Cardioprotective mechanism of ischemic preconditioning is impaired by postinfarct ventricular remodeling through angiotensin II type 1 receptor activation.

abstract：:Of 22 children with congenital complete heart block (CCHB) available for study, 14 (63.6%) were born to 11 mothers with clinical or laboratory evidence of connective tissue disease, primarily lupus erythematosus (LE). Seven mothers had both clinical and laboratory evidence of disease while four had only positive labor...

journal_title：Circulation

authors： McCue CM,Mantakas ME,Tingelstad JB,Ruddy S

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND:Extrahepatic tissues have long been considered critical contributors of cholesterol to nascent HDL particles in the reverse cholesterol transport pathway, in which ABCA1 plays the crucial role. Recent studies, however, including both overexpression and deletion of ABCA1 selectively in the liver, have highlig...

journal_title：Circulation

authors： Singaraja RR,Van Eck M,Bissada N,Zimetti F,Collins HL,Hildebrand RB,Hayden A,Brunham LR,Kang MH,Fruchart JC,Van Berkel TJ,Parks JS,Staels B,Rothblat GH,Fiévet C,Hayden MR

更新日期：2006-09-19 00:00:00

abstract：BACKGROUND:We sought to separately examine the effects of either weight loss or diets varying in protein content and glycemic index without further changes in body weight on cardiovascular risk factors within the Diet, Obesity, and Genes study (DiOGenes). METHODS AND RESULTS:DiOGenes is a pan-European controlled dieta...

journal_title：Circulation

authors： Gögebakan O,Kohl A,Osterhoff MA,van Baak MA,Jebb SA,Papadaki A,Martinez JA,Handjieva-Darlenska T,Hlavaty P,Weickert MO,Holst C,Saris WH,Astrup A,Pfeiffer AF,DiOGenes.

更新日期：2011-12-20 00:00:00

abstract：BACKGROUND:Anisotropy creates nonuniformity in electrical propagation and may contribute to the occurrence of unidirectional conduction block and reentry. We describe the characteristics of reentrant tachycardia in a 2D layer of anisotropic ventricular myocardium. METHODS AND RESULTS:A Langendorff-perfused epicardial ...

journal_title：Circulation

authors： Schalij MJ,Boersma L,Huijberts M,Allessie MA

更新日期：2000-11-21 00:00:00

abstract：BACKGROUND:The cardiovascular adaptation to bed rest leads to orthostatic intolerance, characterized by an excessive fall in stroke volume (SV) in the upright position. We hypothesized that this large fall in SV is due to a change in cardiac mechanics. METHODS AND RESULTS:We measured pulmonary capillary wedge pressure...

journal_title：Circulation

authors： Levine BD,Zuckerman JH,Pawelczyk JA

更新日期：1997-07-15 00:00:00

abstract：:The concept of plaque stabilization was developed to explain how lipid lowering could decrease adverse coronary events without a substantial reduction in the regression of atherosclerosis. Plaques were stabilized by reducing serum cholesterol leading to several favorable pathobiological changes in the vessel wall of l...

journal_title：Circulation

authors： Ambrose JA,Martinez EE

更新日期：2002-04-23 00:00:00

abstract：BACKGROUND:Myocardial salvage is most likely to occur when thrombolytic therapy is administered within 4 to 6 hours of the onset of symptoms of myocardial infarction. The impact of delays within this early time period on final myocardial infarct size are unknown. The purpose of this study was to quantitate the relation...

journal_title：Circulation

authors： Raitt MH,Maynard C,Wagner GS,Cerqueira MD,Selvester RH,Weaver WD

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Endothelial integrity is essential for maintaining vascular homeostasis, and endothelial denudation results in neointimal thickening. Balloon-expandable endovascular stents provide a luminal scaffolding within atherosclerotic arteries with minimal direct contact between balloon and endothelium. We wondered w...

journal_title：Circulation

authors： Rogers C,Parikh S,Seifert P,Edelman ER

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results in low plasma LDL cholesterol and protection against coronary heart disease. Recent evidence indicates that PCSK9 also modulates the metabo...

journal_title：Circulation

authors： Rashid S,Tavori H,Brown PE,Linton MF,He J,Giunzioni I,Fazio S

更新日期：2014-07-29 00:00:00

abstract：:Prior studies have demonstrated the presence of inhomogeneities in myocardial [K+]e after serial 10-minute occlusions of the left anterior descending coronary artery in the pig, even within restricted locations of an ischemic zone. These inhomogeneities are thought to underlie the electrophysiological abnormalities re...

journal_title：Circulation

authors： Johnson TA,Engle CL,Boyd LM,Koch GG,Gwinn M,Gettes LS

更新日期：1991-02-01 00:00:00

abstract：:The National Heart, Lung, and Blood Institute and Office of Rare Diseases at the National Institutes of Health organized a workshop (September 14 to 15, 2006, in Bethesda, Md) to advise on new research directions needed for improved identification and treatment of rare inherited arrhythmias. These included the followi...

journal_title：Circulation

authors： Lehnart SE,Ackerman MJ,Benson DW Jr,Brugada R,Clancy CE,Donahue JK,George AL Jr,Grant AO,Groft SC,January CT,Lathrop DA,Lederer WJ,Makielski JC,Mohler PJ,Moss A,Nerbonne JM,Olson TM,Przywara DA,Towbin JA,Wang LH,M

更新日期：2007-11-13 00:00:00

abstract：BACKGROUND:Intermittent claudication (IC) is associated with an increased risk of cardiovascular disease morbidity and mortality. The relation of alcohol consumption to the risk of IC remains controversial. The purpose of this study was to assess the relation of alcohol consumption and type of beverage to the developme...

journal_title：Circulation

authors： Djoussé L,Levy D,Murabito JM,Cupples LA,Ellison RC

更新日期：2000-12-19 00:00:00

abstract：:To assess whether gross pathologic differences exist between hearts with left bundle branch block (LBBB) and left-axis deviation (LAXD) and those with LBBB and a normal frontal plane axis, we examined 70 hearts with LBBB in a series of 1410 sequential dissections (5%). Thirty-two hearts had LAXD and 34 had normal axes...

journal_title：Circulation

authors： Havelda CJ,Sohi GS,Flowers NC,Horan LG

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:Oxidized LDL (oxLDL) is thought to play a key role in the inflammatory response in the arterial vessel wall. METHODS AND RESULTS:In a prospective, nested, case-control study, the association between plasma oxLDL and risk of an acute coronary heart disease (CHD) event was investigated in men without prevalen...

journal_title：Circulation

authors： Meisinger C,Baumert J,Khuseyinova N,Loewel H,Koenig W

更新日期：2005-08-02 00:00:00

abstract：BACKGROUND:Protease-activated receptor-1 (PAR-1) is the high-affinity receptor for the coagulation protease thrombin. It is expressed by a variety of cell types in the heart, including cardiomyocytes and cardiac fibroblasts. We have shown that tissue factor (TF) and thrombin contribute to infarct size after cardiac isc...

journal_title：Circulation

authors： Pawlinski R,Tencati M,Hampton CR,Shishido T,Bullard TA,Casey LM,Andrade-Gordon P,Kotzsch M,Spring D,Luther T,Abe J,Pohlman TH,Verrier ED,Blaxall BC,Mackman N

更新日期：2007-11-13 00:00:00

abstract：BACKGROUND:Chronic orthostatic intolerance (OI) is characterized by symptoms of inadequate cerebral perfusion with standing, in the absence of significant orthostatic hypotension. A heart rate increase of >/=30 bpm is typical. Possible underlying pathophysiologies include hypovolemia, partial dysautonomia, or a primary...

journal_title：Circulation

authors： Jacob G,Shannon JR,Costa F,Furlan R,Biaggioni I,Mosqueda-Garcia R,Robertson RM,Robertson D

更新日期：1999-04-06 00:00:00

abstract：BACKGROUND:Preconditioning protects the myocardium from ischemia and may be a potent means of endogenous cardioprotection during cardioplegic arrest and rewarming. However, fundamental mechanisms that potentially contribute to the beneficial effects of preconditioning during cardioplegic arrest and rewarming remain unc...

journal_title：Circulation

authors： O SJ,Zellner JL,Cox MH,Hebbar L,Brothers TE,Mukherjee R,Tempel GE,Dorman BH,Crawford FA Jr,Spinale FG

更新日期：1996-11-01 00:00:00

abstract：:From January 1968 to June 1975 tricuspid regurgitation was encountered in 238 patients of a total of 1074 patients undergoing operations on the mitral valve. During this time tricuspid annuloplasty (TA) was performed in 137 patients and the tricuspid valve was replaced (TVR) in 101 patients. Comparison of hospital mor...

journal_title：Circulation

authors： Reed GE,Boyd AD,Spencer FC,Engelman RM,Isom OW,Cunningham JN Jr

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:The results of angiographic studies have suggested that calcium channel-blocking agents may prevent new coronary lesion formation, the progression of minimal lesions, or both. METHODS AND RESULTS:The Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT) was a multicenter, rand...

journal_title：Circulation

authors： Pitt B,Byington RP,Furberg CD,Hunninghake DB,Mancini GB,Miller ME,Riley W

更新日期：2000-09-26 00:00:00

abstract：BACKGROUND:Observational studies suggest that there are differences in adherence to antihypertensive medications in different classes. Our objective was to quantify the association between antihypertensive drug class and adherence in clinical settings. METHODS AND RESULTS:Studies were identified through a systematic s...

journal_title：Circulation

authors： Kronish IM,Woodward M,Sergie Z,Ogedegbe G,Falzon L,Mann DM

更新日期：2011-04-19 00:00:00

abstract：BACKGROUND:Comprehensive data based on single-beat analysis of the ventricular activation sequence during sinus rhythm in infarcted hearts are currently not available. It was the aim of our study (1) to measure and analyze these activation sequences on the epicardial surface of the right and left ventricles and on the ...

journal_title：Circulation

authors： Hatala R,Savard P,Tremblay G,Pagé P,Cardinal R,Molin F,Kus T,Nadeau R

更新日期：1995-03-01 00:00:00

abstract：:Purine compounds modulate sympathetic neurotransmission; this modulation decreases nervous discharge by stimulating presynaptic inhibitory adenosine receptors, an effect antagonized by theophylline, and causes vasoconstriction through the stimulation of postsynaptic ATP receptors. In humans we evaluated the effect of ...

journal_title：Circulation

authors： Taddei S,Pedrinelli R,Salvetti A

更新日期：1990-12-01 00:00:00

abstract：:Over a 3 year period we evaluated 23 patients (16 men, seven women) with apical hypertrophic cardiomyopathy by noninvasive and invasive methods. Sixteen patients had chest pain. In 17, results of cardiovascular examination were normal. The electrocardiogram showed precordial inverted T waves in all patients and these ...

journal_title：Circulation

authors： Keren G,Belhassen B,Sherez J,Miller HI,Megidish R,Berenfeld D,Laniado S

更新日期：1985-01-01 00:00:00

abstract：:The effect of acute alterations in coronary blood flow (CBF) on left ventricular (LV) end-diastolic wall thickness was measured by reflected ultrasound in twelve anesthetized dogs. During five minutes of coronary ligation, wall thickness decreased from a control of 9.0 +/- 0.3 mm to 8.1 +/- 0.3 mm (P less than 0.001);...

journal_title：Circulation

authors： Gaasch WH,Bernard SA

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:Temporal trends regarding the epidemiology of atherosclerotic renovascular disease (ARVD) in dialysis populations are poorly defined. METHODS AND RESULTS:United States Renal Data System data were used to identify patients aged 67 years or older at dialysis inception between 1996 and 2001 (n=146,973). Medica...

journal_title：Circulation

authors： Guo H,Kalra PA,Gilbertson DT,Liu J,Chen SC,Collins AJ,Foley RN

更新日期：2007-01-02 00:00:00

abstract：BACKGROUND:Recurrent cerebrovascular events constitute an estimated 200,000 of the 700,000 strokes reported annually in the United States, which makes secondary stroke prevention an important goal in the management of disease among patients who have experienced stroke or transient ischemic attack. METHODS AND RESULTS:...

journal_title：Circulation

authors： Liao JK

更新日期：2007-03-27 00:00:00

abstract：BACKGROUND:Sharing of patient-level clinical trial data has been widely endorsed. Little is known about how extensively these data have been used for cardiometabolic diseases. We sought to evaluate the availability and use of shared data from cardiometabolic clinical trials. METHODS:We extracted data from ClinicalStud...

journal_title：Circulation

authors： Vaduganathan M,Nagarur A,Qamar A,Patel RB,Navar AM,Peterson ED,Bhatt DL,Fonarow GC,Yancy CW,Butler J

更新日期：2018-02-27 00:00:00

abstract：BACKGROUND:Serum paraoxonase (PON1), an enzyme carried on HDL, inhibits LDL oxidation, and in human population studies, low PON1 activity is associated with atherosclerosis. In addition, PON1 knockout mice are more susceptible to lipoprotein oxidation and atherosclerosis. To evaluate whether PON1 protects against ather...

journal_title：Circulation

authors： Tward A,Xia YR,Wang XP,Shi YS,Park C,Castellani LW,Lusis AJ,Shih DM

更新日期：2002-07-23 00:00:00

abstract：BACKGROUND:Granulocyte-colony stimulating factor (G-CSF) after myocardial infarction does not affect systolic function when compared with placebo. In contrast, intracoronary infusion of bone marrow cells appears to improve ejection fraction. We aimed to evaluate the G-CSF mobilization of subsets of stem cells. METHODS...

journal_title：Circulation

authors： Ripa RS,Haack-Sørensen M,Wang Y,Jørgensen E,Mortensen S,Bindslev L,Friis T,Kastrup J

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:Two phase III trials of enoxaparin for unstable angina/non-Q-wave myocardial infarction have shown it to be superior to unfractionated heparin for preventing a composite of death and cardiac ischemic events. A prospectively planned meta-analysis was performed to provide a more precise estimate of the effects...

journal_title：Circulation

authors： Antman EM,Cohen M,Radley D,McCabe C,Rush J,Premmereur J,Braunwald E

更新日期：1999-10-12 00:00:00