Abstract:
:Eighty-seven patients who had out-of-hospital cardiac arrests received defibrillating shocks delivered by minimally trained first responders before the arrival of paramedics in a city with short emergency response times. Their outcomes were compared with those of 370 other victims who received only basic life support by first responders until paramedics arrived. Survival was improved by early defibrillation in cases in which there was a delay in initiating cardiopulmonary resuscitation and in which paramedic response times exceeded 9 min; there was 62% survival after early defibrillation by first responders and 27% if first responders provided only basic life support (p less than .02). Neurologic recovery was also improved after early defibrillation. Eighteen of 46 resuscitated patients (39%) receiving early defibrillation were awake at 24 hr compared with 49 of 204 patients (24%) who received only basic life support while awaiting paramedics (p less than .02). Incorporating defibrillation as part of basic life support can reduce both mortality and morbidity from cardiac arrest, even in cities with established, rapidly responding emergency care systems.
journal_name
Circulationjournal_title
Circulationauthors
Weaver WD,Copass MK,Bufi D,Ray R,Hallstrom AP,Cobb LAdoi
10.1161/01.cir.69.5.943subject
Has Abstractpub_date
1984-05-01 00:00:00pages
943-8issue
5eissn
0009-7322issn
1524-4539journal_volume
69pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:After a myocardial infarction, the injured region becomes fibrotic and the myocardial scar may expand if the ventricular wall lacks elasticity. Cardiac dilatation may precipitate the vicious cycle of progressive heart failure. The present study evaluated the functional benefits of increasing elastin within a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIRCULATIONAHA.105.523795
更新日期:2005-08-30 00:00:00
abstract::Graft failure occurs in a sizeable proportion of coronary artery bypass conduits. We herein review relevant current evidence to give an overview of the incidence, pathophysiology, and clinical consequences of this multifactorial phenomenon. Thrombosis, endothelial dysfunction, vasospasm, and oxidative stress are diffe...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/CIRCULATIONAHA.117.027597
更新日期:2017-10-31 00:00:00
abstract:BACKGROUND:The aim of this study was to compare the risk conferred by white-coat versus sustained mild hypertension for the development of cardiovascular disease. METHODS AND RESULTS:Patients (n=479) who underwent 24-hour intra-arterial ambulatory blood pressure monitoring on the basis of a persistently elevated clini...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.98.18.1892
更新日期:1998-11-03 00:00:00
abstract:BACKGROUND:Although it has been suggested that elevation of CK-MB after percutaneous coronary intervention is associated with adverse clinical outcomes, limited data are available in the setting of coronary bypass grafting. The aim of the present study was to determine the incidence, predictors, and prognostic signific...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/hc4701.099789
更新日期:2001-11-27 00:00:00
abstract:BACKGROUND:Endothelial vasodilator dysfunction and carotid intima-media thickening (IMT) are 2 indicators of subclinical cardiovascular disease. We examined their correlation and interaction with risk factors in a large, community-based cohort of young adults. METHODS AND RESULTS:As part of the longitudinal Cardiovasc...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000147540.88559.00
更新日期:2004-11-02 00:00:00
abstract:BACKGROUND:Associations of obesity with incidence of heart failure have been observed, but the causality is uncertain. We hypothesized that gastric bypass surgery leads to a lower incidence of heart failure compared with intensive lifestyle modification in obese people. METHODS:We included obese people without previou...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.116.025629
更新日期:2017-04-25 00:00:00
abstract:BACKGROUND:Functional mitral regurgitation (MR) is caused by systolic traction on the mitral leaflets related to ventricular distortion. Little is known about whether chronic tethering causes the mitral leaflet area to adapt to the geometric needs imposed by tethering, in part because of inability to reconstruct leafle...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.749440
更新日期:2008-08-19 00:00:00
abstract:BACKGROUND:Among adults, skipping meals is associated with excess body weight, hypertension, insulin resistance, and elevated fasting lipid concentrations. However, it remains unknown whether specific eating habits regardless of dietary composition influence coronary heart disease (CHD) risk. The objective of this stud...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.001474
更新日期:2013-07-23 00:00:00
abstract::We studied regional myocardial perfusion by scintigraphic computer-assisted analysis of initial distribution, washout rates, and residual activity of 133Xe injected into the left coronary artery of four patients with normal arteriograms and 14 patients with coronary stenosis. At rest, residual activity in poststenotic...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.55.3.423
更新日期:1977-03-01 00:00:00
abstract:BACKGROUND:Prenatal surgery for congenital anomalies can prevent fetal demise or alter the course of organ development, resulting in a more favorable condition at birth. The indications for fetal surgery continue to expand, yet little is known about the acute sequelae of fetal surgery on the human cardiovascular system...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.CIR.0000142294.95388.C4
更新日期:2004-09-21 00:00:00
abstract::Forty-four patients with acute transmural myocardial infarction underwent cardiac catheterization 4.7 +/- 1.3 hours (+/- SD) after the onset of persistent chest discomfort. Thirty-nine patients had total occlusion of infarct-related vessels; 27 of these 39 had successful intracoronary thrombolysis. Twenty of these 27 ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00
abstract::Using a mechanical sector-scanner, two-dimensional echocardiograms were obtained from 28 normal subjects, 15 patients with tetralogy of Fallot, 11 patients with complete transposition of the great arteries and six patients with double outlet right ventricle. The image obtained perpendicular to the long axis of the lef...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.56.2.267
更新日期:1977-08-01 00:00:00
abstract::Balloon dilation angioplasty was attempted in 10 infants and children with severe congenital or operative "venous" obstructions. In five children the obstructions were "vena caval" and followed repair for transposition of the great vessels (four patients) or orthotopic liver transplantation (one patient). In the four ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.70.3.457
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND:Although both 201Tl scintigraphy and low-dose dobutamine echocardiography (LDDE) have been proposed as effective methods of assessing myocardial viability, their relative efficacies are unknown. The aim of the present study was to compare the two imaging techniques in the prediction of improvement of regiona...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.91.11.2748
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Repeated brief episodes of myocardial ischemia performed by mechanical clamping of a coronary artery "precondition" the heart and reduce infarct size after a subsequent sustained ischemia. It is not known, however, whether spontaneous episodes of transient ischemia caused by formation of platelet thrombi, wh...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.85.2.779
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:Previous evidence has shown that increased sympathetic tone enhances the cesium chloride (Cs)-induced early afterdepolarizations (EADs) and ventricular tachycardias (VTs). METHODS AND RESULTS:We assessed the effects of vagal stimulation on Cs-induced EADs and ventricular arrhythmias in the rabbit heart. Mon...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.86.6.1987
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:Cyclooxygenase (COX)-2 expression in the heart increases after myocardial infarction (MI). In murine models of MI, COX-2 inhibition preserves left ventricular dimensions and function. We studied the effect of selective COX-2 inhibition on left ventricular remodeling and function after MI in a pig model. MET...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.647230
更新日期:2007-01-23 00:00:00
abstract::The effect of timolol vs placebo on the frequency of anginal episodes, nitroglycerin consumption and exercise performance was investigated in a double-blind, randomized, crossover study in 23 patients with angina pectoris. The optimal dose of timolol (10-30 mg twice daily) for each patient was titrated by exercise stu...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.61.1.66
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Hypothermic hyperkalemic cardioplegia results in significant myocyte swelling and impaired contractility. These detrimental effects may be eliminated by the addition of an adenosine triphosphate-sensitive potassium (KATP) channel opener. This study evaluated the hypothesis that a KATP channel opener (diazoxi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.104.523746
更新日期:2005-08-30 00:00:00
abstract:BACKGROUND:We previously demonstrated that ischemic postconditioning decreases creatine kinase release, a surrogate marker for infarct size, in patients with acute myocardial infarction. Our objective was to determine whether ischemic postconditioning could afford (1) a persistent infarct size limitation and (2) an imp...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.107.729780
更新日期:2008-02-26 00:00:00
abstract:BACKGROUND:The concept of natriuretic peptide guidance has been extensively studied in patients with chronic heart failure (HF), with only limited success. The effect of NT-proBNP (N-terminal probrain natriuretic peptide)-guided therapy in patients with acute decompensated HF using a relative NT-proBNP target has not b...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.117.029882
更新日期:2018-04-17 00:00:00
abstract:BACKGROUND:Atherosclerosis is a systemic disease that underlies clinical cardiovascular disease. The radiographic finding of abdominal aortic calcific deposits is an indicator of the presence of aortic atherosclerosis and an independent predictor of cardiovascular disease events. Little is known about the heritability ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000022663.26468.5b
更新日期:2002-07-16 00:00:00
abstract:BACKGROUND:Recent data highlight a vital link between well-performed cardiopulmonary resuscitation (CPR) and survival after cardiac arrest; however, the quality of CPR as actually performed by trained healthcare providers is largely unknown. We sought to measure in-hospital chest compression rates and to determine comp...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/01.CIR.0000153811.84257.59
更新日期:2005-02-01 00:00:00
abstract::Although the postoperative hemodynamic and echocardiographic features of idiopathic hypertrophic subaortic stenosis have been studied, the expected consistent postoperative thinning of the interventricular septum has not been reported. In this study, the short-term effects of septal myectomy were evaluated in 16 patie...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.58.5.850
更新日期:1978-11-01 00:00:00
abstract:BACKGROUND:The use of cells derived from human induced pluripotent stem cells as cellular therapy for myocardial injury has yet to be examined in a large-animal model. METHODS AND RESULTS:Immunosuppressed Yorkshire pigs were assigned to 1 of 3 groups: A myocardial infarction group (MI group; distal left anterior desce...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.112.000641
更新日期:2013-03-05 00:00:00
abstract:BACKGROUND:Comprehensive data based on single-beat analysis of the ventricular activation sequence during sinus rhythm in infarcted hearts are currently not available. It was the aim of our study (1) to measure and analyze these activation sequences on the epicardial surface of the right and left ventricles and on the ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.91.5.1480
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:Plasma C-reactive protein (CRP) concentrations are increased in obese and/or hyperinsulinemic individuals. The goal of this study was to determine if the relation between insulin resistance and CRP was independent of obesity. METHODS AND RESULTS:Plasma CRP concentrations were measured before and after 3 mon...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.0000041046.32962.86
更新日期:2002-12-03 00:00:00
abstract:BACKGROUND:Currently, only anecdotal information exists on the presentation and outcome of coronary arterial injury after ablation procedures. METHODS AND RESULTS:Four patients who sustained coronary artery injury of a cohort of patients undergoing 4655 consecutive ablation procedures (0.09%) are described. The patien...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.109.870790
更新日期:2009-10-13 00:00:00
abstract:BACKGROUND:Present therapies for acute coronary syndromes aim toward limiting platelet-platelet adhesion and aggregation processes. However, platelet-leukocyte interactions may contribute importantly to disease progression in the arterial wall. Recent studies suggest that prevention of platelet-leukocyte binding via P-...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000015700.27754.6f
更新日期:2002-05-07 00:00:00
abstract:BACKGROUND:Fibrinogen binding to the active conformation of the alpha(IIb)beta(3) integrin receptor (glycoprotein IIb/IIIa) and cytoskeletal reorganization are important events in platelet function. Tyrosine phosphorylation of platelet proteins plays an essential role in platelet signal transduction pathways. We studie...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.16.1924
更新日期:2000-10-17 00:00:00