Altered contractile response in neonatal myocardium to citrate-phosphate-dextrose infusion.

abstract：BACKGROUND:This study examines the limitations and complex management problems associated with the use of tiered-therapy, implantable cardioverter-defibrillators (ICDs). METHODS AND RESULTS:The study group comprises the first 154 patients undergoing implantation of tiered-therapy ICDs at our institution. Pulse generat...

journal_title：Circulation

authors： Nunain SO,Roelke M,Trouton T,Osswald S,Kim YH,Sosa-Suarez G,Brooks DR,McGovern B,Guy M,Torchiana DF

更新日期：1995-04-15 00:00:00

abstract：BACKGROUND:Chimeric molecules comprising the A-chain of tissue-type plasminogen activator (t-PA) and the catalytic domain of urokinase-type plasminogen activator (u-PA) have intact enzymatic characteristics of u-PA, partial fibrin-binding properties of t-PA, and thrombolytic properties in animal models comparable with ...

journal_title：Circulation

authors： Collen D,Lu HR,Lijnen HR,Nelles L,Stassen JM

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Statins are effective in the primary prevention of atherosclerotic cardiovascular disease. The 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline expands recommended statin use, but its cost-effectiveness has not been compared with other guidelines. METHODS:We used the Cardio...

journal_title：Circulation

authors： Heller DJ,Coxson PG,Penko J,Pletcher MJ,Goldman L,Odden MC,Kazi DS,Bibbins-Domingo K

更新日期：2017-09-19 00:00:00

abstract：:Recent studies have shown that blood flow during closed-chest cardiopulmonary resuscitation (CPR) results primarily from generalized changes in intrathoracic pressure rather than direct compression of the heart. Since ascending aortic and right atrial pressures rise and fall synchronously and to comparable levels duri...

journal_title：Circulation

authors： Ditchey RV,Winkler JV,Rhodes CA

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:Tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) are thought to play critical roles in vascular remodeling after injury, with tPA mediating intravascular clot lysis and uPA modulating cell migration within the vessel wall. In human vascular disease, however, thrombus org...

journal_title：Circulation

authors： Schäfer K,Konstantinides S,Riedel C,Thinnes T,Müller K,Dellas C,Hasenfuss G,Loskutoff DJ

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:To formally test whether the antiapoptotic protein bcl-2 would prevent programmed cell death in cardiac muscle cells provoked by p53, a known trigger of apoptosis in a variety of different cell types, we used replication defective adenovirus encoding either the bcl-2 and p53 genes to deliver bcl-2 and p53 to...

journal_title：Circulation

authors： Kirshenbaum LA,de Moissac D

更新日期：1997-09-02 00:00:00

abstract：BACKGROUND:The novel phosphate binder sevelamer has been shown to prevent the progression of aortic and coronary calcification in uremic patients. Whether it also decreases the progression of atheromatous plaques is unknown. The aim of our study was to examine the effect of sevelamer administration on the development o...

journal_title：Circulation

authors： Phan O,Ivanovski O,Nguyen-Khoa T,Mothu N,Angulo J,Westenfeld R,Ketteler M,Meert N,Maizel J,Nikolov IG,Vanholder R,Lacour B,Drüeke TB,Massy ZA

更新日期：2005-11-01 00:00:00

abstract：:Fibrinopeptide A, platelet factor 4, beta-thromboglobulin, thromboxane B2, and 6-keto-prostaglandin F1 alpha were estimated by radioimmunoassay on venous plasma samples taken within 48 hr of admission from 16 consecutive patients with unstable angina and 15 patients with stable angina matched for clinical variables. T...

journal_title：Circulation

authors： Théroux P,Latour JG,Léger-Gauthier C,De Lara J

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:The importance of clinical presentation and pretransplantation course on outcome in children with dilated cardiomyopathy listed for heart transplantation is not well defined. METHODS AND RESULTS:The impact of age, duration of illness, sex, race, ventricular geometry, and diagnosis of myocarditis on outcome ...

journal_title：Circulation

authors： Pietra BA,Kantor PF,Bartlett HL,Chin C,Canter CE,Larsen RL,Edens RE,Colan SD,Towbin JA,Lipshultz SE,Kirklin JK,Naftel DC,Hsu DT

更新日期：2012-08-28 00:00:00

abstract：:To determine whether cardiac transplant rejection can be detected noninvasively with indium-111 (111In)-labeled lymphocytes, we studied 11 dogs with thoracic heterotopic cardiac transplants without immunosuppression and five dogs with transplants treated with cyclosporine (10 mg/kg/day) and prednisone (1 mg/kg/day). A...

journal_title：Circulation

authors： Eisen HJ,Eisenberg SB,Saffitz JE,Bolman RM 3rd,Sobel BE,Bergmann SR

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the long-term value of dobutamine-atropine stress echocardiography (DSE) for prediction of late cardiac events in patients with proven or suspected coronary artery disease. METHODS AND RESULTS:Clinical data and DSE results were analyzed in 1734 consecutive patients un...

journal_title：Circulation

authors： Poldermans D,Fioretti PM,Boersma E,Bax JJ,Thomson IR,Roelandt JR,Simoons ML

更新日期：1999-02-16 00:00:00

abstract：BACKGROUND:We have previously suggested that the primary arterial switch operation is a feasible strategy for patients with transposition of the great arteries and intact ventricular septum (TGA-IVS) up to age 2 months. This study reports our current results with this approach and examines whether this policy could be ...

journal_title：Circulation

authors： Kang N,de Leval MR,Elliott M,Tsang V,Kocyildirim E,Sehic I,Foran J,Sullivan I

更新日期：2004-09-14 00:00:00

abstract：BACKGROUND:Prenatal surgery for congenital anomalies can prevent fetal demise or alter the course of organ development, resulting in a more favorable condition at birth. The indications for fetal surgery continue to expand, yet little is known about the acute sequelae of fetal surgery on the human cardiovascular system...

journal_title：Circulation

authors： Rychik J,Tian Z,Cohen MS,Ewing SG,Cohen D,Howell LJ,Wilson RD,Johnson MP,Hedrick HL,Flake AW,Crombleholme TM,Adzick NS

更新日期：2004-09-21 00:00:00

abstract：:An asymptomatic 14-year-old male was found at cardiac catheterization to have a coronary artery fistula involving a vessel originating from the left main coronary artery and terminating in the right heart. Chest X-ray and electrocardiogram were within normal limits and shunt flow was too small to be detected by oximet...

journal_title：Circulation

authors： Shubrooks SJ Jr,Naggar CZ

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Two phase III trials of enoxaparin for unstable angina/non-Q-wave myocardial infarction have shown it to be superior to unfractionated heparin for preventing a composite of death and cardiac ischemic events. A prospectively planned meta-analysis was performed to provide a more precise estimate of the effects...

journal_title：Circulation

authors： Antman EM,Cohen M,Radley D,McCabe C,Rush J,Premmereur J,Braunwald E

更新日期：1999-10-12 00:00:00

abstract：:The initial myocardial uptake of thallium-201 depends on myocardial blood flow distribution. The phenomenon of delayed thallium redistribution after transiently or chronically altered myocardial perfusion has been described. The net myocardial accumulation of thallium-201 after injection depends upon the net balance b...

journal_title：Circulation

authors： Grunwald AM,Watson DD,Holzgrefe HH Jr,Irving JF,Beller GA

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND:In the treatment of patients with life-threatening ventricular arrhythmia, transvenous implantable cardioverter/defibrillators provide significant advantages over devices requiring a thoracotomy. This study tested the hypothesis that a new carbon-fiber electrode, designed at the Technische Universität in Mun...

journal_title：Circulation

authors： Alt EU,Fotuhi PC,Callihan RL,Mestre E,Smith WM,Ideker RE

更新日期：1995-09-15 00:00:00

abstract：BACKGROUND AND PURPOSE:The guidelines presented in this consensus statement are intended to serve researchers, clinicians, reviewers, and regulators in the selection of the most appropriate primary outcome for a clinical trial of cardiac arrest therapies. The American Heart Association guidelines for the treatment of c...

journal_title：Circulation

authors： Becker LB,Aufderheide TP,Geocadin RG,Callaway CW,Lazar RM,Donnino MW,Nadkarni VM,Abella BS,Adrie C,Berg RA,Merchant RM,O'Connor RE,Meltzer DO,Holm MB,Longstreth WT,Halperin HR,American Heart Association Emergency Cardiova

更新日期：2011-11-08 00:00:00

abstract：:The relation between left atrial size and atrial fibrillation was examined in 37 patients who had left ventriculomyotomy and myectomy at the National Heart and Lung Institute. Atrial fibrillation was present in 11 of 27 (41%) patients with an echocardiographically measured left atrial dimension greater than 45 mm. No ...

journal_title：Circulation

authors： Watson DC,Henry WL,Epstein SE,Morrow AG

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:The roles of Purkinje fibers (PFs) and focal wave fronts, if any, in the maintenance of ventricular fibrillation (VF) are unknown. If PFs are involved in VF maintenance, it should be possible to map wave fronts propagating from PFs into the working ventricular myocardium during VF. If wave fronts ever arise ...

journal_title：Circulation

authors： Tabereaux PB,Walcott GP,Rogers JM,Kim J,Dosdall DJ,Robertson PG,Killingsworth CR,Smith WM,Ideker RE

更新日期：2007-09-04 00:00:00

abstract：BACKGROUND:Although it has been suggested that elevation of CK-MB after percutaneous coronary intervention is associated with adverse clinical outcomes, limited data are available in the setting of coronary bypass grafting. The aim of the present study was to determine the incidence, predictors, and prognostic signific...

journal_title：Circulation

authors： Costa MA,Carere RG,Lichtenstein SV,Foley DP,de Valk V,Lindenboom W,Roose PC,van Geldorp TR,Macaya C,Castanon JL,Fernandez-Avilèz F,Gonzáles JH,Heyer G,Unger F,Serruys PW

更新日期：2001-11-27 00:00:00

abstract：OBJECTIVE:To assess the outcome of 3 different surgical approaches for treatment of acute aortic dissection type A (AADA). METHODS AND RESULTS:Between October 1990 and October 2003, we operated on 295 patients (pts) for AADA. Follow-up was complete for 257 pts (87%). Supracommissural replacement (SCR) of the ascending...

journal_title：Circulation

authors： Kallenbach K,Oelze T,Salcher R,Hagl C,Karck M,Leyh RG,Haverich A

更新日期：2004-09-14 00:00:00

abstract：:Although previous studies in both animals and humans have suggested that cardiac baroreceptors modulate reflex sympathetic vasoconstriction during exercise, more recent studies in conscious animals have not supported this view. To further test this concept in humans, we measured sympathetic nerve discharge with intran...

journal_title：Circulation

authors： Scherrer U,Vissing SF,Victor RG

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:Hypertrophic cardiomyopathy (HCM) is diagnosed clinically by the presence of left ventricular hypertrophy (LVH). However, LVH is absent in a significant number of genotype-positive patients. Because myocyte dysfunction and disarray are the primary abnormalities in HCM, we reasoned that tissue Doppler imaging...

journal_title：Circulation

authors： Nagueh SF,Kopelen HA,Lim DS,Zoghbi WA,Quiñones MA,Roberts R,Marian AJ

更新日期：2000-09-19 00:00:00

abstract：BACKGROUND:It has been proposed that bone marrow-derived cells infiltrate the neointima, where they differentiate into smooth muscle (SM) cells; however, technical limitations have hindered clear identification of the lineages of bone marrow-derived "SM cell-like" cells. METHODS AND RESULTS:Using a specific antibody a...

journal_title：Circulation

authors： Iwata H,Manabe I,Fujiu K,Yamamoto T,Takeda N,Eguchi K,Furuya A,Kuro-o M,Sata M,Nagai R

更新日期：2010-11-16 00:00:00

abstract：BACKGROUND:Smooth muscle cells (SMCs) play a key role in intimal thickening in atherosclerosis and restenosis. The precise signaling pathways by which the proliferation of SMCs is regulated are largely unknown. The TR3 orphan receptor, the mitogen-induced nuclear orphan receptor (MINOR), and the nuclear receptor of T c...

journal_title：Circulation

authors： Arkenbout EK,de Waard V,van Bragt M,van Achterberg TA,Grimbergen JM,Pichon B,Pannekoek H,de Vries CJ

更新日期：2002-09-17 00:00:00

abstract：BACKGROUND:Outcomes after percutaneous coronary interventions in diabetic patients are shadowed by the increased rate of recurrence compared with nondiabetic patients. METHODS AND RESULTS:We conducted a multicenter, randomized trial to demonstrate the efficacy of sirolimus-eluting stents compared with standard stents ...

journal_title：Circulation

authors： Sabaté M,Jiménez-Quevedo P,Angiolillo DJ,Gómez-Hospital JA,Alfonso F,Hernández-Antolín R,Goicolea J,Bañuelos C,Escaned J,Moreno R,Fernández C,Fernández-Avilés F,Macaya C,DIABETES Investigators.

更新日期：2005-10-04 00:00:00

abstract：BACKGROUND:In PTCA patients with multivessel coronary artery disease, incomplete revascularization (IR) is the result of both pre-PTCA strategy and initial lesion outcome. The unique contribution of these components on long-term patient outcome is uncertain. METHODS AND RESULTS:From the Bypass Angioplasty Revasculariz...

journal_title：Circulation

authors： Kip KE,Bourassa MG,Jacobs AK,Schwartz L,Feit F,Alderman EL,Weiner BH,Weiss MB,Kellett MA Jr,Sharaf BL,Dimas AP,Jones RH,Sopko G,Detre KM

更新日期：1999-08-31 00:00:00

abstract：BACKGROUND:Patients with repaired coarctation are at increased risk of hypertension and cardiovascular disease despite successful repair. We studied the function of conduit arteries in upper and lower limbs of patients late after successful coarctation repair and its relation to age at surgery. METHODS AND RESULTS:Flo...

journal_title：Circulation

authors： de Divitiis M,Pilla C,Kattenhorn M,Zadinello M,Donald A,Leeson P,Wallace S,Redington A,Deanfield JE

更新日期：2001-09-18 00:00:00

abstract：BACKGROUND:Chronic orthostatic intolerance (COI) is a debilitating autonomic condition in young adults. Its neurohumoral and hemodynamic profiles suggest possible alterations of postural sympathetic function and of baroreflex control of heart rate (HR). METHODS AND RESULTS:In 16 COI patients and 16 healthy volunteers,...

journal_title：Circulation

authors： Furlan R,Jacob G,Snell M,Robertson D,Porta A,Harris P,Mosqueda-Garcia R

更新日期：1998-11-17 00:00:00