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The effects of airway pressure on cardiac function in intact dogs and man.

Abstract：

:Ventilation with positive end-expiratory pressure (PEEP) is associated with reduced cardiac output, but the mechanisms involved are controversial. Possible explanations include increased intrathoracic pressure, reflex changes in myocardial inotropism, pulmonary vascular obstruction and abnormal ventricular interaction. Three types of conscious canine preparations were developed to examine simultaneously each of these factors during ventilation with PEEP. In addition, similar measurements were obtained in patients after cardiac surgical procedures and compared with the results of animal experiments. The primary cause of reduced cardiac output during PEEP appeared to be a diminished end-diastolic volume of the left ventricle, and this appeared to be the result of elevated intrathoracic pressure and increased impedance to blood flow through the lungs. Abnormal interventricular septal shifting and reflex autonomic alterations did not appear to be significant in the normal cardiovascular system. These data provide insight into the cardiac effects of PEEP and emphasize the importance of simultaneous quantification of biventricular performance when assessing cardiopulmonary function.

journal_name

Circulation

journal_title

Circulation

authors

Rankin JS,Olsen CO,Arentzen CE,Tyson GS,Maier G,Smith PK,Hammon JW Jr,Davis JW,McHale PA,Anderson RW,Sabiston DC Jr

doi

10.1161/01.cir.66.1.108

subject

Has Abstract

pub_date

1982-07-01 00:00:00

pages

108-20

issue

1

eissn

0009-7322

issn

1524-4539

journal_volume

66

pub_type

杂志文章

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