Characteristics of coronary smooth muscle cells and adventitial fibroblasts.

abstract：BACKGROUND:Influenza infection is a serious event for patients with heart failure (HF). Little knowledge exists about the association between influenza vaccination and outcome in patients with HF. This study sought to determine whether influenza vaccination is associated with improved long-term survival in patients wit...

journal_title：Circulation

authors： Modin D,Jørgensen ME,Gislason G,Jensen JS,Køber L,Claggett B,Hegde SM,Solomon SD,Torp-Pedersen C,Biering-Sørensen T

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:Uncoupling protein 2 (UCP2) regulates the production of reactive oxygen species in macrophages. However, its role in atherosclerosis is unknown. METHODS AND RESULTS:Irradiated low-density lipoprotein receptor deficient mice (LDLR-/-) were transplanted with bone marrow from either UCP2 deficient mice (Ucp2-/...

journal_title：Circulation

authors： Blanc J,Alves-Guerra MC,Esposito B,Rousset S,Gourdy P,Ricquier D,Tedgui A,Miroux B,Mallat Z

更新日期：2003-01-28 00:00:00

abstract：BACKGROUND:Soluble stem cell factor (SCF) has been shown to mobilize bone marrow stem cells and improve cardiac repair after myocardial infarction (MI). However, the effect of membrane-associated SCF on cardiac remodeling after MI is not known. The present study investigated the effects of cardiomyocyte-specific overex...

journal_title：Circulation

authors： Xiang FL,Lu X,Hammoud L,Zhu P,Chidiac P,Robbins J,Feng Q

更新日期：2009-09-22 00:00:00

abstract：BACKGROUND:Hemodialysis vascular access dysfunction is the single most important cause of morbidity in kidney hemodialysis patients. Failure of an arteriovenous polytetrafluoroethylene (PTFE) graft, the most common form of hemodialysis access, is primarily due to intimal hyperplasia and thrombosis at the venous anastom...

journal_title：Circulation

authors： Luo Z,Akita GY,Date T,Treleaven C,Vincent KA,Woodcock D,Cheng SH,Gregory RJ,Jiang C

更新日期：2005-04-05 00:00:00

abstract：:One hundred eighteen consecutive patients undergoing valve replacement for aortic stenosis were analyzed to determine the incidence of and predisposing factors to postoperative atrial tachyarrhythmias. Univariate and multivariate analyses were performed on 70 clinical, hemodynamic, radiographic, electrocardiographic, ...

journal_title：Circulation

authors： Douglas PS,Hirshfeld JW Jr,Edmunds LH Jr

更新日期：1985-09-01 00:00:00

abstract：:The incidence of valvular heart disease is expected to increase over the next several decades as a large proportion of the US demographic advances into the later decades of life. At the same time, the next several years can be anticipated to bring a broad transition of surgical therapy to minimally invasive (minithora...

journal_title：Circulation

authors： Rosengart TK,Feldman T,Borger MA,Vassiliades TA Jr,Gillinov AM,Hoercher KJ,Vahanian A,Bonow RO,O'Neill W,American Heart Association Council on Cardiovascular Surgery and Anesthesia.,American Heart Association Council on Clinical Card

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:The relations of insulin sensitivity (IS) to hypertension incidence may vary according to baseline age, body mass index (BMI), and blood pressure (BP). METHODS AND RESULTS:We investigated the relations of IS (insulin sensitivity index, ISI(0,120)) to 4-year incidence of hypertension and BP progression in 19...

journal_title：Circulation

authors： Arnlöv J,Pencina MJ,Nam BH,Meigs JB,Fox CS,Levy D,D'Agostino RB,Vasan RS

更新日期：2005-09-20 00:00:00

abstract：BACKGROUND:Sirt7, 1 of the 7 members of the mammalian sirtuin family, promotes oncogenic transformation. Tumor growth and metastasis require fibrotic and angiogenic responses. Here, we investigated the role of Sirt7 in cardiovascular tissue repair process. METHODS AND RESULTS:In wild-type mice, Sirt7 expression increa...

journal_title：Circulation

authors： Araki S,Izumiya Y,Rokutanda T,Ianni A,Hanatani S,Kimura Y,Onoue Y,Senokuchi T,Yoshizawa T,Yasuda O,Koitabashi N,Kurabayashi M,Braun T,Bober E,Yamagata K,Ogawa H

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:Adenosine possesses marked cardioprotective properties, but the mechanisms for this beneficial effect are unclear. The objective of this study was to determine the effect of adenosine given before ischemia or at reperfusion on mechanical function, glucose oxidation, glycolysis, and metabolite levels in isola...

journal_title：Circulation

authors： Finegan BA,Lopaschuk GD,Coulson CS,Clanachan AS

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Cystic medial degeneration (CMD) is a histological abnormality that is common in the aortic diseases associated with Marfan's syndrome (MFS). Although little known about the mechanism underlying CMD, several recent reports have demonstrated that vascular smooth muscle cell (VSMC) apoptosis could play a subst...

journal_title：Circulation

authors： Nagashima H,Sakomura Y,Aoka Y,Uto K,Kameyama Ki,Ogawa M,Aomi S,Koyanagi H,Ishizuka N,Naruse M,Kawana M,Kasanuki H

更新日期：2001-09-18 00:00:00

abstract：BACKGROUND:Although aspirin is an effective, inexpensive, and safe treatment of acute myocardial infarction, the frequency of use of aspirin in actual medical practice is not known. Elderly patients, a group with low rates of utilization of effective therapies such as thrombolytic therapy, also may be at risk of not re...

journal_title：Circulation

authors： Krumholz HM,Radford MJ,Ellerbeck EF,Hennen J,Meehan TP,Petrillo M,Wang Y,Kresowik TF,Jencks SF

更新日期：1995-11-15 00:00:00

abstract：BACKGROUND:Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used to treat cardiogenic shock. However, VA-ECMO might hamper myocardial recovery. The Impella unloads the left ventricle. This study aimed to evaluate whether left ventricular unloading in patients with cardiogenic shock treated wit...

journal_title：Circulation

authors： Schrage B,Becher PM,Bernhardt A,Bezerra H,Blankenberg S,Brunner S,Colson P,Cudemus Deseda G,Dabboura S,Eckner D,Eden M,Eitel I,Frank D,Frey N,Funamoto M,Goßling A,Graf T,Hagl C,Kirchhof P,Kupka D,Landmesser U,Li

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:The goal of this study was to examine a possible association between systemic microinflammation, as reflected by C-reactive protein (CRP) serum levels, and coronary vasomotion in patients with coronary risk factors but with angiographically normal coronary arteries. METHODS AND RESULTS:Coronary vasomotor fu...

journal_title：Circulation

authors： Schindler TH,Nitzsche EU,Olschewski M,Magosaki N,Mix M,Prior JO,Facta AD,Solzbach U,Just H,Schelbert HR

更新日期：2004-08-31 00:00:00

abstract：BACKGROUND:Pulmonary hypertension induced by chronic hypoxia is characterized by thickening of pulmonary artery walls, elevated pulmonary vascular resistance, and right-heart failure. Prostacyclin analogues reduce pulmonary pressures in this condition; raising the possibility that cycloxygenase-2 (COX-2) modulates the ...

journal_title：Circulation

authors： Pidgeon GP,Tamosiuniene R,Chen G,Leonard I,Belton O,Bradford A,Fitzgerald DJ

更新日期：2004-10-26 00:00:00

abstract：BACKGROUND:Pulse pressure (PP) increases with age as a result of arterial stiffening and is a powerful predictor of cardiovascular disease. Type 1 diabetes is associated with excessive cardiovascular mortality and increased arterial stiffness. We examined whether the age-related blood pressure changes in type 1 diabeti...

journal_title：Circulation

authors： Rönnback M,Fagerudd J,Forsblom C,Pettersson-Fernholm K,Reunanen A,Groop PH,Finnish Diabetic Nephropathy (FinnDiane) Study Group.

更新日期：2004-08-31 00:00:00

abstract：BACKGROUND:Older coronary patients are at high risk of cardiac disability. Exercise conditioning programs have been demonstrated to improve functional capacity, particularly in younger coronary patients. In this study, the effects of aerobic conditioning on submaximal and maximal indicators of exercise performance were...

journal_title：Circulation

authors： Ades PA,Waldmann ML,Poehlman ET,Gray P,Horton ED,Horton ES,LeWinter MM

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Nafamostat mesilate (FUT-175) is a protease inhibitor inactivating coagulation, fibrinolysis, and platelet aggregation. A prospective, randomized trial was performed to assess the efficacy of FUT-175 in the reduction of postoperative bleeding tendency. METHODS AND RESULTS:FUT-175 was infused at a rate of 40...

journal_title：Circulation

authors： Murase M,Usui A,Tomita Y,Maeda M,Koyama T,Abe T

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:The coagulation system is closely linked with vascular inflammation, although the underlying mechanisms are still obscure. Recent studies show that protease-activated receptor (PAR)-2, a major receptor of activated factor X, is expressed in both vascular cells and leukocytes, suggesting that PAR-2 may contri...

journal_title：Circulation

authors： Hara T,Phuong PT,Fukuda D,Yamaguchi K,Murata C,Nishimoto S,Yagi S,Kusunose K,Yamada H,Soeki T,Wakatsuki T,Imoto I,Shimabukuro M,Sata M

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:Thoracic endovascular aortic repair offers a less invasive approach for the treatment of ruptured descending thoracic aortic aneurysms (rDTAA). Due to the low incidence of this life-threatening condition, little is known about the outcomes of endovascular repair of rDTAA and the factors that affect these out...

journal_title：Circulation

authors： Jonker FH,Verhagen HJ,Lin PH,Heijmen RH,Trimarchi S,Lee WA,Moll FL,Athamneh H,Muhs BE

更新日期：2010-06-29 00:00:00

abstract：BACKGROUND:Denervation supersensitivity has been proposed as a mechanism for the relation between ventricular arrhythmias and the sympathetic nervous system. Evaluation of this phenomenon in humans has become feasible only recently with the development of noninvasive scintigraphic methods for evaluating the pattern of ...

journal_title：Circulation

authors： Calkins H,Allman K,Bolling S,Kirsch M,Wieland D,Morady F,Schwaiger M

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Macrophage migration inhibitory factor (MIF), a cytokine that controls cell-mediated inflammatory responses, is upregulated in atherogenesis; however, its functional contribution to lesion development has not been evaluated. METHODS AND RESULTS:We studied the role of MIF on neointima lesion formation after ...

journal_title：Circulation

authors： Schober A,Bernhagen J,Thiele M,Zeiffer U,Knarren S,Roller M,Bucala R,Weber C

更新日期：2004-01-27 00:00:00

abstract：BACKGROUND:Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy characterized by right ventricular dysfunction and ventricular arrhythmias. A recent study reported mutations in PKP2, encoding the desmosomal protein plakophilin-2, associated with ARVD/C. The purpose of our st...

journal_title：Circulation

authors： Dalal D,Molin LH,Piccini J,Tichnell C,James C,Bomma C,Prakasa K,Towbin JA,Marcus FI,Spevak PJ,Bluemke DA,Abraham T,Russell SD,Calkins H,Judge DP

更新日期：2006-04-04 00:00:00

abstract：BACKGROUND:Reduced insulin sensitivity has been proposed as an important risk factor in the development of atherosclerosis. However, insulin sensitivity is related to many other cardiovascular risk factors, including plasma insulin levels, and it is unclear whether an independent role of insulin sensitivity exists. Lar...

journal_title：Circulation

authors： Howard G,O'Leary DH,Zaccaro D,Haffner S,Rewers M,Hamman R,Selby JV,Saad MF,Savage P,Bergman R

更新日期：1996-05-15 00:00:00

abstract：BACKGROUND:Drugs that simultaneously decrease platelet function and inflammation may improve the treatment of cardiovascular disorders. Here, we determined whether dipyridamole and aspirin, a combination therapy used to prevent recurrent stroke, regulates gene expression in platelet-monocyte inflammatory model systems....

journal_title：Circulation

authors： Weyrich AS,Denis MM,Kuhlmann-Eyre JR,Spencer ED,Dixon DA,Marathe GK,McIntyre TM,Zimmerman GA,Prescott SM

更新日期：2005-02-08 00:00:00

abstract：:Hemodynamic effects of dobutamine and dopamine (both 5, 10, 15 microgram/kg/min) and epinephrine (0.04 microgram/kg/min) were studied immediately following cessation of cardiopulmonary bypass in 34 patients with preoperative evidence of left ventricular dysfunction. Significant increases in mean cardiac index were see...

journal_title：Circulation

authors： Steen PA,Tinker JH,Pluth JR,Barnh;rst DA,Tarhan S

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND:Contrary to expectation, most studies have demonstrated that initiation of an angiotensin-converting enzyme (ACE) inhibitor in conventional doses in patients with heart failure reduces the diuretic efficacy of furosemide. Recently, it has been suggested that single low doses (1 mg) but not high doses (25 mg)...

journal_title：Circulation

authors： Good JM,Brady AJ,Noormohamed FH,Oakley CM,Cleland JG

更新日期：1994-07-01 00:00:00

abstract：:Myocardial fiber disarray is a distinctive histopathologic finding seen in asymmetric hypertrophic cardiomyopathy. We studied 14 hearts with aortic atresia and intact interventricular septum, six hearts with pulmonic atresia and intact interventricular septum, eight normal infant hearts matched for age of the study he...

journal_title：Circulation

authors： Bulkley BH,D'Amico B,Taylor AL

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:C-kit is a receptor tyrosine kinase family member expressed in hematopoietic stem cells. C-kit is also transiently expressed in cardiomyocyte precursors during development and in a rare cell population in the normal adult heart. In the present study, the cardiomyogenic potential of c-kit(+) cells isolated fr...

journal_title：Circulation

authors： Zaruba MM,Soonpaa M,Reuter S,Field LJ

更新日期：2010-05-11 00:00:00

abstract：BACKGROUND:During the development of heart failure (HF), the chief myocardial energy substrate switches from fatty acids to glucose. This metabolic switch, which recapitulates fetal cardiac energy substrate preferences, is thought to maintain aerobic energetic balance. The regulatory mechanisms involved in this metabol...

journal_title：Circulation

authors： Sack MN,Rader TA,Park S,Bastin J,McCune SA,Kelly DP

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Data are conflicting over whether women have higher mortality than men after coronary artery bypass graft (CABG) surgery. Younger but not older women hospitalized for acute myocardial infarction have higher in-hospital mortality rates than men. We hypothesized that younger women also have higher in-hospital ...

journal_title：Circulation

authors： Vaccarino V,Abramson JL,Veledar E,Weintraub WS

更新日期：2002-03-12 00:00:00