Supravalvular pulmonary stenosis after anatomic correction of transposition of the great arteries: causes and prevention.

abstract：:Malignant hyperthermia is a disease resulting from defective cellular membranes, usually presenting as drug-induced pyrexic crises. We describe four patients with life threatening ventricular arrhythmias or chest pain in the absence of pyrexic crises. Three presented with life threatening arrhythmias and the fourth wi...

journal_title：Circulation

authors： Huckell VF,Staniloff HM,Britt BA,Waxman MB,Morch JE

更新日期：1978-11-01 00:00:00

abstract：:The reduced responsiveness of the renin-angiotensin system to hemodynamic changes in patients with congestive heart failure (CHF) could be due to a defect of the juxtaglomerular apparatus. To test this hypothesis, the responses to viprostol, an analog of prostaglandin E2 (PGE2) that is known to stimulate both the macu...

journal_title：Circulation

authors： Olivari MT,Levine TB,Cohn JN

更新日期：1986-12-01 00:00:00

abstract：:Amiodarone is the most effective antiarrhythmic drug for maintaining sinus rhythm for patients with atrial fibrillation. Extra-cardiac side effects have been a limiting factor, especially during chronic use, and may offset its benefits. Dronedarone is a noniodinated benzofuran derivative of amiodarone that has been de...

journal_title：Circulation

authors： Patel C,Yan GX,Kowey PR

更新日期：2009-08-18 00:00:00

abstract：BACKGROUND:After a myocardial infarction, the injured region becomes fibrotic and the myocardial scar may expand if the ventricular wall lacks elasticity. Cardiac dilatation may precipitate the vicious cycle of progressive heart failure. The present study evaluated the functional benefits of increasing elastin within a...

journal_title：Circulation

authors： Mizuno T,Yau TM,Weisel RD,Kiani CG,Li RK

更新日期：2005-08-30 00:00:00

abstract：:Guiding surgical therapy of ventricular tachycardia by preoperative endocardial catheter mapping necessitates improvement of the accuracy of localization of the arrhythmogenic site. We therefore used a new mathematical cineradiographic method during catheter mapping to compute the position of left ventricular arrhythm...

journal_title：Circulation

authors： Hauer RN,de Zwart MT,de Bakker JM,Hitchcock JF,Penn OC,Nijsen-Karelse M,Robles de Medina EO

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:This study examines the cellular basis for the phenotypic appearance of broad-based T waves, increased transmural dispersion of repolarization (TDR), and torsade de pointes (TdP) induced by beta-adrenergic agonists under conditions mimicking the LQT1 form of the congenital long-QT syndrome. METHODS AND RESU...

journal_title：Circulation

authors： Shimizu W,Antzelevitch C

更新日期：1998-11-24 00:00:00

abstract：:Between July 1985 and September 1987, 25 patients underwent 26 carotid endarterectomies based on an abnormal duplex scan (B-mode ultrasonography and pulsed-Doppler sound spectral analysis) indicative of severe stenosis or ulceration. Arteriography was not performed because of severe unstable angina requiring coronary ...

journal_title：Circulation

authors： Marshall WG Jr,Kouchoukos NT,Murphy SF,Pelate C

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Cardiac ischemia on the ambulatory ECG (AECG) and/or on the exercise treadmill test (ETT) is associated with an increased risk of adverse outcome. Myocardial revascularization more often suppresses cardiac ischemia than does medical management alone. However, few studies have compared the effects of percutan...

journal_title：Circulation

authors： Bourassa MG,Knatterud GL,Pepine CJ,Sopko G,Rogers WJ,Geller NL,Dyrda I,Forman SA,Chaitman BR,Sharaf B

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Chronic orthostatic intolerance (OI) is characterized by symptoms of inadequate cerebral perfusion with standing, in the absence of significant orthostatic hypotension. A heart rate increase of >/=30 bpm is typical. Possible underlying pathophysiologies include hypovolemia, partial dysautonomia, or a primary...

journal_title：Circulation

authors： Jacob G,Shannon JR,Costa F,Furlan R,Biaggioni I,Mosqueda-Garcia R,Robertson RM,Robertson D

更新日期：1999-04-06 00:00:00

abstract：BACKGROUND:Although the use of physical signs for the diagnosis of ventricular tachycardia (VT) was described in the early 1900s, their value in this role has never been systematically assessed. METHODS AND RESULTS:Using a blinded, randomized protocol, we examined the ability of 26 clinicians to detect ventriculoatria...

journal_title：Circulation

authors： Garratt CJ,Griffith MJ,Young G,Curzen N,Brecker S,Rickards AF,Camm AJ

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Extracorporeal membrane oxygenation (ECMO) is considered when respiratory failure (RF) persists despite increasing conventional mechanical ventilation (CMV). High-frequency jet ventilation (HFJV) can improve ventilation with comparable mean airway pressure (PAW) to that found on CMV. This study was undertake...

journal_title：Circulation

authors： Kocis KC,Meliones JN,Dekeon MK,Callow LB,Lupinetti FM,Bove EL

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:A low level of HDL cholesterol has been identified as a risk factor for stroke in observational studies. METHODS AND RESULTS:Our objective was to determine whether treatment aimed at raising HDL cholesterol and lowering triglycerides reduces stroke in men with coronary heart disease and low levels of both H...

journal_title：Circulation

authors： Bloomfield Rubins H,Davenport J,Babikian V,Brass LM,Collins D,Wexler L,Wagner S,Papademetriou V,Rutan G,Robins SJ,VA-HIT Study Group.

更新日期：2001-06-12 00:00:00

abstract：:Depression of myocardial conduction velocity can be an important mechanism of action of antiarrhythmic drugs but it can also facilitate arrhythmogenesis. We used lidocaine in an anesthetized canine preparation to address the hypothesis that drug-induced rate-dependent conduction velocity depression causes ventricular ...

journal_title：Circulation

authors： Anderson KP,Walker R,Lux RL,Ershler PR,Menlove R,Williams MR,Krall R,Moddrelle D

更新日期：1990-03-01 00:00:00

abstract：:Prior studies have demonstrated the presence of inhomogeneities in myocardial [K+]e after serial 10-minute occlusions of the left anterior descending coronary artery in the pig, even within restricted locations of an ischemic zone. These inhomogeneities are thought to underlie the electrophysiological abnormalities re...

journal_title：Circulation

authors： Johnson TA,Engle CL,Boyd LM,Koch GG,Gwinn M,Gettes LS

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Extracorporeal circulation with circuits coated with surface-bound heparin has allowed reduced levels of systemic heparinization. Clinical benefits have included reduced postoperative bleeding and less homologous blood usage. However, the effects on the hemostatic and fibrinolytic systems have remained in pa...

journal_title：Circulation

authors： Ovrum E,Brosstad F,Am Holen E,Tangen G,Abdelnoor M

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Inflammation and thrombosis coexist in several disorders. Although it is recognized that leukocytes may induce a procoagulant state at sites of inflammation, the critical molecular determinants of this process remain largely unknown. METHODS AND RESULTS:To examine mechanisms of inflammation-induced thrombos...

journal_title：Circulation

authors： Hirahashi J,Hishikawa K,Kaname S,Tsuboi N,Wang Y,Simon DI,Stavrakis G,Shimosawa T,Xiao L,Nagahama Y,Suzuki K,Fujita T,Mayadas TN

更新日期：2009-09-29 00:00:00

abstract：:To test the hypothesis that an area of slow conduction is present during reentrant ventricular tachycardia in man, and that the earliest activation site during ventricular tachycardia is within or orthodromically just distal to the area of slow conduction in the reentry loop, we studied 12 episodes of ventricular tach...

journal_title：Circulation

authors： Okumura K,Olshansky B,Henthorn RW,Epstein AE,Plumb VJ,Waldo AL

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:Myocardial perfusion during adenosine-induced hyperemia is used both in clinical diagnosis of coronary heart disease and for scientific investigations of the myocardial microcirculation. The objective of this study was to clarify whether adenosine-induced hyperemia is dependent on endothelial NO production o...

journal_title：Circulation

authors： Buus NH,Bøttcher M,Hermansen F,Sander M,Nielsen TT,Mulvany MJ

更新日期：2001-11-06 00:00:00

abstract：:Although evidence suggests that primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy in the majority of patients with ST-segment-elevation myocardial infarction (STEMI), only a minority of patients with STEMI are treated with primary PCI, and of those, only a minority receive the trea...

journal_title：Circulation

authors： Jacobs AK,Antman EM,Ellrodt G,Faxon DP,Gregory T,Mensah GA,Moyer P,Ornato J,Peterson ED,Sadwin L,Smith SC,American Heart Association's Acute Myocardial Infarction Advisory Working Group.

更新日期：2006-05-02 00:00:00

abstract：BACKGROUND:A positive association was previously reported between angiotensin-converting enzyme (ACE) gene polymorphism and several cardiovascular diseases, such as myocardial infarction, left ventricular hypertrophy, and restenosis after percutaneous transluminal coronary angioplasty. Plasma ACE activity and carotid-w...

journal_title：Circulation

authors： Ishigami T,Umemura S,Iwamoto T,Tamura K,Hibi K,Yamaguchi S,Nyuui N,Kimura K,Miyazaki N,Ishii M

更新日期：1995-02-15 00:00:00

abstract：BACKGROUND:Classically, intrinsic coagulation proteins are thought to have a minor role in hemostasis. Recently, these proteins, especially FXII, were implicated as possible key players in the pathogenesis of arterial thrombosis. This study aims to determine the risks of arterial thrombosis conferred by increased activ...

journal_title：Circulation

authors： Siegerink B,Govers-Riemslag JW,Rosendaal FR,Ten Cate H,Algra A

更新日期：2010-11-02 00:00:00

abstract：BACKGROUND:Atrial flutter (AFL) and atrial fibrillation (AF) frequently coexist, yet the specific relationship between these arrhythmias, and particularly whether sustained AFL leads to AF, is unknown. METHODS AND RESULTS:We investigated the electrophysiological consequences of chronic AFL using an ovine anatomic righ...

journal_title：Circulation

authors： Morton JB,Byrne MJ,Power JM,Raman J,Kalman JM

更新日期：2002-01-15 00:00:00

abstract：BACKGROUND:Candidates for cardiac resynchronization therapy (CRT) receive either a biventricular pacemaker or a biventricular pacemaker with an implantable cardioverter-defibrillator (CRT-D). Optimal device selection remains challenging because the benefit of implantable cardioverter-defibrillator therapy may not be un...

journal_title：Circulation

authors： Lindvall C,Chatterjee NA,Chang Y,Chernack B,Jackson VA,Singh JP,Metlay JP

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:Even in high-performing health systems, some patients with diabetes mellitus have poor blood pressure (BP) control because of poor medication adherence and lack of medication intensification. We examined whether the Adherence and Intensification of Medications intervention, a pharmacist-led intervention comb...

journal_title：Circulation

authors： Heisler M,Hofer TP,Schmittdiel JA,Selby JV,Klamerus ML,Bosworth HB,Bermann M,Kerr EA

更新日期：2012-06-12 00:00:00

abstract：BACKGROUND:Hypothermic hyperkalemic cardioplegia results in significant myocyte swelling and impaired contractility. These detrimental effects may be eliminated by the addition of an adenosine triphosphate-sensitive potassium (KATP) channel opener. This study evaluated the hypothesis that a KATP channel opener (diazoxi...

journal_title：Circulation

authors： Mizutani S,Prasad SM,Sellitto AD,Schuessler RB,Damiano RJ Jr,Lawton JS

更新日期：2005-08-30 00:00:00

abstract：BACKGROUND:During ischemia, the intracellular calcium and inorganic phosphate (P(i)) concentrations rise and pH falls. We investigated the effects of these changes on force development in donor and failing human hearts to determine if altered contractile protein composition during heart failure changes the myocardial r...

journal_title：Circulation

authors： van Der Velden J,Klein LJ,Zaremba R,Boontje NM,Huybregts MA,Stooker W,Eijsman L,de Jong JW,Visser CA,Visser FC,Stienen GJ

更新日期：2001-09-04 00:00:00

abstract：:Continuous-wave Doppler echocardiography was used to estimate pulmonary artery pressures by measuring pulmonary regurgitant flow velocity in 21 patients with pulmonary hypertension (mean pulmonary artery pressure greater than or equal to 20 mm Hg) and 24 patients without pulmonary hypertension. The pulmonary regurgita...

journal_title：Circulation

authors： Masuyama T,Kodama K,Kitabatake A,Sato H,Nanto S,Inoue M

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:The involvement of the complement system in brain injury has been scarcely investigated. Here, we document the pivotal role of mannose-binding lectin (MBL), one of the recognition molecules of the lectin complement pathway, in brain ischemic injury. METHODS AND RESULTS:Focal cerebral ischemia was induced in...

journal_title：Circulation

authors： Orsini F,Villa P,Parrella S,Zangari R,Zanier ER,Gesuete R,Stravalaci M,Fumagalli S,Ottria R,Reina JJ,Paladini A,Micotti E,Ribeiro-Viana R,Rojo J,Pavlov VI,Stahl GL,Bernardi A,Gobbi M,De Simoni MG

更新日期：2012-09-18 00:00:00

abstract：BACKGROUND:Sirt7, 1 of the 7 members of the mammalian sirtuin family, promotes oncogenic transformation. Tumor growth and metastasis require fibrotic and angiogenic responses. Here, we investigated the role of Sirt7 in cardiovascular tissue repair process. METHODS AND RESULTS:In wild-type mice, Sirt7 expression increa...

journal_title：Circulation

authors： Araki S,Izumiya Y,Rokutanda T,Ianni A,Hanatani S,Kimura Y,Onoue Y,Senokuchi T,Yoshizawa T,Yasuda O,Koitabashi N,Kurabayashi M,Braun T,Bober E,Yamagata K,Ogawa H

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:Vascular inflammation and lipid deposition are prominent features of atherosclerotic lesion formation. We have shown previously that the dithiol compound alpha-lipoic acid (LA) exerts antiinflammatory effects by inhibiting tumor necrosis factor-alpha- and lipopolysaccharide-induced endothelial and monocyte a...

journal_title：Circulation

authors： Zhang WJ,Bird KE,McMillen TS,LeBoeuf RC,Hagen TM,Frei B

更新日期：2008-01-22 00:00:00