Arterial imaging with a new forward-viewing intravascular ultrasound catheter, II. Three-dimensional reconstruction and display of data.

abstract：BACKGROUND:Surviving cells in the postinfarction border zone are subjected to intense fluctuations of their microenvironment. Recently, border zone cardiomyocytes have been specifically implicated in cardiac regeneration. Here, we defined their unique transcriptional and regulatory properties, and comprehensively valid...

journal_title：Circulation

authors： van Duijvenboden K,de Bakker DEM,Man JCK,Janssen R,Günthel M,Hill MC,Hooijkaas IB,van der Made I,van der Kraak PH,Vink A,Creemers EE,Martin JF,Barnett P,Bakkers J,Christoffels VM

更新日期：2019-09-09 00:00:00

abstract：BACKGROUND:Oxidized low-density lipoprotein plays a key role in the initiation, progression, and destabilization of atherosclerotic plaques and is present in macrophages and the lipid pool. The aim of this study was to assess the feasibility of magnetic resonance imaging of atherosclerotic lesions in mice using micelle...

journal_title：Circulation

authors： Briley-Saebo KC,Shaw PX,Mulder WJ,Choi SH,Vucic E,Aguinaldo JG,Witztum JL,Fuster V,Tsimikas S,Fayad ZA

更新日期：2008-06-24 00:00:00

abstract：:Data from 981 patients evaluated for ischemic heart disease with coronary angiography were reviewed to identify variables predictive of sudden death and duration from onset of symptoms to death. During the period of follow-up, 113 patients died. Of these deaths, 99 were classified as cardiovascular. Forty percent occu...

journal_title：Circulation

authors： Oberman A,Ray M,Turner ME,Barnes G,Grooms C

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Carotid artery stenting (CAS) has recently emerged as a potential alternative to carotid endarterectomy. Cerebral embolization is the most devastating complication of CAS, and the echogenicity of carotid plaque has been indicated as one of the risk factors involved. This is the first study to analyze the rol...

journal_title：Circulation

authors： Biasi GM,Froio A,Diethrich EB,Deleo G,Galimberti S,Mingazzini P,Nicolaides AN,Griffin M,Raithel D,Reid DB,Valsecchi MG

更新日期：2004-08-10 00:00:00

abstract：BACKGROUND:Monitoring implantable cardiac device function and patient condition is important. The Lumos-T Safely Reduces Routine Office Device Follow-Up (TRUST) trial tested the hypothesis that remote home monitoring with automatic daily surveillance (HM) is safe and effective for implantable cardioverter-defibrillator...

journal_title：Circulation

authors： Varma N,Epstein AE,Irimpen A,Schweikert R,Love C,TRUST Investigators.

更新日期：2010-07-27 00:00:00

abstract：:The healthcare system is undergoing a transition from paying for volume to paying for value. Clinicians, as well as public and private payers, are beginning to implement alternative delivery and payment models, such as the patient-centered medical home, accountable care organizations, and bundled payment arrangements....

journal_title：Circulation

authors： Bufalino VJ,Berkowitz SA,Gardner TJ,Piña IL,Konig M,AHA Expert Panel on Payment and Delivery System Reform.

更新日期：2017-08-15 00:00:00

abstract：BACKGROUND:Vasomotor reactivity may contribute to the pathophysiology of ischemic injury. The atherosclerotic vessel may be particularly susceptible to vasoconstriction because of the damaged endothelial layer with resultant loss of vasodilatory factors. While dietary omega 3 fatty acids have been proposed to protect a...

journal_title：Circulation

authors： Malis CD,Leaf A,Varadarajan GS,Newell JB,Weber PC,Force T,Bonventre JV

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Bronchopulmonary dysplasia (BPD) and pulmonary emphysema, both significant global health problems, are characterized by a loss of alveoli. Vascular endothelial growth factor (VEGF) is a trophic factor required for endothelial cell survival and is abundantly expressed in the lung. METHODS AND RESULTS:We repo...

journal_title：Circulation

authors： Thébaud B,Ladha F,Michelakis ED,Sawicka M,Thurston G,Eaton F,Hashimoto K,Harry G,Haromy A,Korbutt G,Archer SL

更新日期：2005-10-18 00:00:00

abstract：:Eighteen of 388 patients with chronic bundle branch block, studied electrophysiologically and followed prospectively, had H-V intervals of 80 msec or greater. Five patients were functional class I, five class II, seven class III, and one class IV. Follow-up ranged from 103 to 1919 days (mean 711 +/- 118). Three patien...

journal_title：Circulation

authors： Dhingra RC,Denes P,Wu D,Wyndham CR,Amat-y-Leon F,Towne WD,Rosen KM

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:Studies on apolipoprotein E (apoE) alleles have reported an increased risk of coronary heart disease in patients with the apoE4 allele. Given the risk factor and histological similarities between coronary and calcific valvular heart disease (aortic stenosis [AS] and mitral annular calcification [MAC]), we po...

journal_title：Circulation

authors： Novaro GM,Sachar R,Pearce GL,Sprecher DL,Griffin BP

更新日期：2003-10-14 00:00:00

abstract：BACKGROUND:Extrahepatic tissues have long been considered critical contributors of cholesterol to nascent HDL particles in the reverse cholesterol transport pathway, in which ABCA1 plays the crucial role. Recent studies, however, including both overexpression and deletion of ABCA1 selectively in the liver, have highlig...

journal_title：Circulation

authors： Singaraja RR,Van Eck M,Bissada N,Zimetti F,Collins HL,Hildebrand RB,Hayden A,Brunham LR,Kang MH,Fruchart JC,Van Berkel TJ,Parks JS,Staels B,Rothblat GH,Fiévet C,Hayden MR

更新日期：2006-09-19 00:00:00

abstract：BACKGROUND:During ischemia, the intracellular calcium and inorganic phosphate (P(i)) concentrations rise and pH falls. We investigated the effects of these changes on force development in donor and failing human hearts to determine if altered contractile protein composition during heart failure changes the myocardial r...

journal_title：Circulation

authors： van Der Velden J,Klein LJ,Zaremba R,Boontje NM,Huybregts MA,Stooker W,Eijsman L,de Jong JW,Visser CA,Visser FC,Stienen GJ

更新日期：2001-09-04 00:00:00

abstract：BACKGROUND:Electrophysiological mechanisms by which adenosine may activate cardiac afferent neurons are unknown. Slow afterhyperpolarizations (AHPs) follow action potentials in a subset of vagal C afferents, rendering them inexcitable. The purpose of this study was to test the hypothesis that adenosine increases vagal ...

journal_title：Circulation

authors： Middlekauff HR,Doering A,Weiss JN

更新日期：2001-03-06 00:00:00

abstract：BACKGROUND:Autoantibodies against the beta 1-adrenoceptor have been detected in the sera of patients with idiopathic dilated cardiomyopathy (DCM). The mechanisms by which these autoantibodies can alter normal receptor function are investigated, and the results are interpreted in the light of the beneficial effects of b...

journal_title：Circulation

authors： Magnusson Y,Wallukat G,Waagstein F,Hjalmarson A,Hoebeke J

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:We recently reported that sodium channel block can produce opposite effects on action potential duration (APD) and refractoriness in epicardial versus endocardial tissues of the canine ventricle. In addition, strong sodium channel current inhibition was found to cause loss of the action potential dome in epi...

journal_title：Circulation

authors： Krishnan SC,Antzelevitch C

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Keratinocyte growth factor (KGF) has been shown to play an important role in pneumocyte proliferation and lung development. We hypothesized that exogenous KGF would enhance postpneumonectomy compensatory lung growth through alveolar proliferation. METHODS AND RESULTS:Adult Sprague-Dawley rats were used. Lef...

journal_title：Circulation

authors： Kaza AK,Kron IL,Leuwerke SM,Tribble CG,Laubach VE

更新日期：2002-09-24 00:00:00

abstract：BACKGROUND:Smoking is a major risk factor for cardiovascular events. One of the potential mechanisms may be related to both coronary endothelial dysfunction and increased inflammatory response. The present study was designed to test the hypothesis that smoking is associated with epicardial coronary endothelial dysfunct...

journal_title：Circulation

authors： Lavi S,Prasad A,Yang EH,Mathew V,Simari RD,Rihal CS,Lerman LO,Lerman A

更新日期：2007-05-22 00:00:00

abstract：BACKGROUND:Paraplegia continues to complicate thoracoabdominal aortic interventions. The elusive mechanism of spinal cord ischemia-reperfusion injury has delayed the development of pharmacological adjuncts. Microglia, the resident macrophages of the central nervous system, can have pathological responses after a variet...

journal_title：Circulation

authors： Bell MT,Puskas F,Agoston VA,Cleveland JC Jr,Freeman KA,Gamboni F,Herson PS,Meng X,Smith PD,Weyant MJ,Fullerton DA,Reece TB

更新日期：2013-09-10 00:00:00

abstract：BACKGROUND:Swimming-induced pulmonary edema (SIPE) occurs during swimming or scuba diving, often in young individuals with no predisposing conditions, and its pathophysiology is poorly understood. This study tested the hypothesis that pulmonary artery and pulmonary artery wedge pressures are higher in SIPE-susceptible ...

journal_title：Circulation

authors： Moon RE,Martina SD,Peacher DF,Potter JF,Wester TE,Cherry AD,Natoli MJ,Otteni CE,Kernagis DN,White WD,Freiberger JJ

更新日期：2016-03-08 00:00:00

abstract：:The indications for biventricular versus left ventricular mechanical circulatory support as a bridge to cardiac transplantation are not well established. In this study, 27 potential heart transplant candidates who were in imminent risk of dying before donor heart procurement were implanted with Thoratec prosthetic ven...

journal_title：Circulation

authors： Farrar DJ,Hill JD,Gray LA Jr,Galbraith TA,Chow E,Hershon JJ

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a life-threatening disease, characterized by vascular smooth muscle cell hyperproliferation. The calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) may play a major role in vascular smooth muscle cell proliferation. METHODS AND RESULTS:We investigated the expres...

journal_title：Circulation

authors： Schermuly RT,Pullamsetti SS,Kwapiszewska G,Dumitrascu R,Tian X,Weissmann N,Ghofrani HA,Kaulen C,Dunkern T,Schudt C,Voswinckel R,Zhou J,Samidurai A,Klepetko W,Paddenberg R,Kummer W,Seeger W,Grimminger F

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Inhaled nitric oxide (NO) is a potent and selective pulmonary vasodilator, which induces cGMP synthesis by activating soluble guanylate cyclase (sGC) in ventilated lung regions. Carbon monoxide (CO) has also been proposed to influence smooth muscle tone via activation of sGC. We examined whether direct stimu...

journal_title：Circulation

authors： Evgenov OV,Ichinose F,Evgenov NV,Gnoth MJ,Falkowski GE,Chang Y,Bloch KD,Zapol WM

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:The metabolic syndrome is associated with increased angiotensin II activity, induction of a proinflammatory and oxidative state, and endothelial dysfunction. We evaluated the ability of irbesartan, an angiotensin receptor blocker, and lipoic acid, an antioxidant, to affect endothelial function and inflammati...

journal_title：Circulation

authors： Sola S,Mir MQ,Cheema FA,Khan-Merchant N,Menon RG,Parthasarathy S,Khan BV

更新日期：2005-01-25 00:00:00

abstract：BACKGROUND:This study sought to evaluate the clinical impact of angiographic complete revascularization (CR) after drug-eluting stent implantation or coronary artery bypass graft surgery for multivessel coronary disease. METHODS AND RESULTS:A total of 1914 consecutive patients with multivessel coronary disease undergo...

journal_title：Circulation

authors： Kim YH,Park DW,Lee JY,Kim WJ,Yun SC,Ahn JM,Song HG,Oh JH,Park JS,Kang SJ,Lee SW,Lee CW,Park SW,Park SJ

更新日期：2011-05-31 00:00:00

abstract：BACKGROUND:Calcium-insensitive transient outward current (I(to)) is important to the development of cardiac memory (CM), which itself reflects the capacity of the heart to remodel electrophysiologically. We used cardiac pacing to test the hypothesis that CM evolution can be explained by developmental maturation of I(to...

journal_title：Circulation

authors： Plotnikov AN,Sosunov EA,Patberg KW,Anyukhovsky EP,Gainullin RZ,Shlapakova IN,Krishnamurthy G,Danilo P Jr,Rosen MR

更新日期：2004-08-03 00:00:00

abstract：BACKGROUND:The pathogenesis of impaired endothelium-dependent coronary vasodilation in angina pectoris and normal coronary arteriograms (microvascular angina pectoris) is not known. We examined whether supplementation with L-arginine, a precursor of endothelium-derived nitric oxide, improves endothelium-dependent coron...

journal_title：Circulation

authors： Egashira K,Hirooka Y,Kuga T,Mohri M,Takeshita A

更新日期：1996-07-15 00:00:00

abstract：BACKGROUND:Left ventricular noncompaction is a cardiomyopathy characterized by excessive trabeculation of the left ventricle, progressive myocardial dysfunction, and early mortality. Left ventricular noncompaction has a heterogeneous clinical presentation that includes arrhythmia and sudden cardiac death. METHODS AND ...

journal_title：Circulation

authors： Brescia ST,Rossano JW,Pignatelli R,Jefferies JL,Price JF,Decker JA,Denfield SW,Dreyer WJ,Smith O,Towbin JA,Kim JJ

更新日期：2013-06-04 00:00:00

abstract：BACKGROUND:Adrenomedullin (AM) is a novel vasodilating peptide thought to have important effects on cardiovascular function. The aim of this study was to assess the activity of endogenous AM in the cardiovascular system using AM knockout mice. METHODS AND RESULTS:Mice heterozygous for an AM-null mutation (AM+/-) and t...

journal_title：Circulation

authors： Niu P,Shindo T,Iwata H,Iimuro S,Takeda N,Zhang Y,Ebihara A,Suematsu Y,Kangawa K,Hirata Y,Nagai R

更新日期：2004-04-13 00:00:00

abstract：:Oral flecainide acetate was administered to 34 patients with documented symptomatic paroxysmal supraventricular tachycardia (PSVT) with a double-blind, placebo-controlled, 8-week crossover trial design. PSVT was defined as a regular tachycardia of at least 120 beats/min without evidence of atrioventricular dissociatio...

journal_title：Circulation

authors： Henthorn RW,Waldo AL,Anderson JL,Gilbert EM,Alpert BL,Bhandari AK,Hawkinson RW,Pritchett EL

更新日期：1991-01-01 00:00:00

abstract：:Hemodynamic effects of dobutamine and dopamine (both 5, 10, 15 microgram/kg/min) and epinephrine (0.04 microgram/kg/min) were studied immediately following cessation of cardiopulmonary bypass in 34 patients with preoperative evidence of left ventricular dysfunction. Significant increases in mean cardiac index were see...

journal_title：Circulation

authors： Steen PA,Tinker JH,Pluth JR,Barnh;rst DA,Tarhan S

更新日期：1978-02-01 00:00:00