Novel associations between bioavailable estradiol and adipokines in elderly women with different phenotypes of obesity: implications for atherogenesis.


BACKGROUND:Peripheral adiposity confers protection against diabetes and atherosclerosis in elderly women. The underlying mechanisms, however, remain to be elucidated. METHODS AND RESULTS:On the basis on dual-energy X-ray absorptiometry measurements of central fat mass (CFM) and peripheral fat mass (PFM), we identified 290 elderly women with distinct forms of body fat distribution (lean, peripheral obesity, central obesity, or general obesity). Study parameters were plasma tumor necrosis factor-alpha, interleukin (IL)-6, adiponectin, estradiol, sex hormone-binding globulin, insulin resistance, and aortic calcification, graded on lateral radiography. In peripherally and generally obese women, plasma estradiol and insulin resistance were significantly lower, whereas sex hormone-binding globulin and adiponectin were significantly higher compared with centrally obese women independent of age, body mass index, total fat mass, and smoking habits (all P<0.05). After adjustment for these confounders, IL-6 in centrally obese women was comparable with that seen in generally obese (similar high CFM%) but significantly higher than in peripherally obese women and lean women (low CFM%). Atherosclerosis was less severe in generally obese (2.5+/-0.3) compared with centrally obese women (5.0+/-0.7, P=0.001). In multiple regression analysis, total fat mass, body fat distribution, insulin resistance, estradiol, current smoking, treated hyperlipidemia, and treated hypertension contributed independently to the variation of aortic calcification (R=0.55, SEE=3.60, P<0.001). CONCLUSIONS:Abundant presence of PFM in generally obese women is associated with increased plasma adiponectin and higher insulin sensitivity, which could explain the apparent protection against the atherogenic effects of IL-6 derived from CFM. Low peripheral exposure to estradiol appears to be a sine qua non of maintained adiponectin secretion from PFM.






Tankó LB,Bruun JM,Alexandersen P,Bagger YZ,Richelsen B,Christiansen C,Larsen PJ




Has Abstract


2004-10-12 00:00:00














  • Exercise training attenuates age-associated diastolic dysfunction in rats.

    abstract:BACKGROUND:In contrast to systolic function, which is relatively well preserved with advancing age, diastolic function declines steadily after age 30. Our goal was to determine whether changes in diastolic function that occur with aging could be reversed with exercise training. Methods and Results-- Adult (6-month-old)...


    pub_type: 杂志文章


    authors: Brenner DA,Apstein CS,Saupe KW

    更新日期:2001-07-10 00:00:00

  • Impaired maximal rate of left ventricular relaxation in patients with coronary artery disease and left ventricular dysfunction.

    abstract::It has been suggested that the rate of left ventricular (LV) relaxation is related to the inotropic state, end-systolic fiber length and peak LV pressure, but little information is available regarding the rate of LV relaxation in patients with coronary artery disease (CAD) and LV dysfunction. To assess the rate of LV ...


    pub_type: 杂志文章


    authors: Papapietro SE,Coghlan HC,Zissermann D,Russell RO Jr,Rackley CE,Rogers WJ

    更新日期:1979-05-01 00:00:00

  • Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study.

    abstract:BACKGROUND:Biomarkers that predict response to cardiac resynchronization therapy (CRT) in heart failure patients with dyssynchrony (HFDYS) would be clinically important. Circulating extracellular microRNAs (miRNAs) have emerged as novel biomarkers that may also play important functional roles, but their relevance as ma...


    pub_type: 杂志文章


    authors: Melman YF,Shah R,Danielson K,Xiao J,Simonson B,Barth A,Chakir K,Lewis GD,Lavender Z,Truong QA,Kleber A,Das R,Rosenzweig A,Wang Y,Kass D,Singh JP,Das S

    更新日期:2015-06-23 00:00:00

  • Evidence for a reversible oxygen radical-mediated component of reperfusion injury: reduction by recombinant human superoxide dismutase administered at the time of reflow.

    abstract::It has been suggested that the beneficial effects of reperfusing ischemic myocardium might be in part reversed by the occurrence of "reperfusion injury." One possible mechanism could be the generation of oxygen free radicals. Superoxide dismutase enzymatically scavenges superoxide radicals by dismutation to hydrogen p...


    pub_type: 杂志文章


    authors: Ambrosio G,Weisfeldt ML,Jacobus WE,Flaherty JT

    更新日期:1987-01-01 00:00:00

  • Pacing as a Treatment for Reflex-Mediated (Vasovagal, Situational, or Carotid Sinus Hypersensitivity) Syncope: A Systematic Review for the 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American Coll

    abstract:OBJECTIVES:To determine, using systematic review of the biomedical literature, whether pacing reduces risk of recurrent syncope and relevant clinical outcomes among adult patients with reflex-mediated syncope. METHODS:MEDLINE (through PubMed), EMBASE, and the Cochrane Central Register of Controlled Trials (through Oct...


    pub_type: 杂志文章,meta分析,评审


    authors: Varosy PD,Chen LY,Miller AL,Noseworthy PA,Slotwiner DJ,Thiruganasambandamoorthy V

    更新日期:2017-08-01 00:00:00

  • Tissue and serum angiogenic activity is associated with low prevalence of ischemic complications in patients with giant-cell arteritis.

    abstract:BACKGROUND:Vascular inflammatory lesions from patients with giant-cell arteritis show a remarkable amount of neovascularization, but its clinical implications have never been investigated. METHODS AND RESULTS:To assess the clinical relevance of neovascularization in giant-cell arteritis, angiogenesis was measured in t...


    pub_type: 临床试验,杂志文章


    authors: Cid MC,Hernández-Rodríguez J,Esteban MJ,Cebrián M,Gho YS,Font C,Urbano-Márquez A,Grau JM,Kleinman HK

    更新日期:2002-09-24 00:00:00

  • Radionuclide assessment of nitroglycerin influence on abnormal left ventricular segmental contraction in patients with coronary heart disease.

    abstract::Noninvasive gated cardiac blood pool imaging with technetium-99m autologous erythrocytes was employed to differentiate reversible verus irreversible abnormal ventricular segmental contraction by regional wall and pump responses to sublingual nitroglycerin in 25 patients with chronic coronary heart disease. In 12 patie...


    pub_type: 杂志文章


    authors: Salel AF,Berman DS,DeNardo GL,Mason DT

    更新日期:1976-06-01 00:00:00

  • Thallium reinjection demonstrates viable myocardium in regions with reverse redistribution.

    abstract:BACKGROUND:The clinical significance and pathophysiological mechanisms of reverse redistribution on stress-redistribution thallium-201 myocardial scintigraphy in patients with chronic coronary artery disease are unclear. Recent studies have shown that thallium-201 reinjection is a useful technique for the detection of ...


    pub_type: 杂志文章


    authors: Marin-Neto JA,Dilsizian V,Arrighi JA,Freedman NM,Perrone-Filardi P,Bacharach SL,Bonow RO

    更新日期:1993-10-01 00:00:00

  • Chronic kidney disease, cardiovascular risk, and response to angiotensin-converting enzyme inhibition after myocardial infarction: the Survival And Ventricular Enlargement (SAVE) study.

    abstract:BACKGROUND:Persons with end-stage renal disease and those with lesser degrees of chronic kidney disease (CKD) have an increased risk of death after myocardial infarction (MI) that is not fully explained by associated comorbidities. Future cardiovascular event rates and the relative response to therapy in persons with m...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tokmakova MP,Skali H,Kenchaiah S,Braunwald E,Rouleau JL,Packer M,Chertow GM,Moyé LA,Pfeffer MA,Solomon SD

    更新日期:2004-12-14 00:00:00

  • Detection of edema associated with myocardial ischemia by computerized tomography in isolated, arrested canine hearts.

    abstract::This study was undertaken to determine if computerized tomography (CT scanning) with an EMI cranial scanner could detect edema associated with myocardial ischemia in canine hearts. A localized area of decreased density in the posterior papillary muscle and surrounding myocardium was detected on serial 8 mm CT scan sli...


    pub_type: 杂志文章


    authors: Powell WJ Jr,wittenberg J,Maturi RA,Dinsmore RE,Miller SW

    更新日期:1977-01-01 00:00:00

  • Prognostic importance of serum sodium concentration and its modification by converting-enzyme inhibition in patients with severe chronic heart failure.

    abstract::Although past reports have identified a variety of prognostic factors in patients with severe chronic heart failure, previous studies have not evaluated the interaction of prognostic variables and drug treatment. We analyzed the association of 30 clinical, hemodynamic, and biochemical variables with survival in 203 co...


    pub_type: 杂志文章


    authors: Lee WH,Packer M

    更新日期:1986-02-01 00:00:00

  • Effect of activation of the H1 receptor on coronary hemodynamics in man.

    abstract::We evaluated the effects of selective activation of H1 receptors on coronary hemodynamics in 16 patients divided into two groups: group A, 11 patients with atypical angina or valvular heart disease and normal coronary arteries, and group B, five patients with spontaneous angina, four of whom had significant (greater t...


    pub_type: 杂志文章


    authors: Vigorito C,Poto S,Picotti GB,Triggiani M,Marone G

    更新日期:1986-06-01 00:00:00

  • Cost-effectiveness of aspirin treatment in the primary prevention of cardiovascular disease events in subgroups based on age, gender, and varying cardiovascular risk.

    abstract:BACKGROUND:Aspirin is effective for the primary prevention of cardiovascular events, but it remains unclear for which subgroups of individuals aspirin is beneficial. We assessed the cost-effectiveness of aspirin separately for men and women of different ages with various levels of cardiovascular disease risk. METHODS ...


    pub_type: 杂志文章


    authors: Greving JP,Buskens E,Koffijberg H,Algra A

    更新日期:2008-06-03 00:00:00

  • Clinical pharmacokinetics and efficacy of amiodarone for refractory tachyarrhythmias.

    abstract::Using a high-pressure liquid chromatographic assay, we measured serum amiodarone concentrations serially in 122 patients treated with amiodarone for 1.5-53 months (mean 9.3 months) for control of refractory symptomatic atrial or symptomatic and life-threatening ventricular tachyarrhythmias. The atrial tachyarrhythmias...


    pub_type: 杂志文章


    authors: Haffajee CI,Love JC,Canada AT,Lesko LJ,Asdourian G,Alpert JS

    更新日期:1983-06-01 00:00:00

  • Progesterone induces human leukocyte antigen-g expression in vascular endothelial and smooth muscle cells.

    abstract:BACKGROUND:Human leukocyte antigen-G (HLA-G) expression in heart transplant patients has been negatively associated with acute cellular rejection and cardiac allograft vasculopathy. We assessed HLA-G expression in vascular human endothelial and smooth muscle cell cultures to determine if future therapeutic agents can b...


    pub_type: 杂志文章


    authors: Sheshgiri R,Rao V,Tumiati LC,Xiao R,Prodger JL,Badiwala M,Librach C,Delgado DH

    更新日期:2008-09-30 00:00:00

  • Electron-beam computed tomography in the assessment of coronary artery disease after heart transplantation.

    abstract:BACKGROUND:Our aim was to compare the electron-beam CT (EBCT) features of coronary arteries in heart transplant recipients with those of biplane coronary angiography and intracoronary ultrasound (ICUS). METHODS AND RESULTS:We examined 112 heart transplant recipients (25 female; age, 17 to 69 years; median, 52 years) 1...


    pub_type: 临床试验,杂志文章


    authors: Knollmann FD,Bocksch W,Spiegelsberger S,Hetzer R,Felix R,Hummel M

    更新日期:2000-05-02 00:00:00

  • CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice.

    abstract:BACKGROUND:Atherosclerosis is a multifactorial disease in which inflammatory processes play an important role. Inflammation underlies lesion evolution at all stages, from establishment to plaque rupture and thrombosis. Costimulatory molecules of the tumor necrosis factor superfamily such as CD40/CD40L and OX40/OX40L ha...


    pub_type: 杂志文章


    authors: Olofsson PS,Söderström LA,Wågsäter D,Sheikine Y,Ocaya P,Lang F,Rabu C,Chen L,Rudling M,Aukrust P,Hedin U,Paulsson-Berne G,Sirsjö A,Hansson GK

    更新日期:2008-03-11 00:00:00

  • Transplantation for idiopathic pulmonary arterial hypertension: improvement in the lung allocation score era.

    abstract:BACKGROUND:Lung transplantation and heart-lung transplantation represent surgical options for treatment of medically refractory idiopathic pulmonary arterial hypertension. The effect of the lung allocation score on wait-list and transplantation outcomes in patients with idiopathic pulmonary arterial hypertension is poo...


    pub_type: 杂志文章


    authors: Schaffer JM,Singh SK,Joyce DL,Reitz BA,Robbins RC,Zamanian RT,Mallidi HR

    更新日期:2013-06-25 00:00:00

  • Smooth muscle cell proliferation is proportional to the degree of balloon injury in a rat model of angioplasty.

    abstract:BACKGROUND:A variable degree of smooth muscle cell (SMC) proliferation after balloon injury has been reported in previous rat studies. It is unknown whether balloon injury induces c-fos expression and whether it is related to the degree of vascular injury in vivo. Therefore, we tested the hypothesis that proportional i...


    pub_type: 杂志文章


    authors: Indolfi C,Esposito G,Di Lorenzo E,Rapacciuolo A,Feliciello A,Porcellini A,Avvedimento VE,Condorelli M,Chiariello M

    更新日期:1995-09-01 00:00:00

  • Reliability of multicenter pediatric echocardiographic measurements of left ventricular structure and function: the prospective P(2)C(2) HIV study.

    abstract:BACKGROUND:To assess the reliability of pediatric echocardiographic measurements, we compared local measurements with those made at a central facility. METHODS AND RESULTS:The comparison was based on the first echocardiographic recording obtained on 735 children of HIV-infected mothers at 10 clinical sites focusing on...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Lipshultz SE,Easley KA,Orav EJ,Kaplan S,Starc TJ,Bricker JT,Lai WW,Moodie DS,Sopko G,Schluchter MD,Colan SD

    更新日期:2001-07-17 00:00:00

  • Thallium 201 kinetics in stunned myocardium characterized by severe postischemic systolic dysfunction.

    abstract::The hypothesis tested in this study was that despite the presence of severe postischemic myocardial dysfunction ("stunning"), the extraction and subsequent intracellular washout of thallium 201 should be preserved as long as irreversible sarcolemmal membrane injury was avoided. To produce myocardial stunning, 19 open-...


    pub_type: 杂志文章


    authors: Moore CA,Cannon J,Watson DD,Kaul S,Beller GA

    更新日期:1990-05-01 00:00:00

  • Quantitative coronary arteriography: estimation of dimensions, hemodynamic resistance, and atheroma mass of coronary artery lesions using the arteriogram and digital computation.

    abstract::More accurate characterization of coronary artery lesions is needed for evaluation of short and long-term interventions in coronary disease. A method of segmental artery analysis has been developed to maximize the information obtained from coronary arteriograms. Coronary lesions are traced from two projected, perpendi...


    pub_type: 杂志文章


    authors: Brown BG,Bolson E,Frimer M,Dodge HT

    更新日期:1977-02-01 00:00:00

  • Endothelial cell damage and thrombus formation after partial arterial constriction: relevance to the role of coronary artery spasm in the pathogenesis of myocardial infarction.

    abstract::The left anterior descending coronary artery of four dogs and the right common carotid artery of 15 rabbits were subjected to 40-60% reduction in transluminal diameter for 1 hour by partial ligation with suture thread. Scanning electron microscopic examination of the luminal surface of these vessels revealed endotheli...


    pub_type: 杂志文章


    authors: Gertz SD,Uretsky G,Wajnberg RS,Navot N,Gotsman MS

    更新日期:1981-03-01 00:00:00

  • Protection of endothelium in vessel segments excised for grafting.

    abstract::Contracture and collapse often complicate dissection and excision of blood vessels for grafting. Subsequent forceful redilatation and leak checking with cold saline almost always lead to partial or total denudation of endothelium, which increases the risk of early occlusion by thrombi or late occlusion by fibrocellula...


    pub_type: 杂志文章


    authors: Haudenschild C,Gould KE,Quist WC,LoGerfo FW

    更新日期:1981-08-01 00:00:00

  • Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice.

    abstract:BACKGROUND:The ability of apolipoprotein (apo)A-I to induce regression of preexisting atherosclerotic lesions has not been determined, and a mouse model of atherosclerosis regression has not yet been reported. METHODS AND RESULTS:LDL receptor-deficient mice were fed a western-type diet for 5 weeks to induce atheroscle...


    pub_type: 杂志文章


    authors: Tangirala RK,Tsukamoto K,Chun SH,Usher D,Puré E,Rader DJ

    更新日期:1999-10-26 00:00:00

  • Anisotropic conduction properties in canine atria analyzed by high-resolution optical mapping: preferential direction of conduction block changes from longitudinal to transverse with increasing age.

    abstract:BACKGROUND:Anisotropic conduction properties may provide a substrate for reentrant arrhythmias. We investigated the age-dependent changes of structural and functional anisotropy in isolated right atria from infant (1 to 2 months), young (6 to 12 months), and old (6 to 10 years) dogs. METHODS AND RESULTS:The histology ...


    pub_type: 杂志文章


    authors: Koura T,Hara M,Takeuchi S,Ota K,Okada Y,Miyoshi S,Watanabe A,Shiraiwa K,Mitamura H,Kodama I,Ogawa S

    更新日期:2002-04-30 00:00:00

  • L-arginine supplementation in peripheral arterial disease: no benefit and possible harm.

    abstract:BACKGROUND:L-arginine is the precursor of endothelium-derived nitric oxide, an endogenous vasodilator. L-arginine supplementation improves vascular reactivity and functional capacity in peripheral arterial disease (PAD) in small, short-term studies. We aimed to determine the effects of long-term administration of L-arg...


    pub_type: 杂志文章,随机对照试验


    authors: Wilson AM,Harada R,Nair N,Balasubramanian N,Cooke JP

    更新日期:2007-07-10 00:00:00

  • Race and Sex Differences in Post-Myocardial Infarction Angina Frequency and Risk of 1-Year Unplanned Rehospitalization.

    abstract:BACKGROUND:Race and sex disparities in in-hospital treatment and outcomes of patients with acute myocardial infarction (MI) have been described, but little is known about race and sex differences in post-MI angina and long-term risk of unplanned rehospitalization. We examined race and sex differences in post-MI angina ...


    pub_type: 杂志文章


    authors: Hess CN,Kaltenbach LA,Doll JA,Cohen DJ,Peterson ED,Wang TY

    更新日期:2017-02-07 00:00:00

  • Relations between enzymatically estimated myocardial infarct size and early ventricular dysrhythmia.

    abstract::The relation between ventricular dysrhythmia during the first 20 hours after hospitalization for acute myocardial infarction and enzymatically estimated infarct size was studied prospectively. The duration of dyshythmia was measured by the total time during which the average premature ventricular depolarization (PVC) ...


    pub_type: 杂志文章


    authors: Cox JR Jr,Roberts R,Ambos HD,Oliver GC,Sobel BE

    更新日期:1976-03-01 00:00:00

  • Vacuolar H(+)-ATPase plays a crucial role in growth and phenotypic modulation of myofibroblasts in cultured human saphenous vein.

    abstract:BACKGROUND:The molecular mechanism of neointimal hyperplasia after vein graft surgery remains elusive. Vacuolar H(+)-ATPase (V-ATPase) is involved in intracellular trafficking and may play a crucial role in neointimal cell growth. METHODS AND RESULTS:Cultured human saphenous vein segments developed neointimal formatio...


    pub_type: 杂志文章


    authors: Otani H,Yamamura T,Nakao Y,Hattori R,Fujii H,Ninomiya H,Kido M,Kawaguchi H,Osako M,Imamura H,Ohta T,Ohkuma S

    更新日期:2000-11-07 00:00:00