Magnetic resonance and echocardiographic imaging of pulmonary artery size throughout stages of Fontan reconstruction.


BACKGROUND:Because pulmonary artery size is considered by most investigators to be a major prognosticator of outcome in patients undergoing staged Fontan reconstruction, the objective of the present study was to determine the efficacy of noninvasive measures in determining pulmonary artery size. METHODS AND RESULTS:This study analyzed the T1-weighted, spin-echo magnetic resonance and echocardiographic images of 36 functional single-ventricle patients throughout stages of Fontan reconstruction (prebidirectional and postbidirectional cavopulmonary anastomosis and after Fontan) and compared them with angiography images at cardiac catheterization. Magnetic resonance imaging had a high degree of agreement with angiography, with the McGoon index agreeing better than the Nakata index and absolute right and left pulmonary diameters. Although echocardiography had fair agreement with angiography, it agreed less well and had a wider standard deviation than magnetic resonance imaging for all indexes and measurements and, based on the prediction interval, would be a poorer prospective measure of pulmonary artery size in this population. In addition, echocardiography was a poorer measure of pulmonary artery size as the size of the vessel increases. Magnetic resonance imaging correctly detected five of five patients with nonconfluent branch pulmonary arteries and six of six patients with stenoses, whereas echocardiography was unable to visualize any of the patients with nonconfluent branch pulmonary arteries with certainty and only two of six (33%) with stenoses. CONCLUSIONS:Magnetic resonance imaging is a useful, noninvasive tool to determine pulmonary artery size in patients undergoing Fontan reconstruction and is superior to echocardiography. Echocardiography was a fair predictor of pulmonary artery size, but magnetic resonance imaging agreed with angiography better than echocardiography and outperformed echocardiography in diagnosing branch pulmonary artery discontinuity and stenoses. Magnetic resonance imaging may avoid unnecessary cardiac catheterization, especially in older patients, and may obviate the need for jugular or subclavian catheterization in those who have undergone bidirectional cavopulmonary anastomosis.






Fogel MA,Donofrio MT,Ramaciotti C,Hubbard AM,Weinberg PM




Has Abstract


1994-12-01 00:00:00












  • Novel MRI contrast agent for molecular imaging of fibrin: implications for detecting vulnerable plaques.

    abstract:BACKGROUND:Molecular imaging of thrombus within fissures of vulnerable atherosclerotic plaques requires sensitive detection of a robust thrombus-specific contrast agent. In this study, we report the development and characterization of a novel ligand-targeted paramagnetic molecular imaging agent with high avidity for fi...


    pub_type: 杂志文章


    authors: Flacke S,Fischer S,Scott MJ,Fuhrhop RJ,Allen JS,McLean M,Winter P,Sicard GA,Gaffney PJ,Wickline SA,Lanza GM

    更新日期:2001-09-11 00:00:00

  • Persistent inhibition of neointimal hyperplasia after sirolimus-eluting stent implantation: long-term (up to 2 years) clinical, angiographic, and intravascular ultrasound follow-up.

    abstract:BACKGROUND:Early results of sirolimus-eluting stent implantation showed a nearly complete abolition of neointimal hyperplasia. The question remains, however, whether the early promising results will still be evident at long-term follow-up. The objective of our study was to evaluate the efficiency of sirolimus-eluting s...


    pub_type: 临床试验,杂志文章


    authors: Degertekin M,Serruys PW,Foley DP,Tanabe K,Regar E,Vos J,Smits PC,van der Giessen WJ,van den Brand M,de Feyter P,Popma JJ

    更新日期:2002-09-24 00:00:00

  • Comparison of high-dose with low-dose aspirin in patients with mechanical heart valve replacement treated with oral anticoagulant.

    abstract:BACKGROUND:There are no reported studies on the safety and efficacy of low-dose aspirin with low-intensity oral anticoagulation in patients with heart valve replacement. In this study, we compared the use of 100 mg/d aspirin with 650 mg/d aspirin in the prevention of systemic embolism and vascular death in patients wit...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Altman R,Rouvier J,Gurfinkel E,Scazziota A,Turpie AG

    更新日期:1996-11-01 00:00:00

  • Calcium antagonists and hypothermia: the temperature dependency of the negative inotropic and anti-ischemic properties of verapamil in the isolated rat heart.

    abstract::Using an isolated rat heart preparation under both aerobic and ischemic conditions we have characterized the temperature dependency of the slow calcium channel-blocking drug verapamil. In the first series of studies, isolated working rat hearts were subjected to global ischemia at 37 degrees, 34 degrees, 31 degrees, 2...


    pub_type: 杂志文章


    authors: Hearse DJ,Yamamoto F,Shattock MJ

    更新日期:1984-09-01 00:00:00

  • Immediate diagnosis of acute myocardial infarction by two-dimensional echocardiography.

    abstract::To define the role of portable two-dimensional echocardiography (2-D echo) in the immediate diagnosis of acute chest pain syndrome, 80 consecutive patients were studied. Adequate 2-D echo studies were obtained in 65 (81%). Thirty-three patients had clinical evidence of transmural or nontransmural acute myocardial infa...


    pub_type: 杂志文章


    authors: Horowitz RS,Morganroth J,Parrotto C,Chen CC,Soffer J,Pauletto FJ

    更新日期:1982-02-01 00:00:00

  • Ninety-minute exclusion of acute myocardial infarction by use of quantitative point-of-care testing of myoglobin and troponin I.

    abstract:BACKGROUND:Diagnostic strategies with ECG and serum cardiac markers have been used to rule out acute myocardial infarction in 6 to 12 hours. The present study evaluated whether a multimarker strategy that used point-of-care measurement of myoglobin, creatine kinase (CK)-MB, and troponin I could exclude acute myocardial...


    pub_type: 杂志文章


    authors: McCord J,Nowak RM,McCullough PA,Foreback C,Borzak S,Tokarski G,Tomlanovich MC,Jacobsen G,Weaver WD

    更新日期:2001-09-25 00:00:00

  • Assessment of systemic right ventricular function in patients with transposition of the great arteries using the myocardial performance index: comparison with cardiac magnetic resonance imaging.

    abstract:BACKGROUND:Assessment of systemic right ventricular (RV) function is a key point in the follow-up of patients with transposition of the great arteries (TGA). Current echocardiographic assessment of RV function is at best an estimate, and cardiac magnetic resonance (CMR) is considered the gold standard. However, this te...


    pub_type: 杂志文章


    authors: Salehian O,Schwerzmann M,Merchant N,Webb GD,Siu SC,Therrien J

    更新日期:2004-11-16 00:00:00

  • Flecainide acetate prevents recurrence of symptomatic paroxysmal supraventricular tachycardia. The Flecainide Supraventricular Tachycardia Study Group.

    abstract::Oral flecainide acetate was administered to 34 patients with documented symptomatic paroxysmal supraventricular tachycardia (PSVT) with a double-blind, placebo-controlled, 8-week crossover trial design. PSVT was defined as a regular tachycardia of at least 120 beats/min without evidence of atrioventricular dissociatio...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Henthorn RW,Waldo AL,Anderson JL,Gilbert EM,Alpert BL,Bhandari AK,Hawkinson RW,Pritchett EL

    更新日期:1991-01-01 00:00:00

  • Endothelium-dependent dilatation is impaired in young healthy subjects with a family history of premature coronary disease.

    abstract:BACKGROUND:A family history of premature coronary artery disease (CAD) in a first-degree relative is an independent risk factor for coronary disease. Both genetic and environmental influences are likely to be responsible and may interact, but their relative importance is unclear. METHODS AND RESULTS:We studied endothe...


    pub_type: 杂志文章


    authors: Clarkson P,Celermajer DS,Powe AJ,Donald AE,Henry RM,Deanfield JE

    更新日期:1997-11-18 00:00:00

  • Transplantation of fetal myocardial tissue into the infarcted myocardium of rat. A potential method for repair of infarcted myocardium?

    abstract:BACKGROUND:Unlike skeletal myocytes, mammalian adult cardiomyocytes cannot regenerate after injury. A possible strategy to increase viability and augment ventricular function after myocardial injury is fetal myocardial tissue transplantation. The engrafted fetal cells are a potential source of growth factors and can be...


    pub_type: 杂志文章


    authors: Leor J,Patterson M,Quinones MJ,Kedes LH,Kloner RA

    更新日期:1996-11-01 00:00:00

  • Autoregulation of cardiac output by passive elastic characteristics of the vascular capacitance system.

    abstract::After a change in cardiac output, the magnitude of potential blood volume redistribution was investigated in 10 dogs anesthetized with chloralose. All of the venous return was pumped into a reservoir, using servocontrolled pumps to maintain fixed superior and inferior vena cava pressures. The cardiac output was set at...


    pub_type: 杂志文章


    authors: Rothe CF,Gaddis ML

    更新日期:1990-01-01 00:00:00

  • Detection of adenoviral genome in the myocardium of adult patients with idiopathic left ventricular dysfunction.

    abstract:BACKGROUND:The use of molecular biological techniques has demonstrated the importance of enteroviral infection of the myocardium in the pathogenesis of myocarditis and dilated cardiomyopathy in adults and adenovirus and enterovirus infection in children. The aim of this study was to determine the frequency of adenovira...


    pub_type: 杂志文章


    authors: Pauschinger M,Bowles NE,Fuentes-Garcia FJ,Pham V,Kühl U,Schwimmbeck PL,Schultheiss HP,Towbin JA

    更新日期:1999-03-16 00:00:00

  • Intravascular ultrasound imaging of human coronary arteries in vivo. Analysis of tissue characterizations with comparison to in vitro histological specimens.

    abstract:BACKGROUND:Intravascular ultrasound imaging was performed in 27 patients after coronary balloon angioplasty to quantify the lumen and atheroma cross-sectional areas. METHODS AND RESULTS:A 20-MHz ultrasound catheter was inserted through a 1.6-mm plastic introducer sheath across the dilated area to obtain real-time imag...


    pub_type: 杂志文章


    authors: Tobis JM,Mallery J,Mahon D,Lehmann K,Zalesky P,Griffith J,Gessert J,Moriuchi M,McRae M,Dwyer ML

    更新日期:1991-03-01 00:00:00

  • Sex-Specific Trends in Acute Myocardial Infarction Within an Integrated Healthcare Network, 2000 Through 2014.

    abstract:BACKGROUND:In recent decades, the rates of incident acute myocardial infarction (AMI) have declined in the United States, yet disparities by sex remain. In an integrated healthcare delivery system, we examined temporal trends in incident AMI among women and men. METHODS:We identified hospitalized AMI among members ≥35...


    pub_type: 杂志文章


    authors: Mefford MT,Li BH,Qian L,Reading SR,Harrison TN,Scott RD,Cavendish JJ,Jacobsen SJ,Kanter MH,Woodward M,Reynolds K

    更新日期:2020-02-18 00:00:00

  • High-frequency jet ventilation for respiratory failure after congenital heart surgery.

    abstract:BACKGROUND:Extracorporeal membrane oxygenation (ECMO) is considered when respiratory failure (RF) persists despite increasing conventional mechanical ventilation (CMV). High-frequency jet ventilation (HFJV) can improve ventilation with comparable mean airway pressure (PAW) to that found on CMV. This study was undertake...


    pub_type: 杂志文章


    authors: Kocis KC,Meliones JN,Dekeon MK,Callow LB,Lupinetti FM,Bove EL

    更新日期:1992-11-01 00:00:00

  • Premature escape beats induced by overdrive pacing in canine Purkinje fibers. Evidence for the role of normal automaticity as an underlying cellular mechanism.

    abstract::Premature escape beats induced in conscious dogs with chronic complete atrioventricular block have been defined as escape beats occurring on cessation of overdrive pacing and having a coupling interval to the last paced beat shorter than the coupling interval between the premature escape beat and the second postpacing...


    pub_type: 杂志文章


    authors: Viamonte VA,Rosen MR

    更新日期:1990-07-01 00:00:00

  • Cardiac Amyloidosis: Evolving Diagnosis and Management: A Scientific Statement From the American Heart Association.

    abstract::Transthyretin amyloid cardiomyopathy (ATTR-CM) results in a restrictive cardiomyopathy caused by extracellular deposition of transthyretin, normally involved in the transportation of the hormone thyroxine and retinol-binding protein, in the myocardium. Enthusiasm about ATTR-CM has grown as a result of 3 simultaneous a...


    pub_type: 杂志文章


    authors: Kittleson MM,Maurer MS,Ambardekar AV,Bullock-Palmer RP,Chang PP,Eisen HJ,Nair AP,Nativi-Nicolau J,Ruberg FL,American Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology.

    更新日期:2020-07-07 00:00:00

  • Differences in beta-adrenergic neuroeffector mechanisms in ischemic versus idiopathic dilated cardiomyopathy.

    abstract:BACKGROUND:We measured the content and activities of components of the beta-adrenergic receptor-G protein-adenylate cyclase complex and adrenergic neurotransmitter levels in left and right ventricular myocardial preparations derived from 77 end-stage failing human hearts from patients with idiopathic dilated cardiomyop...


    pub_type: 杂志文章


    authors: Bristow MR,Anderson FL,Port JD,Skerl L,Hershberger RE,Larrabee P,O'Connell JB,Renlund DG,Volkman K,Murray J

    更新日期:1991-09-01 00:00:00

  • Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice.

    abstract:BACKGROUND:Serum paraoxonase (PON1), an enzyme carried on HDL, inhibits LDL oxidation, and in human population studies, low PON1 activity is associated with atherosclerosis. In addition, PON1 knockout mice are more susceptible to lipoprotein oxidation and atherosclerosis. To evaluate whether PON1 protects against ather...


    pub_type: 杂志文章


    authors: Tward A,Xia YR,Wang XP,Shi YS,Park C,Castellani LW,Lusis AJ,Shih DM

    更新日期:2002-07-23 00:00:00

  • Dose-response of chronic beta-blocker treatment in heart failure from either idiopathic dilated or ischemic cardiomyopathy. Bucindolol Investigators.

    abstract:BACKGROUND:Small-scale clinical investigations have demonstrated that single doses of beta-blocking agents can improve left ventricular function in heart failure from idiopathic dilated cardiomyopathy (IDC). The purpose of this multicenter clinical trial was to determine the dose-effect characteristics of beta-blockade...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Bristow MR,O'Connell JB,Gilbert EM,French WJ,Leatherman G,Kantrowitz NE,Orie J,Smucker ML,Marshall G,Kelly P

    更新日期:1994-04-01 00:00:00

  • Autoimmune response in chronic ongoing myocarditis demonstrated by heterotopic cardiac transplantation in mice.

    abstract:BACKGROUND:Autoimmune mechanisms have been implicated in the pathogenesis of chronic ongoing myocarditis. To investigate this relation, we used an A/J mouse model inoculated with coxsackievirus B3 and determined whether myocarditis would be transferred to normal hearts that were heterotopically transplanted. METHODS A...


    pub_type: 杂志文章


    authors: Nakamura H,Yamamura T,Umemoto S,Fukuta S,Shioi T,Matsumori A,Sasayama S,Matsuzaki M

    更新日期:1996-12-15 00:00:00

  • Enhanced sympathetic and ventilatory responses to central chemoreflex activation in heart failure.

    abstract:BACKGROUND:Sympathetic activation and respiratory abnormalities may each be implicated in the pathophysiology of congestive heart failure (CHF). Chemoreflexes are an important mechanism regulating both sympathetic drive and breathing. We therefore tested the hypothesis that chemoreflex function is altered in CHF. METH...


    pub_type: 临床试验,杂志文章


    authors: Narkiewicz K,Pesek CA,van de Borne PJ,Kato M,Somers VK

    更新日期:1999-07-20 00:00:00

  • Presence of tissue factor pathway inhibitor in human atherosclerotic plaques is associated with reduced tissue factor activity.

    abstract:BACKGROUND:Plaque disruption and exposure of subendothelial procoagulants such as tissue factor (TF) to circulating factor VII/VIIa (FVII/VIIa) lead to intravascular thrombosis. Tissue factor pathway inhibitor (TFPI) is an endogenous inhibitor of TF-induced coagulation that binds to factor Xa and the TF-FVIIa catalytic...


    pub_type: 杂志文章


    authors: Caplice NM,Mueske CS,Kleppe LS,Simari RD

    更新日期:1998-09-15 00:00:00

  • High prevalence of respiratory ciliary dysfunction in congenital heart disease patients with heterotaxy.

    abstract:BACKGROUND:Patients with congenital heart disease (CHD) and heterotaxy show high postsurgical morbidity/mortality, with some developing respiratory complications. Although this finding is often attributed to the CHD, airway clearance and left-right patterning both require motile cilia function. Thus, airway ciliary dys...


    pub_type: 杂志文章


    authors: Nakhleh N,Francis R,Giese RA,Tian X,Li Y,Zariwala MA,Yagi H,Khalifa O,Kureshi S,Chatterjee B,Sabol SL,Swisher M,Connelly PS,Daniels MP,Srinivasan A,Kuehl K,Kravitz N,Burns K,Sami I,Omran H,Barmada M,Olivier K,

    更新日期:2012-05-08 00:00:00

  • Modulation of atrioventricular nodal function by metabolic and allosteric regulators of endogenous adenosine in guinea pig heart.

    abstract:BACKGROUND:There has been increasing interest in the development of agents that utilize endogenous adenosine to exert their actions. We tested the hypothesis that substances that either potentiate the activity (allosteric enhancers) or increase the interstitial concentration (inhibitors of metabolism) of endogenous ade...


    pub_type: 杂志文章


    authors: Dennis DM,Raatikainen MJ,Martens JR,Belardinelli L

    更新日期:1996-11-15 00:00:00

  • Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R(2)CHADS(2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K ant

    abstract:BACKGROUND:We sought to define the factors associated with the occurrence of stroke and systemic embolism in a large, international atrial fibrillation (AF) trial. METHODS AND RESULTS:In ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Piccini JP,Stevens SR,Chang Y,Singer DE,Lokhnygina Y,Go AS,Patel MR,Mahaffey KW,Halperin JL,Breithardt G,Hankey GJ,Hacke W,Becker RC,Nessel CC,Fox KA,Califf RM,ROCKET AF Steering Committee and Investigators.

    更新日期:2013-01-15 00:00:00

  • Enalapril decreases the incidence of atrial fibrillation in patients with left ventricular dysfunction: insight from the Studies Of Left Ventricular Dysfunction (SOLVD) trials.

    abstract:BACKGROUND:Atrial fibrillation (AF) is frequently encountered in patients with heart failure (HF) and is also a predictor of morbidity and mortality in this population. Recent experimental studies have shown electrical and structural atrial remodeling with increased fibrosis in animals with HF and have suggested a prev...


    pub_type: 杂志文章


    authors: Vermes E,Tardif JC,Bourassa MG,Racine N,Levesque S,White M,Guerra PG,Ducharme A

    更新日期:2003-06-17 00:00:00

  • Impairment of collateral formation in lipoprotein(a) transgenic mice: therapeutic angiogenesis induced by human hepatocyte growth factor gene.

    abstract:BACKGROUND:Although lipoprotein(a) (Lp[a]) is a risk factor for atherosclerosis, no study has documented the effects of Lp(a) on angiogenesis. In this study, we examined collateral formation in peripheral arterial disease (PAD) model in Lp(a) transgenic mice. In addition, we examined the feasibility of gene therapy by ...


    pub_type: 杂志文章


    authors: Morishita R,Sakaki M,Yamamoto K,Iguchi S,Aoki M,Yamasaki K,Matsumoto K,Nakamura T,Lawn R,Ogihara T,Kaneda Y

    更新日期:2002-03-26 00:00:00

  • Percutaneous and minimally invasive valve procedures: a scientific statement from the American Heart Association Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology, Functional Genomics and Translational Biology Interdisciplin

    abstract::The incidence of valvular heart disease is expected to increase over the next several decades as a large proportion of the US demographic advances into the later decades of life. At the same time, the next several years can be anticipated to bring a broad transition of surgical therapy to minimally invasive (minithora...


    pub_type: 杂志文章,评审


    authors: Rosengart TK,Feldman T,Borger MA,Vassiliades TA Jr,Gillinov AM,Hoercher KJ,Vahanian A,Bonow RO,O'Neill W,American Heart Association Council on Cardiovascular Surgery and Anesthesia.,American Heart Association Council on Clinical Card

    更新日期:2008-04-01 00:00:00

  • Lumen diameter of normal human coronary arteries. Influence of age, sex, anatomic variation, and left ventricular hypertrophy or dilation.

    abstract:BACKGROUND:Precise knowledge of the expected "normal" lumen diameter at a given coronary anatomic location is a first step toward developing a quantitative estimate of coronary disease severity that could be more useful than the traditional "percent stenosis." METHODS AND RESULTS:Eighty-three arteriograms were careful...


    pub_type: 杂志文章


    authors: Dodge JT Jr,Brown BG,Bolson EL,Dodge HT

    更新日期:1992-07-01 00:00:00