Locus for atrial fibrillation maps to chromosome 6q14-16.


BACKGROUND:Atrial fibrillation (AF), the most common clinical arrhythmia, is a major cause of morbidity and mortality. Although AF is often associated with other cardiovascular conditions, many patients present without an obvious etiology. Inherited forms of AF exist, but the causative gene has been defined only in a single family. We have identified a large family (family FAF-1) in which AF segregates as a Mendelian trait. METHODS AND RESULTS:Thirty-four family members were evaluated by 12-lead ECG, echocardiogram, 24-hour Holter monitoring, and laboratory studies. Individuals with electrocardiographically documented AF were defined as affected. Subjects were considered unaffected if they were >60 years of age, had no personal history of AF, and had no offspring with a history of AF. DNA was extracted and genotypic analyses were performed using polymorphic microsatellite markers. Evidence of linkage was obtained on chromosome 6, with a peak 2-point logarithm of the odds (LOD) score of 3.63 (theta=0) at the marker D6S1021. A maximal multipoint LOD score of 4.9 was obtained between D6S286 and D6S1021, indicating odds of approximately 100 000:1 in favor of this interval as the location of the gene defect responsible for AF in this family. The LOD scores were robust to changes in penetrance and allele frequency. Haplotype analyses further supported this minimal genetic interval. CONCLUSIONS:We have mapped a novel locus for AF to chromosome 6q14-16. The identification of the causative gene in this interval will be an important step in understanding the fundamental mechanisms of AF.






Ellinor PT,Shin JT,Moore RK,Yoerger DM,MacRae CA




Has Abstract


2003-06-17 00:00:00














  • Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation.

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    pub_type: 杂志文章


    authors: Volders PG,Stengl M,van Opstal JM,Gerlach U,Spätjens RL,Beekman JD,Sipido KR,Vos MA

    更新日期:2003-06-03 00:00:00

  • Coronary collateral function in patients without occlusive coronary artery disease.

    abstract::Little is known of the functional capacity of coronary collaterals in humans without occlusive coronary artery disease. We, therefore, measured peripheral coronary pressure (PCP) and retrograde flow (RF) from coronary arteries at aortic valve replacement in seven patients without occlusive coronary artery disease. Usi...


    pub_type: 杂志文章


    authors: Goldstein RE,Michaelis LL,Morrow AG,Epstein SE

    更新日期:1975-01-01 00:00:00

  • Atherogenic dyslipidemia in HIV-infected individuals treated with protease inhibitors. The Swiss HIV Cohort Study.

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    pub_type: 杂志文章


    authors: Périard D,Telenti A,Sudre P,Cheseaux JJ,Halfon P,Reymond MJ,Marcovina SM,Glauser MP,Nicod P,Darioli R,Mooser V

    更新日期:1999-08-17 00:00:00

  • Echocardiographic assessment of left ventricular function in aortic valve disease.

    abstract::Echocardiography was used to study left ventricular size and contraction in 128 patients with isolated aortic valve disease -45 patients with aortic stenosis, 25 with mixed aortic valve disease and 58 with aortic regurgitation. Left ventricular measurements included the end-diastolic internal dimension (LVIDd), mural ...


    pub_type: 杂志文章


    authors: McDonald IG

    更新日期:1976-05-01 00:00:00

  • Premortem assessment of myocardial area at risk with the use of intracoronary technetium macroaggregated albumin and gated nuclear imaging.

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    pub_type: 杂志文章


    authors: Feiring AJ,Bruch P,Husayni TS,Kirchner PT,Marcus ML

    更新日期:1986-03-01 00:00:00

  • Diagnostic thresholds for ambulatory blood pressure monitoring based on 10-year cardiovascular risk.

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    pub_type: 杂志文章


    authors: Kikuya M,Hansen TW,Thijs L,Björklund-Bodegård K,Kuznetsova T,Ohkubo T,Richart T,Torp-Pedersen C,Lind L,Ibsen H,Imai Y,Staessen JA,International Database on Ambulatory blood pressure monitoring in relation to Cardiovascular Outcom

    更新日期:2007-04-24 00:00:00

  • Coronary vasomotor effects of serotonin in patients with angina. Relation to coronary stenosis morphology.

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    pub_type: 杂志文章


    authors: Tousoulis D,Davies G,McFadden E,Clarke J,Kaski JC,Maseri A

    更新日期:1993-10-01 00:00:00

  • Enhanced coronary vasoconstriction to endothelin-B-receptor activation in experimental congestive heart failure.

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    pub_type: 杂志文章


    authors: Cannan CR,Burnett JC Jr,Lerman A

    更新日期:1996-02-15 00:00:00

  • Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes Mellitus.

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    pub_type: 杂志文章


    authors: Hoyer FF,Zhang X,Coppin E,Vasamsetti SB,Modugu G,Schloss MJ,Rohde D,McAlpine CS,Iwamoto Y,Libby P,Naxerova K,Swirski FK,Dutta P,Nahrendorf M

    更新日期:2020-07-21 00:00:00

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    authors: Finkbohner R,Johnston D,Crawford ES,Coselli J,Milewicz DM

    更新日期:1995-02-01 00:00:00

  • Regional Systems of Care Demonstration Project: American Heart Association Mission: Lifeline STEMI Systems Accelerator.

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    pub_type: 杂志文章


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    更新日期:2016-08-02 00:00:00

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    pub_type: 杂志文章,评审


    authors: Acquatella H

    更新日期:2007-03-06 00:00:00

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    pub_type: 杂志文章,多中心研究


    authors: Kenchaiah S,Pocock SJ,Wang D,Finn PV,Zornoff LA,Skali H,Pfeffer MA,Yusuf S,Swedberg K,Michelson EL,Granger CB,McMurray JJ,Solomon SD,CHARM Investigators.

    更新日期:2007-08-07 00:00:00

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    pub_type: 临床试验,杂志文章


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    更新日期:1997-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Mahmud R,Lehmann M,Denker S,Gilbert CJ,Akhtar M

    更新日期:1983-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Ruijtenbeek K,le Noble FA,Janssen GM,Kessels CG,Fazzi GE,Blanco CE,De Mey JG

    更新日期:2000-12-05 00:00:00

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    pub_type: 杂志文章


    authors: Banai S,Jaklitsch MT,Shou M,Lazarous DF,Scheinowitz M,Biro S,Epstein SE,Unger EF

    更新日期:1994-05-01 00:00:00

  • Sudden Cardiac Arrest Survivorship: A Scientific Statement From the American Heart Association.

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    authors: Sarris GE,Fann JI,Sokoloff MH,Smith DL,Loveday M,Kosek JC,Stephens RJ,Cooper AD,May K,Willis AL

    更新日期:1989-09-01 00:00:00

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    pub_type: 临床试验,杂志文章


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    pub_type: 杂志文章,随机对照试验


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    更新日期:2007-11-27 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Sakata Y,Hoit BD,Liggett SB,Walsh RA,Dorn GW 2nd

    更新日期:1998-04-21 00:00:00

  • Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation.

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    pub_type: 杂志文章,多中心研究,随机对照试验


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    pub_type: 杂志文章


    authors: Brezinski M,Saunders K,Jesser C,Li X,Fujimoto J

    更新日期:2001-04-17 00:00:00

  • Effect of baseline or changes in adrenergic activity on clinical outcomes in the beta-blocker evaluation of survival trial.

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


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    更新日期:2004-09-14 00:00:00

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    pub_type: 杂志文章,多中心研究


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    更新日期:2003-07-01 00:00:00

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    pub_type: 杂志文章,随机对照试验


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    更新日期:2015-02-17 00:00:00

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    pub_type: 杂志文章


    authors: Douglas PS,Hirshfeld JW Jr,Edmunds LH Jr

    更新日期:1985-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Villanueva FS,Glasheen WP,Sklenar J,Kaul S

    更新日期:1993-12-01 00:00:00