Sex differences in hospital mortality after coronary artery bypass surgery: evidence for a higher mortality in younger women.

Abstract:

BACKGROUND:Data are conflicting over whether women have higher mortality than men after coronary artery bypass graft (CABG) surgery. Younger but not older women hospitalized for acute myocardial infarction have higher in-hospital mortality rates than men. We hypothesized that younger women also have higher in-hospital mortality rates after CABG. METHODS AND RESULTS:We studied 51 187 patients (30% women) included in the National Cardiovascular Network database who received CABG at 23 clinical centers between October 1993 and December 1999. Compared with men, fewer women were white and more women had risk factors and comorbidities. These differences were more apparent in younger patients. In all age groups, however, women had higher left ventricular ejection fraction and fewer diseased vessels. Women had higher in-hospital mortality rates than men, but sex differences in mortality were more marked among younger patients. Women <50 years of age were 3 times more likely to die than men (3.4% versus 1.1%), and women 50 to 59 years of age were 2.4 times more likely to die than men (2.6% versus 1.1%). In the older age categories, the sex difference in in-hospital mortality was less marked (P<0.001 for the interaction between sex and age). Adjustment for preoperative risk factors only slightly decreased the strength of this interaction. CONCLUSIONS:Younger women undergoing CABG surgery are at a higher risk of in-hospital death than men, but this difference in risk decreases with advancing age. Additional investigation is needed to determine why in-hospital mortality is higher in women after CABG, with particular focus on younger women.

journal_name

Circulation

journal_title

Circulation

authors

Vaccarino V,Abramson JL,Veledar E,Weintraub WS

doi

10.1161/hc1002.105133

subject

Has Abstract

pub_date

2002-03-12 00:00:00

pages

1176-81

issue

10

eissn

0009-7322

issn

1524-4539

journal_volume

105

pub_type

杂志文章
  • Angiography Versus Hemodynamics to Predict the Natural History of Coronary Stenoses: Fractional Flow Reserve Versus Angiography in Multivessel Evaluation 2 Substudy.

    abstract:BACKGROUND:Among patients with documented stable coronary artery disease and in whom no revascularization was performed, we compared the respective values of angiographic diameter stenosis (DS) and fractional flow reserve (FFR) in predicting natural history. METHODS:The present analysis included the 607 patients from ...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/CIRCULATIONAHA.117.028782

    authors: Ciccarelli G,Barbato E,Toth GG,Gahl B,Xaplanteris P,Fournier S,Milkas A,Bartunek J,Vanderheyden M,Pijls N,Tonino P,Fearon WF,Jüni P,De Bruyne B

    更新日期:2018-04-03 00:00:00

  • A reassessment of the echocardiogram in mitral stenosis.

    abstract::Echocardiographic and cardiac catheterization findings were compared in 61 patients with mitral stenosis without other significant lesions in an attempt to determine the clinical usefulness of echocardiography in the assessment of such patients. There was a poor correlation between the E-F slope on the echocardiogram ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.52.4.664

    authors: Cope GD,Kisslo JA,Johnson ML,Behar VS

    更新日期:1975-10-01 00:00:00

  • Mortality and Cerebrovascular Events After Heart Rhythm Disorder Management Procedures.

    abstract:BACKGROUND:Recognition of rates and causes of hard, patient-centered outcomes of death and cerebrovascular events (CVEs) after heart rhythm disorder management (HRDM) procedures is an essential step for the development of quality improvement programs in electrophysiology laboratories. Our primary aim was to assess and ...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.117.030523

    authors: Lee JZ,Ling J,Diehl NN,Hodge DO,Padmanabhan D,Killu AM,Madhavan M,Noseworthy PA,Kapa S,McLeod CJ,Cha YM,Deshmukh AJ,Srivathsan K,Kusumoto FM,Shen WK,Friedman PA,Munger TM,Asirvatham SJ,Packer DL,Mulpuru SK

    更新日期:2018-01-02 00:00:00

  • Abnormal systolic intraventricular flow velocities after valve replacement for aortic stenosis. Mechanisms, predictive factors, and prognostic significance.

    abstract:BACKGROUND:Dynamic intraventricular flow velocities after valve replacement for aortic stenosis have been associated with high in-hospital morbidity and mortality. The aims of the present study were to determine the mechanisms and preoperative predictors of abnormal flow velocity (AFV) after valve replacement for aorti...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.93.4.712

    authors: Bartunek J,Sys SU,Rodrigues AC,van Schuerbeeck E,Mortier L,de Bruyne B

    更新日期:1996-02-15 00:00:00

  • Fatty acid oxidation enzyme gene expression is downregulated in the failing heart.

    abstract:BACKGROUND:During the development of heart failure (HF), the chief myocardial energy substrate switches from fatty acids to glucose. This metabolic switch, which recapitulates fetal cardiac energy substrate preferences, is thought to maintain aerobic energetic balance. The regulatory mechanisms involved in this metabol...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.94.11.2837

    authors: Sack MN,Rader TA,Park S,Bastin J,McCune SA,Kelly DP

    更新日期:1996-12-01 00:00:00

  • Uncontrolled and apparent treatment resistant hypertension in the United States, 1988 to 2008.

    abstract:BACKGROUND:Despite progress, many hypertensive patients remain uncontrolled. Defining characteristics of uncontrolled hypertensives may facilitate efforts to improve blood pressure control. METHODS AND RESULTS:Subjects included 13,375 hypertensive adults from National Health and Nutrition Examination Surveys (NHANESs)...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.111.030189

    authors: Egan BM,Zhao Y,Axon RN,Brzezinski WA,Ferdinand KC

    更新日期:2011-08-30 00:00:00

  • Aminoguanidine prevents the decreased myocardial compliance produced by streptozotocin-induced diabetes mellitus in rats.

    abstract:BACKGROUND:A decreased cardiac compliance is a major feature of the cardiomyopathy of diabetes mellitus. Either an increase in the resistance afterload to the LV or an increase in collagen cross-linking induced by the formation of advanced glycosylation end products (AGEs) of collagen may be responsible for the stiff m...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.93.10.1905

    authors: Norton GR,Candy G,Woodiwiss AJ

    更新日期:1996-05-15 00:00:00

  • Incidence and consequences of periprocedural occlusion. The 1985-1986 National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry.

    abstract::Of 1,801 patients in the 1985-1986 Percutaneous Transluminal Coronary Angioplasty (PTCA) Registry, 122 (6.8%) had periprocedural occlusion (4.9% in the catheterization laboratory, 1.9% outside the laboratory). Baseline patient factors independently associated with increased occlusion rates included triple-vessel disea...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.82.3.739

    authors: Detre KM,Holmes DR Jr,Holubkov R,Cowley MJ,Bourassa MG,Faxon DP,Dorros GR,Bentivoglio LG,Kent KM,Myler RK

    更新日期:1990-09-01 00:00:00

  • Glucose levels predict hospitalization for congestive heart failure in patients at high cardiovascular risk.

    abstract:BACKGROUND:Patients with diabetes mellitus (DM) are at high risk of developing congestive heart failure (CHF). However, the relationships between glucose levels and CHF in people with or without a history of DM have not been well characterized. METHODS AND RESULTS:We evaluated the associations between fasting plasma g...

    journal_title:Circulation

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/CIRCULATIONAHA.106.661405

    authors: Held C,Gerstein HC,Yusuf S,Zhao F,Hilbrich L,Anderson C,Sleight P,Teo K,ONTARGET\/TRANSCEND Investigators.

    更新日期:2007-03-20 00:00:00

  • Fibrinopeptide A and platelet factor levels in unstable angina pectoris.

    abstract::Fibrinopeptide A, platelet factor 4, beta-thromboglobulin, thromboxane B2, and 6-keto-prostaglandin F1 alpha were estimated by radioimmunoassay on venous plasma samples taken within 48 hr of admission from 16 consecutive patients with unstable angina and 15 patients with stable angina matched for clinical variables. T...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.75.1.156

    authors: Théroux P,Latour JG,Léger-Gauthier C,De Lara J

    更新日期:1987-01-01 00:00:00

  • Cardiac tissue engineering in an in vivo vascularized chamber.

    abstract:BACKGROUND:Cardiac tissue engineering offers the prospect of a novel treatment for acquired or congenital heart defects. We have created vascularized pieces of beating cardiac muscle in the rat that are as thick as the adult rat right ventricle wall. METHOD AND RESULTS:Neonatal rat cardiomyocytes in Matrigel were impl...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.657379

    authors: Morritt AN,Bortolotto SK,Dilley RJ,Han X,Kompa AR,McCombe D,Wright CE,Itescu S,Angus JA,Morrison WA

    更新日期:2007-01-23 00:00:00

  • Quantification of myocardial infarct size by thallium-201 single-photon emission computed tomography: experimental validation in the dog.

    abstract::To evaluate the potential advantages of thallium-201 (201T1) single-photon emission computerized tomography (SPECT) to assess myocardial infarct size in the experimental animal, six normal dogs and 14 dogs with 6 to 8 hr closed-chest coronary occlusion (eight left anterior descending and six left circumflex) were stud...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.74.4.852

    authors: Prigent F,Maddahi J,Garcia EV,Satoh Y,Van Train K,Berman DS

    更新日期:1986-10-01 00:00:00

  • QT interval is linked to 2 long-QT syndrome loci in normal subjects.

    abstract:BACKGROUND:The rate-corrected QT interval (QTc) is heritable, and the discovery of quantitative trait loci that influence the QTc would be an important step in identifying the genes responsible for life-threatening arrhythmias in the general population. We studied 66 pairs of unselected normal dizygotic (DZ) twin subje...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.99.24.3161

    authors: Busjahn A,Knoblauch H,Faulhaber HD,Boeckel T,Rosenthal M,Uhlmann R,Hoehe M,Schuster H,Luft FC

    更新日期:1999-06-22 00:00:00

  • Uteroplacental blood flow, cardiac function, and pregnancy outcome in women with congenital heart disease.

    abstract:BACKGROUND:Pregnant women with congenital heart disease (CHD) are susceptible to cardiovascular, obstetric, and offspring complications. In women with CHD, cardiac dysfunction may compromise uteroplacental flow and contribute to the increased incidence of obstetric and offspring events. METHODS AND RESULTS:We performe...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.113.002810

    authors: Pieper PG,Balci A,Aarnoudse JG,Kampman MA,Sollie KM,Groen H,Mulder BJ,Oudijk MA,Roos-Hesselink JW,Cornette J,van Dijk AP,Spaanderman ME,Drenthen W,van Veldhuisen DJ,ZAHARA II investigators.

    更新日期:2013-12-03 00:00:00

  • Cerebral protection with filter devices during carotid artery stenting.

    abstract:BACKGROUND:Distal embolization of debris during percutaneous carotid artery stenting may result in neurological deficit. Filter devices for cerebral protection potentially reduce the risk of embolization. METHODS AND RESULTS:Elective carotid stent implantation using 3 different types of distal filter protection device...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/hc2601.092495

    authors: Reimers B,Corvaja N,Moshiri S,Saccà S,Albiero R,Di Mario C,Pascotto P,Colombo A

    更新日期:2001-07-03 00:00:00

  • Expression of NADH/NADPH oxidase p22phox in human coronary arteries.

    abstract:BACKGROUND:NADH/NADPH oxidase is an important source of superoxide in the vasculature. Recently, we found that polymorphism of the gene p22phox, a critical component of this oxidase, is associated with a risk of coronary artery disease. The aim of this study was to investigate the localization of p22phox in human coron...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.100.14.1494

    authors: Azumi H,Inoue N,Takeshita S,Rikitake Y,Kawashima S,Hayashi Y,Itoh H,Yokoyama M

    更新日期:1999-10-05 00:00:00

  • Ischemic, hemodynamic, and neurohormonal responses to mental and exercise stress. Experience from the Psychophysiological Investigations of Myocardial Ischemia Study (PIMI).

    abstract:BACKGROUND:The pathophysiology of mental stress-induced myocardial ischemia, which occurs at lower heart rates than during physical stress, is not well understood. METHODS AND RESULTS:The Psychophysiological Investigations of Myocardial Ischemia Study (PIMI) evaluated the physiological and neuroendocrine functioning i...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.94.10.2402

    authors: Goldberg AD,Becker LC,Bonsall R,Cohen JD,Ketterer MW,Kaufman PG,Krantz DS,Light KC,McMahon RP,Noreuil T,Pepine CJ,Raczynski J,Stone PH,Strother D,Taylor H,Sheps DS

    更新日期:1996-11-15 00:00:00

  • Resistin is an inflammatory marker of atherosclerosis in humans.

    abstract:BACKGROUND:Resistin, a plasma protein, induces insulin resistance in rodents. Recent reports suggest that circulating levels of resistin are elevated in obese and insulin-resistant rodents and humans. Whereas rodent resistin is made in adipocytes, macrophages are a major source of human resistin. Given the convergence ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000155620.10387.43

    authors: Reilly MP,Lehrke M,Wolfe ML,Rohatgi A,Lazar MA,Rader DJ

    更新日期:2005-02-22 00:00:00

  • Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis.

    abstract:BACKGROUND:We hypothesized that cytomegalovirus (CMV) may contribute to the vasculopathy observed in cardiac allograft recipients by impairing the endothelial nitric oxide synthase pathway. We focused on asymmetric dimethylarginine (ADMA, the endogenous inhibitor of nitric oxide synthase) as a potential mediator of the...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000109692.16004.AF

    authors: Weis M,Kledal TN,Lin KY,Panchal SN,Gao SZ,Valantine HA,Mocarski ES,Cooke JP

    更新日期:2004-02-03 00:00:00

  • Improved preservation of saphenous vein grafts by the use of glyceryl trinitrate-verapamil solution during harvesting.

    abstract:BACKGROUND:High-pressure distension during harvesting damages the saphenous vein (SV) and may contribute to subsequent coronary artery bypass graft (CABG) occlusion. Application of vasodilator agents to the SV during harvesting may reduce the need for high-pressure distension and improve graft quality. We tested the ef...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.92.9.31

    authors: Roubos N,Rosenfeldt FL,Richards SM,Conyers RA,Davis BB

    更新日期:1995-11-01 00:00:00

  • HDL cholesterol and protective factors in atherosclerosis.

    abstract::A low level of high-density lipoprotein cholesterol (HDL-C) is an important risk factor for cardiovascular disease. Epidemiological and clinical studies provide evidence that HDL-C levels are linked to rates of coronary events. The cardioprotective effects of HDL-C have been attributed to its role in reverse cholester...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/01.CIR.0000131512.50667.46

    authors: Assmann G,Gotto AM Jr

    更新日期:2004-06-15 00:00:00

  • National survey of coronary artery bypass grafting for coronary stenosis caused by Kawasaki disease in Japan.

    abstract:BACKGROUND:We surveyed the national experience of coronary artery bypass grafting (CABG) for coronary sequelae of Kawasaki disease (kDa) in 2002. METHODS AND RESULTS:A questionnaire was returned from 323/552 (59%) institutions. Two hundred forty-four patients (188 male 56 female) since 1975 were identified. The mean n...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000138194.61225.10

    authors: Tsuda E,Kitamura S,Cooperative Study Group of Japan.

    更新日期:2004-09-14 00:00:00

  • Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo.

    abstract:BACKGROUND:Isoprostanes (iPs) are free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Several iPs exert biological effects in vitro and may contribute to the functional consequences of oxidant stress. For example, iPF(2alpha)-III (8-iso PGF(2alpha)) and iPE(2)-III modulate plate...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.101.24.2833

    authors: Audoly LP,Rocca B,Fabre JE,Koller BH,Thomas D,Loeb AL,Coffman TM,FitzGerald GA

    更新日期:2000-06-20 00:00:00

  • Altered contractile response in neonatal myocardium to citrate-phosphate-dextrose infusion.

    abstract::The clinical use of citrate-phosphate-dextrose during blood-product transfusion is known to affect ionized calcium levels and can result in depression of myocardial contractility. The immature heart appears to have an intrinsic reduction in contractile state compared with the adult heart and may be more dependent on t...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Rebeyka IM,Yeh T Jr,Hanan SA,Borges MR,Lee KF,Tuchy GE,Abd-Elfattah AS,Wechsler AS

    更新日期:1990-11-01 00:00:00

  • Value of Progression of Coronary Artery Calcification for Risk Prediction of Coronary and Cardiovascular Events: Result of the HNR Study (Heinz Nixdorf Recall).

    abstract:BACKGROUND:Computed tomography (CT) allows estimation of coronary artery calcium (CAC) progression. We evaluated several progression algorithms in our unselected, population-based cohort for risk prediction of coronary and cardiovascular events. METHODS:In 3281 participants (45-74 years of age), free from cardiovascul...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.116.027034

    authors: Lehmann N,Erbel R,Mahabadi AA,Rauwolf M,Möhlenkamp S,Moebus S,Kälsch H,Budde T,Schmermund A,Stang A,Führer-Sakel D,Weimar C,Roggenbuck U,Dragano N,Jöckel KH,Heinz Nixdorf Recall Study Investigators.

    更新日期:2018-02-13 00:00:00

  • Esophageal Injury and Atrioesophageal Fistula Caused by Ablation for Atrial Fibrillation.

    abstract::Esophageal perforation is a dreaded complication of atrial fibrillation ablation that occurs in 0.1% to 0.25% of atrial fibrillation ablation procedures. Delayed diagnosis is associated with the development of atrial-esophageal fistula (AEF) and increased mortality. The relationship between the esophagus and the left ...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCULATIONAHA.117.025827

    authors: Kapur S,Barbhaiya C,Deneke T,Michaud GF

    更新日期:2017-09-26 00:00:00

  • Aortic valve replacement and concomitant mitral valve regurgitation in the elderly: impact on survival and functional outcome.

    abstract:BACKGROUND:The impact of mitral regurgitation (MR) on elderly patients (> or = 70 years) undergoing isolated aortic valve replacement (AVR) is not clearly defined. This study investigates the long-term effects of preoperative, moderate MR on survival and functional outcome in elderly AVR patients. METHODS AND RESULTS:...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.104.526046

    authors: Barreiro CJ,Patel ND,Fitton TP,Williams JA,Bonde PN,Chan V,Alejo DE,Gott VL,Baumgartner WA

    更新日期:2005-08-30 00:00:00

  • Expansion of acute myocardial infarction: an experimental study.

    abstract::Expansion (regional dilatation and thinning) of acutely infarcted myocardium in man has been shown to correlate with overall cardiac dilatation and rupture. We studied gross and histopathologic features and the time course of expansion in rats. Infarcts were produced in 84 rats by ligation of the left coronary artery ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.65.7.1446

    authors: Hochman JS,Bulkley BH

    更新日期:1982-06-01 00:00:00

  • Genetic Predisposition to High Blood Pressure and Lifestyle Factors: Associations With Midlife Blood Pressure Levels and Cardiovascular Events.

    abstract:BACKGROUND:High blood pressure (BP) is a major risk factor for cardiovascular diseases (CVDs), the leading cause of mortality worldwide. Both heritable and lifestyle risk factors contribute to elevated BP levels. We aimed to investigate the extent to which lifestyle factors could offset the effect of an adverse BP gene...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/CIRCULATIONAHA.117.030898

    authors: Pazoki R,Dehghan A,Evangelou E,Warren H,Gao H,Caulfield M,Elliott P,Tzoulaki I

    更新日期:2018-02-13 00:00:00

  • Noninvasive quantitation of valvular regurgitation by gated equilibrium radionuclide angiography.

    abstract::R-wave synchronous equilbrium radionuclide angiography (RNA) is a noninvasive method that provides time-activity curve count information proportional to ventricular volumes and is used for relative volume comparisons within the left or right ventricle to derive the ejection fraction. Comparison of the ventricular coun...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.62.5.1089

    authors: Sorensen SG,O'Rourke RA,Chaudhuri TK

    更新日期:1980-11-01 00:00:00