Abstract:
:While continuing a study of immunologic and virologic aspects of the postpericardiotomy syndrome (PPS) in infants and children, we undertook a companion study in adults. Whereas the incidence in 119 children was 27.8%, as is usual for our hospital, the incidence in 142 adults was 17.6%. Most of the operations (95 of 142) were performed on patients who were 50-69 years old. Incidence decreased as age increased: 28.5% for ages less than 40 years, 19.7% for ages 40--59 years, 14.2% for ages 60--69 years, and 10% for ages 70 years and older. Heart-reactive antibody in high titer was found in all patients with PPS; a rise in antiviral antibody to one or more of a battery of eight common viruses (adenovirus, cytomegalovirus, and coxsackie-virus B 1 to 6) was identified in 68% of these with PPS but in only 5% of those without clinical manifestations. We conclude that in adults, as in children, PPS may be an autoimmune phenomenon triggered by viral illness.
journal_name
Circulationjournal_title
Circulationauthors
Engle MA,Gay WA Jr,McCabe J,Longo E,Johnson D,Senterfit LB,Zabriskie JBsubject
Has Abstractpub_date
1981-08-01 00:00:00pages
II58-60issue
2 Pt 2eissn
0009-7322issn
1524-4539journal_volume
64pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:Dysregulation of adipocyte-derived bioactive molecules plays an important role in the development of atherosclerosis. We previously reported that adiponectin, an adipocyte-specific plasma protein, accumulated in the injured artery from the plasma and suppressed endothelial inflammatory response and vascular ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000042707.50032.19
更新日期:2002-11-26 00:00:00
abstract:BACKGROUND:Aspirin is effective for the primary prevention of cardiovascular events, but it remains unclear for which subgroups of individuals aspirin is beneficial. We assessed the cost-effectiveness of aspirin separately for men and women of different ages with various levels of cardiovascular disease risk. METHODS ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.735340
更新日期:2008-06-03 00:00:00
abstract:BACKGROUND:Ruling out acute myocardial infarction (AMI) on the basis of rapid assays for cardiac markers will allow early triage of patients and cost-effective use of available coronary care facilities. METHODS AND RESULTS:We studied the value of myoglobin, creatine kinase (CK)-MBmass, and troponin T in ruling out an ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.12.3401
更新日期:1995-12-15 00:00:00
abstract:BACKGROUND:Influenza infection is a serious event for patients with heart failure (HF). Little knowledge exists about the association between influenza vaccination and outcome in patients with HF. This study sought to determine whether influenza vaccination is associated with improved long-term survival in patients wit...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.118.036788
更新日期:2019-01-29 00:00:00
abstract:BACKGROUND:During the development of heart failure (HF), the chief myocardial energy substrate switches from fatty acids to glucose. This metabolic switch, which recapitulates fetal cardiac energy substrate preferences, is thought to maintain aerobic energetic balance. The regulatory mechanisms involved in this metabol...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.11.2837
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:From 1958 to 1969, 592 patients (mostly children) with pulmonary stenosis were admitted to the First Natural History Study of Congenital Heart Defects (NHS-1) after cardiac catheterization. Most with gradients < 50 mm Hg were managed medically; most with gradients > or = 80 mm Hg had pulmonary valvotomy. Amo...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiova...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/CIRCULATIONAHA.119.040551
更新日期:2019-10-01 00:00:00
abstract::A reduced rate of diastolic closure of the anterior mitral leaflet has been shown to occur in mitral stenosis, primary pulmonary hypertension, and in cases with reduced left ventricular compliance. Posterior notion of the posterior mitral leaflet in diastole has been the distinguishing feature to rule out the diagnosi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.51.3.511
更新日期:1975-03-01 00:00:00
abstract::To determine whether a ventricular (LV) end-systolic dimension (ESD) greater than or equal to 55 mm and LV left fractional shortening less than 25% are risk factors for aortic valve replacement (AVR) in patients with aortic insufficiency, we analyzed the clinical course and M-mode echocardiograms in 47 consecutive pat...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.67.1.216
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:After repair of aortic coarctation, patients may develop restenosis, aneurysms, and pseudoaneurysms at the site of prior repair. We assessed the outcomes of late reintervention on the descending aorta after aortic coarctation repair. METHODS AND RESULTS:From March 1954 to July 2008, 130 patients had operati...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.109.925172
更新日期:2010-09-14 00:00:00
abstract:BACKGROUND:Conventional x-ray angiography frequently underestimates the true burden of atherosclerosis. Although intravascular ultrasound allows for imaging of coronary plaque, this invasive technique is inappropriate for screening or serial examinations. We therefore sought to develop a noninvasive free-breathing MR t...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.102.21.2582
更新日期:2000-11-21 00:00:00
abstract:BACKGROUND:The mechanism through which ischemic preconditioning causes cardioprotection is unknown. The present study investigated the role of stunning in preconditioning. METHODS AND RESULTS:We studied three different protocols of preconditioning: two cycles of 2-minute ischemia separated by 5-minute reperfusion (2'P...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.6.2504
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND:Increased common carotid artery intima-media thickness (CCA-IMT) is a marker of early atherosclerosis. Low-grade inflammation is associated with the pathogenesis of atherosclerosis. Low-grade inflammation and increased CCA-IMT are observed in end-stage renal disease (ESRD). Oxidative stress is involved in ur...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000035250.66458.67
更新日期:2002-10-22 00:00:00
abstract:BACKGROUND:Considering the controversial results published in the literature concerning associations between human leukocyte antigens (HLA) and rheumatic fever (RF), the purpose of the present study was to investigate by means of cosegregation analysis the participation of HLA genes in susceptibility to RF. METHODS AN...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.89.1.138
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:The patency of AV expanded polytetrafluoroethylene (ePTFE) grafts for hemodialysis is impaired by intimal hyperplasia (IH) at the venous outflow tract. The absence of a functional endothelial monolayer on the prosthetic grafts is an important stimulus for IH. In the present study, we evaluated the feasibilit...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.104.504407
更新日期:2005-07-05 00:00:00
abstract::Using an isolated rat heart preparation under both aerobic and ischemic conditions we have characterized the temperature dependency of the slow calcium channel-blocking drug verapamil. In the first series of studies, isolated working rat hearts were subjected to global ischemia at 37 degrees, 34 degrees, 31 degrees, 2...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1984-09-01 00:00:00
abstract::In 61 patients sinus node function was tested by programmed (sinoatrial conduction time, SACT) and overdrive atrial pacing (sinus node recovery time, SRT). In the control group (N = 20), mean sinus cycle length was 773 +/- 140.2 msec, mean absolute SRT 1044 +/- 215.8 msec [corrected SRT (CSRT) 270 +/- 112.5 msec; mean...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.56.1.43
更新日期:1977-07-01 00:00:00
abstract:BACKGROUND:Randomized trials that studied clinical outcomes after percutaneous coronary intervention (PCI) with bare metal stenting versus coronary artery bypass grafting (CABG) are underpowered to properly assess safety end points like death, stroke, and myocardial infarction. Pooling data from randomized controlled t...
journal_title:Circulation
pub_type: 杂志文章,meta分析
doi:10.1161/CIRCULATIONAHA.107.752147
更新日期:2008-09-09 00:00:00
abstract::Patients with DDD pacemakers who have intact retrograde conduction are known to be at risk of developing ventricular and "endless loop" tachycardia. To address this problem, a pacing protocol was designed in which V2A2 conduction was assessed in 16 patients during ventricular pacing alone (standard method) and during ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.68.1.23
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND:Data from single-center studies suggest that echocardiographic parameters of mechanical dyssynchrony may improve patient selection for cardiac resynchronization therapy (CRT). In a prospective, multicenter setting, the Predictors of Response to CRT (PROSPECT) study tested the performance of these parameters ...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.107.743120
更新日期:2008-05-20 00:00:00
abstract:BACKGROUND:The purpose of the present study was to investigate plasma lipid-independent mechanisms for the sex difference in the development of atherosclerosis. METHODS AND RESULTS:In the first experiment, 20 male and 20 female rabbits were balloon-injured in the middle thoracic aorta and maintained at the same plasma...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.98.24.2731
更新日期:1998-12-15 00:00:00
abstract:BACKGROUND:Brain natriuretic peptide (BNP) levels are used in the evaluation of patients with heart disease, yet there is little understanding of the effect of hypoxia on natriuretic peptide secretion. Furthermore, recent data suggest that oxytocin may mediate stretch-induced atrial natriuretic peptide (ANP) secretion....
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000129305.25115.80
更新日期:2004-06-15 00:00:00
abstract::The reduced responsiveness of the renin-angiotensin system to hemodynamic changes in patients with congestive heart failure (CHF) could be due to a defect of the juxtaglomerular apparatus. To test this hypothesis, the responses to viprostol, an analog of prostaglandin E2 (PGE2) that is known to stimulate both the macu...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.74.6.1203
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:It has been documented that the HMG coenzyme A reductase inhibitors, or statins, can decrease cardiovascular events and mortality in patients with clinical coronary disease and moderately to severely elevated lipid levels. Additional data are required to demonstrate a reduction of vascular events in coronary...
journal_title:Circulation
pub_type: 杂志文章,meta分析
doi:10.1161/01.cir.92.9.2419
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:It is unknown whether adenosine can precondition human myocardium against ischemia in vivo. METHODS AND RESULTS:Thirty patients were randomized to receive a 10-minute intracoronary infusion of adenosine (2 mg/min) or normal saline; 10 minutes later, they underwent percutaneous transluminal coronary angiopla...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.95.11.2500
更新日期:1997-06-03 00:00:00
abstract:BACKGROUND:The relationship between intake of fruits and vegetables (F/V) during young adulthood and coronary atherosclerosis later in life is unclear. METHODS AND RESULTS:We studied participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study, a cohort of young, healthy black and white individu...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.114.012562
更新日期:2015-11-24 00:00:00
abstract:BACKGROUND:The first compounds considered for stent-based delivery, such as heparin, were chosen on the basis of promising tissue culture and animal experiments, and yet they have failed to stop restenosis clinically. More recent compounds, such as paclitaxel, are of a different sort, being hydrophobic in nature, and t...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc3101.092214
更新日期:2001-07-31 00:00:00
abstract::For estimating left ventricular mass (LVM), ECG criteria for left ventricular hypertrophy (LVH) were selected from conventional 12-lead ECGs, orthogonal three-lead ECGs, and multiple-dipole ECGs (MDECG). The three cardiograms were recorded in 139 patients for whom the degree of LVH was independently determined from bi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.60.6.1350
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:Continuous whole-body perfusion for > 3 hours with a cold asanguineous blood substitute, hypothermosol (HTS) solution, has been reported to preserve organ function. We used this solution in a survival animal model to evaluate its possible application in extending the safe duration of deep hypothermic circula...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Erosion and rupture of coronary atheromas are the events preceding the vast majority of acute coronary syndromes. The shoulder regions of atheromas, the sites at which erosion or rupture is most likely to occur, are the sites at which mast cells accumulate. These cells are filled with neutral proteases capab...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.5.1084
更新日期:1995-09-01 00:00:00