dilated cardiomyopathy. METHODS AND RESULTS:Of the 40 patients with dilated cardiomyopathy, 20 were randomized to receive intracoronary injection and 20 received transendo...

journal_title：Circulation

authors： Vrtovec B,Poglajen G,Lezaic L,Sever M,Socan A,Domanovic D,Cernelc P,Torre-Amione G,Haddad F,Wu JC

更新日期：2013-09-10 00:00:00

abstract：:A series of 252 isolated aortic homograft valves in 248 patients have been followed for 9 to 16.5 years (mean 10.8). The valves were sterilized in antibiotic solution and stored in a nutrient medium at 4 degrees C and were nonvital. There were 15 in-hospital deaths (6%) and a mortality of 2.7% in patients undergoing a...

journal_title：Circulation

authors： Barratt-Boyes BG,Roche AH,Subramanyan R,Pemberton JR,Whitlock RM

更新日期：1987-04-01 00:00:00

abstract：:To define the mechanisms of unexpected cardiac arrest in advanced heart failure, we reviewed the causes of cardiac arrest as established from electrocardiographic monitoring and from clinical and autopsy data in patients hospitalized for cardiac transplantation evaluation and management of advanced heart failure (mean...

journal_title：Circulation

authors： Luu M,Stevenson WG,Stevenson LW,Baron K,Walden J

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Coronary sinus access by electrode catheters is easier in patients with atrioventricular junctional reentry tachycardia (AVJRT) than in patients with other supraventricular tachyarrhythmias. The reason for this has not been addressed. METHODS AND RESULTS:The size and shape of the proximal coronary sinus wer...

journal_title：Circulation

authors： Doig JC,Saito J,Harris L,Downar E

更新日期：1995-08-01 00:00:00